Search Results - "SIMUNEK, Tomáš"

Oxidative stress, redox signaling, and metal chelation in anthracycline cardiotoxicity and pharmacological cardioprotection by Stěrba, Martin, Popelová, Olga, Vávrová, Anna, Jirkovský, Eduard, Kovaříková, Petra, Geršl, Vladimír, Simůnek, Tomáš

“…Anthracyclines (doxorubicin, daunorubicin, or epirubicin) rank among the most effective anticancer drugs, but their clinical usefulness is hampered by the risk…”
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Anthracycline-induced cardiotoxicity: Overview of studies examining the roles of oxidative stress and free cellular iron by Šimůnek, Tomáš, Štěrba, Martin, Popelová, Olga, Adamcová, Michaela, Hrdina, Radomír, Geršl, Vladimír

“…The risk of cardiotoxicity is the most serious drawback to the clinical usefulness of anthracycline antineoplastic antibiotics, which include doxorubicin…”
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Exploring the anti-cancer activity of novel thiosemicarbazones generated through the combination of retro-fragments: dissection of critical structure-activity relationships by Serda, Maciej, Kalinowski, Danuta S, Rasko, Nathalie, Potůčková, Eliška, Mrozek-Wilczkiewicz, Anna, Musiol, Robert, Małecki, Jan G, Sajewicz, Mieczysław, Ratuszna, Alicja, Muchowicz, Angelika, Gołąb, Jakub, Simůnek, Tomáš, Richardson, Des R, Polanski, Jaroslaw

“…Thiosemicarbazones (TSCs) are an interesting class of ligands that show a diverse range of biological activity, including anti-fungal, anti-viral and…”
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Hydrophobicity‐enhanced ferritin nanoparticles for efficient encapsulation and targeted delivery of hydrophobic drugs to tumor cells by Incocciati, Alessio, Kubeš, Jan, Piacentini, Roberta, Cappelletti, Chiara, Botta, Sofia, Bertuccini, Lucia, Šimůnek, Tomáš, Boffi, Alberto, Macone, Alberto, Bonamore, Alessandra

“…Ferritin, a naturally occurring iron storage protein, has gained significant attention as a drug delivery platform due to its inherent biocompatibility and…”
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2,6-Dihydroxybenzaldehyde Analogues of the Iron Chelator Salicylaldehyde Isonicotinoyl Hydrazone: Increased Hydrolytic Stability and Cytoprotective Activity against Oxidative Stress by Jansová, Hana, Kubeš, Jan, Reimerová, Petra, Štěrbová-Kovaříková, Petra, Roh, Jaroslav, Šimůnek, Tomáš

“…Salicylaldehyde isonicotinoyl hydrazone (SIH) is a small molecule and lipophilic chelating agent that firmly binds ferric ions from the cellular labile iron…”
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Structure–Activity Relationship Study of Dexrazoxane Analogues Reveals ICRF-193 as the Most Potent Bisdioxopiperazine against Anthracycline Toxicity to Cardiomyocytes Due to Its Strong Topoisomerase IIβ Interactions by Jirkovská, Anna, Karabanovich, Galina, Kubeš, Jan, Skalická, Veronika, Melnikova, Iuliia, Korábečný, Jan, Kučera, Tomáš, Jirkovský, Eduard, Nováková, Lucie, Bavlovič Piskáčková, Hana, Škoda, Josef, Štěrba, Martin, Austin, Caroline A, Šimůnek, Tomáš, Roh, Jaroslav

“…Cardioprotective activity of dexrazoxane (ICRF-187), the only clinically approved drug against anthracycline-induced cardiotoxicity, has traditionally been…”
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Water-soluble non-aggregating zinc phthalocyanine and in vitro studies for photodynamic therapy by Makhseed, Saad, Machacek, Miloslav, Alfadly, Waleed, Tuhl, Ahmad, Vinodh, Mickey, Simunek, Tomas, Novakova, Veronika, Kubat, Pavel, Rudolf, Emil, Zimcik, Petr

“…Newly synthesized zinc phthalocyanine bearing sixteen quaternized imidazolyl moieties on the periphery displays high water-solubility, lack of aggregation and…”
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Examination of diverse iron-chelating agents for the protection of differentiated PC12 cells against oxidative injury induced by 6-hydroxydopamine and dopamine by Hašková, Pavlína, Applová, Lenka, Jansová, Hana, Homola, Pavel, Franz, Katherine J., Vávrová, Kateřina, Roh, Jaroslav, Šimůnek, Tomáš

“…Labile redox-active iron ions have been implicated in various neurodegenerative disorders, including the Parkinson's disease (PD). Iron chelation has been…”
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Development of water-soluble prodrugs of the bisdioxopiperazine topoisomerase IIβ inhibitor ICRF-193 as potential cardioprotective agents against anthracycline cardiotoxicity by Bavlovič Piskáčková, Hana, Jansová, Hana, Kubeš, Jan, Karabanovich, Galina, Váňová, Nela, Kollárová-Brázdová, Petra, Melnikova, Iuliia, Jirkovská, Anna, Lenčová-Popelová, Olga, Chládek, Jaroslav, Roh, Jaroslav, Šimůnek, Tomáš, Štěrba, Martin, Štěrbová-Kovaříková, Petra

“…The bisdioxopiperazine topoisomerase IIβ inhibitor ICRF-193 has been previously identified as a more potent analog of dexrazoxane (ICRF-187), a drug used in…”
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Flavonoids as protectors against doxorubicin cardiotoxicity: Role of iron chelation, antioxidant activity and inhibition of carbonyl reductase by Kaiserová, Helena, Šimůnek, Tomáš, van der Vijgh, Wim J.F., Bast, Aalt, Kvasničková, Eva

“…Anthracycline antibiotics (e.g. doxorubicin and daunorubicin) are among the most effective and widely used anticancer drugs. Unfortunately, their clinical use…”
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Far-Red-Absorbing Cationic Phthalocyanine Photosensitizers: Synthesis and Evaluation of the Photodynamic Anticancer Activity and the Mode of Cell Death Induction by Machacek, Miloslav, Cidlina, Antonin, Novakova, Veronika, Svec, Jan, Rudolf, Emil, Miletin, Miroslav, Kučera, Radim, Simunek, Tomas, Zimcik, Petr

“…Novel zinc, magnesium, and metal-free octasubstituted phthalocyanine photosensitizers bearing [(triethylammonio)­ethyl]­sulfanyl substituents in the peripheral…”
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Clinically Translatable Prevention of Anthracycline Cardiotoxicity by Dexrazoxane Is Mediated by Topoisomerase II Beta and Not Metal Chelation by Jirkovský, Eduard, Jirkovská, Anna, Bavlovič-Piskáčková, Hana, Skalická, Veronika, Pokorná, Zuzana, Karabanovich, Galina, Kollárová-Brázdová, Petra, Kubeš, Jan, Lenčová-Popelová, Olga, Mazurová, Yvona, Adamcová, Michaela, Lyon, Alexander R., Roh, Jaroslav, Šimůnek, Tomáš, Štěrbová-Kovaříková, Petra, Štěrba, Martin

“…Anthracycline-induced heart failure has been traditionally attributed to direct iron-catalyzed oxidative damage. Dexrazoxane (DEX)-the only drug approved for…”
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Exploring the effects of topoisomerase II inhibitor XK469 on anthracycline cardiotoxicity and DNA damage by Keresteš, Veronika, Kubeš, Jan, Applová, Lenka, Kollárová, Petra, Lenčová-Popelová, Olga, Melnikova, Iuliia, Karabanovich, Galina, Khazeem, Mushtaq M, Piskáčková, Hana Bavlovič, Štěrbová-Kovaříková, Petra, Austin, Caroline A, Roh, Jaroslav, Štěrba, Martin, Šimůnek, Tomáš, Jirkovská, Anna

“…Anthracyclines, such as doxorubicin (adriamycin), daunorubicin, or epirubicin, rank among the most effective agents in classical anticancer chemotherapy…”
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Comparison of various iron chelators and prochelators as protective agents against cardiomyocyte oxidative injury by Jansová, Hana, Macháček, Miloslav, Wang, Qin, Hašková, Pavlína, Jirkovská, Anna, Potůčková, Eliška, Kielar, Filip, Franz, Katherine J., Šimůnek, Tomáš

“…Oxidative stress is a common denominator of numerous cardiovascular disorders. Free cellular iron catalyzes the formation of highly toxic hydroxyl radicals,…”
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Molecular remodeling of left and right ventricular myocardium in chronic anthracycline cardiotoxicity and post-treatment follow up by Lenco, Juraj, Lencová-Popelová, Olga, Å imůnek, Tomás, Gersl, Vladimír, Jirkovský, Eduard, Mazurová, Yvona, Adamcová, Michaela, Å tÄrba, Martin

“…Chronic anthracycline cardiotoxicity is a serious clinical issue with well characterized functional and histopathological hallmarks. However, molecular…”
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Cardioprotective effects of iron chelator HAPI and ROS-activated boronate prochelator BHAPI against catecholamine-induced oxidative cellular injury by Hašková, Pavlína, Jansová, Hana, Bureš, Jan, Macháček, Miloslav, Jirkovská, Anna, Franz, Katherine J, Kovaříková, Petra, Šimůnek, Tomáš, Dr

“…Highlights • Fe prochelator BHAPI was examined for protection against catecholamine cardiotoxity. • BHAPI has no affinity for iron ions until it is activated…”
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Iron chelation with salicylaldehyde isonicotinoyl hydrazone protects against catecholamine autoxidation and cardiotoxicity by Haskova, Pavlina, Kovarikova, Petra, Koubkova, Lucie, Vavrova, Anna, Mackova, Eliska, Simunek, Tomas

“…Elevated catecholamine levels are known to induce damage of the cardiac tissue. This catecholamine cardiotoxicity may stem from their ability to undergo…”
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Tetra(3,4-pyrido)porphyrazines Caught in the Cationic Cage: Toward Nanomolar Active Photosensitizers by Machacek, Miloslav, Demuth, Jiri, Cermak, Pavel, Vavreckova, Magda, Hruba, Lenka, Jedlickova, Adela, Kubat, Pavel, Simunek, Tomas, Novakova, Veronika, Zimcik, Petr

“…Investigation of a series of tetra­(3,4-pyrido)­porphyrazines (TPyPzs) substituted with hydrophilic substituents revealed important structure–activity…”
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Aroylhydrazone iron chelators: Tuning antioxidant and antiproliferative properties by hydrazide modifications by Hrušková, Kateřina, Potůčková, Eliška, Hergeselová, Tereza, Liptáková, Lucie, Hašková, Pavlína, Mingas, Panagiotis, Kovaříková, Petra, Šimůnek, Tomáš, Vávrová, Kateřina

“…Aroylhydrazones such as salicylaldehyde isonicotinoyl hydrazone (SIH) are tridentate iron chelators that may possess antioxidant and/or antineoplastic…”
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Catalytic inhibitors of topoisomerase II differently modulate the toxicity of anthracyclines in cardiac and cancer cells by Vavrova, Anna, Jansova, Hana, Mackova, Eliska, Machacek, Miloslav, Haskova, Pavlina, Tichotova, Lucie, Sterba, Martin, Simunek, Tomas

“…Anthracyclines (such as doxorubicin or daunorubicin) are among the most effective anticancer drugs, but their usefulness is hampered by the risk of…”
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