Search Results - "SKILL, N. J"

Transglutaminase transcription and antigen translocation in experimental renal scarring by JOHNSON, T. S, SKILL, N. J, EL NAHAS, A. M, OLDROYD, S. D, THOMAS, G. L, DOUTHWAITE, J. A, HAYLOR, J. L, GRIFFIN, M

“…It was recently demonstrated that renal tissue transglutaminase (tTg) protein and its catalytic product the epsilon(gamma-glutamyl) lysine protein cross-link…”
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Elevated epsilon-(gamma-glutamyl)lysine in human diabetic nephropathy results from increased expression and cellular release of tissue transglutaminase by El Nahas, A M, Abo-Zenah, H, Skill, N J, Bex, S, Wild, G, Griffin, M, Johnson, T S

“…Diabetic nephropathy (DN) is the leading cause of chronic kidney failure, however the mechanisms underlying the characteristic expansion of the extracellular…”
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Role of cyclooxygenase isoforms in prostacyclin biosynthesis and murine prehepatic portal hypertension by Skill, N J, Theodorakis, N G, Wang, Y N, Wu, J M, Redmond, E M, Sitzmann, J V

“…Portal hypertension (PHT) is a common complication of liver cirrhosis and significantly increases morbidity and mortality. Abrogation of PHT using NSAIDs has…”
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Cardiac role in DDAH-P protection against surgically induced hepatic ischemia reperfusion injury by Skill, NJ

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357 - Cardiac role in DDAH-P protection against surgically induced hepatic ischemia reperfusion injury by Skill, NJ

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Expression of apoptosis-related genes and proteins in experimental chronic renal scarring by BIN YANG, JOHNSON, Timothy S, THOMAS, Graham L, WATSON, Philip F, WAGNER, Bart, SKILL, Nicholas J, HAYLOR, John L, EL NAHAS, A. Meguid

“…Apoptosis has been proposed to play an important role in the progression of renal scarring. The mechanisms that determine whether a cell enters the apoptotic…”
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Tissue transglutaminase: A mediator and predictor of chronic allograft nephropathy? by JOHNSON, Timothy S, ABO-ZENAH, Hamdy, SKILL, James N, BEX, Samantha, WILD, Graham, BROWN, Colin B, GRIFFIN, Martin, MEGUID EL NAHAS, A

“…The precise mechanisms underlying the development of chronic allograft nephropathy (CAN) and the associated renal fibrosis remain uncertain. The…”
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Increases in Renal ε-(γ-Glutamyl)-Lysine Crosslinks Result from Compartment-Specific Changes in Tissue Transglutaminase in Early Experimental Diabetic Nephropathy: Pathologic Implications by Skill, N James, Griffin, Martin, El Nahas, A Meguid, Sanai, Toru, Haylor, John L, Fisher, Marie, Jamie, Mathew F, Mould, Nigel N, Johnson, Timothy S

“…Diabetic nephropathy (DN) is characterized by an early, progressive expansion and sclerosis of the glomerular mesangium leading to glomerulosclerosis. This is…”
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Tissue transglutaminase and the progression of human renal scarring by Johnson, Timothy S, El-Koraie, Ahmed F, Skill, N James, Baddour, Nahed M, El Nahas, A Meguid, Njloma, Melvin, Adam, Ahmed G, Griffin, Martin

“…Experimental renal scarring indicates that tissue transglutaminase (tTg) may be associated with the accumulation of extracellular matrix (ECM), both indirectly…”
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Inhibition of Transglutaminase Activity Reduces Extracellular Matrix Accumulation Induced by High Glucose Levels in Proximal Tubular Epithelial Cells by Skill, Nicholas J, Johnson, Timothy S, Coutts, Ian G C, Saint, Robert E, Fisher, Marie, Huang, Linghong, El Nahas, A Meguid, Collighan, Russell J, Griffin, Martin

“…Diabetic nephropathy affects 30–40% of diabetics leading to end-stage kidney failure through progressive scarring and fibrosis. Previous evidence suggests…”
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The role of nitric oxide synthase isoforms in extrahepatic portal hypertension: studies in gene-knockout mice by Theodorakis, Nicholas G, Wang, Yi-ning, Skill, Nicholas J, Metz, Matthew A, Cahill, Paul A, Redmond, Eileen M, Sitzmann, James V

“…Considerable debate exists concerning which isoform of nitric oxide synthase (NOS) is responsible for the increased production of NO in PHT. We used the portal…”
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