Search Results - "SKARPEN, Ellen"

Unrestrained ESCRT-III drives micronuclear catastrophe and chromosome fragmentation by Vietri, Marina, Schultz, Sebastian W., Bellanger, Aurélie, Jones, Carl M., Petersen, Louise I., Raiborg, Camilla, Skarpen, Ellen, Pedurupillay, Christeen Ramane J., Kjos, Ingrid, Kip, Eline, Timmer, Romy, Jain, Ashish, Collas, Philippe, Knorr, Roland L., Grellscheid, Sushma N., Kusumaatmaja, Halim, Brech, Andreas, Micci, Francesca, Stenmark, Harald, Campsteijn, Coen

“…The ESCRT-III membrane fission machinery maintains the integrity of the nuclear envelope. Although primary nuclei resealing takes minutes, micronuclear…”
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Remodeling of secretory lysosomes during education tunes functional potential in NK cells by Goodridge, Jodie P., Jacobs, Benedikt, Saetersmoen, Michelle L., Clement, Dennis, Hammer, Quirin, Clancy, Trevor, Skarpen, Ellen, Brech, Andreas, Landskron, Johannes, Grimm, Christian, Pfefferle, Aline, Meza-Zepeda, Leonardo, Lorenz, Susanne, Wiiger, Merete Thune, Louch, William E., Ask, Eivind Heggernes, Liu, Lisa L., Oei, Vincent Yi Sheng, Kjällquist, Una, Linnarsson, Sten, Patel, Sandip, Taskén, Kjetil, Stenmark, Harald, Malmberg, Karl-Johan

“…Inhibitory signaling during natural killer (NK) cell education translates into increased responsiveness to activation; however, the intracellular mechanism for…”
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Isolation and mass spectrometry analysis of urinary extraexosomal proteins by Hildonen, Siri, Skarpen, Ellen, Halvorsen, Trine Grønhaug, Reubsaet, Léon

“…The aim of the present study was to develop a LC-MS/MS-based proteomic analysis method of urinary exosomal proteins that has the potential to discover disease…”
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Predictive biomarkers for 5‐ALA‐PDT can lead to personalized treatments and overcome tumor‐specific resistances by Mastrangelopoulou, Maria, Grigalavicius, Mantas, Raabe, Tine H., Skarpen, Ellen, Juzenas, Petras, Peng, Qian, Berg, Kristian, Theodossiou, Theodossis A.

“…Background Photodynamic therapy (PDT) is a minimally invasive, clinically approved therapy with numerous advantages over other mainstream cancer therapies…”
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The tankyrase inhibitor G007-LK inhibits small intestine LGR5 + stem cell proliferation without altering tissue morphology by Norum, Jens Henrik, Skarpen, Ellen, Brech, Andreas, Kuiper, Raoul, Waaler, Jo, Krauss, Stefan, Sørlie, Therese

“…The WNT pathway regulates intestinal stem cells and is frequently disrupted in intestinal adenomas. The pathway contains several potential biotargets for…”
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Deciphering the Nongenomic, Mitochondrial Toxicity of Tamoxifens As Determined by Cell Metabolism and Redox Activity by Theodossiou, Theodossis Athanassios, Wälchli, Sébastien, Olsen, Cathrine Elisabeth, Skarpen, Ellen, Berg, Kristian

“…Tamoxifen is not only considered a very potent chemotherapeutic adjuvant for estrogen receptor positive breast cancers but also a very good chemo-preventive…”
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The effect of the chemical chaperone 4-phenylbutyrate on secretion and activity of the p.Q160R missense variant of coagulation factor FVII by Andersen, Elisabeth, Chollet, Maria Eugenia, Baroni, Marcello, Pinotti, Mirko, Bernardi, Francesco, Skarpen, Ellen, Sandset, Per Morten, Skretting, Grethe

“…Congenital coagulation factor (F) VII deficiency is a rare bleeding disorder caused by mutations in the gene. The missense factor FVII variant p.Q160R is the…”
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The PtdIns3P‐Binding Protein Phafin 2 Mediates Epidermal Growth Factor Receptor Degradation by Promoting Endosome Fusion by Pedersen, Nina Marie, Raiborg, Camilla, Brech, Andreas, Skarpen, Ellen, Roxrud, Ingrid, Platta, Harald W., Liestøl, Knut, Stenmark, Harald

“…Phosphatidylinositol 3‐phosphate (PtdIns3P) orchestrates endosomal cargo transport, fusion and motility by recruiting FYVE or PX domain‐containing effector…”
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The Factor VII Variant p.A354V-p.P464Hfs: Clinical versus Intracellular and Biochemical Phenotypes Induced by Chemical Chaperones by Andersen, Elisabeth, Chollet, Maria Eugenia, Bernardi, Francesco, Branchini, Alessio, Baroni, Marcello, Mariani, Guglielmo, Dolce, Alberto, Batorova, Angelika, Skarpen, Ellen, Myklebust, Christiane Filion, Skretting, Grethe, Sandset, Per Morten

“…(1) Background: Congenital factor (F) VII deficiency is caused by mutations in the F7 gene. Patients with modest differences in FVII levels may display large…”
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EGF-induced ERK-activation downstream of FAK requires rac1-NADPH oxidase by Flinder, Liv Ingrid, Timofeeva, Olga A., Rosseland, Carola M., Wierød, Lene, Huitfeldt, Henrik S., Skarpen, Ellen

“…Reactive oxygen species (ROS) function as signaling molecules mainly by reversible oxidation of redox‐sensitive target proteins. ROS can be produced in…”
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EGF Activates Autocrine TGFα to Induce Prolonged EGF Receptor Signaling and Hepatocyte Proliferation by Liu, ShuZheng, Wierød, Lene, Skarpen, Ellen, Grøsvik, Helga, Duan, GuangCai, Huitfeldt, Henrik S.

“…Background/Aims: EGF receptor is a main participant in the regulation of liver regeneration. In primary hepatocyte cultures, EGF or TGFα binding to EGF…”
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MEK1 and MEK2 regulate distinct functions by sorting ERK2 to different intracellular compartments by Skarpen, Ellen, Flinder, Liv Ingrid, Rosseland, Carola Maria, Ørstavik, Sigurd, Wierød, Lene, Oksvold, Morten Pedersen, Skålhegg, Bjørn Steen, Huitfeldt, Henrik Sverre

“…In this study, we provide novel insight into the mechanism of how ERK2 can be sorted to different intracellular compartments and thereby mediate different…”
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Cytoplasmic retention of peroxide-activated ERK provides survival in primary cultures of rat hepatocytes by ROSSELAND, Carola M, WIERØD, Lene, OKSVOLD, Morten P, WERNER, Heidi, ØSTVOLD, Anne Carine, THORESEN, G. Hege, PAULSEN, Ragnhild E, HUITFELDT, Henrik S, SKARPEN, Ellen

“…Reactive oxygen species (ROS) are implicated in tissue damage causing primary hepatic dysfunction following ischemia/reperfusion injury and during inflammatory…”
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Regulation of rat alveolar type 2 cell proliferation in vitro involves type II cAMP-dependent protein kinase by Samuelsen, Jan T, Schwarze, Per E, Huitfeldt, Henrik S, Thrane, E Vibeke, Låg, Marit, Refsnes, Magne, Skarpen, Ellen, Becher, Rune

“…To elucidate the role of cAMP and different cAMP-dependent protein kinases (PKA; A-kinase) in lung cell proliferation, we investigated rat alveolar type 2 cell…”
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Photochemical Internalization of Tamoxifens Transported by a "Trojan-Horse" Nanoconjugate into Breast-Cancer Cell Lines by Theodossiou, Theodossis A., Gonçalves, A. Ricardo, Yannakopoulou, Konstantina, Skarpen, Ellen, Berg, Kristian

“…Photochemical internalization (PCI) has shown great promise as a therapeutic alternative for targeted drug delivery by light‐harnessed activation. However, it…”
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Molecular Characterization of Two Homozygous Factor VII Variants Associated with Intracranial Bleeding by Andersen, Elisabeth, Chollet, Maria Eugenia, Sletten, Marit, Stavik, Benedicte, Skarpen, Ellen, Backe, Paul Hoff, Thiede, Bernd, Glosli, Heidi, Henriksson, Carola Elisabeth, Iversen, Nina

“…Clinical parameters have been extensively studied in factor (F) VII deficiency, but the knowledge of molecular mechanisms of this disease is scarce. We report…”
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Photodynamic Efficacy of Cercosporin in 3D Tumor Cell Cultures by Grigalavicius, Mantas, Mastrangelopoulou, Maria, Arous, Delmon, Juzeniene, Asta, Ménard, Mathilde, Skarpen, Ellen, Berg, Kristian, Theodossiou, Theodossis A.

“…In the present work, we study the photodynamic action of cercosporin (cerco), a naturally occurring photosensitizer, on human cancer multicellular spheroids…”
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Molecular Characterization of Two Homozygous Factor VII Variants Associated with Intracranial Bleeding by Andersen, Elisabeth, Chollet, Maria Eugenia, Sletten, Marit, Stavik, Benedicte, Myklebust, Christiane Filion, Skarpen, Ellen, Hoff Backe, Paul, Sandset, Per Morten, Glosli, Heidi, Henriksson, Carola, Iversen, Nina

“…Introduction Congenital factor (F) VII deficiency is an inherited bleeding disorder with an autosomal recessive inheritance pattern. We report on two probands…”
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Endocytosed Epidermal Growth Factor (EGF) Receptors Contribute to the EGF-Mediated Growth Arrest in A431 Cells by Inducing a Sustained Increase in p21/CIP1 by Skarpen, Ellen, Johannessen, Lene E., Bjerk, Kjetil, Fasteng, Hilde, Guren, Tormod K., Lindeman, Birgitte, Thoresen, G.Hege, Christoffersen, Thoralf, Stang, Espen, Huitfeldt, Henrik S., Madshus, Inger Helene

“…We investigated the ability of endocytosed activated epidermal growth factor receptors (EGFR) to induce expression of the cyclin-interacting protein p21/CIP1…”
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The Chemical Chaperone 4-Phenylbutyrate Increases Secretion and Activity of Missense and Elongated Factor VII Mutants by Andersen, Elisabeth, Chollet, Maria Eugenia, Baroni, Marcello, Pinotti, Mirko, Bernardi, Francesco, Skarpen, Ellen, Sandset, Per Morten, Skretting, Grethe

“…The F7 gene mutations p.Q160R and p.A354V-p.P464Hfs are associated with very low factor VII (FVII) activity and antigen levels and a bleeding phenotype. We…”
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