Search Results - "SINGH, Amar B"

Role of Claudin Proteins in Regulating Cancer Stem Cells and Chemoresistance-Potential Implication in Disease Prognosis and Therapy by Gowrikumar, Saiprasad, Singh, Amar B, Dhawan, Punita

“…Claudins are cell-cell adhesion proteins, which are expressed in tight junctions (TJs), the most common apical cell-cell adhesion. Claudin proteins help to…”
Get full text

Obesity-induces Organ and Tissue Specific Tight Junction Restructuring and Barrier Deregulation by Claudin Switching by Ahmad, Rizwan, Rah, Bilal, Bastola, Dhundy, Dhawan, Punita, Singh, Amar B.

“…Obesity increases susceptibility to multiple organ disorders, however, underlying mechanisms remain unclear. The subclinical inflammation assisted by…”
Get full text

Claudins and cancer: Fall of the soldiers entrusted to protect the gate and keep the barrier intact by Singh, Amar B., Dhawan, Punita

“…The role of the tight junctions (TJ) in controlling paracellular traffic of ions and molecules, through the regulation of claudin proteins, is now established…”
Get full text

Pancreatic Cancer and Therapy: Role and Regulation of Cancer Stem Cells by Barman, Susmita, Fatima, Iram, Singh, Amar B, Dhawan, Punita

“…Despite significant improvements in clinical management, pancreatic cancer (PC) remains one of the deadliest cancer types, as it is prone to late detection…”
Get full text

Gut Microbiota and Metabolic Specificity in Ulcerative Colitis and Crohn's Disease by Sankarasubramanian, Jagadesan, Ahmad, Rizwan, Avuthu, Nagavardhini, Singh, Amar B, Guda, Chittibabu

“…Inflammatory bowel disease (IBD) represents multifactorial chronic inflammatory conditions in the gastrointestinal tract and includes Crohn's disease (CD) and…”
Get full text

MASTL induces Colon Cancer progression and Chemoresistance by promoting Wnt/β-catenin signaling by Uppada, Srijayaprakash Babu, Gowrikumar, Saiprasad, Ahmad, Rizwan, Kumar, Balawant, Szeglin, Bryan, Chen, Xi, Smith, J Joshua, Batra, Surinder K, Singh, Amar B, Dhawan, Punita

“…Chemotherapeutic agents that modulate cell cycle checkpoints and/or tumor-specific pathways have shown immense promise in preclinical and clinical studies…”
Get full text

Claudin-1 Up-regulates the Repressor ZEB-1 to Inhibit E-Cadherin Expression in Colon Cancer Cells by Singh, Amar B, Sharma, Ashok, Smith, J. Joshua, Krishnan, Moorthy, Chen, Xi, Eschrich, Steven, Washington, Mary K, Yeatman, Timothy J, Beauchamp, R. Daniel, Dhawan, Punita

“…Background & Aims Expression of the tight junction protein claudin-1 is dysregulated in colon tumors and associates with their progression. Up-regulation of…”
Get full text

Claudin Family of Proteins and Cancer : An Overview by Singh, Amar B., Sharma, Ashok, Dhawan, Punita

“…Tight junctions are the apical cell-cell adhesion that regulate paracellular permeability and are critical for epithelial cell polarity. Molecular architecture…”
Get full text

MASTL: A novel therapeutic target for Cancer Malignancy by Fatima, Iram, Singh, Amar B., Dhawan, Punita

“…Targeting mitotic kinases is an emerging anticancer approach with promising preclinical outcomes. Microtubule‐associated serine/threonine kinase like (MASTL),…”
Get full text

The role of the EGF family of ligands and receptors in renal development, physiology and pathophysiology by Zeng, Fenghua, Singh, Amar B., Harris, Raymond C.

“…Mammalian kidney expresses all of the members of the ErbB family of receptors and their respective ligands. Studies support a role for ErbB family receptor…”
Get full text

Claudin-2 inhibits renal clear cell carcinoma progression by inhibiting YAP-activation by Kumar, Balawant, Ahmad, Rizwan, Giannico, Giovanna A, Zent, Roy, Talmon, Geoffrey A, Harris, Raymond C, Clark, Peter E, Lokeshwar, Vinata, Dhawan, Punita, Singh, Amar B

“…Claudin-2 expression is upregulated in multiple cancers and promotes cancer malignancy. Remarkably, the regulation of claudin-2 expression in kidney cell lines…”
Get full text

Claudin-1 overexpression in intestinal epithelial cells enhances susceptibility to adenamatous polyposis coli-mediated colon tumorigenesis by Pope, Jillian L, Ahmad, Rizwan, Bhat, Ajaz A, Washington, Mary K, Singh, Amar B, Dhawan, Punita

“…The tight junction protein Claudin-1, a claudin family member, has been implicated in several gastro-intestinal pathologies including inflammatory bowel…”
Get full text

Colonoscopy-based intramucosal transplantation of cancer cells for mouse modeling of colon cancer and lung metastasis by Ahmad, Rizwan, Kumar, Balawant, Tamang, Raju Lama, Xu, Wei, Talmon, Geoffrey A, Mohs, Aaron M, Dhawan, Punita, Singh, Amar B

“…The conventional orthotopic/xenograft models or genetically engineered murine models of colon cancer (CRC) are limited in their scope for a true understanding…”
Get full text

Identification and characterization of a first-generation inhibitor of claudin-1 in colon cancer progression and metastasis by Fatima, Iram, Uppada, Jaya Prakash, Chhonker, Yashpal S., Gowrikumar, Saiprasad, Barman, Susmita, Roy, Sourav, Tolentino, Kirsten T., Palermo, Nicholas, Natarajan, Amar, Beauchamp, Daniel R., Vecchio, Alex, Murry, Daryl J., Singh, Amar B., Hopkins, Corey R., Dhawan, Punita

“…Colorectal cancer (CRC) is a leading cause of the cancer-related deaths worldwide. Thus, developing novel and targeted therapies for inhibiting CRC progression…”
Get full text

High-fructose diet downregulates long-chain acyl-CoA synthetase 3 expression in liver of hamsters via impairing LXR/RXR signaling pathway[S] by Dong, Bin, Kan, Chin Fung Kelvin, Singh, Amar B., Liu, Jingwen

“…Long-chain acyl-CoA synthetases (ACSL) play key roles in fatty acid metabolism in liver and other metabolic tissues in an isozyme-specific manner. In this…”
Get full text

Loss of claudin-3 expression increases colitis risk by promoting Gut Dysbiosis by Ahmad, Rizwan, Kumar, Balawant, Thapa, Ishwor, Talmon, Geoffrey A., Salomon, Jeffrey, Ramer-Tait, Amanda E., Bastola, Dhundy K., Dhawan, Punita, Singh, Amar B.

“…Dysregulation of both the gut barrier and microbiota (dysbiosis) promotes susceptibility to and severity of Inflammatory Bowel Diseases (IBD). Leaky gut and…”
Get full text

Piglet cardiopulmonary bypass induces intestinal dysbiosis and barrier dysfunction associated with systemic inflammation by Salomon, Jeffrey D, Qiu, Haowen, Feng, Dan, Owens, Jacob, Khailova, Ludmila, Osorio Lujan, Suzanne, Iguidbashian, John, Chhonker, Yashpal S, Murry, Daryl J, Riethoven, Jean-Jack, Lindsey, Merry L, Singh, Amar B, Davidson, Jesse A

“…The intestinal microbiome is essential to human health and homeostasis, and is implicated in the pathophysiology of disease, including congenital heart disease…”
Get full text

Caudal homeobox protein Cdx-2 cooperates with Wnt pathway to regulate claudin-1 expression in colon cancer cells by Bhat, Ajaz A, Sharma, Ashok, Pope, Jillian, Krishnan, Moorthy, Washington, Mary K, Singh, Amar B, Dhawan, Punita

“…Dysregulation of tight junctions (TJs) is often associated with human diseases including carcinogenesis and recent studies support role of TJ integral proteins…”
Get full text

MyD88 regulates a prolonged adaptation response to environmental dust exposure-induced lung disease by Johnson, Amber N, Harkema, Jack R, Nelson, Amy J, Dickinson, John D, Kalil, Julianna, Duryee, Michael J, Thiele, Geoffrey M, Kumar, Balawant, Singh, Amar B, Gaurav, Rohit, Glover, Sarah C, Tang, Ying, Romberger, Debra J, Kielian, Tammy, Poole, Jill A

“…Environmental organic dust exposures enriched in Toll-like receptor (TLR) agonists can reduce allergic asthma development but are associated with occupational…”
Get full text

Pyrroline-5-Carboxylate Reductase-2 Promotes Colorectal Carcinogenesis by Modulating Microtubule-Associated Serine/Threonine Kinase-like/Wnt/β-Catenin Signaling by Lama Tamang, Raju, Kumar, Balawant, Patel, Sagar M, Thapa, Ishwor, Ahmad, Alshomrani, Kumar, Vikas, Ahmad, Rizwan, Becker, Donald F, Bastola, Dundy Kiran, Dhawan, Punita, Singh, Amar B

“…Despite significant progress in clinical management, colorectal cancer (CRC) remains the third most common cause of cancer-related deaths. A positive…”
Get full text