Search Results - "SISKO, Joseph"

Synthesis of Fused Dihydropyrano(furano)pyridines via [4 + 2]-Cycloaddition of 5-Alkenoxy Substituted Oxazoles by Goodman, Steven N, Mans, Douglas M, Sisko, Joseph, Yin, Hao

“…A three-step procedure to access fused pyridines has been developed utilizing inexpensive amino acids and alkenols to form the key oxazole precursors. Yields…”
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Hypertensive end-organ damage and premature mortality are p38 mitogen-activated protein kinase-dependent in a rat model of cardiac hypertrophy and dysfunction by BEHR, Thomas M, NERURKAR, Sandhya S, OHLSTEIN, Eliot H, ANGERMANN, Christiane E, ADAMS, Jerry L, SISKO, Joseph, SACKNER-BERNSTEIN, Jonathan D, WILLETTE, Robert N, NELSON, Allen H, COATNEY, Robert W, WOODS, Tina N, SULPIZIO, Anthony, CHANDRA, Sudeep, BROOKS, David P, KUMAR, Sanjay, LEE, John C

“…Numerous pathological mediators of cardiac hypertrophy (eg, neurohormones, cytokines, and stretch) have been shown to activate p38 MAPK. The purpose of the…”
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Development of a general process for the synthesis of highly substituted imidazoles by Sisko, Joseph, Mellinger, Mark

“…Several highly substituted imidazoles have been under investigation at GlaxoSmithKline as potential therapies for the treatment of rheumatoid arthritis and…”
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Sustained activation of p38 mitogen-activated protein kinase contributes to the vascular response to injury by Ju, Haisong, Nerurkar, Sandhya, Sauermelch, Charles F, Olzinski, Alan R, Mirabile, Rosanna, Zimmerman, Dawn, Lee, John C, Adams, Jerry, Sisko, Joseph, Berova, Marinella, Willette, Robert N

“…The vascular response to mechanical injury involves inflammatory and fibroproliferative processes that result in the formation of neointima and vascular…”
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Construction of the tricyclic core of the marine alkaloid sarain A by Sisko, Joseph, Weinreb, Steven M

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An Investigation of Imidazole and Oxazole Syntheses Using Aryl-Substituted TosMIC Reagents1 by Sisko, Joseph, Kassick, Andrew J, Mellinger, Mark, Filan, John J, Allen, Andrew, Olsen, Mark A

“…This article describes efficient and mild protocols for preparing polysubstituted imidazoles in a single pot from aryl-substituted tosylmethyl isocyanide…”
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A One-Pot Synthesis of 1-(2,2,6,6-tetramethyl-4-piperidinyl)-4- (4-fluorophenyl)-5-(2-amino-4-pyrimidinyl)- imidazole:  A Potent Inhibitor of P38 MAP Kinase by Sisko, Joseph

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Annulative ring expansions. Direct conversion of .omega.-alkynyl acetals to polycyclic unsaturated ketones by Sisko, Joseph, Balog, Aaron, Curran, Dennis P

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An expedient synthesis of cis/trans-1,3-disubstituted cyclobutanols by Calad, Stacie, Mans, Douglas, Morin, Justin-Alexander, O’Neill-Slawecki, Stacy, Sisko, Joseph

“…A two-step procedure is described to access 3-alkoxycyclobutanones from chloroacetyl chloride utilizing a step-wise [2+2] ketene cycloaddition followed by…”
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Addition of Grignard and organolithium reagents to N-sulfonyl aldimines generated in situ from aldehydes and N-sulfinylsulfonamides by Sisko, Joseph, Weinreb, Steven M

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An investigation of imidazole and oxazole syntheses using aryl-substituted TosMIC reagents by Sisko, J, Kassick, A J, Mellinger, M, Filan, J J, Allen, A, Olsen, M A

“…This article describes efficient and mild protocols for preparing polysubstituted imidazoles in a single pot from aryl-substituted tosylmethyl isocyanide…”
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Formation and Characterization of Crystals Containing a Pleuromutilin Derivative, Succinic Acid and Water by Clawson, Jacalyn S, Vogt, Frederick G, Brum, Jeffrey, Sisko, Joseph, Patience, Daniel B, Dai, Wenning, Sharpe, Sonja, Jones, Alan D, Pham, Tran N, Johnson, Matthew N, Copley, Royston C. P

“…An unusual pharmaceutical solid containing a pleuromutilin derivative, succinic acid and water is studied with a combination of physiochemical methods. The…”
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Development of a Scalable Synthesis of GSK183390A, a PPAR α/γ Agonist by Oh, Lynette M, Wang, Huan, Shilcrat, Susan C, Herrmann, Robert E, Patience, Daniel B, Spoors, P. Grant, Sisko, Joseph

“…A scalable synthesis of GSK183390A, a PPAR α/γ agonist, is described. This synthesis is highlighted by (1) a regioselective formal 1,3-dipolar cycloaddition…”
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Process Development for A Novel Pleuromutilin-Derived Antibiotic by Andemichael, Yemane, Chen, Jun, Clawson, Jacalyn S, Dai, Wenning, Diederich, Ann, Downing, Susan V, Freyer, Alan J, Liu, Peng, Oh, Lynette M, Patience, Daniel B, Sharpe, Sonja, Sisko, Joseph, Tsui, Julie, Vogt, Frederick G, Wang, Jun, Wernersbach, Lori, Webb, Edward C, Wertman, James, Zhou, Leon

“…A scalable synthesis of a novel pleuromutilin-based antibiotic is reported. The synthesis features the scale-up of an interesting skeletal rearrangement of the…”
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Monitoring organic reactions with on-line atmospheric pressure ionization mass spectrometry: the hydrolysis of isatin by Brum, Jeffrey, Dell'Orco, Philip, Lapka, Sara, Muske, Kenneth, Sisko, Joseph

“…Time‐resolved electrospray ionization mass spectrometry (ESI‐MS) is a powerful tool for interrogating solution‐phase reaction systems. Both mechanistic and…”
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A convenient synthesis of trisubstituted pyrido[2,3- d]pyrimidin-7-ones by Kasparec, Jiri, Adams, Jerry L., Sisko, Joseph, Silva, Domingos J.

“…A novel, highly efficient and scalable route for the synthesis of trisubstituted pyrido[2,3- d]pyrimidin-7-ones was developed. The target compounds were…”
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An efficient method for the synthesis of substituted TosMIC precursors by Sisko, Joseph, Mellinger, Mark, Sheldrake, Peter W., Baine, Neil H.

“…Substituted tosylmethyl isocyanides (TosMICs) are useful reagents for which no general method of preparation is available. We describe here a high-yielding…”
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Development of a strategy for synthesis of the unusual marine alkaloid sarain A by Sisko, Joseph, Henry, James R, Weinreb, Steven M

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An Investigation of Imidazole and Oxazole Syntheses Using Aryl-Substituted TosMIC Reagents 1 by Sisko, Joseph, Kassick, Andrew J., Mellinger, Mark, Filan, John J., Allen, Andrew, Olsen, Mark A.

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Unexpected Reactivity of Imidazo[2,1-b]thiazolines with Organometallic Reagents by Sisko, Joseph, Kassick, Andrew J, Shetzline, Steven B

“…The reaction of imidazo[2,1-b]thiazolines with various organometallic reagents is described. Nucleophilic attack of organolithium reagents on sulfur occurs…”
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