Search Results - "SIMON, Laureano"

Targeting carcinoma‐associated mesothelial cells with antibody–drug conjugates in ovarian carcinomatosis by Pascual‐Antón, Lucía, Sandoval, Pilar, González‐Mateo, Guadalupe T, Kopytina, Valeria, Tomero‐Sanz, Henar, Arriero‐País, Eva María, Jiménez‐Heffernan, José Antonio, Fabre, Myriam, Egaña, Isabel, Ferrer, Cristina, Simón, Laureano, González‐Cortijo, Lucía, Sainz de la Cuesta, Ricardo, López‐Cabrera, Manuel

“…Ovarian carcinomatosis is characterized by the accumulation of carcinoma‐associated mesothelial cells (CAMs) in the peritoneal stroma and mainly originates…”
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OMTX705, a Novel FAP-Targeting ADC Demonstrates Activity in Chemotherapy and Pembrolizumab-Resistant Solid Tumor Models by Fabre, Myriam, Ferrer, Cristina, Domínguez-Hormaetxe, Saioa, Bockorny, Bruno, Murias, Laura, Seifert, Oliver, Eisler, Stephan A, Kontermann, Roland E, Pfizenmaier, Klaus, Lee, So Young, Vivanco, María dM, López-Casas, Pedro P, Perea, Sofia, Abbas, Muhammad, Richter, Wolfgang, Simon, Laureano, Hidalgo, Manuel

“…The tumor microenvironment plays a key role in cancer development and progression and is involved in resistance to chemo- and immunotherapy. Cancer-associated…”
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Preclinical Efficacy of Endoglin-Targeting Antibody-Drug Conjugates for the Treatment of Ewing Sarcoma by Puerto-Camacho, Pilar, Amaral, Ana Teresa, Lamhamedi-Cherradi, Salah-Eddine, Menegaz, Brian A, Castillo-Ecija, Helena, Ordóñez, José Luis, Domínguez, Saioa, Jordan-Perez, Carmen, Diaz-Martin, Juan, Romero-Pérez, Laura, Lopez-Alvarez, Maria, Civantos-Jubera, Gema, Robles-Frías, María José, Biscuola, Michele, Ferrer, Cristina, Mora, Jaume, Cuglievan, Branko, Schadler, Keri, Seifert, Oliver, Kontermann, Roland, Pfizenmaier, Klaus, Simón, Laureano, Fabre, Myriam, Carcaboso, Ángel M, Ludwig, Joseph A, de Álava, Enrique

“…Endoglin (ENG; CD105) is a coreceptor of the TGFβ family that is highly expressed in proliferating endothelial cells. Often coopted by cancer cells, ENG can…”
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Overexpression of COL11A1 by cancer-associated fibroblasts: clinical relevance of a stromal marker in pancreatic cancer by García-Pravia, Carmen, Galván, José A, Gutiérrez-Corral, Natalia, Solar-García, Lorena, García-Pérez, Eva, García-Ocaña, Marcos, Del Amo-Iribarren, Jokin, Menéndez-Rodríguez, Primitiva, García-García, Juan, de Los Toyos, Juan R, Simón-Buela, Laureano, Barneo, Luis

“…The collagen11A1 (COL11A1) gene is overexpressed in pancreatic cancer. The expression of COL11A1 protein could be involved in desmoplastic events in pancreatic…”
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Genetic variants for prediction of gestational diabetes mellitus and modulation of susceptibility by a nutritional intervention based on a Mediterranean diet by Ramos-Levi, Ana, Barabash, Ana, Valerio, Johanna, García de la Torre, Nuria, Mendizabal, Leire, Zulueta, Mirella, de Miguel, Maria Paz, Diaz, Angel, Duran, Alejandra, Familiar, Cristina, Jimenez, Inés, Del Valle, Laura, Melero, Veronica, Moraga, Inmaculada, Herraiz, Miguel A, Torrejon, María José, Arregi, Maddi, Simón, Laureano, Rubio, Miguel A, Calle-Pascual, Alfonso L

“…Gestational diabetes mellitus (GDM) entails a complex underlying pathogenesis, with a specific genetic background and the effect of environmental factors. This…”
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Genetic Variants in Folate and Cobalamin Metabolism-Related Genes in Pregnant Women of a Homogeneous Spanish Population: The Need for Revisiting the Current Vitamin Supplementation Strategies by Rodriguez-Carnero, Gemma, Lorenzo, Paula M., Canton-Blanco, Ana, Mendizabal, Leire, Arregi, Maddi, Zulueta, Mirella, Simon, Laureano, Macia-Cortiñas, Manuel, Casanueva, Felipe F., Crujeiras, Ana B.

“…Polymorphisms of genes involved in the metabolism and transport of folate and cobalamin could play relevant roles in pregnancy outcomes. This study assessed…”
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Development and validation of a multivariable genotype-informed gestational diabetes prediction algorithm for clinical use in the Mexican population: insights into susceptibility mechanisms by Zulueta, Mirella, Gallardo-Rincón, Héctor, Martinez-Juarez, Luis Alberto, Lomelin-Gascon, Julieta, Ortega-Montiel, Janinne, Montoya, Alejandra, Mendizabal, Leire, Arregi, Maddi, Martinez-Martinez, María de los Angeles, Camarillo Romero, Eneida del Socorro, Mendieta Zerón, Hugo, Garduño García, José de Jesús, Simón, Laureano, Tapia-Conyer, Roberto

“…IntroductionGestational diabetes mellitus (GDM) is underdiagnosed in Mexico. Early GDM risk stratification through prediction modeling is expected to improve…”
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Collagen, type XI, alpha 1: An accurate marker for differential diagnosis of breast carcinoma invasiveness in core needle biopsies by Freire, Javier, Domínguez-Hormaetxe, Saioa, Pereda, Saray, De Juan, Ana, Vega, Alfonso, Simón, Laureano, Gómez-Román, Javier

“…Accurate diagnosis of invasive breast lesions, when analyzed by Core Needle Biopsy, may suppose a major challenge for the pathologist. Various markers of…”
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Reliable Low-Density DNA Array Based on Allele-Specific Probes for Detection of 118 Mutations Causing Familial Hypercholesterolemia by Tejedor, Diego, Castillo, Sergio, Mozas, Pilar, Jimenez, Elisa, Lopez, Monica, Tejedor, M. Teresa, Artieda, Marta, Alonso, Rodrigo, Mata, Pedro, Simon, Laureano, Martinez, Antonio, Pocovi, Miguel, Spanish FH Group

“…Patients with familial hypercholesterolemia (FH) have a high risk of premature cardiovascular disease (PCVD). Mutations in the LDL receptor (LDLR) gene and the…”
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Improved prediction of biochemical recurrence after radical prostatectomy by genetic polymorphisms by Morote, Juan, Del Amo, Jokin, Borque, Angel, Ars, Elisabet, Hernández, Carlos, Herranz, Felipe, Arruza, Antonio, Llarena, Roberto, Planas, Jacques, Viso, María J, Palou, Joan, Raventós, Carles X, Tejedor, Diego, Artieda, Marta, Simón, Laureano, Martínez, Antonio, Rioja, Luis A

“…Single nucleotide polymorphisms are inherited genetic variations that can predispose or protect individuals against clinical events. We hypothesized that…”
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Prediction of functional impairment and remission in rheumatoid arthritis patients by biochemical variables and genetic polymorphisms by Balsa, Alejandro, del Amo, Jokin, Blanco, Francisco, Caliz, Rafael, Silva, Lucía, Sanmarti, Raimon, Martínez, Francisco G., Tejedor, Diego, Artieda, Marta, Pascual-Salcedo, Dora, Oreiro, Natividad, Collado, Maria D., Andreu, Jose L., Graell, Eduard, Simón, Laureano, Martínez, Antonio, Mulero, Juan

“…Objective. To develop a model to predict RA outcome based on biochemical variables and single nucleotide polymorphisms (SNPs). Methods. We collected baseline…”
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Simultaneous Detection of Collagen I Alpha II and Cytokeratin 19 mRNA by Multiplex qPCR in Liquid Biopsy in Diagnosis of Patients with Resectable Solid Tumors by Estévez Pérez, Lara Sofía, Alén, Begoña O, Otero Alén, María, Hormaetxe, Saioa Domínguez, Simón, Laureano, Concha, Ángel

“…The early detection of tumors is one of the key factors in increasing overall survival in cancer patients. A wide range of cancers still do not have a system…”
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Expression of Epithelial and Mesenchymal Markers in Plasmatic Extracellular Vesicles as a Diagnostic Tool for Neoplastic Processes by Alen, Begoña O, Estévez-Pérez, Lara Sofía, Otero Alén, María, Domínguez Hormaetxe, Saioa, Simón, Laureano, Concha, Ángel

“…Tumor-derived extracellular vesicles (TD-EVs) have active roles as cancer hallmark enablers. EVs RNA of epithelial and stromal cells carry information that…”
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The use of gene array technology and proteomics in the search of new targets of diseases for therapeutics by Ferrer-Alcón, Marcel, Arteta, David, Guerrero, M.ª José, Fernandez-Orth, Dietmar, Simón, Laureano, Martinez, Antonio

“…The advent of functional genomics has been greatly broadening our view and accelerating our way in numerous medical research fields. The complete genomic data…”
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Comprehensive Proteomic Analysis of Human Endometrial Fluid Aspirate by Casado-Vela, Juan, Rodriguez-Suarez, Eva, Iloro, Ibon, Ametzazurra, Amagoia, Alkorta, Nere, García-Velasco, Juan Antonio, Matorras, Roberto, Prieto, Begoña, González, Sandra, Nagore, Daniel, Simón, Laureano, Elortza, Felix

“…The endometrial fluid is a noninvasive sample which contains numerous secreted proteins representative of endometrial function and reflects the state of the…”
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Identification of chitotriosidase isoforms in plasma of Gaucher disease patients by two dimensional gel electrophoresis by Quintana, Lucía, Monasterio, Alberto, Escuredo, Kepa, del Amo, Jokin, Alfonso, Pilar, Elortza, Felix, Santa Cruz, Simon, Simón, Laureano, Martínez, Antonio, Giraldo, Pilar, Pocoví, Miguel, Luis Castrillo, José

“…Chitotriosidase protein (ChT) is the most important biochemical marker described for Gaucher disease (GD). ChT activity is increased several hundred-fold in…”
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Fibroblast Growth Factor Receptor 3 Is Overexpressed in Urinary Tract Carcinomas and Modulates the Neoplastic Cell Growth by GOMEZ-ROMAN, J. Javier, SAENZ, Pilar, ESPARZA, Clara, VAL-BERNAL, J. Fernando, CUEVAS GONZALEZ, Jorge, ESCUREDO, Kepa, SANTA CRUZ, Simon, JUNQUERA, Corina, SIMON, Laureano, MARTINEZ, Antonio, GUTIERREZ BANOS, J. Luis, LOPEZ-BREA, Marta

“…Purpose: Fibroblast growth factor receptor 3 ( FGFR3 ) mutations have been associated with achondroplastic syndromes and urinary bladder carcinomas. Here we…”
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2002-LB: New Model for Type 1 Diabetes Differential Screening by Mendizabal, Leire, Saso-Jiménez, Laura, Apaolaza, Naiara, Martínez, Rosa, Zulueta, Mirella, Urrutia, Inés M, Simon, Laureano, Castano, Luis

“…Introduction & Objective: Determining whether a patient has type 1 (T1D), type 2 (T2D) or monogenic diabetes is an important diagnostic and therapeutic…”
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146-LB: Association of Serum 1,5-Anhydroglucitol with Severe COVID-19 in T2D patients by SONIA, GAZTAMBIDE, BUTTON, ERIC A., ZULUETA, MIRELLA, ARANA, EUNATE, DE LA HOZ, ANA B., MENDIZABAL, LEIRE, DEL OLMO, JUAN, MUÑOZ, RAQUEL, SIMON, LAUREANO, CASTANO, LUIS

“…Background: Hyperglycemia worsens the prognosis and severity in Covid-19 patients. Objective: To assess the impact of glycemic control on COVID-19 severity…”
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Characterization of a novel mouse monoclonal antibody, clone 1E8.33, highly specific for human procollagen 11A1, a tumor-associated stromal component by GARCIA-OCANA, Marcos, VAZQUEZ, Fernando, GARCIA-PRAVIA, Carmen, FUENTES-MARTINEZ, Nelson, MENENDEZ-RODRIGUEZ, Primitiva, FRESNO-FORCELLEDO, Florentino, BARNEO-SERRA, Luis, AMO-IRIBARREN, Jokin Del, SIMON-BUELA, Laureano, DE LOS TOYOS, Juan R

“…A novel IgG1, κ mouse monoclonal antibody (clone 1E8.33) to human procollagen 11A1 has been generated. This antibody is poorly mutated, essentially in germ…”
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