Search Results - "SKORPEN, Frank"

DNA methylation markers detected in blood, stool, urine, and tissue in colorectal cancer: a systematic review of paired samples by Laugsand, Eivor Alette, Brenne, Siv Sellæg, Skorpen, Frank

“…Purpose Methylated cell-free DNA in liquid biopsies are promising non-invasive biomarkers for colorectal cancer (CRC). Optimal markers would have high…”
Get full text

Health care providers underestimate symptom intensities of cancer patients: a multicenter European study by Laugsand, Eivor A, Sprangers, Mirjam A G, Bjordal, Kristin, Skorpen, Frank, Kaasa, Stein, Klepstad, Pål

“…Many patients with advanced cancer depend upon health care providers for symptom assessment. The extent of agreement between patient and provider symptom…”
Get full text

Cancer cachexia associates with a systemic autophagy-inducing activity mimicked by cancer cell-derived IL-6 trans-signaling by Pettersen, Kristine, Andersen, Sonja, Degen, Simone, Tadini, Valentina, Grosjean, Joël, Hatakeyama, Shinji, Tesfahun, Almaz N., Moestue, Siver, Kim, Jana, Nonstad, Unni, Romundstad, Pål R., Skorpen, Frank, Sørhaug, Sveinung, Amundsen, Tore, Grønberg, Bjørn H., Strasser, Florian, Stephens, Nathan, Hoem, Dag, Molven, Anders, Kaasa, Stein, Fearon, Kenneth, Jacobi, Carsten, Bjørkøy, Geir

“…The majority of cancer patients with advanced disease experience weight loss, including loss of lean body mass. Severe weight loss is characteristic for cancer…”
Get full text

The prognostic role of circulating tumour DNA detected prior to clinical diagnosis of colorectal cancer in the HUNT study by Brenne, Siv Stakset, Madsen, Poul Henning, Pedersen, Inge Søkilde, Hveem, Kristian, Skorpen, Frank, Krarup, Henrik Bygum, Xanthoulis, Athanasios, Laugsand, Eivor Alette

“…Today, the prognostic tools available at the time of diagnosis in colorectal cancer (CRC) are limited. Better prognostic tools are a prerequisite for…”
Get full text

Exploring joint effects of genes and the clinical efficacy of morphine for cancer pain: OPRM1 and COMT gene by Reyes-Gibby, Cielito C., Shete, Sanjay, Rakvåg, Trude, Bhat, Samrat V., Skorpen, Frank, Bruera, Eduardo, Kaasa, Stein, Klepstad, Pål

“…Pain is a complex human trait. It is likely that the interaction of multiple genes, each with a small individual effect, along with the effect of environmental…”
Get full text

Passive smoking in relation to lung cancer incidence and histologic types in Norwegian adults: the HUNT study by Sun, Yi-Qian, Chen, Yue, Langhammer, Arnulf, Skorpen, Frank, Wu, Chunsen, Mai, Xiao-Mei

“…Passive smoking has been proposed as a risk factor for lung cancer. The increased risks for lung cancer overall and different histologic types in relation to…”
Get full text

The Val158Met polymorphism of the human catechol -O-methyltransferase (COMT) gene may influence morphine requirements in cancer pain patients by Rakvåg, Trude Teoline, Klepstad, Pål, Baar, Cecilie, Kvam, Tor-Morten, Dale, Ola, Kaasa, Stein, Krokan, Hans Einar, Skorpen, Frank

“…Catechol- O-methyltransferase (COMT) inactivates dopamine, epinephrine and norepinephrine in the nervous system. A common functional polymorphism (Val158Met)…”
Get full text

Serum 25-hydroxyvitamin D levels and risk of lung cancer and histologic types: a Mendelian randomisation analysis of the HUNT study by Sun, Yi-Qian, Brumpton, Ben M, Bonilla, Carolina, Lewis, Sarah J, Burgess, Stephen, Skorpen, Frank, Chen, Yue, Nilsen, Tom I L, Romundstad, Pål Richard, Mai, Xiao-Mei

“…We aimed to investigate potential causal associations between serum 25-hydroxyvitamin D (25(OH)D) levels and incidence of lung cancer overall and histologic…”
Get full text

Identification of genetic polymorphisms modulating nausea and vomiting in two series of opioid-treated cancer patients by Colombo, Francesca, Pintarelli, Giulia, Galvan, Antonella, Noci, Sara, Corli, Oscar, Skorpen, Frank, Klepstad, Pål, Kaasa, Stein, Pigni, Alessandra, Brunelli, Cinzia, Roberto, Anna, Piazza, Rocco, Pirola, Alessandra, Gambacorti-Passerini, Carlo, Caraceni, Augusto Tommaso

“…Nausea and vomiting are often associated with opioid analgesia in cancer patients; however, only a subset of patients develop such side effects. Here, we…”
Get full text

Investigating the causal effect of smoking on hay fever and asthma: a Mendelian randomization meta-analysis in the CARTA consortium by Skaaby, Tea, Taylor, Amy E., Jacobsen, Rikke K., Paternoster, Lavinia, Thuesen, Betina H., Ahluwalia, Tarunveer S., Larsen, Sofus C., Zhou, Ang, Wong, Andrew, Gabrielsen, Maiken E., Bjørngaard, Johan H., Flexeder, Claudia, Männistö, Satu, Hardy, Rebecca, Kuh, Diana, Barry, Sarah J., Tang Møllehave, Line, Cerqueira, Charlotte, Friedrich, Nele, Bonten, Tobias N., Noordam, Raymond, Mook-Kanamori, Dennis O., Taube, Christian, Jessen, Leon E., McConnachie, Alex, Sattar, Naveed, Upton, Mark N., McSharry, Charles, Bønnelykke, Klaus, Bisgaard, Hans, Schulz, Holger, Strauch, Konstantin, Meitinger, Thomas, Peters, Annette, Grallert, Harald, Nohr, Ellen A., Kivimaki, Mika, Kumari, Meena, Völker, Uwe, Nauck, Matthias, Völzke, Henry, Power, Chris, Hyppönen, Elina, Hansen, Torben, Jørgensen, Torben, Pedersen, Oluf, Salomaa, Veikko, Grarup, Niels, Langhammer, Arnulf, Romundstad, Pål R., Skorpen, Frank, Kaprio, Jaakko, R Munafò, Marcus, Linneberg, Allan

“…Observational studies on smoking and risk of hay fever and asthma have shown inconsistent results. However, observational studies may be biased by confounding…”
Get full text

Association between a 15q25 gene variant, smoking quantity and tobacco-related cancers among 17 000 individuals by Lips, Esther H, Gaborieau, Valerie, McKay, James D, Chabrier, Amelie, Hung, Rayjean J, Boffetta, Paolo, Hashibe, Mia, Zaridze, David, Szeszenia-Dabrowska, Neonilia, Lissowska, Jolanta, Rudnai, Peter, Fabianova, Eleonora, Mates, Dana, Bencko, Vladimir, Foretova, Lenka, Janout, Vladimir, Field, John K, Liloglou, Triantafillos, Xinarianos, George, McLaughlin, John, Liu, Geoffrey, Skorpen, Frank, Elvestad, Maiken Bratt, Hveem, Kristian, Vatten, Lars, Study, EPIC, Benhamou, Simone, Lagiou, Pagona, Holcátová, Ivana, Merletti, Franco, Kjaerheim, Kristina, Agudo, Antonio, Castellsagué, Xavier, Macfarlane, Tatiana V, Barzan, Luigi, Canova, Cristina, Lowry, Ray, Conway, David I, Znaor, Ariana, Healy, Claire, Curado, Maria Paula, Koifman, Sergio, Eluf-Neto, Jose, Matos, Elena, Menezes, Ana, Fernandez, Leticia, Metspalu, Andres, Heath, Simon, Lathrop, Mark, Brennan, Paul

“…Background Genetic variants in 15q25 have been identified as potential risk markers for lung cancer (LC), but controversy exists as to whether this is a direct…”
Get full text

Human and bacterial oxidative demethylases repair alkylation damage in both RNA and DNA by Krokan, Hans E, Aas, Per Arne, Otterlei, Marit, Falnes, Pål Ø, Vågbø, Cathrine B, Skorpen, Frank, Akbari, Mansour, Sundheim, Ottar, Bjørås, Magnar, Slupphaug, Geir, Seeberg, Erling

“…Repair of DNA damage is essential for maintaining genome integrity, and repair deficiencies in mammals are associated with cancer, neurological disease and…”
Get full text

Genetic Variation in the Catechol-O-Methyltransferase (COMT) Gene and Morphine Requirements in Cancer Patients with Pain by Rakvåg, Trude T, Ross, Joy R, Sato, Hiroe, Skorpen, Frank, Kaasa, Stein, Klepstad, Pål

“…Background: Genetic variation contributes to differences in pain sensitivity and response to different analgesics. Catecholamines are involved in the…”
Get full text

Prediction of opioid dose in cancer pain patients using genetic profiling: not yet an option with support vector machine learning by Olesen, Anne Estrup, Grønlund, Debbie, Gram, Mikkel, Skorpen, Frank, Drewes, Asbjørn Mohr, Klepstad, Pål

“…Use of opioids for pain management has increased over the past decade; however, inadequate analgesic response is common. Genetic variability may be related to…”
Get full text

Presence of anti-GAD in a non-diabetic population of adults; time dynamics and clinical influence: results from the HUNT study by Sørgjerd, Elin Pettersen, Thorsby, Per M, Torjesen, Peter A, Skorpen, Frank, Kvaløy, Kirsti, Grill, Valdemar

“…BackgroundIt is well known that anti-GAD (glutamic acid decarboxylase) serves as a marker for development of autoimmune diabetes in adults. On the other hand,…”
Get full text

hUNG2 Is the Major Repair Enzyme for Removal of Uracil from U:A Matches, U:G Mismatches, and U in Single-stranded DNA, with hSMUG1 as a Broad Specificity Backup by Kavli, Bodil, Sundheim, Ottar, Akbari, Mansour, Otterlei, Marit, Nilsen, Hilde, Skorpen, Frank, Aas, Per Arne, Hagen, Lars, Krokan, Hans E, Slupphaug, Geir

“…hUNG2 and hSMUG1 are the only known glycosylases that may remove uracil from both double- and single-stranded DNA in nuclear chromatin, but their relative…”
Get full text

The N-terminally truncated µ3 and µ3-like opioid receptors are transcribed from a novel promoter upstream of exon 2 in the human OPRM1 gene by Andersen, Sonja, Baar, Cecilie, Fladvad, Torill, Laugsand, Eivor Alette, Skorpen, Frank

“…The human µ opioid receptor gene, OPRM1, produces a multitude of alternatively spliced transcripts encoding full-length or truncated receptor variants with…”
Get full text

Clinical and Genetic Factors Related to Cancer‐Induced Bone Pain and Bone Pain Relief by Scarpi, Emanuela, Calistri, Daniele, Klepstad, Pål, Kaasa, Stein, Skorpen, Frank, Habberstad, Ragnhild, Nanni, Oriana, Amadori, Dino, Maltoni, Marco

“…Objective. The study objective was to evaluate whether there are clinical or genetic differences between patients with cancer‐induced bone pain (CIBP) and…”
Get full text

Base excision repair of DNA in mammalian cells by Krokan, Hans E, Nilsen, Hilde, Skorpen, Frank, Otterlei, Marit, Slupphaug, Geir

“…Base excision repair (BER) of DNA corrects a number of spontaneous and environmentally induced genotoxic or miscoding base lesions in a process initiated by…”
Get full text

Multiple Loci Modulate Opioid Therapy Response for Cancer Pain by GALVAN, Antonella, SKORPEN, Frank, DRAGANI, Tommaso A, KLEPSTAD, Pål, KNUDSEN, Anne Kari, FLADVAD, Torill, FALVELLA, Felicia S, PIGNI, Alessandra, BRUNELLI, Cinzia, CARACENI, Augusto, KAASA, Stein

“…Patients treated with opioid drugs for cancer pain experience different relief responses, raising the possibility that genetic factors play a role in opioid…”
Get full text