Search Results - "SKAPTASON, Judith"

Pharmacokinetic-Pharmacodynamic Modeling of Biomarker Response and Tumor Growth Inhibition to an Orally Available cMet Kinase Inhibitor in Human Tumor Xenograft Mouse Models by YAMAZAKI, Shinji, SKAPTASON, Judith, ROMERO, David, LEE, Joseph H, ZOU, Helen Y, CHRISTENSEN, James G, KOUP, Jeffrey R, SMITH, Bill J, KOUDRIAKOVA, Tatiana

“…( R )-3-[1-(2,6-Dichloro-3-fluoro-phenyl)-ethoxy]-5-(1-piperidin-4-yl-1 H -pyrazol-4-yl)-pyridin-2-ylamine (PF02341066) was identified as an orally available,…”
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Application of Stable Isotope Methodology in the Evaluation of the Pharmacokinetics of (S,S)-3-[3-(Methylsulfonyl)phenyl]-1-propylpiperidine Hydrochloride in Rats by YAMAZAKI, Shinji, TOTH, Lisa N, KIMOTO, Emi, BOWER, Janice, SKAPTASON, Judith, ROMERO, David, HEATH, Timothy G

“…The primary objective of this study was to demonstrate the use of stable isotope (SI)-labeled compound as an approach for pharmacokinetic analysis such as…”
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Identification of (R)‑(2-Chloro-3-(trifluoromethyl)phenyl)(1-(5-fluoropyridin-2-yl)-4-methyl-6,7-dihydro‑1H‑imidazo[4,5‑c]pyridin-5(4H)‑yl)methanone (JNJ 54166060), a Small Molecule Antagonist of the P2X7 receptor by Swanson, Devin M, Savall, Brad M, Coe, Kevin J, Schoetens, Freddy, Koudriakova, Tatiana, Skaptason, Judith, Wall, Jessica, Rech, Jason, Deng, Xiahou, De Angelis, Meri, Everson, Anita, Lord, Brian, Wang, Qi, Ao, Hong, Scott, Brian, Sepassi, Kia, Lovenberg, Timothy W, Carruthers, Nicholas I, Bhattacharya, Anindya, Letavic, Michael A

“…The synthesis and SAR of a series of 4,5,6,7-tetrahydro-imidazo­[4,5-c]­pyridine P2X7 antagonists are described. Addressing P2X7 affinity and liver microsomal…”
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Prediction of Oral Pharmacokinetics of cMet Kinase Inhibitors in Humans: Physiologically Based Pharmacokinetic Model Versus Traditional One-Compartment Model by YAMAZAKI, Shinji, SKAPTASON, Judith, ROMERO, David, VEKICH, Sylvia, JONES, Hannah M, WEIWEI TAN, WILNER, Keith D, KOUDRIAKOVA, Tatiana

“…The objective of this study was to assess the physiologically based pharmacokinetic (PBPK) model for predicting plasma concentration-time profiles of orally…”
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Dihydroxyphenylisoindoline Amides as Orally Bioavailable Inhibitors of the Heat Shock Protein 90 (Hsp90) Molecular Chaperone by Kung, Pei-Pei, Huang, Buwen, Zhang, Gang, Zhou, Joe Zhongxiang, Wang, Jeff, Digits, Jennifer A, Skaptason, Judith, Yamazaki, Shinji, Neul, David, Zientek, Michael, Elleraas, Jeff, Mehta, Pramod, Yin, Min-Jean, Hickey, Michael J, Gajiwala, Ketan S, Rodgers, Caroline, Davies, Jay F, Gehring, Michael R

“…The discovery and optimization of potency and metabolic stability of a novel class of dihyroxyphenylisoindoline amides as Hsp90 inhibitors are presented…”
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Characterization of JNJ-2482272 [4-(4-methyl-2-(4-(trifluoromethyl)phenyl)thiazole-5-yl)pyrimidine-2-amine] as a Strong AhR Activator in Rat and Human by Coe, Kevin J, Feinstein, Mark, Higgins, J William, Leung, Perry, Scott, Brian P, Skaptason, Judith, Tam, Yuen, Volak, Laurie P, Kinong, Jennifer, Bittner, Anton, McAllister, Heather, Lim, Nathan M, Hack, Michael, Koudriakova, Tatiana

“…JNJ-2482272, under investigation as an anti-inflammatory agent, was orally administered to rats at 60 mg/kg for six consecutive days. Despite high plasma…”
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Identification of ( R )-(2-Chloro-3-(trifluoromethyl)phenyl)(1-(5-fluoropyridin-2-yl)-4-methyl-6,7-dihydro-1 H -imidazo[4,5- c ]pyridin-5(4 H )-yl)methanone (JNJ 54166060), a Small Molecule Antagonist of the P2X7 receptor by Swanson, Devin M., Savall, Brad M., Coe, Kevin J., Schoetens, Freddy, Koudriakova, Tatiana, Skaptason, Judith, Wall, Jessica, Rech, Jason, Deng, Xiahou, De Angelis, Meri, Everson, Anita, Lord, Brian, Wang, Qi, Ao, Hong, Scott, Brian, Sepassi, Kia, Lovenberg, Timothy W., Carruthers, Nicholas I., Bhattacharya, Anindya, Letavic, Michael A.

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Pharmacologic properties of AG-012986, a pan-cyclin-dependent kinase inhibitor with antitumor efficacy by Zhang, Cathy, Lundgren, Karen, Yan, Zhengming, Arango, Maria E, Price, Sharon, Huber, Andrea, Higgins, Joseph, Troche, Gabriel, Skaptason, Judith, Koudriakova, Tatiana, Nonomiya, Jim, Yang, Michelle, O'Connor, Patrick, Bender, Steve, Los, Gerrit, Lewis, Cristina, Jessen, Bart

“…AG-012986 is a multitargeted cyclin-dependent kinase (CDK) inhibitor active against CDK1, CDK2, CDK4/6, CDK5, and CDK9, with selectivity over a diverse panel…”
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