Search Results - "SKOOG, M. T"

Activity of Purified Biosynthetic Proteinase of Human Immunodeficiency Virus on Natural Substrates and Synthetic Peptides by Kräusslich, Hans-Georg, Ingraham, Richard H., Skoog, Mark T., Wimmer, Eckard, Pallai, Peter V., Carter, Carol A.

“…Retroviral capsid proteins and replication enzymes are synthesized as polyproteins that are proteolytically processed to the mature products by a virus-encoded…”
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Mechanism and activation for allosteric adenosine 5‘-monophosphate nucleosidase. Kinetic alpha-deuterium isotope effects for the enzyme-catalyzed hydrolysis of adenosine 5‘-monophosphate and nicotinamide mononucleotide by Skoog, M T

“…The kinetic alpha-deuterium isotope effect on Vmax/Km for hydrolysis of NMN catalyzed by AMP nucleosidase at saturating concentrations of the allosteric…”
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Substituted naphthalenones as a new structural class of HIV-1 reverse transcriptase inhibitors by Alam, M, Bechtold, C M, Patick, A K, Skoog, M T, Gant, T G, Colonno, R J, Meyers, A I, Li, H, Trimble, J, Lin, P F

“…A novel substituted naphthalenone (TGG-II-23A) has been found that inhibits HIV-1 infection of CEM-SS cells at concentrations that are not cytotoxic. Time of…”
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Activity of soybean lipoxygenase in the absence of lipid hydroperoxide by Wiseman, Jeffrey S, Skoog, Mark T, Clapp, Charles H

“…Soybean lipoxygenase was assayed under conditions such that the concentration of the enzyme was in excess of the concentration of the substrate, arachidonic…”
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Kinetics of leukotriene A4 synthesis by 5-lipoxygenase from rat polymorphonuclear leukocytes by Wiseman, Jeffrey S, Skoog, Mark T, Nichols, James S, Harrison, Boyd L

“…When arachidonic acid is added to lysates of rat polymorphonuclear leukocytes, it is oxidized to (5S)-hydroperoxy-6(E),8(Z),11(Z),14(Z)-eicosatetraenoic acid…”
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5-lipoxygenase from rat PMN lysate by Skoog, M T, Nichols, J S, Wiseman, J S

“…The products of arachidonic acid metabolism in the 15,000xg supernatant of sonicated rat PMN are described. Only products derived from 5-lipoxygenase are…”
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Inhibition of 5-lipoxygenase by substituted 3,4-dihydro-2H-1,4-thiazines by Weintraub, P M, Skoog, M T, Nichols, J S, Wiseman, J S, Huber, E W, Baugh, L E, Farrell, A M

“…A series of substituted 3,4-dihydro-2H-1,4-thiazines inhibit 5-lipoxygenase from rat leukocytes and exhibit submicromolar IC50 values. A novel synthesis of…”
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Steady state kinetics and inhibition of HIV-1 reverse transcriptase by a non-nucleoside dipyridodiazepinone, BI-RG-587, using a heteropolymeric template by KOPP, E. B, MIGLIETTA, J. J, SHRUTKOWSKI, A. G, CHENG-KON SHIH, GROB, P. M, SKOOG, M. T

“…Steady state kinetics and inhibition by a dipyridodiazepinone of the reverse transcriptase from human immunodeficiency virus type 1 (HIV) were studied using a…”
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Glutathione peroxidase is neither required nor kinetically competent for conversion of 5-HPETE to 5-HETE in rat PMN lysates by Skoog, M T, Nichols, J S, Harrison, B L, Wiseman, J S

“…In the 5-lipoxygenase pathway for arachidonic acid metabolism, reduction of 5-hydroperoxyeicosatetraenoic acid (5-HPETE) to 5-hydroxyeicosatetraenoic acid…”
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Reactions of pyridines and primary amines with N-phosphorylated pyridines by Skoog, Mark T., Jencks, William P.

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Rapid, sensitive and efficient HPLC assays for HIV-1 proteinase by Betageri, R, Hopkins, J L, Thibeault, D, Emmanuel, M J, Chow, G C, Skoog, M T, de Dreu, P, Cohen, K A

“…The proteinase encoded by human immunodeficiency virus type 1 (HIV-1) cleaves peptide substrates of sequences derived from processing sites in HIV-1 gag-pol…”
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Inhibition of HIV-1 reverse transcriptase and virus replication by a non-nucleoside dipyridodiazepinone BI-RG-587 (Nevirapine) by Skoog, M T, Hargrave, K D, Miglietta, J J, Kopp, E B, Merluzzi, V J

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Specificity of an HPETE peroxidase from rat PMN by Skoog, M T, Nichols, J S, Harrison, B L, Wiseman, J S

“…The 15,000xg supernatant of sonicated rat PMN contains 5-lipoxygenase that converts arachidonic acid to 5-hydroperoxyeicosatetraenoic acid (5-HPETE) and…”
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Rhinovirus 3C protease catalyzes efficient cleavage of a fluorescein-labeled peptide affording a rapid and robust assay by Hopkins, J L, Betageri, R, Cohen, K A, Emmanuel, M J, Joseph, C R, Bax, P M, Pallai, P V, Skoog, M T

“…The 3C protease encoded by human rhinovirus type 2 catalyzes with equal efficiency cleavage of a peptide substrate with or without a fluorescein label attached…”
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The specificity of two proteinases that cleave adjacent to arginine, C1 esterase and acrosin, for peptide p-nitroanilide substrates by Skoog, M T, Mehdi, S, Wiseman, J S, Bey, P

“…Relative values of Vmax/Km for hydrolysis of 40 peptide p-nitroanilides catalyzed by human Cl-s and human acrosin are reported. For Cl-s, Ac-Lys(gamma…”
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Novel non-nucleoside inhibitors of HIV-1 reverse transcriptase. I, Tricyclic pyridobenzo- and dipyridodiazepinones by HARGRAVE, K. D, PROUDFOOT, J. R, KLUNDER, J. M, PAL, K, SKILES, J. W, MCNEIL, D. W, ROSE, J. M, CHOW, G. C, SKOOG, M. T, WU, J. C, SCHMIDT, G, ENGEL, W. W, GROZINGER, K. G, CULLEN, E, KAPADIA, S. R, PATEL, U. R, FUCHS, V. U, MAULDIN, S. C, VITOUS, J, BEHNKE, M. L

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Phosphoryl transfer between pyridines by Skoog, Mark T, Jencks, William P

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Recent patent cases: affect validity and scope of biotechnology patents: quality patent work is more important than ever by Skoog, Mark T, Kowalchyk, Katherine M

“…Skoog and Kowalchyk discuss the impact of recent patent cases on the validity and scope of biotechnology patents. Two important patent cases decided this past…”
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