Search Results - "SIMMONDS, R. G"

Benzothienyloxy phenylpropanamines, novel dual inhibitors of serotonin and norepinephrine reuptake by BOOT, J. R, BRACE, G, RATHMELL, R. E, RICHARDS, S. J, SIMMONDS, R. G, WALLACE, L, WHATTON, M. A, DELATOUR, C. L, DEZUTTER, N, FAIRHURST, J, FINDLAY, J, GALLAGHER, P. T, HOES, I, MAHADEVAN, S, MITCHELL, S. N

“…A series of benzothienyloxy propylamines have been prepared and are demonstrated to be inhibitors of both serotonin and norepinephrine reuptake…”
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N-Alkyl-N-arylmethylpiperidin-4-amines: Novel dual inhibitors of serotonin and norepinephrine reuptake by Boot, J.R., Boulet, S.L., Clark, B.P., Cases-Thomas, M.J., Delhaye, L., Diker, K., Fairhurst, J., Findlay, J., Gallagher, P.T., Gilmore, J., Harris, J.R., Masters, J.J., Mitchell, S.N., Naik, M., Simmonds, R.G., Smith, S.M., Richards, S.J., Timms, G.H., Whatton, M.A., Wolfe, C.N., Wood, V.A.

“…A series of N-alkyl-N-arylmethylpiperidin-4-amines have been prepared and are demonstrated to be inhibitors of both serotonin and norepinephrine reuptake. A…”
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Drug localisation and growth inhibition studies of vindesine-monoclonal anti-CEA conjugates in a human tumour xenograft by ROWLAND, G. F, SIMMONDS, R. G, GORE, V. A, MARSDEN, C. H, SMITH, W

“…The distribution of tritiated vindesine (3H-VDS) was studied in the tissues and tumours of athymic mice bearing a human colorectal tumour xenograft. Selective…”
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Purification of mouse haptoglobin by antibody affinity chromatography and development of an ELISA to measure serum haptoglobin levels by Marsden, C H, Simmonds, R G

“…Mouse haptoglobin was isolated from acute-phase serum initially by affinity chromatography on haemoglobin-Sepharose. This proved inefficient, but sufficient…”
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Localisation and toxicity study of a vindesine-anti-CEA conjugate in patients with advanced cancer by Ford, C H, Newman, C E, Johnson, J R, Woodhouse, C S, Reeder, T A, Rowland, G F, Simmonds, R G

“…Safety of administration of a vindesine (VDS)-anti-CEA conjugate and its ability to localise after radiolabelling were investigated in patients with advanced…”
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Synthesis of disulfide-bridged fragments of omega-conotoxins GVIA and MVIIA. Use of Npys as a protecting/activating group for cysteine in Fmoc syntheses by Simmonds, R G, Tupper, D E, Harris, J R

“…The 3-nitro-2-pyridinesulphenyl (Npys) moiety is finding increasing utility as a protecting-activating group for cysteine, particularly in the synthesis of…”
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Antitumor properties of vindesine-monoclonal antibody conjugates by ROWLAND, G. F, AXTON, C. A, MARSDEN, C. H, PIMM, M. V, SIMMONDS, R. G, SMITH, W, BALDWIN, R. W, BROWN, J. P, CORVALAN, J. R. F, EMBLETON, M. J, GORE, V. A, HELLSTROM, I, HELLSTROM, K. E, JACOBS, E

“…The anticancer alkaloid vindesine (VDS) was conjugated to four mouse monoclonal antibodies recognizing human tumor-associated antigens. The antibodies were…”
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Use of the Hmb backbone-protecting group in the synthesis of difficult sequences by Simmonds, R G

“…Aggregation due to hydrogen-bonded interchain association is thought to be the cause of difficult sequences in solid-phase peptide synthesis. Hmb…”
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Positive and negative selection of cells by hapten-modified antibodies by Clark, N W, Parkhouse, R M, Simmonds, R G

“…A method for simultaneous positive and negative selection of cells identified by an antibody is described. It is an adaption of the panning technique using…”
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Global and regional emissions of HFC-125 (CHF2CF3) from in situ and air archive atmospheric observations at AGAGE and SOGE observatories by O'Doherty, S., Cunnold, D. M., Miller, B. R., Mühle, J., McCulloch, A., Simmonds, P. G., Manning, A. J., Reimann, S., Vollmer, M. K., Greally, B. R., Prinn, R. G., Fraser, P. J., Steele, L. P., Krummel, P. B., Dunse, B. L., Porter, L. W., Lunder, C. R., Schmidbauer, N., Hermansen, O., Salameh, P. K., Harth, C. M., Wang, R. H. J., Weiss, R. F.

“…High‐frequency, in situ observations from the Advanced Global Atmospheric Gases Experiment (AGAGE) and System for Observation of halogenated Greenhouse gases…”
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Selective cytotoxicity against human tumour cells by a vindesine-monoclonal antibody conjugate by Embleton, M J, Rowland, G F, Simmonds, R G, Jacobs, E, Marsden, C H, Baldwin, R W

“…The anti-mitotic drug vindesine was coupled chemically to a monoclonal antibody raised originally against the human osteogenic sarcoma cell line, 791T. The…”
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Isolation and Preliminary Characterization of Soil Polysaccharides by BARKER, S. A, FINCH, P, HAYES, M. H. B, SIMMONDS, R. G, STACEY, M

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A vindesine-anti-CEA conjugate cytotoxic for human cancer cells in vitro by Johnson, J R, Ford, C H, Newman, C E, Woodhouse, C S, Rowland, G F, Simmonds, R G

“…In this communication the authors report the cytotoxic effects of a videsine-anti-CEA Ig. conjugate on cancer cells using a terminal super(3)H-uridine uptake…”
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The relationship between hyperglycaemia and renal immune complex deposition in mice with inherited diabetes by Meade, C J, Brandon, D R, Smith, W, Simmonds, R G, Harris, S, Sowter, C

“…Kidney lesions were studied by light microscopy and immunofluorescence in diabetic (db/db) and obese (ob/ob) mutant mice. The db/db mutation was studied both…”
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3-phenylazo-4-hydroxyphenylisothiocyanates: reagents for efficient haptenation of immunoglobulin and other carrier molecules by Simmonds, R G, Smith, W, Marsden, H

“…The synthesis of 2 non-cross-reacting 3-(substituted-phenyl)-azo-4-hydroxyphenylisothiocyanates is described. These compounds are designed as alternatives to…”
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Experience in the preparation and experimental use of immunocytostatics by Embleton, M J, Pimm, M V, Garnett, M C, Rowland, G F, Simmonds, R G, Baldwin, R W

“…Vindesine (VDS) was coupled directly to a monoclonal antibody (791T/36) raised against a human osteogenic sarcoma cell line, and methotrexate (MTX) was coupled…”
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Synthesis of some phenanthridone derivatives by Cookson, R. F., James, J. W., Rodway, R. E., Simmonds, R. G.

“…The alkylation of phenanthridone and some nuclear‐substituted phenanthridones using sodium hydride in DMF/benzene is reported. Various…”
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Criteria for evaluating directionally drilled crossings by BOIVIN, R. P, RIZKALLA, M, MARSHALL, R. G, SIMMONDS, G. R

“…Directional drilling technology as related to the installation of small- and large-diameter pipelines at water crossings is continually improving. The current…”
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Non-nucleophilic base (KHMDS) mediated nucleophilic conversion of Merrifield resin into aminomethyl resin by Sampson, David F.J, Simmonds, Robin G, Bradley, Mark

“…During a series of alkylation reactions on Merrifield resin involving a number of alkoxides, generated in situ by the treatment of alcohols with a variety of…”
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Stereospecific inversion of (R)-(-)-benoxaprofen in rat and man by Simmonds, R G, Woodage, T J, Duff, S M, Green, J N

“…(R)-(-)-benoxaprofen is stereospecifically inverted to the (S)-(+)-enantiomer by rats and humans. The rate of inversion is much faster in rats (t 1/2 ca. 2.5…”
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