Search Results - "SIMON, J. H"

A Lipidomic Analysis of Placenta in Preeclampsia: Evidence for Lipid Storage by Brown, Simon H J, Eather, Samuel R, Freeman, Dilys J, Meyer, Barbara J, Mitchell, Todd W

“…In preeclampsia, maternal insulin resistance leads to defective expansion of adipocytes, enhanced adipocyte lipolysis, up-regulation of very low density…”
Get full text

Molecular basis for RNA polymerase-dependent transcription complex recycling by the helicase-like motor protein HelD by Newing, Timothy P., Oakley, Aaron J., Miller, Michael, Dawson, Catherine J., Brown, Simon H. J., Bouwer, James C., Tolun, Gökhan, Lewis, Peter J.

“…In bacteria, transcription complexes stalled on DNA represent a major source of roadblocks for the DNA replication machinery that must be removed in order to…”
Get full text

Structural basis of promiscuous substrate transport by Organic Cation Transporter 1 by Zeng, Yi C., Sobti, Meghna, Quinn, Ada, Smith, Nicola J., Brown, Simon H. J., Vandenberg, Jamie I., Ryan, Renae M., O’Mara, Megan L., Stewart, Alastair G.

“…Organic Cation Transporter 1 (OCT1) plays a crucial role in hepatic metabolism by mediating the uptake of a range of metabolites and drugs. Genetic variations…”
Get full text

Variation in structural motifs within SARS-related coronavirus spike proteins by Hills, Francesca R, Eruera, Alice-Roza, Hodgkinson-Bean, James, Jorge, Fátima, Easingwood, Richard, Brown, Simon H J, Bouwer, James C, Li, Yi-Ping, Burga, Laura N, Bostina, Mihnea

“…SARS-CoV-2 is the third known coronavirus (CoV) that has crossed the animal-human barrier in the last two decades. However, little structural information…”
Get full text

Broadly neutralizing SARS-CoV-2 antibodies through epitope-based selection from convalescent patients by Rouet, Romain, Henry, Jake Y., Johansen, Matt D., Sobti, Meghna, Balachandran, Harikrishnan, Langley, David B., Walker, Gregory J., Lenthall, Helen, Jackson, Jennifer, Ubiparipovic, Stephanie, Mazigi, Ohan, Schofield, Peter, Burnett, Deborah L., Brown, Simon H. J., Martinello, Marianne, Hudson, Bernard, Gilroy, Nicole, Post, Jeffrey J., Kelleher, Anthony, Jäck, Hans-Martin, Goodnow, Christopher C., Turville, Stuart G., Rawlinson, William D., Bull, Rowena A., Stewart, Alastair G., Hansbro, Philip M., Christ, Daniel

“…Emerging variants of concern (VOCs) are threatening to limit the effectiveness of SARS-CoV-2 monoclonal antibodies and vaccines currently used in clinical…”
Get full text

Structural characterisation of the complete cycle of sliding clamp loading in Escherichia coli by Xu, Zhi-Qiang, Jergic, Slobodan, Lo, Allen T. Y., Pradhan, Alok C., Brown, Simon H. J., Bouwer, James C., Ghodke, Harshad, Lewis, Peter J., Tolun, Gökhan, Oakley, Aaron J., Dixon, Nicholas E.

“…Ring-shaped DNA sliding clamps are essential for DNA replication and genome maintenance. Clamps need to be opened and chaperoned onto DNA by clamp loader…”
Get full text

Changes in lipid composition during sexual development of the malaria parasite Plasmodium falciparum by Tran, Phuong N, Brown, Simon H J, Rug, Melanie, Ridgway, Melanie C, Mitchell, Todd W, Maier, Alexander G

“…The development of differentiated sexual stages (gametocytes) within human red blood cells is essential for the propagation of the malaria parasite, since only…”
Get full text

An Improved High-Throughput Lipid Extraction Method for the Analysis of Human Brain Lipids by Abbott, Sarah K., Jenner, Andrew M., Mitchell, Todd W., Brown, Simon H. J., Halliday, Glenda M., Garner, Brett

“…We have developed a protocol suitable for high-throughput lipidomic analysis of human brain samples. The traditional Folch extraction (using chloroform and…”
Get full text

Cholesteryl ester levels are elevated in the caudate and putamen of Huntington’s disease patients by Phillips, Gabrielle R., Hancock, Sarah E., Brown, Simon H. J., Jenner, Andrew M., Kreilaus, Fabian, Newell, Kelly A., Mitchell, Todd W.

“…Huntington’s disease (HD) is an autosomal dominant neurodegenerative illness caused by a mutation in the huntingtin gene (HTT) and subsequent protein (mhtt),…”
Get full text

Rectal prolapse in Winnie mice with spontaneous chronic colitis: changes in intrinsic and extrinsic innervation of the rectum by Rahman, Ahmed A., Robinson, Ainsley M., Brookes, Simon J. H., Eri, Rajaraman, Nurgali, Kulmira

“…Rectal prolapse is associated with diminished anal sensitivity and rectal motor activity. Both sensory and motor functions are controlled by the extrinsic and…”
Get full text

A comparison of patient matched meibum and tear lipidomes by Brown, Simon H J, Kunnen, Carolina M E, Duchoslav, Eva, Dolla, Naveen K, Kelso, Michael J, Papas, Eric B, Lazon de la Jara, Percy, Willcox, Mark D P, Blanksby, Stephen J, Mitchell, Todd W

“…To quantify the molecular lipid composition of patient-matched tear and meibum samples and compare tear and meibum lipid molecular profiles. Lipids were…”
Get full text

Regulation of mitochondrial metabolism in murine skeletal muscle by the medium‐chain fatty acid receptor Gpr84 by Montgomery, Magdalene K., Osborne, Brenna, Brandon, Amanda E., O'Reilly, Liam, Fiveash, Corrine E., Brown, Simon H. J., Wilkins, Brendan P., Samsudeen, Azrah, Yu, Josephine, Devanapalli, Beena, Hertzog, Ashley, Tolun, Adviye A., Kavanagh, Tomas, Cooper, Antony A., Mitchell, Todd W., Biden, Trevor J., Smith, Nicola J., Cooney, Gregory J., Turner, Nigel

“…Fatty acid receptors have been recognized as important players in glycaemic control. This study is the first to describe a role for the medium‐chain fatty acid…”
Get full text

Mass spectrometry-directed structure elucidation and total synthesis of ultra-long chain (O-acyl)-ω-hydroxy fatty acids by Hancock, Sarah E., Ailuri, Ramesh, Marshall, David L., Brown, SimonH.J., Saville, Jennifer T., Narreddula, Venkateswara R., Boase, Nathan R., Poad, BerwyckL.J., Trevitt, Adam J., Willcox, MarkD.P., Kelso, Michael J., Mitchell, Todd W., Blanksby, Stephen J.

“…The (O-acyl)-ω-hydroxy FAs (OAHFAs) comprise an unusual lipid subclass present in the skin, vernix caseosa, and meibomian gland secretions. Although they are…”
Get full text

Neural mechanisms of peristalsis in the isolated rabbit distal colon: a neuromechanical loop hypothesis by Dinning, Phil G, Wiklendt, Lukasz, Omari, Taher, Arkwright, John W, Spencer, Nick J, Brookes, Simon J H, Costa, Marcello

“…Propulsive contractions of circular muscle are largely responsible for the movements of content along the digestive tract. Mechanical and electrophysiological…”
Get full text

Homeodomain-interacting protein kinase (Hipk) plays roles in nervous system and muscle structure and function by Wang, Simon J H, Sinclair, Donald A R, Kim, Hae-Yoon, Kinsey, Stephen D, Yoo, Byoungjoo, Shih, Claire R Y, Wong, Kenneth K L, Krieger, Charles, Harden, Nicholas, Verheyen, Esther M

“…Homeodomain-interacting protein kinases (Hipks) have been previously associated with cell proliferation and cancer, however, their effects in the nervous…”
Get full text

Roles of three distinct neurogenic motor patterns during pellet propulsion in guinea‐pig distal colon by Costa, Marcello, Keightley, Lauren J., Wiklendt, Lukasz, Hibberd, Timothy J., Arkwright, John W., Omari, Taher, Wattchow, David A., Zagorodnyuk, Vladimir, Brookes, Simon J. H., Dinning, Phil G., Spencer, Nick J.

“…Key points Enteric neural circuits enable isolated preparations of guinea‐pig distal colon to propel solid and fluid contents by a self‐sustaining…”
Get full text

Sympathetic Pathways Target Cholinergic Neurons in the Human Colonic Myenteric Plexus by Parker, Dominic R, Wiklendt, Lukasz, Humenick, Adam, Chen, Bao Nan, Sia, Tiong Cheng, Wattchow, David A, Dinning, Phil G, Brookes, Simon J H

“…The sympathetic nervous system inhibits human colonic motility largely by effects on enteric neurons. Noradrenergic axons, which branch extensively in the…”
Get full text

Automated Analysis Using a Bayesian Functional Mixed-Effects Model With Gaussian Process Responses for Wavelet Spectra of Spatiotemporal Colonic Manometry Signals by Wiklendt, Lukasz, Costa, Marcello, Scott, Mark S, Brookes, Simon J H, Dinning, Phil G

“…Manual analysis of human high-resolution colonic manometry data is time consuming, non-standardized and subject to laboratory bias. In this article we present…”
Get full text

A female gametocyte-specific ABC transporter plays a role in lipid metabolism in the malaria parasite by Tran, Phuong N., Brown, Simon H. J., Mitchell, Todd W., Matuschewski, Kai, McMillan, Paul J., Kirk, Kiaran, Dixon, Matthew W. A., Maier, Alexander G.

“…ATP-binding cassette (ABC) transporters serve a variety of physiological functions as well as play key roles in drug resistance. The genome of the human…”
Get full text

Characterization of viscerofugal neurons in human colon by retrograde tracing and multi-layer immunohistochemistry by Chen, Bao Nan, Humenick, Adam G, Hibberd, Timothy James, Yew, Wai Ping, Wattchow, David A, Dinning, Phil G, Costa, Marcello, Spencer, Nick J, Brookes, Simon J H

“…Viscerofugal neurons (VFNs) have cell bodies in the myenteric plexus and axons that project to sympathetic prevertebral ganglia. In animals they activate…”
Get full text