Search Results - "SINGH, BHUVANESH"

Comparison of oral microbiota in tumor and non-tumor tissues of patients with oral squamous cell carcinoma by Pushalkar, Smruti, Ji, Xiaojie, Li, Yihong, Estilo, Cherry, Yegnanarayana, Ramanathan, Singh, Bhuvanesh, Li, Xin, Saxena, Deepak

“…Bacterial infections have been linked to malignancies due to their ability to induce chronic inflammation. We investigated the association of oral bacteria in…”
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Recurrent somatic mutation of FAT1 in multiple human cancers leads to aberrant Wnt activation by Morris, Luc G T, Kaufman, Andrew M, Gong, Yongxing, Ramaswami, Deepa, Walsh, Logan A, Turcan, Şevin, Eng, Stephanie, Kannan, Kasthuri, Zou, Yilong, Peng, Luke, Banuchi, Victoria E, Paty, Phillip, Zeng, Zhaoshi, Vakiani, Efsevia, Solit, David, Singh, Bhuvanesh, Ganly, Ian, Liau, Linda, Cloughesy, Timothy C, Mischel, Paul S, Mellinghoff, Ingo K, Chan, Timothy A

“…Tim Chan and colleagues report the identification of recurrent somatic mutations in FAT1 in glioblastoma, colon cancer and head and neck cancer and show that…”
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Targeting cellular and molecular drivers of head and neck squamous cell carcinoma: current options and emerging perspectives by Ausoni, Simonetta, Boscolo-Rizzo, Paolo, Singh, Bhuvanesh, Da Mosto, Maria Cristina, Spinato, Giacomo, Tirelli, Giancarlo, Spinato, Roberto, Azzarello, Giuseppe

“…Despite improvements in functional outcomes attributable to advances in radiotherapy, chemotherapy, surgical techniques, and imaging techniques, survival in…”
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An International Multi-Institutional Validation of Age 55 Years as a Cutoff for Risk Stratification in the AJCC/UICC Staging System for Well-Differentiated Thyroid Cancer by Nixon, Iain J, Wang, Laura Y, Migliacci, Jocelyn C, Eskander, Antoine, Campbell, Michael J, Aniss, Ahmad, Morris, Lilah, Vaisman, Fernanda, Corbo, Rossana, Momesso, Denise, Vaisman, Mario, Carvalho, Andre, Learoyd, Diana, Leslie, William D, Nason, Richard W, Kuk, Deborah, Wreesmann, Volkert, Morris, Luc, Palmer, Frank L, Ganly, Ian, Patel, Snehal G, Singh, Bhuvanesh, Tuttle, R Michael, Shaha, Ashok R, Gönen, Mithat, Pathak, K Alok, Shen, Wen T, Sywak, Mark, Kowalski, Luis, Freeman, Jeremy, Perrier, Nancy, Shah, Jatin P

“…Age is a critical factor in outcome for patients with well-differentiated thyroid cancer. Currently, age 45 years is used as a cutoff in staging, although…”
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Defining a Valid Age Cutoff in Staging of Well-Differentiated Thyroid Cancer by Nixon, Iain J., Kuk, Deborah, Wreesmann, Volkert, Morris, Luc, Palmer, Frank L., Ganly, Ian, Patel, Snehal G., Singh, Bhuvanesh, Tuttle, R. Michael, Shaha, Ashok R., Gönen, Mithat, Shah, Jatin P.

“…Background Age 45 years is used as a cutoff in the staging of well-differentiated thyroid cancer (WDTC) as it represents the median age of most datasets. The…”
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Molecular pathogenesis of head and neck cancers by Singh, Bhuvanesh

“…Head and neck cancers represent a progressive genetic malady, with genetic aberrations accumulating in response to carcinogen exposure. Although individual…”
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Discovery of an Orally Bioavailable Inhibitor of Defective in Cullin Neddylation 1 (DCN1)-Mediated Cullin Neddylation by Hammill, Jared T, Bhasin, Deepak, Scott, Daniel C, Min, Jaeki, Chen, Yizhe, Lu, Yan, Yang, Lei, Kim, Ho Shin, Connelly, Michele C, Hammill, Courtney, Holbrook, Gloria, Jeffries, Cynthia, Singh, Bhuvanesh, Schulman, Brenda A, Guy, R. Kiplin

“…We previously reported the discovery, validation, and structure–activity relationships of a series of piperidinyl ureas that potently inhibit the DCN1–UBE2M…”
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EGF Receptor Gene Mutations Are Common in Lung Cancers from "Never Smokers" and Are Associated with Sensitivity of Tumors to Gefitinib and Erlotinib by Pao, William, Miller, Vincent, Zakowski, Maureen, Doherty, Jennifer, Politi, Katerina, Sarkaria, Inderpal, Singh, Bhuvanesh, Heelan, Robert, Rusch, Valerie, Fulton, Lucinda, Mardis, Elaine, Kupfer, Doris, Wilson, Richard, Kris, Mark, Varmus, Harold

“…Somatic mutations in the tyrosine kinase (TK) domain of the epidermal growth factor receptor (EGFR) gene are reportedly associated with sensitivity of lung…”
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Blocking an N-terminal acetylation–dependent protein interaction inhibits an E3 ligase by Scott, Daniel C, Hammill, Jared T, Min, Jaeki, Rhee, David Y, Connelly, Michele, Sviderskiy, Vladislav O, Bhasin, Deepak, Chen, Yizhe, Ong, Su-Sien, Chai, Sergio C, Goktug, Asli N, Huang, Guochang, Monda, Julie K, Low, Jonathan, Kim, Ho Shin, Paulo, Joao A, Cannon, Joe R, Shelat, Anang A, Chen, Taosheng, Kelsall, Ian R, Alpi, Arno F, Pagala, Vishwajeeth, Wang, Xusheng, Peng, Junmin, Singh, Bhuvanesh, Harper, J Wade, Schulman, Brenda A, Guy, R Kip

“…High-throughput screening and structure-guided design identified small-molecule inhibitors that prevent the interaction between N-terminally acetylated E2…”
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Decreased Lymphangiogenesis and Lymph Node Metastasis by mTOR Inhibition in Head and Neck Cancer by PATEL, Vyomesh, MARSH, Christina A, SILVIO GUTKIND, J, DORSAM, Robert T, MIKELIS, Constantinos M, MASEDUNSKAS, Andrius, AMORNPHIMOLTHAM, Panomwat, ANN NATHAN, Cherie, SINGH, Bhuvanesh, WEIGERT, Roberto, MOLINOLO, Alfredo A

“…Despite our improved understanding of cancer, the 5-year survival rate for head and neck squamous cell carcinomas (HNSCC) patients remains relatively unchanged…”
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Oral tongue cancer gene expression profiling: Identification of novel potential prognosticators by oligonucleotide microarray analysis by Estilo, Cherry L, O-charoenrat, Pornchai, Talbot, Simon, Socci, Nicholas D, Carlson, Diane L, Ghossein, Ronald, Williams, Tijaana, Yonekawa, Yoshihiro, Ramanathan, Yegnanarayana, Boyle, Jay O, Kraus, Dennis H, Patel, Snehal, Shaha, Ashok R, Wong, Richard J, Huryn, Joseph M, Shah, Jatin P, Singh, Bhuvanesh

“…The present study is aimed at identifying potential candidate genes as prognostic markers in human oral tongue squamous cell carcinoma (SCC) by large scale…”
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tyrosine phosphatase PTPRD is a tumor suppressor that is frequently inactivated and mutated in glioblastoma and other human cancers by Veeriah, Selvaraju, Brennan, Cameron, Meng, Shasha, Singh, Bhuvanesh, Fagin, James A, Solit, David B, Paty, Philip B, Rohle, Dan, Vivanco, Igor, Chmielecki, Juliann, Pao, William, Ladanyi, Marc, Gerald, William L, Liau, Linda, Cloughesy, Timothy C, Mischel, Paul S, Sander, Chris, Taylor, Barry, Schultz, Nikolaus, Major, John, Heguy, Adriana, Fang, Fang, Mellinghoff, Ingo K, Chan, Timothy A

“…Tyrosine phosphorylation plays a critical role in regulating cellular function and is a central feature in signaling cascades involved in oncogenesis. The…”
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A Survey of Detection and Mitigation for Fake Images on Social Media Platforms by Sharma, Dilip Kumar, Singh, Bhuvanesh, Agarwal, Saurabh, Garg, Lalit, Kim, Cheonshik, Jung, Ki-Hyun

“…Recently, the spread of fake images on social media platforms has become a significant concern for individuals, organizations, and governments. These images…”
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Preliminary evaluation of the reliability and validity of the Shame and Stigma Scale in head and neck cancer by Kissane, David W., Patel, Snehal G., Baser, Raymond E., Bell, Rachel, Farberov, Maria, Ostroff, Jamie S., Li, Yuelin, Singh, Bhuvanesh, Kraus, Dennis H., Shah, Jatin P.

“…Background Facial disfigurement from head and neck cancer can lead to the development of shame and a perception of stigma. We sought to develop the Shame and…”
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A 20-year perspective on the International Fanconi Anemia Registry (IFAR) by Kutler, David I., Singh, Bhuvanesh, Satagopan, Jaya, Batish, Sat Dev, Berwick, Marianne, Giampietro, Philip F., Hanenberg, Helmut, Auerbach, Arleen D.

“…Fanconi anemia (FA) is an autosomal recessive disorder characterized by cellular hypersensitivity to DNA cross-linking agents and cancer predisposition. Recent…”
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Sentinel Lymph Node Biopsy for Cutaneous Head and Neck Melanoma: Mapping the Parotid Gland by Picon, Antonio I., Coit, Daniel G., Shaha, Ashok R., Brady, Mary S., Boyle, Jay O., Singh, Bhuvanesh B., Wong, Richard J., Busam, Klaus J., Shah, Jatin P., Kraus, Dennis H.

“…Background Sentinel lymph node biopsy (SLNB) for primary cutaneous head and neck melanoma (CHNM) has been shown to be successful and is the current standard of…”
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Mouse DCUN1D1 (SCCRO) is required for spermatogenetic individualization by Huang, Guochang, Kaufman, Andrew J, Ryan, Russell J H, Romin, Yevgeniy, Huryn, Laryssa, Bains, Sarina, Manova-Todorova, Katia, Morris, Patricia L, Hunnicutt, Gary R, Adelman, Carrie A, Petrini, John H J, Ramanathan, Y, Singh, Bhuvanesh

“…Squamous cell carcinoma-related oncogene (SCCRO, also known as DCUN1D1) is a component of the E3 for neddylation. As such, DCUN1D1 regulates the neddylation of…”
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Postoperative complications of salvage total laryngectomy by Ganly, Ian, Patel, Snehal, Matsuo, Jeanette, Singh, Bhuvanesh, Kraus, Dennis, Boyle, Jay, Wong, Richard, Lee, Nancy, Pfister, David G., Shaha, Ashok, Shah, Jatin

“…BACKGROUND The objectives of the current study were to report the incidence of postoperative complications for salvage total laryngectomy (STL) compared with…”
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Genomic dissection of the epidermal growth factor receptor (EGFR)/PI3K pathway reveals frequent deletion of the EGFR phosphatase PTPRS in head and neck cancers by Morris, Luc G. T, Taylor, Barry S, Bivona, Trever G, Gong, Yongxing, Eng, Stephanie, Brennan, Cameron W, Kaufman, Andrew, Kastenhuber, Edward R, Banuchi, Victoria E, Singh, Bhuvanesh, Heguy, Adriana, Viale, Agnes, Mellinghoff, Ingo K, Huse, Jason, Ganly, Ian, Chan, Timothy A

“…Activation of the PI3K and epidermal growth factor receptor (EGFR) pathway is able to drive oncogenesis in multiple human cancers, including head and neck…”
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Use of Cigarette-Smoking History to Estimate the Likelihood of Mutations in Epidermal Growth Factor Receptor Gene Exons 19 and 21 in Lung Adenocarcinomas by PHAM, Duykhanh, KRIS, Mark G, WILSON, Richard K, SINGH, Bhuvanesh, RUSCH, Valerie W, RIELY, Gregory J, SARKARIA, Inderpal S, MCDONOUGH, Tiffani, CHUAI, Shaokun, VENKATRAMAN, Ennapadam S, MILLER, Vincent A, LADANYI, Marc, PAO, William

“…Lung adenocarcinomas with mutations in exons 19 and 21 of the epidermal growth factor receptor gene (EGFR) demonstrate sensitivity to gefitinib or erlotinib…”
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