Search Results - "SIVAN, Sarit"

Controlled and time‐scheduled drug delivery: Polyanhydride‐based nanoparticles as ocular medication carriers by Sheskin, Tali, Geyer, Orna, Lotan, Noah, Sivan, Sarit

“…Nanoparticles offer an ideal opportunity for the efficient local anesthetic drug delivery required during and after ocular procedures. Currently available…”
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Toward a mechanically biocompatible intervertebral disc: Engineering of combined biomimetic annulus fibrosus and nucleus pulposus analogs by Mordechai, Haim S., Aharonov, Adi, Sharon, Smadar E., Bonshtein, Iris, Simon, Chen, Sivan, Sarit S., Sharabi, Mirit

“…Intervertebral disc (IVD) degeneration and accompanying lower back pain impose global medical and societal challenges, affecting over 600 million people…”
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Factors regulating viable cell density in the intervertebral disc: blood supply in relation to disc height by Boubriak, Olga. A., Watson, Natasha, Sivan, Sarit. S., Stubbens, Naomi, Urban, Jill P. G.

“…The intervertebral disc is an avascular tissue, maintained by a small population of cells that obtain nutrients mainly by diffusion from capillaries at the…”
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Molecular modeling study of the swelling of glycosaminoglycan‐analog biomimetics for intervertebral disc repair by Knani, Dafna, Eylon, Moran, Sivan, Sarit S.

“…Aggrecan, one of the main components of the intervertebral disc, belongs to the family of proteoglycans (PGs) that are composed of glycosaminoglycan (GAG)…”
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Comparative Bioinformatic Analysis Reveals Conserved Regions in SARS-CoV-2 Genome for RAPID Pandemic Response by Karpuj, Marcela Viviana, Shaytov, D R, Shemer-Avni, Yonat, Gideon, Michael, Frenkel, Zakharia M, Sivan, Sarit

“…In the face of the SARS-CoV-2 pandemic, characterized by the virus's rapid mutation rates, developing timely and targeted therapeutic and diagnostic…”
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Copper oxide loaded PLGA nanospheres: towards a multifunctional nanoscale platform for ultrasound-based imaging and therapy by Perlman, Or, Weitz, Iris S, Sivan, Sarit S, Abu-Khalla, Hiba, Benguigui, Madeleine, Shaked, Yuval, Azhari, Haim

“…Copper oxide nanoparticles (CuO-NPs) are increasingly becoming the subject of investigation exploring their potential use for diagnostic and therapeutic…”
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Collagen Turnover in Normal and Degenerate Human Intervertebral Discs as Determined by the Racemization of Aspartic Acid by Sivan, Sarit-Sara, Wachtel, Ellen, Tsitron, Eve, Sakkee, Nico, van der Ham, Frits, DeGroot, Jeroen, Roberts, Sally, Maroudas, Alice

“…Knowledge of rates of protein turnover is important for a quantitative understanding of tissue synthesis and catabolism. In this work, we have used the…”
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Encapsulation of Human-Bone-Marrow-Derived Mesenchymal Stem Cells in Small Alginate Beads Using One-Step Emulsification by Internal Gelation: In Vitro, and In Vivo Evaluation in Degenerate Intervertebral Disc Model by Sivan, Sarit S, Bonstein, Iris, Marmor, Yariv N, Pelled, Gadi, Gazit, Zulma, Amit, Michal

“…Cell microencapsulation in gel beads contributes to many biomedical processes and pharmaceutical applications. Small beads (<300 µm) offer distinct advantages,…”
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Prolyl hydroxylation in elastin is not random by Schmelzer, Christian E.H., Nagel, Marcus B.M., Dziomba, Szymon, Merkher, Yulia, Sivan, Sarit S., Heinz, Andrea

“…This study aimed to investigate the prolyl and lysine hydroxylation in elastin from different species and tissues. Enzymatic digests of elastin samples from…”
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Age-related accumulation of pentosidine in aggrecan and collagen from normal and degenerate human intervertebral discs by Sivan, Sarit Sara, Tsitron, Eve, Wachtel, Ellen, Roughley, Peter, Sakkee, Nico, van der Ham, Frits, Degroot, Jeroen, Maroudas, Alice

“…During aging and degeneration, many changes occur in the structure and composition of human cartilaginous tissues, which include the accumulation of the AGE…”
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Aggrecan Turnover in Human Intervertebral Disc as Determined by the Racemization of Aspartic Acid by Sivan, Sarit S., Tsitron, Eve, Wachtel, Ellen, Roughley, Peter J., Sakkee, Nico, van der Ham, Frits, DeGroot, Jeroen, Roberts, Sally, Maroudas, Alice

“…We have used the racemization of aspartic acid as a marker for the “molecular age” of aggrecan components of the human intervertebral disc matrix (aggregating…”
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Longevity of elastin in human intervertebral disc as probed by the racemization of aspartic acid by Sivan, Sarit-Sara, Van El, Benno, Merkher, Yulia, Schmelzer, Christian E.H., Zuurmond, Anne-Marie, Heinz, Andrea, Wachtel, Ellen, Varga, Peter-Paul, Lazary, Aron, Brayda-Bruno, Marco, Maroudas, Alice

“…Aging and degeneration of human intervertebral disc (IVD) are associated with biochemical changes, including racemization and glycation. These changes can only…”
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Bovine explant model of degeneration of the intervertebral disc by Roberts, Sally, Menage, Janis, Sivan, Sarit, Urban, Jill P G

“…Many new treatments for degeneration of the intervertebral disc are being developed which can be delivered through a needle. These require testing in model…”
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Structure, function, aging and turnover of aggrecan in the intervertebral disc by Sivan, Sarit Sara, Wachtel, Ellen, Roughley, Peter

“…Aggrecan is the major non-collagenous component of the intervertebral disc. It is a large proteoglycan possessing numerous glycosaminoglycan chains and the…”
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Human intervertebral disc cells promote nerve growth over substrata of human intervertebral disc aggrecan by JOHNSON, William E. B, SIVAN, Sarit, WRIGHT, Karina T, EISENSTEIN, Stephen M, MAROUDAS, Alice, ROBERTS, Sally

“…Coculture assays of the migration and interaction of human intervertebral disc cells and chick sensory nerves on alternate substrata of collagen and aggrecan…”
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Biofilm‐Inspired Encapsulation of Probiotics for the Treatment of Complex Infections by Li, Zhihao, Behrens, Adam M., Ginat, Nitzan, Tzeng, Stephany Y., Lu, Xueguang, Sivan, Sarit, Langer, Robert, Jaklenec, Ana

“…The emergence of antimicrobial resistance poses a major challenge to healthcare. Probiotics offer a potential alternative treatment method but are often…”
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Copper oxide nanoparticles inhibit pancreatic tumor growth primarily by targeting tumor initiating cells by Benguigui, Madeleine, Weitz, Iris S., Timaner, Michael, Kan, Tal, Shechter, Dvir, Perlman, Or, Sivan, Sarit, Raviv, Ziv, Azhari, Haim, Shaked, Yuval

“…Cancer stem cells, also termed tumor initiating cells (TICs), are a rare population of cells within the tumor mass which initiate tumor growth and metastasis…”
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In vitro evaluation of copper release from MRI-visible, PLGA-based nanospheres by Weitz, Iris Sonia, Perlman, Or, Azhari, Haim, Sivan, Sarit Sara

“…Copper nanostructures offer remarkable therapeutic potential. In particular, copper oxide nanoparticles (CuO NPs) are increasingly studied for diagnostic and…”
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Biochemical composition and turnover of the extracellular matrix of the normal and degenerate intervertebral disc by Sivan, Sarit Sara, Hayes, Anthony J., Wachtel, Ellen, Caterson, Bruce, Merkher, Yulia, Maroudas, Alice, Brown, Sharon, Roberts, Sally

“…Background The intervertebral disc (IVD) is a complex cartilaginous structure which functions to resist biomechanical loads during spinal movement. It consists…”
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Liposomes Act as Effective Biolubricants for Friction Reduction in Human Synovial Joints by Sivan, Sarit, Schroeder, Avi, Verberne, Gabi, Merkher, Yulia, Diminsky, Dvora, Priev, Aba, Maroudas, Alice, Halperin, Gregory, Nitzan, Dorrit, Etsion, Izhak, Barenholz, Yechezkel

“…Phospholipids (PL) form the matrix of biological membranes and of the lipoprotein envelope monolayer, and are responsible for many of the unique…”
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