Search Results - "SINGHRAO, Sim K"

Assessing the role of Porphyromonas gingivalis in periodontitis to determine a causative relationship with Alzheimer's disease by Singhrao, Sim K., Olsen, Ingar

“…Chronic periodontitis of 10 years' duration is reported to become a twofold risk factor for the development of Alzheimer's disease (AD). Periodontitis is…”
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Determining the presence of periodontopathic virulence factors in short-term postmortem Alzheimer's disease brain tissue by Poole, Sophie, Singhrao, Sim K, Kesavalu, Lakshmyya, Curtis, Michael A, Crean, StJohn

“…The aim of this study was to establish a link between periodontal disease and Alzheimer's disease (AD) with a view to identifying the major periodontal disease…”
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Porphyromonas gingivalis Periodontal Infection and Its Putative Links with Alzheimer's Disease by Kesavalu, Lakshmyya, Poole, Sophie, Harding, Alice, Singhrao, Sim K., Crean, StJohn

“…Periodontal disease (PD) and Alzheimer’s disease (AD) are inflammatory conditions affecting the global adult population. In the pathogenesis of PD, subgingival…”
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Can oral infection be a risk factor for Alzheimer's disease? by Olsen, Ingar, Singhrao, Sim K.

“…Alzheimer's disease (AD) is a scourge of longevity that will drain enormous resources from public health budgets in the future. Currently, there is no…”
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Active invasion of Porphyromonas gingivalis and infection-induced complement activation in ApoE-/- mice brains by Poole, Sophie, Singhrao, Sim K, Chukkapalli, Sasanka, Rivera, Mercedes, Velsko, Irina, Kesavalu, Lakshmyya, Crean, StJohn

“…Periodontal disease is a polymicrobial inflammatory disease that leads to chronic systemic inflammation and direct infiltration of bacteria/bacterial…”
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Is there a link between genetic defects in the complement cascade and Porphyromonas gingivalis in Alzheimer's disease? by Olsen, Ingar, Singhrao, Sim K

“…Defects, as determined by Genome-Wide Association Studies (GWAS), in the complement cascade of innate immunity have been suggested to play a key role in…”
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Importance of heterogeneity in Porhyromonas gingivalis lipopolysaccharide lipid A in tissue specific inflammatory signalling by Olsen, Ingar, Singhrao, Sim K.

“…Lipopolysaccharide (LPS) of Porphyromonas gingivalis exists in at least two known forms, O-LPS and A-LPS. A-LPS shows heterogeneity in which two isoforms…”
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Citrullination as a plausible link to periodontitis, rheumatoid arthritis, atherosclerosis and Alzheimer's disease by Olsen, Ingar, Singhrao, Sim K., Potempa, Jan

“…Periodontitis, rheumatoid arthritis (RA), atherosclerosis (AS), and Alzheimer's disease (AD) are examples of complex human diseases with chronic inflammatory…”
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Interaction between genetic factors, Porphyromonas gingivalis and microglia to promote Alzheimer's disease by Olsen, Ingar, Singhrao, Sim K.

“…In late-onset Alzheimer disease (AD) pathogenesis, genes, infections and immunity could be significant factors. We have reviewed if the keystone periodontal…”
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Porphyromonas gingivalis suppresses adaptive immunity in periodontitis, atherosclerosis, and Alzheimer's disease by Olsen, Ingar, Taubman, Martin A., Singhrao, Sim K.

“…Porphyromonas gingivalis, a keystone pathogen in chronic periodontitis, has been found to associate with remote body organ inflammatory pathologies, including…”
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Exploring the Association between Alzheimer's Disease, Oral Health, Microbial Endocrinology and Nutrition by Harding, Alice, Gonder, Ulrike, Robinson, Sarita J, Crean, StJohn, Singhrao, Sim K

“…Longitudinal monitoring of patients suggests a causal link between chronic periodontitis and the development of Alzheimer's disease (AD). However, the…”
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The Porphyromonas gingivalis /Host Interactome Shows Enrichment in GWASdb Genes Related to Alzheimer's Disease, Diabetes and Cardiovascular Diseases by Carter, Chris J, France, James, Crean, StJohn, Singhrao, Sim K

“…Periodontal disease is of established etiology in which polymicrobial synergistic ecology has become dysbiotic under the influence of . Following breakdown of…”
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Periodontitis, Microbiomes and their Role in Alzheimer's Disease by Pritchard, Anna B, Crean, StJohn, Olsen, Ingar, Singhrao, Sim K

“…As far back as the eighteenth and early nineteenth centuries, microbial infections were responsible for vast numbers of deaths. The trend reversed with the…”
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Porphyromonas gingivalis is a Strong Risk Factor for Alzheimer’s Disease by Kanagasingam, Shalini, Chukkapalli, Sasanka S., Welbury, Richard, Singhrao, Sim K.

“…Porphyromonas gingivalis (P. gingivalis) is one of the several important bacterial pathogens associated with the sporadic Alzheimer’s disease (AD). Different…”
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The comparison of equine articular cartilage progenitor cells and bone marrow-derived stromal cells as potential cell sources for cartilage repair in the horse by McCarthy, Helen E., Bara, Jennifer J., Brakspear, Karen, Singhrao, Sim K., Archer, Charles W.

“…A chondrocyte progenitor population isolated from the surface zone of articular cartilage presents a promising cell source for cell-based cartilage repair. In…”
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Identification and clonal characterisation of a progenitor cell sub-population in normal human articular cartilage by Williams, Rebecca, Khan, Ilyas M, Richardson, Kirsty, Nelson, Larissa, McCarthy, Helen E, Analbelsi, Talal, Singhrao, Sim K, Dowthwaite, Gary P, Jones, Rhiannon E, Baird, Duncan M, Lewis, Holly, Roberts, Selwyn, Shaw, Hannah M, Dudhia, Jayesh, Fairclough, John, Briggs, Timothy, Archer, Charles W

“…Articular cartilage displays a poor repair capacity. The aim of cell-based therapies for cartilage defects is to repair damaged joint surfaces with a…”
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Chronic Porphyromonas gingivalis infection accelerates the occurrence of age-related granules in ApoE-/- mice brains by Singhrao, Sim K., Chukkapalli, Sasanka, Poole, Sophie, Velsko, Irina, Crean, St John, Kesavalu, Lakshmyya

“…This study explored the origin of age-related granules in the apolipoprotein E gene knockout (ApoE −/− ) B6 background mice brains following chronic gingival…”
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Periodontitis, pathogenesis and progression: miRNA-mediated cellular responses to Porphyromonas gingivalis by Olsen, Ingar, Singhrao, Sim K., Osmundsen, Harald

“…Porphyromonas gingivalis is considered a keystone pathogen in periodontitis, a disease typically driven by dysbiosis of oral inflammophilic polymicrobial…”
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Oral flora in acute stroke patients: A prospective exploratory observational study by Boaden, Elizabeth, Lyons, Mary, Singhrao, Sim K., Dickinson, Hazel, Leathley, Michael, Lightbody, Catherine E., McLoughlin, Alison, Khan, Zarine, Crean, Stjohn, Smith, Craig, Higham, Susan, Watkins, Caroline

“…Objective To describe the bacterial profile of the oral flora during the first 2 weeks following a stroke, examining changes in the condition of the oral…”
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Inflammasome Involvement in Alzheimer's Disease by Olsen, Ingar, Singhrao, Sim K

“…Inflammasomes are responsible for the maturation of pro-inflammatory cytokines such as interleukin (IL)-1β, IL-18, and IL-33 and activation of inflammatory…”
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