Search Results - "SKYLER, JAY S."

Prevention and reversal of type 1 diabetes--past challenges and future opportunities by Skyler, Jay S

“…Over the past three decades there have been a number of clinical trials directed at interdicting the type 1 diabetes (T1D) disease process in an attempt to…”
Get full text

Empagliflozin as Adjunctive to Insulin Therapy in Type 1 Diabetes: The EASE Trials by Rosenstock, Julio, Marquard, Jan, Laffel, Lori M, Neubacher, Dietmar, Kaspers, Stefan, Cherney, David Z, Zinman, Bernard, Skyler, Jay S, George, Jyothis, Soleymanlou, Nima, Perkins, Bruce A

“…To evaluate the safety and efficacy of empagliflozin 10- and 25-mg doses plus a unique lower dose (2.5 mg) as adjunct to intensified insulin in patients with…”
Get full text

The management of type 1 diabetes in adults. A consensus report by the American Diabetes Association (ADA) and the European Association for the Study of Diabetes (EASD) by Holt, Richard I. G., DeVries, J. Hans, Hess-Fischl, Amy, Hirsch, Irl B., Kirkman, M. Sue, Klupa, Tomasz, Ludwig, Barbara, Nørgaard, Kirsten, Pettus, Jeremy, Renard, Eric, Skyler, Jay S., Snoek, Frank J., Weinstock, Ruth S., Peters, Anne L.

“…The American Diabetes Association (ADA) and the European Association for the Study of Diabetes (EASD) convened a writing group to develop a consensus statement…”
Get full text

The artificial pancreas: current status and future prospects in the management of diabetes by Peyser, Thomas, Dassau, Eyal, Breton, Marc, Skyler, Jay S.

“…Recent advances in insulins, insulin pumps, continuous glucose‐monitoring systems, and control algorithms have resulted in an acceleration of progress in the…”
Get full text

Differentiation of Diabetes by Pathophysiology, Natural History, and Prognosis by Skyler, Jay S, Bakris, George L, Bonifacio, Ezio, Darsow, Tamara, Eckel, Robert H, Groop, Leif, Groop, Per-Henrik, Handelsman, Yehuda, Insel, Richard A, Mathieu, Chantal, McElvaine, Allison T, Palmer, Jerry P, Pugliese, Alberto, Schatz, Desmond A, Sosenko, Jay M, Wilding, John P H, Ratner, Robert E

“…The American Diabetes Association, JDRF, the European Association for the Study of Diabetes, and the American Association of Clinical Endocrinologists convened…”
Get full text

Staging presymptomatic type 1 diabetes: a scientific statement of JDRF, the Endocrine Society, and the American Diabetes Association by Insel, Richard A, Dunne, Jessica L, Atkinson, Mark A, Chiang, Jane L, Dabelea, Dana, Gottlieb, Peter A, Greenbaum, Carla J, Herold, Kevan C, Krischer, Jeffrey P, Lernmark, Åke, Ratner, Robert E, Rewers, Marian J, Schatz, Desmond A, Skyler, Jay S, Sosenko, Jay M, Ziegler, Anette-G

“…Insights from prospective, longitudinal studies of individuals at risk for developing type 1 diabetes have demonstrated that the disease is a continuum that…”
Get full text

The effect of age on longitudinal measures of beta cell function and insulin sensitivity during the progression of early stage type 1 diabetes by Ferrannini, Ele, Mari, Andrea, Monaco, Gabriela S. F., Skyler, Jay S., Evans-Molina, Carmella

“…Aim/hypothesis The risk of progressing from autoantibody positivity to type 1 diabetes is inversely related to age. Separately, whether age influences patterns…”
Get full text

Toward Primary Prevention of Type 1 Diabetes by Skyler, Jay S

“…The incidence of type 1 diabetes has been progressively increasing during the past several decades, particularly among children younger than 5 years. At the…”
Get full text

Co-stimulation modulation with abatacept in patients with recent-onset type 1 diabetes: a randomised, double-blind, placebo-controlled trial by Orban, Tihamer, MD, Bundy, Brian, PhD, Becker, Dorothy J, Prof, DiMeglio, Linda A, MD, Gitelman, Stephen E, Prof, Goland, Robin, Prof, Gottlieb, Peter A, Prof, Greenbaum, Carla J, MD, Marks, Jennifer B, Prof, Monzavi, Roshanak, MD, Moran, Antoinette, Prof, Raskin, Philip, Prof, Rodriguez, Henry, Prof, Russell, William E, Prof, Schatz, Desmond, Prof, Wherrett, Diane, MD, Wilson, Darrell M, Prof, Krischer, Jeffrey P, Prof, Skyler, Jay S, Dr, Prof

“…Summary Background The immunopathogenesis of type 1 diabetes mellitus is associated with T-cell autoimmunity. To be fully active, immune T cells need a…”
Get full text

Antigen-based therapy with glutamic acid decarboxylase (GAD) vaccine in patients with recent-onset type 1 diabetes: a randomised double-blind trial by Wherrett, Diane K, MD, Bundy, Brian, PhD, Becker, Dorothy J, Prof, DiMeglio, Linda A, MD, Gitelman, Stephen E, Prof, Goland, Robin, Prof, Gottlieb, Peter A, Prof, Greenbaum, Carla J, MD, Herold, Kevan C, Prof, Marks, Jennifer B, Prof, Monzavi, Roshanak, MD, Moran, Antoinette, Prof, Orban, Tihamer, MD, Palmer, Jerry P, MD, Raskin, Philip, Prof, Rodriguez, Henry, Prof, Schatz, Desmond, Prof, Wilson, Darrell M, Prof, Krischer, Jeffrey P, Prof, Skyler, Jay S, Dr, Prof

“…Summary Background Glutamic acid decarboxylase (GAD) is a major target of the autoimmune response that occurs in type 1 diabetes mellitus. In animal models of…”
Get full text

Phenotypes Associated With Zones Defined by Area Under the Curve Glucose and C-peptide in a Population With Islet Autoantibodies by Sosenko, Jay M, Cuthbertson, David, Sims, Emily K, Ismail, Heba M, Nathan, Brandon M, Jacobsen, Laura M, Atkinson, Mark A, Evans-Molina, Carmella, Herold, Kevan C, Skyler, Jay S, Redondo, Maria J

“…Metabolic zones were developed to characterize heterogeneity of individuals with islet autoantibodies. Baseline 2-h oral glucose tolerance test data from 6,620…”
Get full text

Pancreatic Islet Autoantibodies as Predictors of Type 1 Diabetes in the Diabetes Prevention Trial-Type 1 by Orban, Tihamer, Sosenko, Jay M, Cuthbertson, David, Krischer, Jeffrey P, Skyler, Jay S, Jackson, Richard, Yu, Liping, Palmer, Jerry P, Schatz, Desmond, Eisenbarth, George

“…OBJECTIVE: There is limited information from large-scale prospective studies regarding the prediction of type 1 diabetes by specific types of pancreatic islet…”
Get full text

Progression to Diabetes in Relatives of Type 1 Diabetic Patients: Mechanisms and Mode of Onset by FERRANNINI, Ele, MARI, Andrea, NOFRATE, Valentina, SOSENKO, Jay M, SKYLER, Jay S

“…Relatives of type 1 diabetic patients are at enhanced risk of developing diabetes. We investigated the mode of onset of hyperglycemia and how insulin…”
Get full text

Novel therapies with precision mechanisms for type 2 diabetes mellitus by Perreault, Leigh, Skyler, Jay S., Rosenstock, Julio

“…Type 2 diabetes mellitus (T2DM) is one of the greatest health crises of our time and its prevalence is projected to increase by >50% globally by 2045…”
Get full text

Discovery of Phosphorylated Peripherin as a Major Humoral Autoantigen in Type 1 Diabetes Mellitus by Doran, Todd M, Morimoto, Jumpei, Simanski, Scott, Koesema, Eric J, Clark, Lorraine F, Pels, Kevin, Stoops, Sydney L, Pugliese, Alberto, Skyler, Jay S, Kodadek, Thomas

“…A major goal in understanding autoimmune diseases is to define the antigens that elicit a self-destructive immune response, but this is a difficult endeavor…”
Get more information

Effect of rituximab on human in vivo antibody immune responses by Pescovitz, Mark D., MD, Torgerson, Troy R., MD, PhD, Ochs, Hans D., MD, Dr Med, Ocheltree, Elizabeth, BS, McGee, Paula, MS, Krause-Steinrauf, Heidi, MS, Lachin, John M., ScD, Canniff, Jennifer, BS, Greenbaum, Carla, MD, Herold, Kevan C., MD, Skyler, Jay S., MD, Weinberg, Adriana, MD

“…Background B-lymphocyte depletion with rituximab has been shown to benefit patients with various autoimmune diseases. We have previously demonstrated that this…”
Get full text

Hope vs hype: where are we in type 1 diabetes? by Skyler, Jay S.

“…Much progress has been made in type 1 diabetes research. Biological replacement of islet function has been achieved with pancreas transplantation and with…”
Get full text

Two-Year Safety and Efficacy of Inhaled Human Insulin (Exubera) in Adult Patients With Type 1 Diabetes by Skyler, Jay S, Jovanovic, Lois, Klioze, Sol, Reis, Joann, Duggan, William

“…OBJECTIVE:--The purpose of this study was to evaluate the long-term (2-year) safety and efficacy of inhaled human insulin (Exubera [insulin human (rDNA…”
Get full text

Weekly Insulin Becoming a Reality by Skyler, Jay S.

“…Buoyed by the successful use of once-weekly glucagon-like peptide 1 receptor agonists (GLP-1 RA) for the treatment of type 2 diabetes, manufacturers have begun…”
Get full text

The TrialNet Natural History Study of the Development of Type 1 Diabetes: objectives, design, and initial results by Mahon, Jeffrey L, Sosenko, Jay M, Rafkin-Mervis, Lisa, Krause-Steinrauf, Heidi, Lachin, John M, Thompson, Clinton, Bingley, Polly J, Bonifacio, Ezio, Palmer, Jerry P, Eisenbarth, George S, Wolfsdorf, Joseph, Skyler, Jay S

“…Objectives:  TrialNet’s goal to test preventions for type 1 diabetes has created an opportunity to gain new insights into the natural history of pre‐type 1…”
Get full text