Search Results - "SJOVALL, J"

Bile acids: analysis in biological fluids and tissues by Griffiths, W. J., Sjovall, J.

“…The formation of bile acids/bile alcohols is of major importance for the maintenance of cholesterol homeostasis. Besides their functions in lipid absorption,…”
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Population pharmacokinetic analysis of ropivacaine and its metabolite 2′,6′-pipecoloxylidide from pooled data in neonates, infants, and children by Aarons, L., Sadler, B., Pitsiu, M., Sjövall, J., Henriksson, J., Molnár, V.

“…The aim was to characterize ropivacaine and 2′,6′-pipecoloxylidide (PPX) pharmacokinetics and factors affecting them in paediatric anaesthesia. Population…”
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Fifty years with bile acids and steroids in health and disease by Sjovall, J

“…Cholesterol and its metabolites, e.g., steroid hormones and bile acids, constitute a class of compounds of great biological importance. Their chemistry,…”
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Polyunsaturated fatty acids including docosahexaenoic and arachidonic acid bind to the retinoid X receptor alpha ligand-binding domain by Lengqvist, Johan, Mata De Urquiza, Alexander, Bergman, Ann-Charlotte, Willson, Timothy M, Sjövall, Jan, Perlmann, Thomas, Griffiths, William J

“…Nuclear receptors (NRs) constitute a large and highly conserved family of ligand-activated transcription factors that regulate diverse biological processes…”
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Bile acids and progesterone metabolites in intrahepatic cholestasis of pregnancy by Reyes, H, Sjövall, J

“…The pathogenesis of intrahepatic cholestasis of pregnancy (ICP) can be related to abnormalities in the metabolism and disposition of sex hormones and/or bile…”
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Cholestatic liver disease in adults may be due to an inherited defect in bile acid biosynthesis by Fischler, B., Bodin, K., Stjernman, H., Olin, M., Hansson, M., Sjövall, J., Björkhem, I.

“… Background.  An increasing number of treatable inborn errors of bile acid synthesis have been described, primarily in infants with severe cholestatic liver…”
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Pregnenolone sulfate in the brain: A controversial neurosteroid by Schumacher, Michael, Liere, Philippe, Akwa, Yvette, Rajkowski, Krzysztof, Griffiths, William, Bodin, Karl, Sjövall, Jan, Baulieu, Etienne-Emile

“…Pregnenolone sulfate (PREGS) has been shown, either at high nanomolar or at micromolar concentrations, to increase neuronal activity by inhibiting GABAergic…”
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Neurosteroids in Rat Brain:  Extraction, Isolation, and Analysis by Nanoscale Liquid Chromatography−Electrospray Mass Spectrometry by Liu, Suya, Sjövall, Jan, Griffiths, William J

“…A method designed for the analysis of sulfated neurosteroids and unconjugated ketonic neurosteroids in rat brain using nanoscale liquid…”
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Analysis of Oxysterols by Electrospray Tandem Mass Spectrometry by Griffiths, William J., Wang, Yuqin, Alvelius, Gunvor, Liu, Suya, Bodin, Karl, Sjövall, Jan

“…Oxysterols are oxygenated derivatives of cholesterol. They are intermediates in cholesterol excretion pathways and may also be regarded as transport forms of…”
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Derivatisation for the characterisation of neutral oxosteroids by electrospray and matrix-assisted laser desorption/ionisation tandem mass spectrometry: the Girard P derivative by Griffiths, William J., Liu, Suya, Alvelius, Gunvor, Sjövall, Jan

“…The identification, quantification and localisation of steroids in biological fluids and tissues are subjects of considerable importance. Not only do steroids…”
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Matrix-Assisted Laser Desorption/Ionization High-Energy Collision-Induced Dissociation of Steroids:  Analysis of Oxysterols in Rat Brain by Wang, Yuqin, Hornshaw, Martin, Alvelius, Gunvor, Bodin, Karl, Liu, Suya, Sjövall, Jan, Griffiths, William J

“…Neutral steroids have traditionally been analyzed by gas chromatography/mass spectrometry (GC/MS) after necessary derivatization reactions. However, GC/MS is…”
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From brain to bile. Evidence that conjugation and omega-hydroxylation are important for elimination of 24S-hydroxycholesterol (cerebrosterol) in humans by Bjorkhem, I, Andersson, U, Ellis, E, Alvelius, G, Ellegard, L, Diczfalusy, U, Sjovall, J, Einarsson, C

“…The brain is the almost exclusive site of formation of 24S-hydroxycholesterol in man, and there is a continuous flux of this oxysterol across the blood-brain…”
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Mandibulotomy access to tumour sites: fewer complications for postoperative compared with preoperative radiotherapy by Carlwig, K., Fransson, P., Bengtsson, M., Gebre-Medhin, M., Sjövall, J., Greiff, L.

“…The purpose of this study was to compare complication rates at the mandibulotomy site between patients receiving preoperative radiotherapy (RT) and those…”
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Efficacy and uptake of ropivacaine and bupivacaine after single intra‐articular injection in the knee joint by Convery, P.N., Milligan, K.R., Quinn, P., Sjövall, J., Gustafsson, U.

“…The efficacy of ropivacaine 100 mg (5 mg ml–1), 150 mg (7.5 mg ml–1) and 200 mg (10 mg ml–1) and bupivacaine 100 mg (5 mg ml–1) given by intra‐articular…”
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Mutation in the Sterol 27‐Hydroxylase Gene Associated with Fatal Cholestasis in Infancy by Bahr, Sara, Björkhem, Ingemar, Hooft, Ferdinand, Alvelius, Gunvor, Nemeth, Antal, Sjövall, Jan, Fischler, Björn

“…Inborn errors of bile acid synthesis are rare but potentially treatable causes of neonatal cholestasis. We here present a cholestatic infant with an ongoing…”
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Identification of unusual 7-oxygenated bile acid sulfates in a patient with Niemann-Pick disease, type C by Alvelius, G, Hjalmarson, O, Griffiths, W J, Björkhem, I, Sjövall, J

“…Niemann-Pick disease, type C, was diagnosed in a 3-month-old boy with hepatosplenomegaly, mild signs of cholestasis, hepatic inflammation and extramedullary…”
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Capillary Liquid Chromatography/Electrospray Mass Spectrometry for Analysis of Steroid Sulfates in Biological Samples by Liu, Suya, Griffiths, William J., Sjövall, Jan

“…A new procedure for capillary liquid chromatography−electrospray (CLC−ES) mass spectrometry is described. Using this procedure, coupling of a CLC column to a…”
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Analysis of oxosteroids by nano-electrospray mass spectrometry of their oximes by Liu, Suya, Sjövall, Jan, Griffiths, William J.

“…A method for the analysis of neutral oxosteroids by electrospray mass spectrometry is described. The oxosteroids are converted into their oximes by treatment…”
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Paracrine glucocorticoid activity produced by mouse thymic epithelial cells by Pazirandeh, Ahmad, Xue, Yintong, Rafter, Ingalill, Sjövall, Jan, Jondal, Mikael, Okret, Sam

“…ABSTRACT Previous data have suggested that glucocorticoids (GCs) are involved in the differentiation of thymocytes into mature T cells. In this report we…”
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Analysis of derivatised steroids by matrix-assisted laser desorption/ionisation and post-source decay mass spectrometry by Khan, Muhammad Atif, Wang, Yuqin, Heidelberger, Sibylle, Alvelius, Gunvor, Liu, Suya, Sjövall, Jan, Griffiths, William J.

“…Neutral steroids are difficult to analyse using desorption ionisation methods coupled with mass spectrometry (MS). However, steroids with an unhindered ketone…”
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