Search Results - "SINGH, Rajeeva"

Tumor Delivery and In Vivo Processing of Disulfide-Linked and Thioether-Linked Antibody−Maytansinoid Conjugates by Erickson, Hans K, Widdison, Wayne C, Mayo, Michele F, Whiteman, Kathleen, Audette, Charlene, Wilhelm, Sharon D, Singh, Rajeeva

“…Antibody−drug conjugates (ADCs) are designed to eradicate cancer cells that express the target antigen on their cell surface. A key component of an ADC is the…”
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Synthesis and Evaluation of Hydrophilic Linkers for Antibody–Maytansinoid Conjugates by Zhao, Robert Y, Wilhelm, Sharon D, Audette, Charlene, Jones, Gregory, Leece, Barbara A, Lazar, Alexandru C, Goldmacher, Victor S, Singh, Rajeeva, Kovtun, Yelena, Widdison, Wayne C, Lambert, John M, Chari, Ravi V. J

“…The synthesis and biological evaluation of hydrophilic heterobifunctional cross-linkers for conjugation of antibodies with highly cytotoxic agents are…”
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Disulfide-Linked Antibody−Maytansinoid Conjugates: Optimization of In Vivo Activity by Varying the Steric Hindrance at Carbon Atoms Adjacent to the Disulfide Linkage by Kellogg, Brenda A, Garrett, Lisa, Kovtun, Yelena, Lai, Katharine C, Leece, Barbara, Miller, Michael, Payne, Gillian, Steeves, Rita, Whiteman, Kathleen R, Widdison, Wayne, Xie, Hongsheng, Singh, Rajeeva, Chari, Ravi V. J, Lambert, John M, Lutz, Robert J

“…In this report, we describe the synthesis of a panel of disulfide-linked huC242 (anti-CanAg) antibody maytansinoid conjugates (AMCs), which have varying levels…”
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A DNA-Interacting Payload Designed to Eliminate Cross-Linking Improves the Therapeutic Index of Antibody-Drug Conjugates (ADCs) by Miller, Michael L, Shizuka, Manami, Wilhelm, Alan, Salomon, Paulin, Reid, Emily E, Lanieri, Leanne, Sikka, Surina, Maloney, Erin K, Harvey, Lauren, Qiu, Qifeng, Archer, Katie E, Bai, Chen, Vitharana, Dilrukshi, Harris, Luke, Singh, Rajeeva, Ponte, Jose F, Yoder, Nicholas C, Kovtun, Yelena, Lai, Katharine C, Ab, Olga, Pinkas, Jan, Keating, Thomas A, Chari, Ravi V J

“…Tumor-selective delivery of cytotoxic agents in the form of antibody-drug conjugates (ADCs) is now a clinically validated approach for cancer treatment. In an…”
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Antibody-Maytansinoid Conjugates Designed to Bypass Multidrug Resistance by KOVTUN, Yelena V, AUDETTE, Charlene A, LAI, Katharine C, WIDDISON, Wayne C, KELLOGG, Brenda, JOHNSON, Holly, PINKAS, Jan, LUTZ, Robert J, SINGH, Rajeeva, GOLDMACHER, Victor S, CHARI, Ravi V. J, MAYO, Michele F, JONES, Gregory E, DOHERTY, Heather, MALONEY, Erin K, ERICKSON, Hans K, XIUXIA SUN, WILHELM, Sharon, AB, Olga

“…Conjugation of cytotoxic compounds to antibodies that bind to cancer-specific antigens makes these drugs selective in killing cancer cells. However, many of…”
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198 Spectrum of symptoms in covid-19 paediatric patients across four district general hospitals in Yorkshire by Chan, Sharon, Singh, Rajeeva, Shuttleworth, Alexander-John

“…BackgroundDespite increasing reports and studies about COVID-19 in children over the last nine months, there is still much to be discovered about the true…”
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Down-regulation of insulin receptor by antibodies against the type I insulin-like growth factor receptor : Implications for anti-insulin-like growth factor therapy in breast cancer by SACHDEV, Deepali, SINGH, Rajeeva, FUJITA-YAMAGUCHI, Yoko, YEE, Douglas

“…Insulin-like growth factor-I (IGF-I), IGF-II, and insulin have all been implicated in regulating several aspects of the malignant phenotype via the type I IGF…”
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1646 Spectrum of symptoms in COVID-19 paediatric patients across four district general hospitals in yorkshire by Chan, Sharon, Singh, Rajeeva, Shuttleworth, Alexander-John

“…BackgroundDespite increasing reports and studies about COVID-19 in children over the last nine months, there is still much to be discovered about the true…”
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Insight Into the Degradation Pathways of an AAV9 by Rodriguez, Antonela, Jalimarada-Shivakumar, Supriya, Banazadeh, Ali, Afroz, Sharmin, Ali, Amr, Deng, Kangwen, Huang, Lili, Galibert, Lionel, Singh, Rajeeva, Zhou, Chen

“…The use of recombinant adeno-associated virus (AAV) vectors is a popular choice for in vivo gene therapy, with hundreds of ongoing clinical trials targeting…”
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IMGN853, a Folate Receptor-α (FRα)-Targeting Antibody-Drug Conjugate, Exhibits Potent Targeted Antitumor Activity against FRα-Expressing Tumors by Ab, Olga, Whiteman, Kathleen R, Bartle, Laura M, Sun, Xiuxia, Singh, Rajeeva, Tavares, Daniel, LaBelle, Alyssa, Payne, Gillian, Lutz, Robert J, Pinkas, Jan, Goldmacher, Victor S, Chittenden, Thomas, Lambert, John M

“…A majority of ovarian and non-small cell lung adenocarcinoma cancers overexpress folate receptor α (FRα). Here, we report the development of an anti-FRα…”
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Sensitive ELISA Method for the Measurement of Catabolites of Antibody–Drug Conjugates (ADCs) in Target Cancer Cells by Salomon, Paulin L, Singh, Rajeeva

“…A new, sensitive ELISA method has been developed which measures catabolites in cells and media upon processing of antibody–drug conjugates (ADCs) by target…”
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Catalysis of Reduction of Disulfide by Selenol by Singh, Rajeeva, Kats, Lana

“…The reduction of a disulfide to thiols, using sodium borohydride or dithiothreitol as reductant, is catalyzed by selenol. The rates of reduction of oxidized…”
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Formation of N-Substituted 2-Iminothiolanes When Amino Groups in Proteins and Peptides Are Modified by 2-Iminothiolane by Singh, Rajeeva, Kats, Lana, Blättler, Walter A., Lambert, John M.

“…The reagent 2-iminothiolane (2-IT) is used to introduce thiol groups into proteins and peptides by reactions of their amino groups. In this study, we report…”
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Design of Antibody−Maytansinoid Conjugates Allows for Efficient Detoxification via Liver Metabolism by Sun, Xiuxia, Widdison, Wayne, Mayo, Michele, Wilhelm, Sharon, Leece, Barbara, Chari, Ravi, Singh, Rajeeva, Erickson, Hans

“…Antibody−maytansinoid conjugates (AMCs) are targeted chemotherapeutic agents consisting of a potent microtubule-depolymerizing maytansinoid (DM1 or DM4)…”
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Selenols catalyze the interchange reactions of dithiols and disulfides in water by Singh, Rajeeva, Whitesides, George M

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OC13 Sydenham’s chorea – A rare condition? by Singh, Rajeeva, Sharma, Vijay, Pulla, Jaya Mallika, Vijay, Swapna

“…Sydenham’s chorea (SC) is considered a ‘rare disease’ in Western Europe and not much is known about its incidence in the UK 1.SC is a major criteria for…”
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Increased incidence of severe nutritional anaemia in Yorkshire and Humber during the COVID-19 pandemic with critical clinical decompensation by Parmenter, Kate, Brookes, Andrew, Burn, Sarah, Gamwell, Emma, Jenkins, Peter, McPhee, Maria, Webb, Sarah, Singh, Rajeeva, Uka, Sal, James, Beki

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Abstract 230: Antibody-drug conjugates (ADCs) with indolinobenzodiazepine dimer (IGN) payloads: DNA-binding mechanism of IGN catabolites in target cancer cells by Singh, Rajeeva, Harris, Luke, Salomon, Paulin, Reid, Emily E., Miller, Michael L., Chari, Ravi V., Keating, Thomas A.

“…Abstract A DNA-interacting indolinobenzodiazepine dimer (IGN) payload was designed with a single reactive imine group towards the goal of eliminating DNA…”
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A New Class of Antibody-Drug Conjugates with Potent DNA Alkylating Activity by Miller, Michael L, Fishkin, Nathan E, Li, Wei, Whiteman, Kathleen R, Kovtun, Yelena, Reid, Emily E, Archer, Katie E, Maloney, Erin K, Audette, Charlene A, Mayo, Michele F, Wilhelm, Alan, Modafferi, Holly A, Singh, Rajeeva, Pinkas, Jan, Goldmacher, Victor, Lambert, John M, Chari, Ravi V J

“…The promise of tumor-selective delivery of cytotoxic agents in the form of antibody-drug conjugates (ADC) has now been realized, evidenced by the approval of…”
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Abstract B130: Correlation of in vitro cytotoxicity and catabolism of antibody-drug conjugates (ADCs) in target cancer cells by Singh, Rajeeva, Salomon, Paulin, Setiady, Yulius, Ponte, Jose

“…Abstract A sensitive and convenient ELISA method has been developed to quantify catabolites generated upon treatment of target cancer cells with an…”
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