Search Results - "SINDERMANN, HERBERT"

Oral Miltefosine for Leishmaniasis in Immunocompromised Patients: Compassionate Use in 39 Patients with HIV Infection by Sindermann, Herbert, Engel, Kirsten R., Fischer, Christina, Bommer, Wolfgang

“…Oral miltefosine was administered to 39 human immunodeficiency virus (HIV)–infected patients with leishmaniasis for whom standard leishmaniasis treatment had…”
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Efficacy and Tolerability of Miltefosine for Childhood Visceral Leishmaniasis in India by Bhattacharya, Sujit K., Jha, T. K., Sundar, Shyam, Thakur, C. P., Engel, Juergen, Sindermann, Herbert, Junge, Klaus, Karbwang, Juntra, Bryceson, Anthony D. M., Berman, Jonathan D.

“…Miltefosine has previously been shown to cure 97% of cases of visceral leishmaniasis (VL) in Indian adults. Because approximately one-half of cases of VL occur…”
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A physiologically based pharmacokinetic (PBPK) parent-metabolite model of the chemotherapeutic zoptarelin doxorubicin—integration of in vitro results, Phase I and Phase II data and model application for drug–drug interaction potential analysis by Hanke, Nina, Teifel, Michael, Moj, Daniel, Wojtyniak, Jan-Georg, Britz, Hannah, Aicher, Babette, Sindermann, Herbert, Ammer, Nicola, Lehr, Thorsten

“…Purpose Zoptarelin doxorubicin is a fusion molecule of the chemotherapeutic doxorubicin and a luteinizing hormone-releasing hormone receptor (LHRHR) agonist,…”
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Efficacy and safety of AEZS-108 (INN: Zoptarelin Doxorubicin Acetate) an LHRH agonist linked to doxorubicin in women with platinum refractory or resistant ovarian cancer expressing LHRH receptors: A multicenter Phase II trial of the ago-study group (AGO GYN 5) by Emons, Günter, Gorchev, Grigor, Sehouli, Jalid, Wimberger, Pauline, Stähle, Anne, Hanker, Lars, Hilpert, Felix, Sindermann, Herbert, Gründker, Carsten, Harter, Philipp

“…Abstract Objectives To evaluate the activity and toxicity of AEZS-108 (Zoptarelin Doxorubicin Acetate) an LHRH agonist linked to doxorubicin in women with…”
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Oral Miltefosine for Indian Visceral Leishmaniasis by Sundar, Shyam, Jha, T.K, Thakur, C.P, Engel, Juergen, Sindermann, Herbert, Fischer, Christina, Junge, Klaus, Bryceson, Anthony, Berman, Jonathan

“…Miltefosine has been shown to have activity against Indian visceral leishmaniasis, and this agent can be taken orally. This randomized trial in India compared…”
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Phase 4 Trial of Miltefosine for the Treatment of Indian Visceral Leishmaniasis by Bhattacharya, Sujit Kumar, Sinha, Prabhat Kumar, Sundar, Shyam, Thakur, Chandreshar Prasad, Jha, Tara Kant, Pandey, Krishna, Das, Vidyanand Rabi, Kumar, Naveen, Lal, Chandrasekhar, Verma, Neena, Singh, Vijay Pratap, Ranjan, Alok, Verma, Rakesh Bihari, Anders, Gerlind, Sindermann, Herbert, Ganguly, Nirmal Kumar

“…Background. Visceral leishmaniasis (VL) is a major public health problem in Bihar, accounting for 90% of all cases in India. Development of high levels of…”
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Efficacy and safety of AEZS-108 (LHRH agonist linked to doxorubicin) in women with advanced or recurrent endometrial cancer expressing LHRH receptors: a multicenter phase 2 trial (AGO-GYN5) by Emons, Günter, Gorchev, Grigor, Harter, Philipp, Wimberger, Pauline, Stähle, Anne, Hanker, Lars, Hilpert, Felix, Beckmann, Matthias W, Dall, Peter, Gründker, Carsten, Sindermann, Herbert, Sehouli, Jalid

“…Advanced or recurrent endometrial cancer (EC) no longer amenable to surgery or radiotherapy is a life-threatening disease with limited therapeutic options…”
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First-time-in-man and pharmacokinetic study of weekly oral perifosine in patients with solid tumours by Unger, Clemens, Berdel, Wolfgang, Hanauske, Axel-R, Sindermann, Herbert, Engel, Jürgen, Mross, Klaus

“…Abstract Aim To identify the maximum-tolerated dose (MTD) and pharmacokinetics of oral perifosine. Methods Patients with solid tumours received perifosine at…”
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Dose escalation and pharmacokinetic study of AEZS-108 (AN-152), an LHRH agonist linked to doxorubicin, in women with LHRH receptor-positive tumors by Emons, Günter, Kaufmann, Manfred, Gorchev, Grigor, Tsekova, Valentina, Gründker, Carsten, Günthert, Andreas R, Hanker, Lars C, Velikova, Maya, Sindermann, Herbert, Engel, Jürgen, Schally, Andrew V

“…Abstract Objectives Receptors for luteinizing hormone-releasing hormone (LHRH) can be utilized for targeted chemotherapy of cytotoxic LHRH analogs. The…”
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Luteinizing hormone-releasing hormone receptor-targeted chemotherapy using AN-152 by Emons, Günter, Sindermann, Herbert, Engel, Jürgen, Schally, Andrew V, Gründker, Carsten

“…The luteinizing hormone-releasing hormone (LHRH; also known as gonadotropin-releasing hormone) receptor can be utilized for targeted chemotherapy with…”
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Phase I and pharmacokinetic study of combined treatment with perifosine and radiation in patients with advanced solid tumours by Vink, Stefan R., Schellens, Jan H.M., Beijnen, Jos H., Sindermann, Herbert, Engel, Jürgen, Dubbelman, Ria, Moppi, Gemi, Hillebrand, Michel J.X., Bartelink, Harry, Verheij, Marcel

“…Perifosine is an orally applicable, membrane-targeted alkylphosphocholine analogue with antitumour activity and radiosensitising properties in preclinical…”
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Relapse of new world diffuse cutaneous leishmaniasis caused by Leishmania (Leishmania) mexicana after miltefosine treatment by Calvopina, Manuel, Gomez, Eduardo A, Sindermann, Herbert, Cooper, Philip J, Hashiguchi, Yoshihisa

“…A 35-year-old man with a 19-year history of slowly evolving diffuse cutaneous leishmaniasis was treated with oral miltefosine, 50 mg three times a day. The…”
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Oral miltefosine treatment in children with mild to moderate Indian visceral leishmaniasis by SUNDAR, SHYAM, JHA, T K, SINDERMANN, HERBERT, JUNGE, KLAUS, BACHMANN, PETER, BERMAN, JONATHAN

“…BACKGROUND.Miltefosine is the first oral drug with demonstrable success in treating visceral leishmaniasis in adults. Because approximately one-half of the…”
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Treatment of diffuse cutaneous leishmaniasis with miltefosine: a case report by Zerpa, Olga, Blanco, Belkys, Kannee, Carmen, Ulrich, Marian, Sindermann, Herbert, Engel, Juergen, Convit, Jacinto

“…Background  A 31‐year‐old man who has suffered since age 3 from diffuse cutaneous leishmaniasis (DCL), a disease with profound physical and psychosocial…”
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Tropical medicine rounds: Treatment of diffuse cutaneous leishmaniasis with miltefosine: a case report by Zerpa, Olga, Blanco, Belkys, Kannee, Carmen, Ulrich, Marian, Sindermann, Herbert, Engel, Juergen, Convit, Jacinto

“…Background: A 31-year-old man who has suffered since age 3 from diffuse cutaneous leishmaniasis (DCL), a disease with profound physical and psychosocial…”
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Miltefosine in visceral leishmaniasis by Olliaro, Piero L, Ridley, Robert G, Engel, Jurgen, Sindermann, Herbert, Bryceson, Anthony D M

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Topical administration of hexadecylphosphocholine in patients with cutaneous lymphomas: results of a phase I/II study by Dummer, R, Krasovec, M, Röger, J, Sindermann, H, Burg, G

“…Hexadecylphosphocholine is a new antineoplastic drug that inhibits tumor cell growth directly and, in addition, might have immunoregulatory properties. We…”
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Leishmaniasis--oral treatment with hexadecylphosphocholine by Bommer, Wolfgang, Eibl, Hans J, Engel, Kirsten R, Kuhlencord, Armin, Sindermann, Herbert, Sundar, Sham, Zappel, Hildegard

“…Hexadecylphosphocholine (HDPC, Miltefosine, Impavido) was synthesized at the Max-Planck-Institut für Biophysikalische Chemie in Göttingen, Germany and…”
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Escherichia coli single-strand deoxyribonucleic acid binding protein: stability, specificity, and kinetics of complexes with oligonucleotides and deoxyribonucleic acid by Krauss, Gerhard, Sindermann, Herbert, Schomburg, Ulrich, Maass, Guenter

“…The complex formation between the single-strand DNA binding protein (ssB protein) from Escherichia coli and oligonucleotides and single-stranded DNA has been…”
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Hexadecylphosphocholine in the topical treatment of skin metastases in breast cancer patients by Unger, C, Peukert, M, Sindermann, H, Hilgard, P, Nagel, G, Eibl, H

“…Widespread local recurrence of breast cancer, untreatable by surgery or radiation therapy, can present a serious therapeutic problem predominantly in patients…”
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