Search Results - "SINGLETON, Andrew"

The genetic architecture of Parkinson's disease by Blauwendraat, Cornelis, Nalls, Mike A, Singleton, Andrew B

“…Parkinson's disease is a complex neurodegenerative disorder for which both rare and common genetic variants contribute to disease risk, onset, and progression…”
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Genetics in Parkinson disease: Mendelian versus non‐Mendelian inheritance by Hernandez, Dena G., Reed, Xylena, Singleton, Andrew B.

“…Parkinson's disease is a common, progressive neurodegenerative disorder, affecting 3% of those older than 75 years of age. Clinically, Parkinson's disease (PD)…”
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Genomewide Association Studies and Human Disease by Hardy, John, Singleton, Andrew

“…Genomewide association studies have uncovered many genetic variants that confer susceptibility to disease. This article describes the genomewide association…”
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Genetics of Parkinson's disease: An introspection of its journey towards precision medicine by Bandres-Ciga, Sara, Diez-Fairen, Monica, Kim, Jonggeol Jeff, Singleton, Andrew B.

“…A substantial proportion of risk for Parkinson's disease (PD) is driven by genetics. Progress in understanding the genetic basis of PD has been significant. So…”
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The genetics and neuropathology of Parkinson’s disease by Houlden, Henry, Singleton, Andrew B.

“…There has been tremendous progress toward understanding the genetic basis of Parkinson’s disease and related movement disorders. We summarize the genetic,…”
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Reply to: ‘Letter to the Editor on “Sex Differences in Parkinson's Disease Phenotype and Caregiving Disparities”’ by Antar, Tarek, Iwaki, Hirotaka, Singleton, Andrew

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The Evolution of Genetics: Alzheimer’s and Parkinson’s Diseases by Singleton, Andrew, Hardy, John

“…Genetic discoveries underlie the majority of the current thinking in neurodegenerative disease. This work has been driven by the significant gains made in…”
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Progress in the genetic analysis of Parkinson’s disease by Singleton, Andrew, Hardy, John

“…Abstract The pace of genetic discovery in complex disease has accelerated exponentially over the last decade. Our fund of knowledge of the foundational…”
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Virus exposure and neurodegenerative disease risk across national biobanks by Levine, Kristin S., Leonard, Hampton L., Blauwendraat, Cornelis, Iwaki, Hirotaka, Johnson, Nicholas, Bandres-Ciga, Sara, Ferrucci, Luigi, Faghri, Faraz, Singleton, Andrew B., Nalls, Mike A.

“…With recent findings connecting the Epstein-Barr virus to an increased risk of multiple sclerosis and growing concerns regarding the neurological impact of the…”
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The genetics of Parkinson's disease: Progress and therapeutic implications by Singleton, Andrew B., Farrer, Matthew J., Bonifati, Vincenzo

“…The past 15 years has witnessed tremendous progress in our understanding of the genetic basis for Parkinson's disease (PD). Notably, whereas most mutations,…”
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A meta-analysis of genome-wide association studies identifies 17 new Parkinson's disease risk loci by Chang, Diana, Nalls, Mike A, Hallgrímsdóttir, Ingileif B, Hunkapiller, Julie, van der Brug, Marcel, Cai, Fang, Kerchner, Geoffrey A, Ayalon, Gai, Bingol, Baris, Sheng, Morgan, Hinds, David, Behrens, Timothy W, Singleton, Andrew B, Bhangale, Tushar R, Graham, Robert R

“…Robert Graham and colleagues carried out a GWAS meta-analysis for Parkinson's disease (PD) and report 17 new risk loci. Their analyses support a key role for…”
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Parkinson's disease age at onset genome‐wide association study: Defining heritability, genetic loci, and α‐synuclein mechanisms by Blauwendraat, Cornelis, Heilbron, Karl, Vallerga, Costanza L., Bandres‐Ciga, Sara, von Coelln, Rainer, Pihlstrøm, Lasse, Simón‐Sánchez, Javier, Schulte, Claudia, Sharma, Manu, Krohn, Lynne, Siitonen, Ari, Iwaki, Hirotaka, Leonard, Hampton, Noyce, Alastair J., Tan, Manuela, Gibbs, J. Raphael, Hernandez, Dena G., Scholz, Sonja W., Jankovic, Joseph, Shulman, Lisa M., Lesage, Suzanne, Corvol, Jean‐Christophe, Brice, Alexis, van Hilten, Jacobus J., Marinus, Johan, Eerola‐Rautio, Johanna, Tienari, Pentti, Majamaa, Kari, Toft, Mathias, Grosset, Donald G., Gasser, Thomas, Heutink, Peter, Shulman, Joshua M., Wood, Nicolas, Hardy, John, Morris, Huw R., Hinds, David A., Gratten, Jacob, Visscher, Peter M., Gan‐Or, Ziv, Nalls, Mike A., Singleton, Andrew B.

“…Background Increasing evidence supports an extensive and complex genetic contribution to PD. Previous genome‐wide association studies (GWAS) have shed light on…”
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Genetic variability in the regulation of gene expression in ten regions of the human brain by Ramasamy, Adaikalavan, Trabzuni, Daniah, Guelfi, Sebastian, Varghese, Vibin, Smith, Colin, Walker, Robert, De, Tisham, Coin, Lachlan, de Silva, Rohan, Cookson, Mark R, Singleton, Andrew B, Hardy, John, Ryten, Mina, Weale, Michael E

“…Expression quantitative trait loci (eQTLs) are genomic regions that regulate gene expression. Here the authors provide a publicly available data set of…”
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Abundant quantitative trait loci exist for DNA methylation and gene expression in human brain by Gibbs, J Raphael, van der Brug, Marcel P, Hernandez, Dena G, Traynor, Bryan J, Nalls, Michael A, Lai, Shiao-Lin, Arepalli, Sampath, Dillman, Allissa, Rafferty, Ian P, Troncoso, Juan, Johnson, Robert, Zielke, H Ronald, Ferrucci, Luigi, Longo, Dan L, Cookson, Mark R, Singleton, Andrew B

“…A fundamental challenge in the post-genome era is to understand and annotate the consequences of genetic variation, particularly within the context of human…”
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Genome-wide CRISPRi/a screens in human neurons link lysosomal failure to ferroptosis by Tian, Ruilin, Abarientos, Anthony, Hong, Jason, Hashemi, Sayed Hadi, Yan, Rui, Dräger, Nina, Leng, Kun, Nalls, Mike A., Singleton, Andrew B., Xu, Ke, Faghri, Faraz, Kampmann, Martin

“…Single-cell transcriptomics provide a systematic map of gene expression in different human cell types. The next challenge is to systematically understand…”
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A CRISPRi/a platform in human iPSC-derived microglia uncovers regulators of disease states by Dräger, Nina M., Sattler, Sydney M., Huang, Cindy Tzu-Ling, Teter, Olivia M., Leng, Kun, Hashemi, Sayed Hadi, Hong, Jason, Aviles, Giovanni, Clelland, Claire D., Zhan, Lihong, Udeochu, Joe C., Kodama, Lay, Singleton, Andrew B., Nalls, Mike A., Ichida, Justin, Ward, Michael E., Faghri, Faraz, Gan, Li, Kampmann, Martin

“…Microglia are emerging as key drivers of neurological diseases. However, we lack a systematic understanding of the underlying mechanisms. Here, we present a…”
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Menopause accelerates biological aging by Levine, Morgan E., Lu, Ake T., Chen, Brian H., Hernandez, Dena G., Singleton, Andrew B., Ferrucci, Luigi, Bandinelli, Stefania, Salfati, Elias, Manson, JoAnn E., Quach, Austin, Kusters, Cynthia D. J., Kuh, Diana, Wong, Andrew, Teschendorff, Andrew E., Widschwendter, Martin, Ritz, Beate R., Absher, Devin, Assimes, Themistocles L., Horvath, Steve

“…Although epigenetic processes have been linked to aging and disease in other systems, it is not yet known whether they relate to reproductive aging. Recently,…”
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The Discovery of LRRK2 Mutations as a Cause of Parkinson's Disease by Singleton, Andrew B., Gasser, Thomas

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Super‐Clausius–Clapeyron scaling of rainfall in a model squall line by Singleton, Andrew, Toumi, Ralf

“…The sensitivity of squall rainfall to changes in atmospheric temperature is investigated. For instantaneous rainrates and accumulations up to one hour, extreme…”
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Genome‐Wide Association Studies of Cognitive and Motor Progression in Parkinson's Disease by Tan, Manuela M.X., Lawton, Michael A., Jabbari, Edwin, Reynolds, Regina H., Iwaki, Hirotaka, Blauwendraat, Cornelis, Kanavou, Sofia, Pollard, Miriam I., Hubbard, Leon, Malek, Naveed, Grosset, Katherine A., Marrinan, Sarah L., Bajaj, Nin, Barker, Roger A., Burn, David J., Bresner, Catherine, Foltynie, Thomas, Wood, Nicholas W., Williams‐Gray, Caroline H., Hardy, John, Nalls, Michael A., Singleton, Andrew B., Williams, Nigel M., Ben‐Shlomo, Yoav, Hu, Michele T.M., Grosset, Donald G., Shoai, Maryam, Morris, Huw R.

“…ABSTRACT Background There are currently no treatments that stop or slow the progression of Parkinson's disease (PD). Case–control genome‐wide association…”
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