Search Results - "SIMELL, S"

Dynamics of Diabetes-Associated Autoantibodies in Young Children with Human Leukocyte Antigen-Conferred Risk of Type 1 Diabetes Recruited from the General Population by Kukko, M., Kimpimäki, T., Korhonen, S., Kupila, A., Simell, S., Veijola, R., Simell, T., Ilonen, J., Simell, O., Knip, M.

“…This study characterized the dynamics of islet cell antibodies (ICA), insulin antibodies (IAA), glutamic acid decarboxylase antibodies (GADA), and IA-2…”
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Antibody responses to deamidated gliadin peptide show high specificity and parallel antibodies to tissue transglutaminase in developing coeliac disease by Ankelo, M, Kleimola, V, Simell, S, Simell, O, Knip, M, Jokisalo, E, Tarkia, M, Westerlund, A, He, Q, Viander, M, Ilonen, J, Hinkkanen, A.E

“…Coeliac disease (CD) is an enteropathy induced in genetically susceptible individuals by gluten components, gliadin, hordein and secalin, polypeptides present…”
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The effect of HLA class II, insulin and CTLA4 gene regions on the development of humoral beta cell autoimmunity by HERMANN, Robert, LAINE, A. P, VEIJOLA, R, VAHLBERG, T, SIMELL, S, LÄHDE, J, SIMELL, O, KNIP, M, ILONEN, J

“…The aim of this study was to explore the contribution of genetic factors to the emergence of beta-cell-specific humoral autoimmunity. We analysed the effect of…”
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Isolation of enterovirus strains from children with preclinical Type 1 diabetes by Salminen, K. K., Vuorinen, T., Oikarinen, S., Helminen, M., Simell, S., Knip, M., Ilonen, J., Simell, O., Hyöty, H.

“…Aims  To develop methods for isolation of enterovirus strains from subjects with preclinical Type 1 diabetes and evaluate if their presence in stools is…”
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Affinity maturation of immunoglobulin A anti-tissue transglutaminase autoantibodies during development of coeliac disease by Westerlund, A, Ankelo, M, Simell, S, Ilonen, J, Knip, M, Simell, O, Hinkkanen, A.E

“…Coeliac disease (CD) is an immune-mediated enteropathy triggered by ingestion of wheat gluten and related cereals in genetically predisposed individuals…”
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IA‐2 antibody isotypes and epitope specificity during the prediabetic process in children with HLA‐conferred susceptibility to type I diabetes by Hoppu, S., Härkönen, T., Ronkainen, M. S., Simell, S., Hekkala, A., Toivonen, A., Ilonen, J., Simell, O., Knip, M.

“…Summary The natural history of preclinical diabetes is partly characterized, but there is still limited information on the dynamics of the immune response to…”
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Humoral β‐cell autoimmunity is rare in patients with the congenital rubella syndrome by VISKARI, H., PARONEN, J., KESKINEN, P., SIMELL, S., ZAWILINSKA, B., ZGORNIAK‐NOWOSIELSKA, I., KORHONEN, S., ILONEN, J., SIMELL, O., HAAPALA, A‐M., KNIP, M., HYÖTY, H.

“…SUMMARY The congenital rubella syndrome (CRS) is associated with increased risk for diabetes and thyroid disease. However, the mechanisms by which the rubella…”
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Nasal insulin to prevent type 1 diabetes in children with HLA genotypes and autoantibodies conferring increased risk of disease: a double-blind, randomised controlled trial by Näntö-Salonen, Kirsti, Dr, Kupila, Antti, MD, Simell, Satu, MD, Siljander, Heli, MD, Salonsaari, Tiina, MD, Hekkala, Anne, MD, Korhonen, Sari, MD, Erkkola, Risto, Prof, Sipilä, Jukka I, MD, Haavisto, Lotta, MD, Siltala, Marja, MSSc, Tuominen, Juhani, Prof, Hakalax, Jari, BSc, Hyöty, Heikki, Prof, Ilonen, Jorma, Prof, Veijola, Riitta, MD, Simell, Tuula, PhD, Knip, Mikael, Prof, Simell, Olli, Prof

“…Summary Background In mouse models of diabetes, prophylactic administration of insulin reduced incidence of the disease. We investigated whether administration…”
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Persistent Alterations in Plasma Lipid Profiles Before Introduction of Gluten in the Diet Associated With Progression to Celiac Disease by Sen, Partho, Carlsson, Cecilia, Virtanen, Suvi M, Simell, Satu, Hyöty, Heikki, Ilonen, Jorma, Toppari, Jorma, Veijola, Riitta, Hyötyläinen, Tuulia, Knip, Mikael, Orešič, Matej

“…Celiac disease (CD) is a chronic enteropathy characterized by an autoimmune reaction in the small intestine of genetically susceptible individuals. The…”
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Natural history of transglutaminase autoantibodies and mucosal changes in children carrying HLA-conferred celiac disease susceptibility by Simell, Satu, Kupila, Antti, Hoppu, Sanna, Hekkala, Anne, Simell, Tuula, Stahlberg, Marja-Riitta, Viander, Markku, Hurme, Timo, Knip, Mikael, Ilonen, Jorma, Hyoty, Heikki, Simell, Olli

“…The natural history of the appearance and fate of transglutaminase autoantibodies (TGAs) and mucosal changes in children carrying HLA-conferred celiac disease…”
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Geographical Variation in Risk HLA-DQB1 Genotypes for Type 1 Diabetes and Signs of β-Cell Autoimmunity in a High-Incidence Country by KUKKO, Marika, VIRTANEN, Suvi M, TOIVONEN, Anna, SIMELL, Satu, KORHONEN, Sari, ILONEN, Jorma, SIMEL, Olli, KNIP, Mikael

“…Geographical Variation in Risk HLA-DQB1 Genotypes for Type 1 Diabetes and Signs of β-Cell Autoimmunity in a High-Incidence Country Marika Kukko , MD 1 2 , Suvi…”
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Insulin autoantibody isotypes during the prediabetic process in young children with increased genetic risk of Type 1 diabetes by HOPPU, Sanna, RONKAINEN, Matti S, KIMPIMÄKI, Teija, SIMELL, Satu, KORHONEN, Sari, ILONEN, Jorma, SIMELL, Olli, KNIP, Mikael

“…This work aimed to assess the maturation of the humoral immune response to insulin in preclinical type 1 diabetes by observing the emergence of various…”
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Humoral (beta)-cell autoimmunity is rare in patients with the congenital rubella syndrome by Viskari, H, Paronen, J, Keskinen, P, Simell, S

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