Search Results - "SKWARCHUK, M. W"

Late rectal toxicity after conformal radiotherapy of prostate cancer (I): multivariate analysis and dose-response by Skwarchuk, M W, Jackson, A, Zelefsky, M J, Venkatraman, E S, Cowen, D M, Levegrün, S, Burman, C M, Fuks, Z, Leibel, S A, Ling, C C

“…The purpose of this paper is to use the outcome of a dose escalation protocol for three-dimensional conformal radiation therapy (3D-CRT) of prostate cancer to…”
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Changes in histology and fibrogenic cytokines in irradiated colorectum of two murine strains by Skwarchuk, M W, Travis, E L

“…A strain difference in the development of radiation-induced fibrosis of the colorectum was recently observed. C57B1/6 mice developed colorectal obstruction…”
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Analysis of biopsy outcome after three-dimensional conformal radiation therapy of prostate cancer using dose-distribution variables and tumor control probability models by Levegrün, S, Jackson, A, Zelefsky, M J, Venkatraman, E S, Skwarchuk, M W, Schlegel, W, Fuks, Z, Leibel, S A, Ling, C C

“…To investigate tumor control following three-dimensional conformal radiation therapy (3D-CRT) of prostate cancer and to identify dose-distribution variables…”
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The cytotoxicity of melphalan and its relationship to pH, hypoxia and drug uptake by Skarsgard, L D, Skwarchuk, M W, Vinczan, A, Kristl, J, Chaplin, D J

“…In the present in vitro studies we examined the effect of hypoxia and acidic pH, two important consequences of reduced blood flow in vivo, on the cytotoxicity…”
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Murine strain differences in the volume effect and incidence of radiation-induced colorectal obstruction by Skwarchuk, M W, Travis, E L

“…Interindividual variation in the level of normal tissue damage after radiotherapy has been clinically observed. Murine models have suggested that there may be…”
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Disruption of Dag1 in Differentiated Skeletal Muscle Reveals a Role for Dystroglycan in Muscle Regeneration by Cohn, Ronald D., Henry, Michael D., Michele, Daniel E., Barresi, Rita, Saito, Fumiaki, Moore, Steven A., Flanagan, Jason D., Skwarchuk, Mark W., Robbins, Michael E., Mendell, Jerry R., Williamson, Roger A., Campbell, Kevin P.

“…Striated muscle-specific disruption of the dystroglycan (DAG1) gene results in loss of the dystrophin-glycoprotein complex in differentiated muscle and a…”
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Volume Effects and Epithelial Regeneration in Irradiated Mouse Colorectum by Skwarchuk, Mark W., Travis, Elizabeth L.

“…The use of three-dimensional treatment planning and volume-reduction techniques in radiotherapy has prompted the development of a number of mathematical models…”
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Substructure in the Radiation Survival Response at Low Dose in Cells of Human Tumor Cell Lines by Skarsgard, Lloyd D., Skwarchuk, Mark W., Wouters, Bradly G., Durand, Ralph E.

“…In earlier studies using asynchronously growing Chinese hamster cells, we observed substructure in the survival response at low doses. The substructure…”
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The Survival of Asynchronous V79 Cells at Low Radiation Doses: Modeling the Response of Mixed Cell Populations by Skarsgard, L. D., Skwarchuk, M. W., Wouters, B. G.

“…We have observed that when a single linear-quadratic (LQ) function is used to fit the radiation survival response of an asynchronously dividing population of…”
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The effect of pH on the aerobic and hypoxic cytotoxicity of SR4233 in HT-29 cells by SKARSGARD, L. D, SKWARCHUK, M. W, VINCZAN, A, CHAPLIN, D. J

“…We have observed that low pH can substantially potentiate the cytotoxic effect of the bioreductive drug SR4233 in aerobic HT-29 human tumour cells. No such…”
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Substructure in the radiation survival response at low dose: asynchronous and partially synchronized V79-WNRE cells by Skwarchuk, M W, Wouters, B G, Skarsgard, L D

“…The radiation survival response of asynchronously-dividing populations of the cell line V79-WNRE indicates substructure in the low dose region that can be…”
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Fitting tumor control probability models to biopsy outcome after three-dimensional conformal radiation therapy of prostate cancer: pitfalls in deducing radiobiologic parameters for tumors from clinical data by Levegrün, S, Jackson, A, Zelefsky, M J, Skwarchuk, M W, Venkatraman, E S, Schlegel, W, Fuks, Z, Leibel, S A, Ling, C C

“…The goal of tumor control probability (TCP) models is to predict local control for inhomogeneous dose distributions. All existing fits of TCP models to…”
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The effect of low pH and hypoxia on the cytotoxic effects of SR4233 and mitomycin C in vitro by Skarsgard, L D, Vinczan, A, Skwarchuk, M W, Chaplin, D J

“…We examined the effect of acidic pH and hypoxia on the cytotoxicity of SR4233 and mitomycin C in vitro. The importance of tumor microenvironment to the…”
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The effect of hypoxia and low pH on the cytotoxicity of chlorambucil by Skarsgard, L D, Chaplin, D J, Wilson, D J, Skwarchuk, M W, Vinczan, A, Kristl, J

“…Studies with mouse tumors have shown that the effectiveness of certain chemotherapeutic agents can be enhanced if they are used in appropriate combination with…”
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The use of radiochromic film to measure dose distributions resulting from high dose rate 192Iridium single catheter treatments by Skwarchuk, M W, Ochran, T G, Komaki, R, Cundiff, J, Travis, E L

“…Radiochromic film was used to measure and compare the dose distributions parallel to a high dose rate (HDR) 192Iridium (192Ir) brachytherapy afterloading…”
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High dose rate (HDR) and low dose rate (LDR) interstitial irradiation (IRT) of the rat spinal cord by Pop, Lucas A.M., van der Plas, Mirjam, Skwarchuk, Mark W., Hanssen, Alex E.J., van der Kogel, Albert J.

“…Purpose: To describe a newly developed technique to study radiation tolerance of rat spinal cord to continuous interstitial irradiation (IRT) at different dose…”
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Risk group dependence of dose–response for biopsy outcome after three-dimensional conformal radiation therapy of prostate cancer by Levegrün, Sabine, Jackson, Andrew, Zelefsky, Michael J, Venkatraman, Ennapadam S, Skwarchuk, Mark W, Schlegel, Wolfgang, Fuks, Zvi, Leibel, Steven A, Ling, C.Clifton

“…Background and purpose: We fit phenomenological tumor control probability (TCP) models to biopsy outcome after three-dimensional conformal radiation therapy…”
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Does prone positioning reduce small bowel dose in pelvic radiation with intensity-modulated radiotherapy for gynecologic cancer? by Adli, Mustafa, Mayr, Nina A, Kaiser, Heather S, Skwarchuk, Mark W, Meeks, Sanford L, Mardirossian, George, Paulino, Arnold C, Montebello, Joseph F, Gaston, Robert C, Sorosky, Joel I, Buatti, John M

“…Intensity-modulated radiotherapy (IMRT) has been shown to reduce the radiation dose to small bowel in pelvic RT in gynecology patients. Prone positioning has…”
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Late rectal bleeding after conformal radiotherapy of prostate cancer. II. Volume effects and dose-volume histograms by Jackson, A, Skwarchuk, M W, Zelefsky, M J, Cowen, D M, Venkatraman, E S, Levegrun, S, Burman, C M, Kutcher, G J, Fuks, Z, Liebel, S A, Ling, C C

“…Late rectal bleeding is a potentially dose limiting complication of three-dimensional conformal radiotherapy (3D-CRT) for prostate cancer. The frequency of…”
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In vivo determination of extra-target doses received from serial tomotherapy by Meeks, Sanford L., Paulino, Arnold C., Pennington, Edward C., Simon, James H., Skwarchuk, Mark W., Buatti, John M.

“…Background and purpose: The purpose of this study was to perform in-vivo measurements of extracranial doses received by patients undergoing serial tomotherapy…”
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