Search Results - "SKLENAR, A. R"

Depsipeptide (FR 901228) promotes histone acetylation, gene transcription, apoptosis and its activity is enhanced by DNA methyltransferase inhibitors in AML1/ETO-positive leukemic cells by KLISOVIC, M. I, MAGHRABY, E. A, RUSH, L. J, PLASS, C, GREVER, M. R, BYRD, J. C, MARCUCCI, G, PARTHUN, M. R, GUIMOND, M, SKLENAR, A. R, WHITMAN, S. P, CHAN, K. K, MURPHY, T, ANON, J, ARCHER, K. J

“…In t(8;21) acute myeloid leukemia (AML), the AML1/ETO fusion protein promotes leukemogenesis by recruiting histone deacetylase (HDAC) and silencing AML1target…”
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A phase 1 and pharmacodynamic study of depsipeptide (FK228) in chronic lymphocytic leukemia and acute myeloid leukemia by Byrd, John C., Marcucci, Guido, Parthun, Mark R., Xiao, Jim J., Klisovic, Rebecca B., Moran, Mollie, Lin, Thomas S., Liu, Shujun, Sklenar, Amy R., Davis, Melanie E., Lucas, David M., Fischer, Beth, Shank, Roshini, Tejaswi, Sooraj L., Binkley, Philip, Wright, John, Chan, Kenneth K., Grever, Michael R.

“…Preclinical studies with the histone deacetylase (HDAC) inhibitor depsipeptide (FK228) in chronic lymphocytic leukemia (CLL) and acute myeloid leukemia (AML)…”
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Application of mass spectrometry to the identification and quantification of histone post-translational modifications by Freitas, Michael A., Sklenar, Amy R., Parthun, Mark R.

“…The core histones are the primary protein component of chromatin, which is responsible for the packaging of eukaryotic DNA. The NH2‐terminal tail domains of…”
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