Search Results - "SKULACHEV, M. V"

Mitochondrion-targeted antioxidant SkQ1 prevents rapid animal death caused by highly diverse shocks by Skulachev, V. P., Vyssokikh, M. Yu, Chernyak, B. V., Averina, O. A., Andreev-Andrievskiy, A. A., Zinovkin, R. A., Lyamzaev, K. G., Marey, M. V., Egorov, M. V., Frolova, O. J., Zorov, D. B., Skulachev, M. V., Sadovnichii, V. A.

“…The response to stress involves the activation of pathways leading either to protection from the stress origin, eventually resulting in development of stress…”
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Design, synthesis, and some aspects of the biological activity of mitochondria-targeted antioxidants by Korshunova, G. A., Shishkina, A. V., Skulachev, M. V.

“…This review summarizes for the first time data on the design and synthesis of biologically active compounds of a new generation–mitochondria-targeted…”
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Mitochondrial-targeted plastoquinone derivatives. Effect on senescence and acute age-related pathologies by Skulachev, M V, Antonenko, Y N, Anisimov, V N, Chernyak, B V, Cherepanov, D A, Chistyakov, V A, Egorov, M V, Kolosova, N G, Korshunova, G A, Lyamzaev, K G, Plotnikov, E Y, Roginsky, V A, Savchenko, A Y, Severina, I I, Severin, F F, Shkurat, T P, Tashlitsky, V N, Shidlovsky, K M, Vyssokikh, M Y, Zamyatnin, Jr, A A, Zorov, D B, Skulachev, V P

“…Plastoquinone, a very effective electron carrier and antioxidant of chloroplasts, was conjugated with decyltriphenylphosphonium to obtain a cation easily…”
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Mitochondria-targeted plastoquinone derivatives as tools to interrupt execution of the aging program. 1. Cationic plastoquinone derivatives: Synthesis and in vitro studies by Antonenko, Y. N, Avetisyan, A. V, Bakeeva, L. E, Chernyak, B. V, Chertkov, V. A, Domnina, L. V, Ivanova, O. Yu, Izyumov, D. S, Khailova, L. S, Klishin, S. S, Korshunova, G. A, Lyamzaev, K. G, Muntyan, M. S, Nepryakhina, O. K, Pashkovskaya, A. A, Pletjushkina, O. Yu, Pustovidko, A. V, Roginsky, V. A, Rokitskaya, T. I, Ruuge, E. K, Saprunova, V. B, Severina, I. I, Simonyan, R. A, Skulachev, I. V, Skulachev, M. V, Sumbatyan, N. V, Sviryaeva, I. V, Tashlitsky, V. N, Vassiliev, J. M, Vyssokikh, M. Yu, Yaguzhinsky, L. S, Zamyatnin, A. A. Jr, Skulachev, V. P

“…Synthesis of cationic plastoquinone derivatives (SkQs) containing positively charged phosphonium or rhodamine moieties connected to plastoquinone by decane or…”
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Mitochondria-targeted plastoquinone derivatives as tools to interrupt execution of the aging program. 2. Treatment of some ROS- and Age-related diseases (heart arrhythmia, heart infarctions, kidney ischemia, and stroke) by Bakeeva, L. E., Barskov, I. V., Egorov, M. V., Isaev, N. K., Kapelko, V. I., Kazachenko, A. V., Kirpatovsky, V. I., Kozlovsky, S. V., Lakomkin, V. L., Levina, S. B., Pisarenko, O. I., Plotnikov, E. Y., Saprunova, V. B., Serebryakova, L. I., Skulachev, M. V., Stelmashook, E. V., Studneva, I. M., Tskitishvili, O. V., Vasilyeva, A. K., Victorov, I. V., Zorov, D. B., Skulachev, V. P.

“…Effects of 10-(6′-plastoquinonyl) decyltriphenylphosphonium (SkQ1) and 10-(6′-plastoquinonyl) decylrhod-amine 19 (SkQR1) on rat models of H 2 O 2 - and…”
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Mitochondria-targeted plastoquinone derivatives as tools to interrupt execution of the aging program. 4. Age-related eye disease. SkQ1 returns vision to blind animals by Neroev, V. V, Archipova, M. M, Bakeeva, L. E, Fursova, A. Zh, Grigorian, E. N, Grishanova, A. Yu, Iomdina, E. N, Ivashchenko, Zh. N, Katargina, L. A, Khoroshilova-Maslova, I. P, Kilina, O. V, Kolosova, N. G, Kopenkin, E. P, Korshunov, S. S, Kovaleva, N. A, Novikova, Yu. P, Philippov, P. P, Pilipenko, D. I, Robustova, O. V, Saprunova, V. B, Senin, I. I, Skulachev, M. V, Sotnikova, L. F, Stefanova, N. A, Tikhomirova, N. K, Tsapenko, I. V, Shchipanova, A. I, Zinovkin, R. A, Skulachev, V. P

“…Mitochondria-targeted cationic plastoquinone derivative SkQ1 (10-(6'-plastoquinonyl) decyltriphenylphosphonium) has been investigated as a potential tool for…”
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Mitochondria-targeted plastoquinone derivatives as tools to interrupt execution of the aging program. 3. Inhibitory effect of SkQ1 on tumor development from p53-deficient cells by Agapova, L. S, Chernyak, B. V, Domnina, L. V, Dugina, V. B, Efimenko, A. Yu, Fetisova, E. K, Ivanova, O. Yu, Kalinina, N. I, Khromova, N. V, Kopnin, B. P, Kopnin, P. B, Korotetskaya, M. V, Lichinitser, M. R, Lukashev, A. L, Pletjushkina, O. Yu, Popova, E. N, Skulachev, M. V, Shagieva, G. S, Stepanova, E. V, Titova, E. V, Tkachuk, V. A, Vasiliev, J. M, Skulachev, V. P

“…It was proposed that increased level of mitochondrial reactive oxygen species (ROS), mediating execution of the aging program of an organism, could also be…”
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Programmed aging of mammals: Proof of concept and prospects of biochemical approaches for anti-aging therapy by Skulachev, M. V., Skulachev, V. P.

“…(i) In 2015-2017 we compared possible reasons for longevity of two mammalian highly social species, i.e. naked mole rats and humans. We proposed that in both…”
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Stability of plant mRNAs depends on the length of the 3'-untranslated region by Schwartz, A M, Komarova, T V, Skulachev, M V, Zvereva, A S, Dorokhov, Iu L, Atabekov, J G

“…Eukaryotic mRNAs that prematurely terminate translation are recognized and degraded by nonsense mediated decay (NMD). This degradation pathway is well studied…”
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internal ribosome entry site located upstream of the crucifer-infecting tobamovirus coat protein (CP) gene can be used for CP synthesis in vivo by Dorokhov, Y.L, Ivanov, P.A, Komarova, T.V, Skulachev, M.V, Atabekov, J.G

“…It was previously shown that, unlike the type member of the genus Tobamovirus (TMV U1), a crucifer-infecting tobamovirus (crTMV) contains a 148 nt internal…”
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New viral vector for efficient production of target proteins in plants by Komarova, T V, Skulachev, M V, Zvereva, A S, Schwartz, A M, Dorokhov, Yu L, Atabekov, J G

“…A new potato virus X (PVX)-based viral vector for superproduction of target proteins in plants has been constructed. The triple gene block and coat protein…”
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New data on programmed aging — slow phenoptosis by Skulachev, M. V., Skulachev, V. P.

“…This review summarizes the latest data on biochemistry and physiology of living organisms. These data suggest that aging, i.e. coordinated age-dependent…”
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Mitochondrial genome and longevity by Zinovkin, R. A., Skulachev, M. V., Skulachev, V. P.

“…The mitochondrial genome provides not only respiratory chain function, but it also ensures the impact of mitochondria on nearly all crucial metabolic…”
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The Antioxidant Effect of Mitochondrially Targeted Antioxidant SkQ1 on the Isolated Rat Heart Model by Senokosova, E. A., Krutitsky, S. S., Gruzdev, O. V., Antonova, L. V., Skulachev, M. V., Grigoriev, E. V.

“…Mitochondrially targeted antioxidants based on Skulachev ions (SkQ1) are extremely attractive for neutralizing reactive oxygen species directly in the…”
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Evidence for contribution of an internal ribosome entry site to intercellular transport of a tobamovirus by Zvereva, S.D, Ivanov, P.A, Skulachev, M.V, Klyushin, A.G, Dorokhov, Yu.L, Atabekov, J.G

“…1 Department of Virology, Moscow State University, Vorobiovy Gory Moscow 119899, Russia 2 A. N. Belozersky Institute of Physico-Chemical Biology, Moscow State…”
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Influence of 10-(6′-plastoquinonyl)decyltriphenylphosphonium (SkQ1) on oxidative status in rats with protamine sulfate-induced hyperglycemia by Voronkova, Ya. G., Popova, T. N., Agarkov, A. A., Skulachev, M. V.

“…An influence of 10-(6'-plastoquinonyl)decyltriphenylphosphonium (SkQ1) on oxidative status and activity of some antioxidant enzymes in the liver and blood…”
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Receptor regulation of senile phenoptosis by Skulachev, M. V., Severin, F. F., Skulachev, V. P.

“…Here we present a concept that considers organism aging as an additional facultative function promoting evolution, but counterproductive for an individual. We…”
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Lithium salts — Simple but magic by Plotnikov, E. Y., Silachev, D. N., Zorova, L. D., Pevzner, I. B., Jankauskas, S. S., Zorov, S. D., Babenko, V. A., Skulachev, M. V., Zorov, D. B.

“…For many decades pharmacological drugs based on lithium salts have been successfully used in psychiatry to treat bipolar disorder, and they remain the “gold…”
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Mitochondria-targeted plastoquinone derivatives as tools to interrupt execution of the aging program. 5. SkQ1 prolongs lifespan and prevents development of traits of senescence by Anisimov, V. N., Bakeeva, L. E., Egormin, P. A., Filenko, O. F., Isakova, E. F., Manskikh, V. N., Mikhelson, V. M., Panteleeva, A. A., Pasyukova, E. G., Pilipenko, D. I., Piskunova, T. S., Popovich, I. G., Roshchina, N. V., Rybina, O. Yu, Saprunova, V. B., Samoylova, T. A., Semenchenko, A. V., Skulachev, M. V., Spivak, I. M., Tsybul’ko, E. A., Tyndyk, M. L., Vyssokikh, M. Yu, Yurova, M. N., Zabezhinsky, M. A., Skulachev, V. P.

“…Very low (nano- and subnanomolar) concentrations of 10-(6′-plastoquinonyl) decyltriphenylphosphonium (SkQ1) were found to prolong lifespan of a fungus (…”
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Prevention of peroxidation of cardiolipin liposomes by quinol-based antioxidants by Lokhmatikov, A. V., Voskoboynikova, N. E., Cherepanov, D. A., Sumbatyan, N. V., Korshunova, G. A., Skulachev, M. V., Steinhoff, H. -J., Skulachev, V. P., Mulkidjanian, A. Y.

“…In mammalian mitochondria, cardiolipin molecules are the primary targets of oxidation by reactive oxygen species. The interaction of oxidized cardiolipin…”
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