Search Results - "SIMPSON, JODIE"

Inhaled budesonide in the treatment of early COVID-19 (STOIC): a phase 2, open-label, randomised controlled trial by Ramakrishnan, Sanjay, Nicolau, Dan V, Langford, Beverly, Mahdi, Mahdi, Jeffers, Helen, Mwasuku, Christine, Krassowska, Karolina, Fox, Robin, Binnian, Ian, Glover, Victoria, Bright, Stephen, Butler, Christopher, Cane, Jennifer L, Halner, Andreas, Matthews, Philippa C, Donnelly, Louise E, Simpson, Jodie L, Baker, Jonathan R, Fadai, Nabil T, Peterson, Stefan, Bengtsson, Thomas, Barnes, Peter J, Russell, Richard E K, Bafadhel, Mona

“…Multiple early reports of patients admitted to hospital with COVID-19 showed that patients with chronic respiratory disease were significantly…”
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Effect of azithromycin on asthma exacerbations and quality of life in adults with persistent uncontrolled asthma (AMAZES): a randomised, double-blind, placebo-controlled trial by Gibson, Peter G, Yang, Ian A, Upham, John W, Reynolds, Paul N, Hodge, Sandra, James, Alan L, Jenkins, Christine, Peters, Matthew J, Marks, Guy B, Baraket, Melissa, Powell, Heather, Taylor, Steven L, Leong, Lex E X, Rogers, Geraint B, Simpson, Jodie L

“…Exacerbations of asthma cause a substantial global illness burden. Adults with uncontrolled persistent asthma despite maintenance treatment require additional…”
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Transcriptional phenotypes of asthma defined by gene expression profiling of induced sputum samples by Baines, Katherine J., PhD, BBiomedSci (Hons), Simpson, Jodie L., PhD, BSc (Hons), Wood, Lisa G., PhD, BSc (Hons), Scott, Rodney J., DSc, FRCPath, FHGSA, Gibson, Peter G., MBBS, FRACP

“…Background Previous studies have identified clinical or inflammatory phenotypes of asthma on the basis of clinical and demographic parameters or sputum cell…”
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Sputum gene expression signature of 6 biomarkers discriminates asthma inflammatory phenotypes by Baines, Katherine J., PhD, Simpson, Jodie L., PhD, Wood, Lisa G., PhD, Scott, Rodney J., PhD, Fibbens, Naomi L., DipPathTech, Powell, Heather, MMedSci, Cowan, Douglas C., PhD, Taylor, D. Robin, DSc, Cowan, Jan O, Gibson, Peter G., MBBS

“…Background Airway inflammation is associated with asthma exacerbation risk, treatment response, and disease mechanisms. Objective This study aimed to identify…”
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Airway inflammation in COPD: Is it worth measuring and is it clinically meaningful? by Simpson, Jodie L.

“…See related Article See related Article…”
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Long-Term Azithromycin Reduces Haemophilus influenzae and Increases Antibiotic Resistance in Severe Asthma by Taylor, Steven L, Leong, Lex E X, Mobegi, Fredrick M, Choo, Jocelyn M, Wesselingh, Steve, Yang, Ian A, Upham, John W, Reynolds, Paul N, Hodge, Sandra, James, Alan L, Jenkins, Christine, Peters, Matthew J, Baraket, Melissa, Marks, Guy B, Gibson, Peter G, Rogers, Geraint B, Simpson, Jodie L

“…The macrolide antibiotic azithromycin reduces exacerbations in adults with persistent symptomatic asthma. However, owing to the pleotropic properties of…”
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Haemophilus influenzae infection drives IL-17-mediated neutrophilic allergic airways disease by Essilfie, Ama-Tawiah, Simpson, Jodie L, Horvat, Jay C, Preston, Julie A, Dunkley, Margaret L, Foster, Paul S, Gibson, Peter G, Hansbro, Philip M

“…A subset of patients with stable asthma has prominent neutrophilic and reduced eosinophilic inflammation, which is associated with attenuated airways…”
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Peripheral blood eosinophils: a surrogate marker for airway eosinophilia in stable COPD by Negewo, Netsanet A, McDonald, Vanessa M, Baines, Katherine J, Wark, Peter Ab, Simpson, Jodie L, Jones, Paul W, Gibson, Peter G

“…Sputum eosinophilia occurs in approximately one-third of stable chronic obstructive pulmonary disease (COPD) patients and can predict exacerbation risk and…”
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Towards the elimination of chronic obstructive pulmonary disease: a Lancet Commission by Stolz, Daiana, Mkorombindo, Takudzwa, Schumann, Desiree M, Agusti, Alvar, Ash, Samuel Y, Bafadhel, Mona, Bai, Chunxue, Chalmers, James D, Criner, Gerard J, Dharmage, Shyamali C, Franssen, Frits M E, Frey, Urs, Han, MeiLan, Hansel, Nadia N, Hawkins, Nathaniel M, Kalhan, Ravi, Konigshoff, Melanie, Ko, Fanny W, Parekh, Trisha M, Powell, Pippa, Rutten-van Mölken, Maureen, Simpson, Jodie, Sin, Don D, Song, Yuanlin, Suki, Bela, Troosters, Thierry, Washko, George R, Welte, Tobias, Dransfield, Mark T

“…Despite substantial progress in reducing the global impact of many non-communicable diseases, including heart disease and cancer, morbidity and mortality due…”
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Saturated fatty acids, obesity, and the nucleotide oligomerization domain–like receptor protein 3 (NLRP3) inflammasome in asthmatic patients by Wood, Lisa G., Li, Qian, Scott, Hayley A., Rutting, Sandra, Berthon, Bronwyn S., Gibson, Peter G., Hansbro, Philip M., Williams, Evan, Horvat, Jay, Simpson, Jodie L., Young, Paul, Oliver, Brian G., Baines, Katherine J.

“…Both obesity and high dietary fat intake activate the nucleotide oligomerization domain–like receptor protein 3 (NLRP3) inflammasome. We aimed to examine NLRP3…”
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The effect of azithromycin in adults with stable neutrophilic COPD: a double blind randomised, placebo controlled trial by Simpson, Jodie L, Powell, Heather, Baines, Katherine J, Milne, David, Coxson, Harvey O, Hansbro, Philip M, Gibson, Peter G

“…Chronic Obstructive Pulmonary Disease (COPD) is a progressive airway disease characterised by neutrophilic airway inflammation or bronchitis. Neutrophilic…”
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Inflammatory phenotypes in patients with severe asthma are associated with distinct airway microbiology by Taylor, Steven L., Leong, Lex E.X., Choo, Jocelyn M., Wesselingh, Steve, Yang, Ian A., Upham, John W., Reynolds, Paul N., Hodge, Sandra, James, Alan L., Jenkins, Christine, Peters, Matthew J., Baraket, Melissa, Marks, Guy B., Gibson, Peter G., Simpson, Jodie L., Rogers, Geraint B.

“…Asthma pathophysiology and treatment responsiveness are predicted by inflammatory phenotype. However, the relationship between airway microbiology and asthma…”
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Mechanisms and treatments for severe, steroid‐resistant allergic airway disease and asthma by Hansbro, Philip M., Kim, Richard Y., Starkey, Malcolm R., Donovan, Chantal, Dua, Kamal, Mayall, Jemma R., Liu, Gang, Hansbro, Nicole G., Simpson, Jodie L., Wood, Lisa G., Hirota, Jeremy A., Knight, Darryl A., Foster, Paul S., Horvat, Jay C.

“…Summary Severe, steroid‐resistant asthma is clinically and economically important since affected individuals do not respond to mainstay corticosteroid…”
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Role for NLRP3 Inflammasome-mediated, IL-1β-Dependent Responses in Severe, Steroid-Resistant Asthma by Kim, Richard Y, Pinkerton, James W, Essilfie, Ama T, Robertson, Avril A B, Baines, Katherine J, Brown, Alexandra C, Mayall, Jemma R, Ali, M Khadem, Starkey, Malcolm R, Hansbro, Nicole G, Hirota, Jeremy A, Wood, Lisa G, Simpson, Jodie L, Knight, Darryl A, Wark, Peter A, Gibson, Peter G, O'Neill, Luke A J, Cooper, Matthew A, Horvat, Jay C, Hansbro, Philip M

“…Severe, steroid-resistant asthma is the major unmet need in asthma therapy. Disease heterogeneity and poor understanding of pathogenic mechanisms hampers the…”
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Sputum TNF markers are increased in neutrophilic and severe asthma and are reduced by azithromycin treatment by Niessen, Natalie M., Gibson, Peter G., Baines, Katherine J., Barker, Daniel, Yang, Ian A., Upham, John W., Reynolds, Paul N., Hodge, Sandra, James, Alan L., Jenkins, Christine, Peters, Matthew J., Marks, Guy B., Baraket, Melissa, Simpson, Jodie L., Fricker, Michael

“…Background The AMAZES randomized controlled trial demonstrated that long‐term low‐dose azithromycin treatment reduces exacerbations of poorly controlled…”
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Elevated expression of the NLRP3 inflammasome in neutrophilic asthma by SIMPSON, Jodie L, PHIPPS, Simon, BAINES, Katherine J, OREO, Kevin M, GUNAWARDHANA, Lakshitha, GIBSON, Peter G

“…Asthma is a heterogeneous inflammatory airways disorder where interleukin (IL)-1β is thought to be a key mediator, especially in the neutrophilic subtype of…”
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Galectin-3: its role in asthma and potential as an anti-inflammatory target by Gao, Peng, Simpson, Jodie L, Zhang, Jie, Gibson, Peter G

“…Galectins constitute an evolutionary conserved family that bind to β-galactosides. Increasing evidence shows that galectins are involved in many fundamental…”
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Airway dysbiosis: Haemophilus influenzae and Tropheryma in poorly controlled asthma by Simpson, Jodie L, Daly, Joshua, Baines, Katherine J, Yang, Ian A, Upham, John W, Reynolds, Paul N, Hodge, Sandra, James, Alan L, Hugenholtz, Philip, Willner, Dana, Gibson, Peter G

“…Asthma is a chronic inflammatory disorder of the airways where bacteria may act as protagonists of chronic inflammation. Little is known about the relation of…”
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Airway abundance of Haemophilus influenzae predicts response to azithromycin in adults with persistent uncontrolled asthma by Taylor, Steven L, Ivey, Kerry L, Gibson, Peter G, Simpson, Jodie L, Rogers, Geraint B

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Clarithromycin Targets Neutrophilic Airway Inflammation in Refractory Asthma by Simpson, Jodie L, Powell, Heather, Boyle, Michael J, Scott, Rodney J, Gibson, Peter G

“…Patients with refractory asthma have persistent symptoms despite maximal treatment with inhaled corticosteroids and long-acting bronchodilators. The…”
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