Search Results - "SIMON, Adam J"

A novel pathway for amyloid precursor protein processing by Portelius, Erik, Price, Eric, Brinkmalm, Gunnar, Stiteler, Mark, Olsson, Maria, Persson, Rita, Westman-Brinkmalm, Ann, Zetterberg, Henrik, Simon, Adam J, Blennow, Kaj

“…Abstract Amyloid precursor protein (APP) can be proteolytically processed along two pathways, the amyloidogenic that leads to the formation of the 40–42 amino…”
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Evaluation of Plasma Proteomic Data for Alzheimer Disease State Classification and for the Prediction of Progression From Mild Cognitive Impairment to Alzheimer Disease by Llano, Daniel A., Devanarayan, Viswanath, Simon, Adam J.

“…Previous studies that have examined the potential for plasma markers to serve as biomarkers for Alzheimer disease (AD) have studied single analytes and focused…”
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Machine learning for comprehensive forecasting of Alzheimer’s Disease progression by Fisher, Charles K., Smith, Aaron M., Walsh, Jonathan R.

“…Most approaches to machine learning from electronic health data can only predict a single endpoint. The ability to simultaneously simulate dozens of patient…”
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Regulation of Gene Expression by Lithium and Depletion of Inositol in Slices of Adult Rat Cortex by Brandish, Philip E., Su, Ming, Holder, Daniel J., Hodor, Paul, Szumiloski, John, Kleinhanz, Robert R., Forbes, Jaime E., McWhorter, Mollie E., Duenwald, Sven J., Parrish, Mark L., Na, Sang, Liu, Yuan, Phillips, Robert L., Renger, John J., Sankaranarayanan, Sethu, Simon, Adam J., Scolnick, Edward M.

“…Lithium inhibits inositol monophosphatase at therapeutically effective concentrations, and it has been hypothesized that depletion of brain inositol levels is…”
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Qualification of the analytical and clinical performance of CSF biomarker analyses in ADNI by Shaw, Leslie M., Vanderstichele, Hugo, Knapik-Czajka, Malgorzata, Figurski, Michal, Coart, Els, Blennow, Kaj, Soares, Holly, Simon, Adam J., Lewczuk, Piotr, Dean, Robert A., Siemers, Eric, Potter, William, Lee, Virginia M.-Y., Trojanowski, John Q.

“…The close correlation between abnormally low pre-mortem cerebrospinal fluid (CSF) concentrations of amyloid-β1-42 (Aβ 1–42 ) and plaque burden measured by…”
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Design, synthesis, and SAR of macrocyclic tertiary carbinamine BACE-1 inhibitors by Lindsley, Stacey R., Moore, Keith P., Rajapakse, Hemaka A., Selnick, Harold G., Young, Mary Beth, Zhu, Hong, Munshi, Sanjeev, Kuo, Lawrence, McGaughey, Georgia B., Colussi, Dennis, Crouthamel, Ming-Chih, Lai, Ming-Tain, Pietrak, Beth, Price, Eric A., Sankaranarayanan, Sethu, Simon, Adam J., Seabrook, Guy R., Hazuda, Daria J., Pudvah, Nicole T., Hochman, Jerome H., Graham, Samuel L., Vacca, Joseph P., Nantermet, Philippe G.

“…This Letter describes the design and synthesis of tertiary carbinamine macrocyclic inhibitors of the β-secretase (BACE-1) enzyme. These macrocyclic inhibitors,…”
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Design and Synthesis of 2,3,5-Substituted Imidazolidin-4-one Inhibitors of BACE-1 by Barrow, James C., Rittle, Kenneth E., Ngo, Phung L., Selnick, Harold G., Graham, Samuel L., Pitzenberger, Steven M., McGaughey, Georgia B., Colussi, Dennis, Lai, Ming-Tain, Huang, Qian, Tugusheva, Katherine, Espeseth, Amy S., Simon, Adam J., Munshi, Sanjeev K., Vacca, Joseph P.

“…Structure‐based drug design was used to incorporate the traditional hydroxyethyl amine aspartyl protease inhibitor motif into 2,3,5‐substituted…”
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Persistent Replication of Hepatitis C Virus Replicons Expressing the β-Lactamase Reporter in Subpopulations of Highly Permissive Huh7 Cells by Murray, Edward M, Grobler, Jay A, Markel, Eric J, Pagnoni, Marco F, Paonessa, Giacomo, Simon, Adam J, Flores, Osvaldo A

“…Article Usage Stats Services JVI Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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Exploration of EEG features of Alzheimer’s disease using continuous wavelet transform by Ghorbanian, Parham, Devilbiss, David M., Hess, Terry, Bernstein, Allan, Simon, Adam J., Ashrafiuon, Hashem

“…We have developed a novel approach to elucidate several discriminating EEG features of Alzheimer’s disease. The approach is based on the use of a variety of…”
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Biochemical and cell-based assays for characterization of BACE-1 inhibitors by Pietrak, Beth L., Crouthamel, Ming-Chih, Tugusheva, Katherine, Lineberger, Janet E., Xu, Min, DiMuzio, Jillian M., Steele, Thomas, Espeseth, Amy S., Stachel, Shawn J., Coburn, Craig A., Graham, Samuel L., Vacca, Joseph P., Shi, Xiao-Ping, Simon, Adam J., Hazuda, Daria J., Lai, Ming-Tain

“…The deposition of β-amyloid peptides (Aβ42 and Aβ40) in neuritic plaques is one of the hallmarks of Alzheimer’s disease (AD). Aβ peptides are derived from…”
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Identification of Resting and Active State EEG Features of Alzheimer’s Disease using Discrete Wavelet Transform by Ghorbanian, Parham, Devilbiss, David M., Verma, Ajay, Bernstein, Allan, Hess, Terry, Simon, Adam J., Ashrafiuon, Hashem

“…Alzheimer’s disease (AD) is associated with deficits in a number of cognitive processes and executive functions. Moreover, abnormalities in the…”
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Altering Expression Levels of Human Immunodeficiency Virus Type 1 gp120-gp41 Affects Efficiency but Not Kinetics of Cell-Cell Fusion by Lineberger, Janet E, Danzeisen, Renee, Hazuda, Daria J, Simon, Adam J, Miller, Michael D

“…Article Usage Stats Services JVI Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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Characterization of plasma β-secretase (BACE1) activity and soluble amyloid precursor proteins as potential biomarkers for Alzheimer's disease by Wu, Guoxin, Sankaranarayanan, Sethu, Wong, Jacky, Tugusheva, Katherine, Michener, Maria S., Shi, Xiaoping, Cook, Jacquelynn J., Simon, Adam J., Savage, Mary J.

“…Reduction in cerebrospinal fluid (CSF) amyloid β42 (Aβ42) and elevation in total tau and phospho‐thr181 tau consistently differentiate between Alzheimer's…”
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Days to criterion as an indicator of toxicity associated with human Alzheimer amyloid-β oligomers by Gandy, Sam, Simon, Adam J., Steele, John W., Lublin, Alex L., Lah, James J., Walker, Lary C., Levey, Allan I., Krafft, Grant A., Levy, Efrat, Checler, Frédéric, Glabe, Charles, Bilker, Warren B., Abel, Ted, Schmeidler, James, Ehrlich, Michelle E.

“…Objective Recent evidence suggests that high molecular weight soluble oligomeric Aβ (oAβ) assemblies (also known as Aβ‐derived diffusible ligands, or ADDLs)…”
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Acute gamma-secretase inhibition of nonhuman primate CNS shifts amyloid precursor protein (APP) metabolism from amyloid-beta production to alternative APP fragments without amyloid-beta rebound by Cook, Jacquelynn J, Wildsmith, Kristin R, Gilberto, David B, Holahan, Marie A, Kinney, Gene G, Mathers, Parker D, Michener, Maria S, Price, Eric A, Shearman, Mark S, Simon, Adam J, Wang, Jennifer X, Wu, Guoxin, Yarasheski, Kevin E, Bateman, Randall J

“…The accumulation of amyloid beta (Abeta) in Alzheimer's disease is caused by an imbalance of production and clearance, which leads to increased soluble Abeta…”
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First demonstration of cerebrospinal fluid and plasma A beta lowering with oral administration of a beta-site amyloid precursor protein-cleaving enzyme 1 inhibitor in nonhuman primates by Sankaranarayanan, Sethu, Holahan, Marie A, Colussi, Dennis, Crouthamel, Ming-Chih, Devanarayan, Viswanath, Ellis, Joan, Espeseth, Amy, Gates, Adam T, Graham, Samuel L, Gregro, Allison R, Hazuda, Daria, Hochman, Jerome H, Holloway, Katharine, Jin, Lixia, Kahana, Jason, Lai, Ming-tain, Lineberger, Janet, McGaughey, Georgia, Moore, Keith P, Nantermet, Philippe, Pietrak, Beth, Price, Eric A, Rajapakse, Hemaka, Stauffer, Shaun, Steinbeiser, Melissa A, Seabrook, Guy, Selnick, Harold G, Shi, Xiao-Ping, Stanton, Matthew G, Swestock, John, Tugusheva, Katherine, Tyler, Keala X, Vacca, Joseph P, Wong, Jacky, Wu, Guoxin, Xu, Min, Cook, Jacquelynn J, Simon, Adam J

“…beta-Site amyloid precursor protein (APP)-cleaving enzyme (BACE) 1 cleavage of amyloid precursor protein is an essential step in the generation of the…”
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Structure-Based Design of Potent and Selective Cell-Permeable Inhibitors of Human β-Secretase (BACE-1) by Stachel, Shawn J, Coburn, Craig A, Steele, Thomas G, Jones, Kristen G, Loutzenhiser, Elizabeth F, Gregro, Alison R, Rajapakse, Hemaka A, Lai, Ming-Tain, Crouthamel, Ming-Chih, Xu, Min, Tugusheva, Katherine, Lineberger, Janet E, Pietrak, Beth L, Espeseth, Amy S, Shi, Xiao-Ping, Chen-Dodson, Elizabeth, Holloway, M. Katharine, Munshi, Sanjeev, Simon, Adam J, Kuo, Lawrence, Vacca, Joseph P

“…We describe the development of cell-permeable β-secretase inhibitors that demonstratively inhibit the production of the secreted amino terminal fragment of an…”
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Effects of Exercise on EEG Activity and Standard Tools Used to Assess Concussion by Simon, Adam J., Kothare, Mayuresh V., Dussourd, Christopher R., Dunn, Emily, Etnoyer-Slaski, Jena L., Devilbiss, David M., Martino, Stephen J.

“…A variety of cognitive assessment tools are used to determine the functional status of the brain before and after injury in athletes. Questionnaires,…”
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Decrease in brain soluble amyloid precursor protein β (sAPPβ) in Alzheimer's disease cortex by Wu, Guoxin, Sankaranarayanan, Sethu, Hsieh, Sidney H.-K., Simon, Adam J., Savage, Mary J.

“…Amyloid‐β peptide (Aβ) is generated by sequential cleavage of the amyloid precursor protein (APP) by β‐site amyloid precursor protein cleaving enzyme 1…”
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Cisterna magna cannulated repeated CSF sampling rat model – effects of a gamma-secretase inhibitor on Aβ levels by Shapiro, Jennifer S., Stiteler, Mark, Wu, Guoxin, Price, Eric A., Simon, Adam J., Sankaranarayanan, Sethu

“…► Developed a cisterna magna cannulated rat model for repeated CSF sampling. ► Robust intra-animal and inter-animal consistency in CSF Aβ levels over time. ►…”
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