Search Results - "SINGEWALD, N"

Pharmacology of cognitive enhancers for exposure-based therapy of fear, anxiety and trauma-related disorders by Singewald, N, Schmuckermair, C, Whittle, N, Holmes, A, Ressler, K J

“…Pathological fear and anxiety are highly debilitating and, despite considerable advances in psychotherapy and pharmacotherapy they remain insufficiently…”
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role of substance P in stress and anxiety responses by Ebner, K, Singewald, N

“…Substance P (SP) is one of the most abundant peptides in the central nervous system and has been implicated in a variety of physiological and…”
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Potential of microRNAs as novel targets in the alleviation of pathological fear by Murphy, C. P., Singewald, N.

“…The current treatment of post‐traumatic stress disorder (PTSD), phobias and other anxiety disorders, remains insufficient particularly in producing…”
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Magnesium deficiency induces anxiety and HPA axis dysregulation: Modulation by therapeutic drug treatment by Sartori, S.B., Whittle, N., Hetzenauer, A., Singewald, N.

“…Preclinical and some clinical studies suggest a relationship between perturbation in magnesium (Mg2+) homeostasis and pathological anxiety, although the…”
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Pharmacotherapy of anxiety disorders-Guideline-conform treatment and new developments by Zwanzger, P, Singewald, N, Bandelow, B

“…Besides cognitive behavioral therapy (CBT), psychopharmacotherapy belongs to the first-line treatment approaches for anxiety disorders according to all…”
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Zinc deficiency induces enhanced depression-like behaviour and altered limbic activation reversed by antidepressant treatment in mice by Whittle, N, Lubec, G, Singewald, N

“…A relationship between zinc (Zn)-deficiency and mood disorders has been suspected. Here we examined for the first time whether experimentally-induced…”
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Effects of disrupted ghrelin receptor function on fear processing, anxiety and saccharin preference in mice by Pierre, A., Regin, Y., Van Schuerbeek, A., Fritz, E.M., Muylle, K., Beckers, T., Smolders, I.J., Singewald, N., De Bundel, D.

“…•Exposure to a high-fat diet reduces ghrelin receptor function.•Exposure to a high-fat diet does not alter fear or anxiety-like behaviour but lowers saccharin…”
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Durable fear memories require PSD-95 by Fitzgerald, P J, Pinard, C R, Camp, M C, Feyder, M, Sah, A, Bergstrom, H C, Graybeal, C, Liu, Y, Schlüter, O M, Grant, S G, Singewald, N, Xu, W, Holmes, A

“…Traumatic fear memories are highly durable but also dynamic, undergoing repeated reactivation and rehearsal over time. Although overly persistent fear memories…”
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Role of voltage-gated L-type Ca2+ channel isoforms for brain function by Striessnig, J, Koschak, A, Sinnegger-Brauns, M J, Hetzenauer, A, Nguyen, N K, Busquet, P, Pelster, G, Singewald, N

“…Voltage-gated LTCCs (L-type Ca2+ channels) are established drug targets for the treatment of cardiovascular diseases. LTCCs are also expressed outside the…”
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Substance P excites GABAergic neurons in the mouse central amygdala through neurokinin 1 receptor activation by Sosulina, L, Strippel, C, Romo-Parra, H, Walter, A L, Kanyshkova, T, Sartori, S B, Lange, M D, Singewald, N, Pape, H-C

“…Substance P (SP) is implicated in stress regulation and affective and anxiety-related behavior. Particularly high expression has been found in the main output…”
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Conditional mouse mutants highlight mechanisms of corticotropin-releasing hormone effects on stress-coping behavior by Lu, A, Steiner, M A, Whittle, N, Vogl, A M, Walser, S M, Ableitner, M, Refojo, D, Ekker, M, Rubenstein, J L, Stalla, G K, Singewald, N, Holsboer, F, Wotjak, C T, Wurst, W, Deussing, J M

“…Hypersecretion of central corticotropin-releasing hormone (CRH) has been implicated in the pathophysiology of affective disorders. Both, basic and clinical…”
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Enhancing dopaminergic signaling and histone acetylation promotes long-term rescue of deficient fear extinction by Whittle, N, Maurer, V, Murphy, C, Rainer, J, Bindreither, D, Hauschild, M, Scharinger, A, Oberhauser, M, Keil, T, Brehm, C, Valovka, T, Striessnig, J, Singewald, N

“…Extinction-based exposure therapy is used to treat anxiety- and trauma-related disorders; however, there is the need to improve its limited efficacy in…”
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Increased novelty-induced motor activity and reduced depression-like behavior in neuropeptide Y (NPY)–Y4 receptor knockout mice by Tasan, R.O, Lin, S, Hetzenauer, A, Singewald, N, Herzog, H, Sperk, G

“…Abstract There is growing evidence that neuropeptide Y (NPY) acting through Y1 and Y2 receptors has a prominent role in modulating anxiety- and depression-like…”
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Sub-chronic dietary tryptophan depletion – An animal model of depression with improved face and good construct validity by Franklin, M, Bermudez, I, Murck, H, Singewald, N, Gaburro, S

“…Abstract Sub-chronic tryptophan depletion (SCTD) is proposed as an animal model for depression. Aims were to test the hypothesis and optimise the time of…”
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Altered GABA transmission in a mouse model of increased trait anxiety by Tasan, R.O, Bukovac, A, Peterschmitt, Y.N, Sartori, S.B, Landgraf, R, Singewald, N, Sperk, G

“…Abstract Anxiety disorders are the most prevalent central nervous system diseases imposing a high social burden to our society. Emotional processing is…”
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Inhibitory Function of the Dorsomedial Hypothalamic Nucleus on the Hypothalamic-Pituitary-Adrenal Axis Response to an Emotional Stressor but not Immune Challenge by Ebner, K., Muigg, P., Singewald, N.

“…Accumulating evidence implicates the dorsomedial hypothalamic nucleus (DMH) in the regulation of autonomic and neuroendocrine stress responses. However,…”
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Neuroanatomical targets of anxiogenic drugs in the hindbrain as revealed by Fos immunocytochemistry by Singewald, N, Sharp, T

“…It is speculated that specific hindbrain transmitter pathways centred on the periaqueductal gray and locus coeruleus are an important integrative neural…”
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Effect of chronic psychosocial stress-induced by subordinate colony (CSC) housing on brain neuronal activity patterns in mice by Singewald, G M, Nguyen, N K, Neumann, I D, Singewald, N, Reber, S O

“…Chronic subordinate colony (CSC) housing has been recently validated as a murine model of chronic psychosocial stress which induces alterations of…”
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Impaired Pavlovian fear extinction is a common phenotype across genetic lineages of the 129 inbred mouse strain by Camp, M., Norcross, M., Whittle, N., Feyder, M., D’Hanis, W., Yilmazer‐Hanke, D., Singewald, N., Holmes, A.

“…Fear extinction is impaired in psychiatric disorders such as post‐traumatic stress disorder and schizophrenia, which have a major genetic component. However,…”
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Bidirectional rescue of extreme genetic predispositions to anxiety: impact of CRH receptor 1 as epigenetic plasticity gene in the amygdala by Sotnikov, S V, Markt, P O, Malik, V, Chekmareva, N Y, Naik, R R, Sah, A, Singewald, N, Holsboer, F, Czibere, L, Landgraf, R

“…The continuum of physiological anxiety up to psychopathology is not merely dependent on genes, but is orchestrated by the interplay of genetic predisposition,…”
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