Search Results - "SIMELL, Olli"

Seroconversion to Multiple Islet Autoantibodies and Risk of Progression to Diabetes in Children by Ziegler, Anette G, Rewers, Marian, Simell, Olli, Simell, Tuula, Lempainen, Johanna, Steck, Andrea, Winkler, Christiane, Ilonen, Jorma, Veijola, Riitta, Knip, Mikael, Bonifacio, Ezio, Eisenbarth, George S

“…IMPORTANCE Type 1 diabetes usually has a preclinical phase identified by circulating islet autoantibodies, but the rate of progression to diabetes after…”
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The 6 year incidence of diabetes-associated autoantibodies in genetically at-risk children: the TEDDY study by Krischer, Jeffrey P., Lynch, Kristian F., Schatz, Desmond A., Ilonen, Jorma, Lernmark, Åke, Hagopian, William A., Rewers, Marian J., She, Jin-Xiong, Simell, Olli G., Toppari, Jorma, Ziegler, Anette-G., Akolkar, Beena, Bonifacio, Ezio

“…Aims/hypothesis Islet autoantibodies, in addition to elevated blood glucose, define type 1 diabetes. These autoantibodies are detectable for a variable period…”
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Respiratory infections are temporally associated with initiation of type 1 diabetes autoimmunity: the TEDDY study by Lönnrot, Maria, Lynch, Kristian F., Elding Larsson, Helena, Lernmark, Åke, Rewers, Marian J., Törn, Carina, Burkhardt, Brant R., Briese, Thomas, Hagopian, William A., She, Jin-Xiong, Simell, Olli G., Toppari, Jorma, Ziegler, Anette-G., Akolkar, Beena, Krischer, Jeffrey P., Hyöty, Heikki

“…Aims/hypothesis Respiratory infections and onset of islet autoimmunity are reported to correlate positively in two small prospective studies. The Environmental…”
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Gut microbiome metagenomics analysis suggests a functional model for the development of autoimmunity for type 1 diabetes by Brown, Christopher T, Davis-Richardson, Austin G, Giongo, Adriana, Gano, Kelsey A, Crabb, David B, Mukherjee, Nabanita, Casella, George, Drew, Jennifer C, Ilonen, Jorma, Knip, Mikael, Hyöty, Heikki, Veijola, Riitta, Simell, Tuula, Simell, Olli, Neu, Josef, Wasserfall, Clive H, Schatz, Desmond, Atkinson, Mark A, Triplett, Eric W

“…Recent studies have suggested a bacterial role in the development of autoimmune disorders including type 1 diabetes (T1D). Over 30 billion nucleotide bases of…”
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Predictors of Progression From the Appearance of Islet Autoantibodies to Early Childhood Diabetes: The Environmental Determinants of Diabetes in the Young (TEDDY) by Steck, Andrea K, Vehik, Kendra, Bonifacio, Ezio, Lernmark, Ake, Ziegler, Anette-G, Hagopian, William A, She, JinXiong, Simell, Olli, Akolkar, Beena, Krischer, Jeffrey, Schatz, Desmond, Rewers, Marian J

“…While it is known that there is progression to diabetes in <10 years in 70% of children with two or more islet autoantibodies, predictors of the progression to…”
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Toward defining the autoimmune microbiome for type 1 diabetes by Giongo, Adriana, Gano, Kelsey A, Crabb, David B, Mukherjee, Nabanita, Novelo, Luis L, Casella, George, Drew, Jennifer C, Ilonen, Jorma, Knip, Mikael, Hyöty, Heikki, Veijola, Riitta, Simell, Tuula, Simell, Olli, Neu, Josef, Wasserfall, Clive H, Schatz, Desmond, Atkinson, Mark A, Triplett, Eric W

“…Several studies have shown that gut bacteria have a role in diabetes in murine models. Specific bacteria have been correlated with the onset of diabetes in a…”
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Enterovirus RNA in Blood Is Linked to the Development of Type 1 Diabetes by OIKARINEN, Sami, MARTISKAINEN, Mika, TAURIAINEN, Sisko, HUHTALA, Heini, ILONEN, Jorma, VEIJOLA, Riitta, SIMELL, Olli, KNIP, Mikael, HYÖTY, Heikki

“…To assess whether the detection of enterovirus RNA in blood predicts the development of clinical type 1 diabetes in a prospective birth cohort study. Further,…”
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Role of Type 1 Diabetes-Associated SNPs on Risk of Autoantibody Positivity in the TEDDY Study by Törn, Carina, Hadley, David, Lee, Hye-Seung, Hagopian, William, Lernmark, Åke, Simell, Olli, Rewers, Marian, Ziegler, Anette, Schatz, Desmond, Akolkar, Beena, Onengut-Gumuscu, Suna, Chen, Wei-Min, Toppari, Jorma, Mykkänen, Juha, Ilonen, Jorma, Rich, Stephen S, She, Jin-Xiong, Steck, Andrea K, Krischer, Jeffrey

“…The Environmental Determinants of Diabetes in the Young (TEDDY) study prospectively follows 8,677 children enrolled from birth who carry HLA-susceptibility…”
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Association Between Early-Life Antibiotic Use and the Risk of Islet or Celiac Disease Autoimmunity by Kemppainen, Kaisa M, Vehik, Kendra, Lynch, Kristian F, Larsson, Helena Elding, Canepa, Ronald J, Simell, Ville, Koletzko, Sibylle, Liu, Edwin, Simell, Olli G, Toppari, Jorma, Ziegler, Anette G, Rewers, Marian J, Lernmark, Åke, Hagopian, William A, She, Jin-Xiong, Akolkar, Beena, Schatz, Desmond A, Atkinson, Mark A, Blaser, Martin J, Krischer, Jeffrey P, Hyöty, Heikki, Agardh, Daniel, Triplett, Eric W

“…Evidence is lacking regarding the consequences of antibiotic use in early life and the risk of certain autoimmune diseases. To test the association between…”
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Plasma 25-Hydroxyvitamin D Concentration and Risk of Islet Autoimmunity by Norris, Jill M, Lee, Hye-Seung, Frederiksen, Brittni, Erlund, Iris, Uusitalo, Ulla, Yang, Jimin, Lernmark, Åke, Simell, Olli, Toppari, Jorma, Rewers, Marian, Ziegler, Anette-G, She, Jin-Xiong, Onengut-Gumuscu, Suna, Chen, Wei-Min, Rich, Stephen S, Sundvall, Jouko, Akolkar, Beena, Krischer, Jeffrey, Virtanen, Suvi M, Hagopian, William

“…We examined the association between plasma 25-hydroxyvitamin D [25(OH)D] concentration and islet autoimmunity (IA) and whether vitamin D gene polymorphisms…”
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Food diversity in infancy and the risk of childhood asthma and allergies by Nwaru, Bright I., MPhil, PhD, Takkinen, Hanna-Mari, MSc, Kaila, Minna, MD, PhD, Erkkola, Maijaliisa, PhD, Ahonen, Suvi, MSc, Pekkanen, Juha, MD, PhD, Simell, Olli, MD, PhD, Veijola, Riitta, MD, PhD, Ilonen, Jorma, MD, PhD, Hyöty, Heikki, MD, PhD, Knip, Mikael, MD, PhD, Virtanen, Suvi M., MD, PhD

“…Background Recently, the bacterial diversity of the intestinal flora and the diversity of various environmental factors during infancy have been linked to the…”
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Dysregulation of lipid and amino acid metabolism precedes islet autoimmunity in children who later progress to type 1 diabetes by Oresic, Matej, Simell, Satu, Sysi-Aho, Marko, Näntö-Salonen, Kirsti, Seppänen-Laakso, Tuulikki, Parikka, Vilhelmiina, Katajamaa, Mikko, Hekkala, Anne, Mattila, Ismo, Keskinen, Päivi, Yetukuri, Laxman, Reinikainen, Arja, Lähde, Jyrki, Suortti, Tapani, Hakalax, Jari, Simell, Tuula, Hyöty, Heikki, Veijola, Riitta, Ilonen, Jorma, Lahesmaa, Riitta, Knip, Mikael, Simell, Olli

“…The risk determinants of type 1 diabetes, initiators of autoimmune response, mechanisms regulating progress toward beta cell failure, and factors determining…”
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Early Infant Diet and Islet Autoimmunity in the TEDDY Study by Uusitalo, Ulla, Lee, Hye-Seung, Andrén Aronsson, Carin, Vehik, Kendra, Yang, Jimin, Hummel, Sandra, Silvis, Katherine, Lernmark, Åke, Rewers, Marian, Hagopian, William, She, Jin-Xiong, Simell, Olli, Toppari, Jorma, Ziegler, Anette-G, Akolkar, Beena, Krischer, Jeffrey, Virtanen, Suvi M, Norris, Jill M

“…To examine duration of breastfeeding and timing of complementary foods and risk of islet autoimmunity (IA). The Environmental Determinants of Diabetes in the…”
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Non-HLA gene effects on the disease process of type 1 diabetes: From HLA susceptibility to overt disease by Lempainen, Johanna, Laine, Antti-Pekka, Hammais, Anna, Toppari, Jorma, Simell, Olli, Veijola, Riitta, Knip, Mikael, Ilonen, Jorma

“…Abstract In addition to the HLA region numerous other gene loci have shown association with type 1 diabetes. How these polymorphisms exert their function has…”
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Early glucose metabolism in children at risk for type 1 diabetes based on islet autoantibodies compared to low-risk control groups by Helminen, Olli, Pokka, Tytti, Aspholm, Susanna, Ilonen, Jorma, Simell, Olli, Knip, Mikael, Veijola, Riitta

“…Anatomic variation or early differences in glucose metabolism have been linked to the development of type 1 diabetes. We aimed to describe early glucose…”
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Early childhood gut microbiomes show strong geographic differences among subjects at high risk for type 1 diabetes by Kemppainen, Kaisa M, Ardissone, Alexandria N, Davis-Richardson, Austin G, Fagen, Jennie R, Gano, Kelsey A, León-Novelo, Luis G, Vehik, Kendra, Casella, George, Simell, Olli, Ziegler, Anette G, Rewers, Marian J, Lernmark, Åke, Hagopian, William, She, Jin-Xiong, Krischer, Jeffrey P, Akolkar, Beena, Schatz, Desmond A, Atkinson, Mark A, Triplett, Eric W

“…Gut microbiome dysbiosis is associated with numerous diseases, including type 1 diabetes. This pilot study determines how geographical location affects the…”
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Influenza A virus antibodies show no association with pancreatic islet autoantibodies in children genetically predisposed to type 1 diabetes by Kondrashova, Anita, Nurminen, Noora, Patrikainen, Maarit, Huhtala, Heini, Lehtonen, Jussi, Toppari, Jorma, Ilonen, Jorma, Simell, Olli G., Veijola, Riitta, Knip, Mikael, Hyöty, Heikki

“…Aims/hypothesis Viral infections have long been considered potential triggers of beta cell autoimmunity and type 1 diabetes. Recent studies have suggested that…”
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Nasal insulin to prevent type 1 diabetes in children with HLA genotypes and autoantibodies conferring increased risk of disease: a double-blind, randomised controlled trial by Näntö-Salonen, Kirsti, Dr, Kupila, Antti, MD, Simell, Satu, MD, Siljander, Heli, MD, Salonsaari, Tiina, MD, Hekkala, Anne, MD, Korhonen, Sari, MD, Erkkola, Risto, Prof, Sipilä, Jukka I, MD, Haavisto, Lotta, MD, Siltala, Marja, MSSc, Tuominen, Juhani, Prof, Hakalax, Jari, BSc, Hyöty, Heikki, Prof, Ilonen, Jorma, Prof, Veijola, Riitta, MD, Simell, Tuula, PhD, Knip, Mikael, Prof, Simell, Olli, Prof

“…Summary Background In mouse models of diabetes, prophylactic administration of insulin reduced incidence of the disease. We investigated whether administration…”
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Association of human bocavirus 1 infection with respiratory disease in childhood follow-up study, Finland by Meriluoto, Mira, Hedman, Lea, Tanner, Laura, Simell, Ville, Mäkinen, Marjaana, Simell, Satu, Mykkänen, Juha, Korpelainen, Jan, Ruuskanen, Olli, Ilonen, Jorma, Knip, Mikael, Simell, Olli, Hedman, Klaus, Söderlund-Venermo, Maria

“…Human bocavirus 1 (HBoV1) DNA is frequently detected in the upper airways of young children with respiratory symptoms. Because of its persistence and frequent…”
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Maternal dietary folate, folic acid and vitamin D intakes during pregnancy and lactation and the risk of cows’ milk allergy in the offspring by Tuokkola, Jetta, Luukkainen, Päivi, Kaila, Minna, Takkinen, Hanna-Mari, Niinistö, Sari, Veijola, Riitta, Virta, Lauri J., Knip, Mikael, Simell, Olli, Ilonen, Jorma, Virtanen, Suvi M.

“…Maternal nutrient intake during pregnancy and lactation potentially influences the development of allergic diseases. Cows’ milk allergy (CMA) is often the…”
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