Search Results - "SINGH, Gurmit"

Is chronic pain as an autoimmune disease? by Singh, Gurmit

“…Autoimmune diseases frequently occur in females, and a parallel sexually dimorphic suffering is observed in individuals who suffer chronic pain. Though…”
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Microbial exposure during early human development primes fetal immune cells by Mishra, Archita, Lai, Ghee Chuan, Yao, Leong Jing, Aung, Thet Tun, Shental, Noam, Rotter-Maskowitz, Aviva, Shepherdson, Edwin, Singh, Gurmit Singh Naranjan, Pai, Rhea, Shanti, Adhika, Wong, Regina Men Men, Lee, Andrea, Khyriem, Costerwell, Dutertre, Charles Antoine, Chakarov, Svetoslav, Srinivasan, K.G., Shadan, Nurhidaya Binte, Zhang, Xiao-Meng, Khalilnezhad, Shabnam, Cottier, Fabien, Tan, Alrina Shin Min, Low, Gillian, Chen, Phyllis, Fan, Yiping, Hor, Pei Xiang, Lee, Avery Khoo May, Choolani, Mahesh, Vermijlen, David, Sharma, Ankur, Fuks, Garold, Straussman, Ravid, Pavelka, Norman, Malleret, Benoit, McGovern, Naomi, Albani, Salvatore, Chan, Jerry Kok Yen, Ginhoux, Florent

“…The human fetal immune system begins to develop early during gestation; however, factors responsible for fetal immune-priming remain elusive. We explored…”
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Biological Mechanisms of Cancer-Induced Depression by Young, Kimberly, Singh, Gurmit

“…Patients with cancer are more likely to develop depression than the general population, which negatively impacts their quality of life and prognosis. In order…”
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Onco-fetal Reprogramming of Endothelial Cells Drives Immunosuppressive Macrophages in Hepatocellular Carcinoma by Sharma, Ankur, Seow, Justine Jia Wen, Dutertre, Charles-Antoine, Pai, Rhea, Blériot, Camille, Mishra, Archita, Wong, Regina Men Men, Singh, Gurmit Singh Naranjan, Sudhagar, Samydurai, Khalilnezhad, Shabnam, Erdal, Sergio, Teo, Hui Min, Khalilnezhad, Ahad, Chakarov, Svetoslav, Lim, Tony Kiat Hon, Fui, Alexander Chung Yaw, Chieh, Alfred Kow Wei, Chung, Cheow Peng, Bonney, Glenn Kunnath, Goh, Brian Kim-Poh, Chan, Jerry K.Y., Chow, Pierce K.H., Ginhoux, Florent, DasGupta, Ramanuj

“…We employed scRNA sequencing to extensively characterize the cellular landscape of human liver from development to disease. Analysis of ∼212,000 cells…”
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Mitochondrial FAD-linked Glycerol-3-phosphate Dehydrogenase: A Target for Cancer Therapeutics by Singh, Gurmit

“…Imbalances in cellular redox state are frequently observed in cancer cells, and contribute significantly to cancer progression and apoptotic resistance…”
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Giant cell tumor of bone: A basic science perspective by Cowan, Robert W, Singh, Gurmit

“…Abstract Comprehending the pathogenesis of giant cell tumor of bone (GCT) is of critical importance for developing novel targeted treatments for this…”
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Expression of xCT and activity of system xc(-) are regulated by NRF2 in human breast cancer cells in response to oxidative stress by Habib, Eric, Linher-Melville, Katja, Lin, Han-Xin, Singh, Gurmit

“…Cancer cells adapt to high levels of oxidative stress in order to survive and proliferate by activating key transcription factors. One such master regulator,…”
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Sestrin2 modulates AMPK subunit expression and its response to ionizing radiation in breast cancer cells by Sanli, Toran, Linher-Melville, Katja, Tsakiridis, Theodoros, Singh, Gurmit

“…The sestrin family of stress-responsive genes (SESN1-3) are suggested to be involved in regulation of metabolism and aging through modulation of the AMPK-mTOR…”
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Ionizing Radiation Activates AMP-Activated Kinase (AMPK): A Target for Radiosensitization of Human Cancer Cells by Sanli, Toran, M.Sc, Rashid, Ayesha, B.Sc, Liu, Caiqiong, M.Sc, Harding, Shane, B.Sc, Bristow, Robert G., M.D., Ph.D, Cutz, Jean-Claude, M.D, Singh, Gurmit, Ph.D, Wright, James, M.D, Tsakiridis, Theodoros, M.D., Ph.D

“…Purpose Adenosine monophosphate (AMP)–activated kinase (AMPK) is a molecular energy sensor regulated by the tumor suppressor LKB1. Starvation and growth…”
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Azathioprine can be safely used in HIV-infected individuals by Chamberlain, Florence E, Dinani, Naila, Jagjit Singh, Gurmit K, Bower, Mark, Nelson, Mark

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Computational modeling to study the impact of changes in Nav1.8 sodium channel on neuropathic pain by Kan, Peter, Zhu, Yong Fang, Ma, Junling, Singh, Gurmit

“…Nav1.8 expression is restricted to sensory neurons; it was hypothesized that aberrant expression and function of this channel at the site of injury contributed…”
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Chronic Hepatitis E as a cause for cryptogenic cirrhosis in HIV by Jagjit Singh, Gurmit K, Ijaz, Samreen, Rockwood, Neesha, Farnworth, Simon P, Devitt, Emma, Atkins, Mark, Tedder, Richard, Nelson, Mark

“…Summary Chronic Hepatitis E infection (HEV) is reported in immunocompromised patients. A 45-year-old HIV-infected man had no cause found for a persistent…”
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Evaluation of the preclinical analgesic efficacy of naturally derived, orally administered oil forms of Δ9-tetrahydrocannabinol (THC), cannabidiol (CBD), and their 1:1 combination by Linher-Melville, Katja, Zhu, Yong Fang, Sidhu, Jesse, Parzei, Natalka, Shahid, Ayesha, Seesankar, Gireesh, Ma, Danny, Wang, Zhi, Zacal, Natalie, Sharma, Manu, Parihar, Vikas, Zacharias, Ramesh, Singh, Gurmit

“…Chronic neuropathic pain (NP) is a growing clinical problem for which effective treatments, aside from non-steroidal anti-inflammatory drugs and opioids, are…”
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Overview of Glutamatergic Dysregulation in Central Pathologies by Miladinovic, Tanya, Nashed, Mina G, Singh, Gurmit

“…As the major excitatory neurotransmitter in the mammalian central nervous system, glutamate plays a key role in many central pathologies, including gliomas,…”
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Electrochemical Sensing of Cannabinoids in Biofluids: A Noninvasive Tool for Drug Detection by Klimuntowski, Martin, Alam, Maksud M, Singh, Gurmit, Howlader, Matiar M. R

“…Cannabinoid sensing in biofluids provides great insight into the effects of medicinal cannabis on the body. The prevalence of cannabis for pain management and…”
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Sex differences in neuro(auto)immunity and chronic sciatic nerve pain by Linher-Melville, Katja, Shah, Anita, Singh, Gurmit

“…Chronic pain occurs with greater frequency in women, with a parallel sexually dimorphic trend reported in sufferers of many autoimmune diseases. There is a…”
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Interferon gamma release assays for the diagnosis of latent TB infection in HIV-infected individuals in a low TB burden country by Cheallaigh, Clíona Ní, Fitzgerald, Ian, Grace, Jacinta, Singh, Gurmit Jagjit, El-Eraki, Nahla, Gibbons, Noel, Keane, Joseph, Rogers, Thomas R, Clarke, Susan, Bergin, Colm

“…Interferon gamma release assays (IGRAs) are used to diagnose latent tuberculosis infection. Two IGRAs are commercially available: the Quantiferon TB Gold In…”
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Tumour-Derived Glutamate: Linking Aberrant Cancer Cell Metabolism to Peripheral Sensory Pain Pathways by Fazzari, Jennifer, Linher-Melville, Katja, Singh, Gurmit

“…Background: Chronic pain is a major symptom that develops in cancer patients, most commonly emerging during advanced stages of the disease. The nature of…”
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Spinal microglia contribute to cancer-induced pain through system xC−-mediated glutamate release by Miladinovic, Tanya, Singh, Gurmit

“…Introduction:. Microglial cells, the resident macrophages of the central nervous system, are a key contributor to the generation and maintenance of…”
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An online abstract mentoring programme for junior researchers and healthcare professionals by Singh, Gurmit

“…Dissemination of findings about the HIV epidemic at international conferences has been dominated by researchers from developed countries working in…”
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