Search Results - "SINCLAIR, D. K"

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    Developmental programming: Preconceptional and gestational exposure of sheep to a real-life environmental chemical mixture alters maternal metabolome in a fetal sex-specific manner by Thangaraj, S.V., Kachman, M., Halloran, K.M., Sinclair, K.D., Lea, R., Bellingham, M., Evans, N.P., Padmanabhan, V.

    Published in The Science of the total environment (15-03-2023)
    “…Everyday, humans are exposed to a mixture of environmental chemicals some of which have endocrine and/or metabolism disrupting actions which may contribute to…”
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    Journal Article
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    Antibiotic-eluting resorbable bone-void filler evaluated in a large animal infection prevention model by Ferrell, Z, Grainger, D W, Sinclair, K D

    Published in European cells & materials (08-04-2019)
    “…Periprosthetic infection in total knee arthroplasty is a difficult-to-treat complication. Current implant revision procedures use non-degradable,…”
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    Journal Article
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    Healthy ageing of cloned sheep by Sinclair, K. D., Corr, S. A., Gutierrez, C. G., Fisher, P. A., Lee, J.-H., Rathbone, A. J., Choi, I., Campbell, K. H. S., Gardner, D. S.

    Published in Nature communications (26-07-2016)
    “…The health of cloned animals generated by somatic-cell nuclear transfer (SCNT) has been of concern since its inception; however, there are no detailed…”
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    Journal Article
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    Complex Langevin Simulations of QCD at Finite Density – Progress Report by Sinclair, D. K., Kogut, J. B.

    Published in EPJ Web of Conferences (01-01-2018)
    “…We simulate lattice QCD at finite quark-number chemical potential to study nuclear matter, using the complex Langevin equation (CLE). The CLE is used because…”
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    Journal Article Conference Proceeding
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    Dietary omega-3 and -6 polyunsaturated fatty acids affect the composition and development of sheep granulosa cells, oocytes and embryos by Wonnacott, K E, Kwong, W Y, Hughes, J, Salter, A M, Lea, R G, Garnsworthy, P C, Sinclair, K D

    Published in Reproduction (Cambridge, England) (01-01-2010)
    “…The evidence that omega-3 (n-3) and -6 (n-6) polyunsaturated fatty acids (PUFAs) have differential effects on ovarian function, oocytes and embryo quality is…”
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    Journal Article
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    Endogenous folates and single-carbon metabolism in the ovarian follicle, oocyte and pre-implantation embryo by Kwong, W Y, Adamiak, S J, Gwynn, A, Singh, R, Sinclair, K D

    Published in Reproduction (Cambridge, England) (01-04-2010)
    “…Maternal B-vitamin status at conception can affect fertility and the health of offspring. This study details transcript expression for genes encoding key…”
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    Journal Article
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    Epigenetics and Reproductive Medicine by Huntriss, J, Balen, AH, Sinclair, KD, Brison, DR, Picton, HM

    “…In 1942, Conrad H Waddington introduced the term ‘epigenetics’, to describe a biological process that takes place between the genotype and phenotype.1…”
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    Journal Article
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    Effect of the early-life nutritional environment on fecundity and fertility of mammals by Gardner, D. S., Ozanne, S. E., Sinclair, K. D.

    “…The early-life developmental environment is instrumental in shaping our overall adult health and well-being. Early-life diet and endocrine exposure may…”
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    Journal Article
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    Effect of dietary-induced changes in plasma insulin concentrations during the early post partum period on pregnancy rate in dairy cows by Garnsworthy, P C, Fouladi-Nashta, A A, Mann, G E, Sinclair, K D, Webb, R

    Published in Reproduction (Cambridge, England) (01-04-2009)
    “…Dietary stimulation of insulin in post partum dairy cows has been found to enhance ovarian follicle development but to impair oocyte developmental competence…”
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    Journal Article
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    Effects of single or serial embryo splitting on the development and morphokinetics of in vitro produced bovine embryos by Silvestri, G., Turner, K. J., Silcock, J. L., Sinclair, K. D., Griffin, D. K.

    Published in European zoological journal (31-12-2022)
    “…Embryo splitting can be used in cattle in vitro production (IVP) to improve embryo availability and to increase selection intensity. Despite this widespread…”
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    Journal Article
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    Body composition, dietary carbohydrates and fatty acids determine post-fertilisation development of bovine oocytes in vitro by Adamiak, S J, Powell, K, Rooke, J A, Webb, R, Sinclair, K D

    Published in Reproduction (Cambridge, England) (01-02-2006)
    “…This study assessed the interactive effects of carbohydrate type (fibre vs starch) and fatty acid (FA) supplementation (0% vs 6% calcium soaps of palm oil FA)…”
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    Journal Article
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    Nutrition, metabolism, and fertility in dairy cows: 1. Dietary energy source and ovarian function by Garnsworthy, P C, Lock, A, Mann, G E, Sinclair, K D, Webb, R

    Published in Journal of dairy science (01-10-2008)
    “…In previous studies, high plasma insulin was associated with earlier resumption of postpartum estrous cycles in dairy cows. The objective of this experiment…”
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    Journal Article
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    Molecular determinants of a competent bovine corpus luteum: first- vs final-wave dominant follicles by Gregson, E, Webb, R, Sheldrick, E L, Campbell, B K, Mann, G E, Liddell, S, Sinclair, K D

    Published in Reproduction (Cambridge, England) (01-06-2016)
    “…Abstract Reproductive management in cattle requires the synchrony of follicle development and oestrus before insemination. However, ovulation of follicles that…”
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    Journal Article
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    Development of a broad spectrum polymer-released antimicrobial coating for the prevention of resistant strain bacterial infections by Sinclair, K. D., Pham, T. X., Farnsworth, R. W., Williams, D. L., Loc-Carrillo, C., Horne, L. A., Ingebretsen, S. H., Bloebaum, R. D.

    “…More than 400,000 primary hip and knee replacement surgeries are performed each year in the United States. From these procedures, approximately 0.5–3% will…”
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    Journal Article
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    Amino acid and fatty acid composition of follicular fluid as predictors of in-vitro embryo development by Sinclair, KD, Lunn, LA, Kwong, WY, Wonnacott, K, Linforth, RST, Craigon, J

    Published in Reproductive biomedicine online (2008)
    “…Abstract The value of using the amino acid and fatty acid composition of follicular fluid as predictors of embryo development was assessed in a bovine model of…”
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    Journal Article
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    Impact of Nutrition on Oocyte Quality: Cumulative Effects of Body Composition and Diet Leading to Hyperinsulinemia in Cattle by ADAMIAK, S. J, MACKIE, K, WATT, R. G, WEBB, R, SINCLAIR, K. D

    Published in Biology of reproduction (01-11-2005)
    “…The present study sought to assess the combined effects of body composition and diet (level of feeding) on the postfertilization developmental potential of…”
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    Journal Article
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    Effect of Dietary Energy and Protein on Bovine Follicular Dynamics and Embryo Production In Vitro: Associations with the Ovarian Insulin-Like Growth Factor System by ARMSTRONG, D. G, MCEVOY, T. G, BAXTER, G, ROBINSON, J. J, HOGG, C. O, WOAD, K. J, WEBB, R, SINCLAIR, K. D

    Published in Biology of reproduction (01-06-2001)
    “…Heifers were assigned either low or high (HE) levels of energy intake and low or high concentrations of dietary crude protein. The effect of these diets on the…”
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    Journal Article