Search Results - "SIPKEMA, P"

Thrombin-induced endothelial barrier disruption in intact microvessels: role of RhoA/Rho kinase-myosin phosphatase axis by van Nieuw Amerongen, G P, Musters, R J P, Eringa, E C, Sipkema, P, van Hinsbergh, V W M

“…Endothelial hyperpermeability is regulated by a myosin light chain-2 (MLC2) phosphorylation-dependent contractile mechanism. Thrombin is a potent inducer of…”
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Molecular Mechanisms of Acute Renal Failure following Ischemia/Reperfusion by Versteilen, A.M.G., Di Maggio, F., Leemreis, J.R., Groeneveld, A.B.J., Musters, R.J.P., Sipkema, P.

“…Acute renal failure (ARF) necessitating renal replacement therapy is a common problem associated with high morbidity and mortality in the critically ill…”
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Differential structural adaptation to haemodynamics along single rat cremaster arterioles by Bakker, E N T P, Versluis, J P, Sipkema, P, VanTeeffelen, J W G E, Rolf, T M, Spaan, J A E, VanBavel, E

“…We tested the hypothesis that under physiological conditions, arterioles match their diameter to the level of shear stress. Haemodynamic and anatomical data…”
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Varying elastance concept may explain coronary systolic flow impediment by Krams, R, Sipkema, P, Westerhof, N

“…We measured phasic arterial coronary inflow in the blood-perfused isolated cat heart (n = 5) with a balloon in the left ventricle under well-defined…”
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Increased coronary perfusion augments cardiac contractility in the rat through stretch-activated ion channels by Lamberts, R R, van Rijen, M H P, Sipkema, P, Fransen, P, Sys, S U, Westerhof, N

“…The role of stretch-activated ion channels (SACs) in coronary perfusion-induced increase in cardiac contractility was investigated in isolated isometrically…”
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Interaction of oxyradicals, antioxidants, and nitric oxide during sepsis by Groeneveld, A B. Johan, Sipkema, Pieter

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The role of inducible nitric oxide synthase in lipopolysaccharide-mediated hyporeactivity to vasoconstrictors differs among isolated rat arteries by Piepot, H A, Groeneveld, A B J, van Lambalgen, A A, Sipkema, P

“…We investigated whether organ-specific differences exist in the role of inducible nitric oxide synthase (iNOS) in hyporeactivity to vasoconstrictors following…”
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Contractility is the main determinant of coronary systolic flow impediment by Krams, R, Sipkema, P, Zegers, J, Westerhof, N

“…We measured the relation between coronary flow amplitude (delta F = Fd-Fs; where d is diastolic and s is systolic) and developed left ventricular pressure…”
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Estrogens, homocysteine, vasodilatation and menopause: basic mechanisms, interactions and clinical implications by SMOLDERS, R. G. V, VAN DER MOOREN, M. J, SIPKEMA, P, KENEMANS, P

“…Estrogens influence the independent cardiovascular risk factor homocysteine as well as vasodilatation. Homocysteine alone also influences vasodilatation,…”
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Regional wave travel and reflections along the human aorta: a study with six simultaneous micromanometric pressures by LATHAM, R. D, WESTERHOF, N, SIPKEMA, P, RUBAL, B. J, REUDERINK, P, MURGO, J. P

“…The human aorta and its terminal branches were investigated in normal subjects during elective cardiac catheterization to evaluate regional wave travel and…”
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Modeling pressure-flow relations in cardiac muscle in diastole and systole by Vis, M A, Sipkema, P, Westerhof, N

“…Pressure-flow relations were calculated for a symmetrical, maximally dilated, crystalloid-perfused coronary vascular network embedded in cardiac muscle in…”
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Effect of ventricular contraction, pressure, and wall stretch on vessels at different locations in the wall by Vis, M A, Bovendeerd, P H, Sipkema, P, Westerhof, N

“…A cylindrical model of the heart was used to calculate the influence of ventricular filling and (isovolumic and isobaric) contraction on the cross-sectional…”
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Left coronary pressure-flow relations of the beating and arrested rabbit heart at different ventricular volumes by SIPKEMA, P, TAKKENBERG, J. J. M, ZEEUWE, P. E. M, WESTERHOF, N

“…To study the effect of cardiac contraction on left coronary artery pressure-flow relations at different vascular volumes and to compare these relations in the…”
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Perfusion-induced changes in cardiac O2 consumption and contractility are based on different mechanisms by Dijkman, M A, Heslinga, J W, Sipkema, P, Westerhof, N

“…Increased cardiac perfusion results in increased oxygen consumption (VO2) and increased contractility (Gregg phenomenon) in the isolated heart. We investigated…”
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Modeling pressure-area relations of coronary blood vessels embedded in cardiac muscle in diastole and systole by Vis, M A, Sipkema, P, Westerhof, N

“…Pressure-cross-sectional area (P-A) relations of a (thick-walled) arteriole and (thin-walled) small vein (both maximally dilated), embedded in cardiac muscle…”
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Vasomotor tone affects diastolic coronary flow and flow impediment by cardiac contraction similarly by Bouma, P, Sipkema, P, Westerhof, N

“…We studied the effect of cardiac contraction on coronary arterial flow with vasomotor tone (control) and during maximal vasodilation with adenosine in the…”
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Compression of intramyocardial arterioles during cardiac contraction is attenuated by accompanying venules by Vis, M A, Sipkema, P, Westerhof, N

“…It was calculated how cardiac contraction influences the luminal cross-sectional area of a maximally dilated coronary arteriole (37-micron inner diameter at a…”
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Coronary oscillatory flow amplitude is more affected by perfusion pressure than ventricular pressure by Krams, R, Sipkema, P, Westerhof, N

“…In this study on the isolated, maximally vasodilated, blood-perfused cat heart we investigated the relation between left ventricular developed pressure (delta…”
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Effect of perfusion pressure on diastolic stress-strain relations of isolated rat papillary muscle by Allaart, C P, Sipkema, P, Westerhof, N

“…The effect of perfusion on diastolic muscle properties was investigated in six isolated right ventricular papillary muscles from rat hearts perfused with a…”
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Coronary artery resistance changes depend on how surrounding myocardial tissue is stretched by Sipkema, P, Yamada, H, Yin, F C

“…Deforming the tissue surrounding a coronary artery may change its hydraulic resistance. In excised blocks of dog left ventricular walls we examined how…”
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