Search Results - "SKIBA, N. P"

Hidradenitis suppurativa among patients with HIV: investigating patient and disease characteristics and misdiagnosis by Bui, H., Skiba, P.N., Breskin, A., Sayed, C.

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The Effector Enzyme Regulates the Duration of G Protein Signaling in Vertebrate Photoreceptors by Increasing the Affinity between Transducin and RGS Protein by Skiba, Nikolai P., Hopp, Johnathan A., Arshavsky, Vadim Y.

“…The photoreceptor-specific G protein transducin acts as a molecular switch, stimulating the activity of its downstream effector in its GTP-bound form and…”
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The 2.0 Å crystal structure of a heterotrimeric G protein by Lambright, David G, Sondek, John, Bohm, Andrew, Skiba, Nikolai P, Hamm, Heidi E, Sigler, Paul B

“…The structure of a heterotrimeric G protein reveals the mechanism of the nucleotide-dependent engagement of the alpha and beta gamma subunits that regulates…”
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Regulation of transducin GTPase activity in bovine rod outer segments by ARSHAVSKY, V. Y, DUMKE, C. L, YUN ZHU, ARTEMYEV, N. O, SKIBA, N. P, HAMM, H. E, BOWNDS, M. D

“…The photoreceptor G-protein, transducin, belongs to the class of heterotrimeric GTP-binding proteins that transfer information from activated seven-span…”
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Sites of interaction between rod G-protein alpha-subunit and cGMP-phosphodiesterase gamma-subunit. Implications for the phosphodiesterase activation mechanism by ARTEMYEV, N. O, RARICK, H. M, MILLS, J. S, SKIBA, N. P, HAMM, H. E

“…In photoreceptor cells of vertebrates light activates a series of protein-protein interactions resulting in activation of a cGMP-phosphodiesterase (PDE)…”
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The 2.0 angstrom crystal structure of a heterotrimeric G protein by Lambright, David G, Sondek, John, Bohm, Andrew, Skiba, Nikolai P

“…The structure of a heterotrimeric G protein reveals the mechanism of the nucleotide-dependent engagement of the alpha and beta gamma subunits that regulates…”
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Molecular basis for interactions of G protein beta gamma subunits with effectors by Ford, Carolyn E, Hamm, Heidi E

“…Both the [Alpha] and [Beta][Gamma] subunits of heterotrimeric guanine nucleotide-binding proteins (G proteins) communicate signals from receptors to effectors…”
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RGS9-G beta 5 substrate selectivity in photoreceptors. Opposing effects of constituent domains yield high affinity of RGS interaction with the G protein-effector complex by Skiba, N P, Martemyanov, K A, Elfenbein, A, Hopp, J A, Bohm, A, Simonds, W F, Arshavsky, V Y

“…RGS proteins regulate the duration of G protein signaling by increasing the rate of GTP hydrolysis on G protein alpha subunits. The complex of RGS9 with type 5…”
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Functional Roles of the Two Domains of Phosducin and Phosducin-like Protein by Savage, Justin R., McLaughlin, Joseph N., Skiba, Nikolai P., Hamm, Heidi E., Willardson, Barry M.

“…Phosducin and phosducin-like protein regulate G protein signaling pathways by binding the βγ subunit complex (Gβγ) and blocking Gβγ association with Gα…”
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The Carboxyl Terminus of the γ-Subunit of Rod cGMP Phosphodiesterase Contains Distinct Sites of Interaction with the Enzyme Catalytic Subunits and the α-Subunit of Transducin by Skiba, Nikolai P., Artemyev, Nikolai O., Hamm, Heidi E.

“…The interaction between the GTP-bound form of the transducin α-subunit (Gαt) and the γ-subunit (Pγ) of cGMP phosphodiesterase (PDE) is a key event in effector…”
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Synthesis of DNA coding for human proinsulin by Ovchinnikov, Y A, Efimov, V A, Ivanova, I N, Reverdatto, S V, Skiba, N P, Chakhmakhcheva, O G

“…A chemical-enzymatic synthesis of 271- and 286-bp DNA duplexes, each of which contains the entire sequence coding for human proinsulin has been accomplished…”
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Molecular Basis for Interactions of G Protein βγ Subunits with Effectors by Ford, Carolyn E., Skiba, Nikolai P., Hyunsu, Bae, Daaka, Yehia, Reuveny, Eitan, Shekter, Lee R., Rosal, Ramon, Weng, Gezhi, Yang, Chii-Shen, Iyengar, Ravi, Miller, Richard J., Jan, Lily Y., Lefkowitz, Robert J., Hamm, Heidi E.

“…Both the α and βγ subunits of heterotrimeric guanine nucleotide-binding proteins (G proteins) communicate signals from receptors to effectors. Gβγ subunits can…”
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Fluorescent probes as indicators of conformation changes in transducin on activation by Yang, C S, Skiba, N P, Mazzoni, M R, Thomas, T O, Hamm, H E

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Mapping of effector binding sites of transducin alpha-subunit using G alpha t/G alpha i1 chimeras by Skiba, N P, Bae, H, Hamm, H E

“…The G protein transducin has been an often-used model for biochemical, structural, and mechanistic studies of G protein function. Experimental studies have…”
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Optimization of in vivo crosslinking technique for the study of AlpB-protein interactions in Lysobacter sp. XL1 cells by Krasovskaya, Ludmila A., Rudenko, Natalya V., Shuvalova, Olesia P., Sukharicheva, Natalya A., Abbasova, Svetlana G., Skiba, Nikolai P., Stepnaya, Olga A.

“…•DSP-mediated crosslinking in bacterial cells of Lysobacter sp. XL1.•Selection of DSP cross-linker optimal concentration.•Determination of optimal crosslinking…”
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Rapid and Sensitive Method for Detection of Y402, H402, I62, and V62 Variants of Complement Factor H in Human Plasma Samples Using Mass Spectrometry by Kelly, Una, Rickman, Catherine Bowes, Postel, Eric A, Hauser, Michael A, Hageman, Gregory S, Arshavsky, Vadim Y, Skiba, Nikolai P

“…Variations in the complement factor H (CFH) gene are tightly associated with age-related macular degeneration (AMD) across diverse populations. Of the many…”
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Specific peptide probes for G-protein interaction with effectors by Rarick, H M, Artemyev, N O, Mills, J S, Skiba, N P, Hamm, H E

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Site-directed mutagenesis of the inhibitory subunit of retinal rod cyclic GMP phosphodiesterase by Lipkin, V M, Udovichenko, I P, Bondarenko, V A, Yurovskaya, A A, Telnykh, E V, Skiba, N P

“…In order to study the role of individual amino acids in the function of the inhibitory subunit, gamma, of retinal rod phosphodiesterase (PDE), the following…”
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R7BP, a Novel Neuronal Protein Interacting with RGS Proteins of the R7 Family by Martemyanov, Kirill A., Yoo, Peter J., Skiba, Nikolai P., Arshavsky, Vadim Y.

“…The R7 subfamily of the regulators of G protein signaling (RGS) proteins is represented by four members broadly expressed in the mammalian nervous system. Here…”
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G alpha t/G alpha i1 chimeras used to define structural basis of specific functions of G alpha t by Skiba, N P, Thomas, T O, Hamm, H E

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