ANTIBIOTIC CONCENTRATIONS IN NORMAL CEREBROSPINAL FLUID FOM, CMNX, ABPC, DKB
Concentrations of several antibiotics, FOM, CMNX, ABPC and DKB, in normal cerebrospinal fluid (CSF) were determined after a continuous intravenous drip infusion for 30 minutes in humans. Serum concentrations of the antibiotics were also determined simultaneously. The biological halflives of FOM, CMN...
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| Published in: | CHEMOTHERAPY Vol. 36; no. 5; pp. 403 - 411 |
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| Main Authors: | , , |
| Format: | Journal Article |
| Language: | English Japanese |
| Published: |
Japanese Society of Chemotherapy
1988
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| Subjects: | |
| Online Access: | Get full text |
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| Summary: | Concentrations of several antibiotics, FOM, CMNX, ABPC and DKB, in normal cerebrospinal fluid (CSF) were determined after a continuous intravenous drip infusion for 30 minutes in humans. Serum concentrations of the antibiotics were also determined simultaneously. The biological halflives of FOM, CMNX, ABPC and DKB were 2.6, 2.2, 1.1 and 1.7h, respectively. These four antibiotics appeared in CSF c. 60-120 min after termination of the infusion. The peak concentrations in CSF were observed 180-240 min after termination of the infusion.Thereafter CSF concentrations decreased very slowly. The peak concentration of FOM in CSF was highest among the antibiotics examined, being 5-10μg/ml. The peak concentrations of the other threeantibiotics in CSF were below 1 μg/ml. |
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| ISSN: | 0009-3165 1884-5894 |
| DOI: | 10.11250/chemotherapy1953.36.403 |