Search Results - "SIMM, Andreas"

Protein glycation during aging and in cardiovascular disease by Simm, Andreas

“…Advanced glycation endproducts (AGEs), pathophysiological important posttranslational modifications, are formed in vivo by a non-enzymatic reaction of proteins…”
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Role of advanced glycation end products in cellular signaling by Ott, Christiane, Jacobs, Kathleen, Haucke, Elisa, Navarrete Santos, Anne, Grune, Tilman, Simm, Andreas

“…Improvements in health care and lifestyle have led to an elevated lifespan and increased focus on age-associated diseases, such as neurodegeneration,…”
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Sex-Specific Protection of Endothelial Function after Vascular Ischemia/Reperfusion Injury by the Senomorphic Agent Ruxolitinib by Saemann, Lars, Naujoks, Paula, Hartrumpf, Lotta, Pohl, Sabine, Simm, Andreas, Szabó, Gábor

“…Ischemia/reperfusion (I/R)-induced endothelial dysfunction occurs in various cardiovascular disorders. I/R injury is partially driven by the release of…”
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RAGE-Dependent Effect of Exogenous Methylglyoxal Intake on Lung Biomechanics in Mice by Al-Robaiy, Samiya, Navarrete Santos, Alexander, Simm, Andreas

“…Methylglyoxal (MG) is a known highly reactive dicarbonyl and precursor to free radicals and advanced glycation end-products (AGEs). It is discussed to be…”
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Rye Bread Crust as an Inducer of Antioxidant Genes and Suppressor of NF-κB Pathway In Vivo by Wächter, Kristin, Gohde, Birte, Szabó, Gábor, Simm, Andreas

“…Heat-processed food, like bread, containing high amounts of advanced glycation end products (AGEs), is controversially discussed regarding the effects on…”
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Reduction of Glycolysis Intermediate Concentrations in the Cerebrospinal Fluid of Alzheimer's Disease Patients by Bergau, Nick, Maul, Stephan, Rujescu, Dan, Simm, Andreas, Navarrete Santos, Alexander

“…The profile of 122 metabolites in the cerebrospinal fluid (CSF) of patients suffering from Alzheimer's disease (AD) and controls was studied. Among the 122…”
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Caloric restriction reduces sympathetic activity similar to beta-blockers but conveys additional mitochondrio-protective effects in aged myocardium by Niemann, Bernd, Li, Ling, Simm, Andreas, Molenda, Nicole, Kockskämper, Jens, Boening, Andreas, Rohrbach, Susanne

“…Increased activation of sympathetic nervous system contributes to congestive heart failure (CHF) progression, and inhibition of sympathetic overactivation by…”
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The preventive strategy for pandemics in the elderly is to collect in advance samples & data to counteract chronic inflammation (inflammaging) by Fuellen, Georg, Liesenfeld, Oliver, Kowald, Axel, Barrantes, Israel, Bastian, Manuela, Simm, Andreas, Jansen, Ludger, Tietz-Latza, Alexander, Quandt, Dagmar, Franceschi, Claudio, Walter, Michael

“…•The COVID-19 health crisis strongly motivates biomarker studies of immunity in elderly people.•Sampling for biomarker studies can include swabs, dried blood,…”
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Improving Diastolic and Microvascular Function in Heart Transplantation with Donation after Circulatory Death by Saemann, Lars, Georgevici, Adrian-Iustin, Hoorn, Fabio, Gharpure, Nitin, Veres, Gábor, Korkmaz-Icöz, Sevil, Karck, Matthias, Simm, Andreas, Wenzel, Folker, Szabó, Gábor

“…The impact of the machine perfusion of donation after circulatory death (DCD) hearts with the novel Custodiol-N solution on diastolic and coronary…”
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HTK vs. HTK-N for Coronary Endothelial Protection during Hypothermic, Oxygenated Perfusion of Hearts Donated after Circulatory Death by Saemann, Lars, Wächter, Kristin, Gharpure, Nitin, Pohl, Sabine, Hoorn, Fabio, Korkmaz-Icöz, Sevil, Karck, Matthias, Veres, Gábor, Simm, Andreas, Szabó, Gábor

“…Protection of the coronary arteries during donor heart maintenance is pivotal to improve results and prevent the development of coronary allograft…”
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Transcriptomic Changes in the Myocardium and Coronary Artery of Donation after Circulatory Death Hearts following Ex Vivo Machine Perfusion by Saemann, Lars, Wächter, Kristin, Georgevici, Adrian-Iustin, Pohl, Sabine, Hoorn, Fabio, Veres, Gábor, Korkmaz-Icöz, Sevil, Karck, Matthias, Simm, Andreas, Szabó, Gábor

“…Donation after circulatory death (DCD) hearts are predominantly maintained by normothermic blood perfusion (NBP). Nevertheless, it was shown that hypothermic…”
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Comparison of Extracellular Vesicles from Induced Pluripotent Stem Cell-Derived Brain Cells by Xavier, Gabriela, Navarrete Santos, Alexander, Hartmann, Carla, Santoro, Marcos L, Flegel, Nicole, Reinsch, Jessica, Majer, Annika, Ehrhardt, Toni, Pfeifer, Jenny, Simm, Andreas, Hollemann, Thomas, Belangero, Sintia I, Rujescu, Dan, Jung, Matthias

“…The pathophysiology of many neuropsychiatric disorders is still poorly understood. Identification of biomarkers for these diseases could benefit patients due…”
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Human CD133+ Progenitor Cells Promote the Healing of Diabetic Ischemic Ulcers by Paracrine Stimulation of Angiogenesis and Activation of Wnt Signaling by Barcelos, Lucíola S, Duplaa, Cécile, Kränkel, Nicolle, Graiani, Gallia, Invernici, Gloria, Katare, Rajesh, Siragusa, Mauro, Meloni, Marco, Campesi, Ilaria, Monica, Manuela, Simm, Andreas, Campagnolo, Paola, Mangialardi, Giuseppe, Stevanato, Lara, Alessandri, Giulio, Emanueli, Costanza, Madeddu, Paolo

“…We evaluated the healing potential of human fetal aorta–derived CD133 progenitor cells and their conditioned medium (CD133 CCM) in a new model of ischemic…”
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AGE-Rich Bread Crust Extract Boosts Oxidative Stress Interception via Stimulation of the NRF2 Pathway by Wächter, Kristin, Navarrete Santos, Alexander, Großkopf, Anne, Baldensperger, Tim, Glomb, Marcus A., Szabó, Gábor, Simm, Andreas

“…Advanced glycation end products (AGEs) result from a non-enzymatic reaction of proteins with reactive carbohydrates. Heat-processed food, such as bread,…”
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AMPK Activation Is Indispensable for the Protective Effects of Caloric Restriction on Left Ventricular Function in Postinfarct Myocardium by Niemann, Bernd, Pan, Ruping, Issa, Hassan, Simm, Andreas, Schulz, Rainer, Rohrbach, Susanne

“…Caloric restriction (CR) extends lifespan in many species, including mammals. CR is cardioprotective in senescent myocardium by correcting pre-existing…”
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It’s all in our skin—Skin autofluorescence—A promising outcome predictor in cardiac surgery: A single centre cohort study by Hofmann, Britt, Gerull, Kristin Anja, Bloch, Katja, Riemer, Marcus, Erbs, Christian, Fröhlich, Anna, Richter, Sissy, Ehrhardt, Martin, Zitterbart, Christopher, Bartel, Friederike Fee, Siegel, Pauline, Wienke, Andreas, Silber, Rolf-Edgar, Simm, Andreas

“…Background The optimum risk score determining perioperative mortality and morbidity in cardiac surgery remains debated. Advanced glycation end products (AGEs)…”
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Advanced glycation end products and their ratio to soluble receptor are associated with limitations in physical functioning only in women: results from the CARLA cohort by Ebert, Helen, Lacruz, Maria Elena, Kluttig, Alexander, Simm, Andreas, Greiser, Karin Halina, Tiller, Daniel, Kartschmit, Nadja, Mikolajczyk, Rafael

“…Advanced glycation end products (AGEs), modifications of proteins or amino acids, are increasingly produced and accumulated with age-related diseases. Recent…”
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Central and Peripheral Circulation Differ during Off-Pump Coronary Artery Bypass Grafting by Saemann, Lars, Zubarevich, Alina, Wenzel, Folker, Soethoff, Jasmin, Korkmaz-Icöz, Sevil, Hoorn, Fabio, Karck, Matthias, Simm, Andreas, Szabó, Gábor, Veres, Gábor

“…Off-pump coronary artery bypass grafting (OPCAB) is an alternative to on-pump coronary artery bypass grafting (CABG) with cardiopulmonary bypass (CPB). During…”
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Bread crust extract protects rats’ vascular grafts from in vitro ischemia/reperfusion injury by Korkmaz-Icöz, Sevil, Schwär, Marcel, Loganathan, Sivakkanan, Wächter, Kristin, Georgevici, Adrian-Iustin, Kraft, Patricia, Mayer, Tobias, Simm, Andreas, Karck, Matthias, Szabó, Gábor

“…[Display omitted] •Ischemia/reperfusion (IR) injury affects vascular grafts during bypass surgery.•Better organ preservation solutions against IR injury are…”
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Peptide-Bound Glycative, AGE and Oxidative Modifications as Biomarkers for the Diagnosis of Alzheimer's Disease-A Feasibility Study by Grosskopf, Anne, Rahn, Jette, Kim, Ahyoung, Szabó, Gábor, Rujescu, Dan, Klawonn, Frank, Frolov, Andrej, Simm, Andreas

“…The diagnosis of Alzheimer's disease (AD) relies on core cerebrospinal fluid (CSF) biomarkers, amyloid beta (Aβ) and tau. As the brain is then already damaged,…”
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