Search Results - "SILVIA, Annette"

Mycobactericidal activity of sutezolid (PNU-100480) in sputum (EBA) and blood (WBA) of patients with pulmonary tuberculosis by Wallis, Robert S, Dawson, Rodney, Friedrich, Sven O, Venter, Amour, Paige, Darcy, Zhu, Tong, Silvia, Annette, Gobey, Jason, Ellery, Craig, Zhang, Yao, Eisenach, Kathleen, Miller, Paul, Diacon, Andreas H

“…Sutezolid (PNU-100480) is a linezolid analog with superior bactericidal activity against Mycobacterium tuberculosis in the hollow fiber, whole blood and mouse…”
Get full text

Pharmacokinetics and Whole-Blood Bactericidal Activity against Mycobacterium tuberculosis of Single Doses of PNU-100480 in Healthy Volunteers by Wallis, Robert S., Jakubiec, Wesley M., Kumar, Vikas, Silvia, Annette M., Paige, Darcy, Dimitrova, Dessislava, Li, Xiaoxi, Ladutko, Lynn, Campbell, Sheldon, Friedland, Gerald, Mitton-Fry, Mark, Miller, Paul F.

“…Background. The oxazolidinone PNU-100480 is superior to linezolid against experimental murine tuberculosis. Two metabolites contribute to but do not fully…”
Get full text

Biomarker-Assisted Dose Selection for Safety and Efficacy in Early Development of PNU-100480 for Tuberculosis by WALLIS, Robert S, JAKUBIEC, Wesley, MILLER, Paul F, KUMAR, Vikas, BEDARIDA, Gabriella, SILVIA, Annette, PAIGE, Darcy, TONG ZHU, MITTON-FRY, Mark, LADUTKO, Lynn, CAMPBELL, Sheldon

“…Classifications Services AAC Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit…”
Get full text

Rapid evaluation in whole blood culture of regimens for XDR-TB containing PNU-100480 (sutezolid), TMC207, PA-824, SQ109, and pyrazinamide by Wallis, Robert S, Jakubiec, Wesley, Mitton-Fry, Mark, Ladutko, Lynn, Campbell, Sheldon, Paige, Darcy, Silvia, Annette, Miller, Paul F

“…There presently is no rapid method to assess the bactericidal activity of new regimens for tuberculosis. This study examined PNU-100480, TMC207, PA-824, SQ109,…”
Get full text

5-Heteroatom substituted pyrazoles as canine COX-2 inhibitors. Part 1: Structure–activity relationship studies of 5-alkylamino pyrazoles and discovery of a potent, selective, and orally active analog by Sakya, Subas M., Lundy DeMello, Kristin M., Minich, Martha L., Rast, Bryson, Shavnya, Andrei, Rafka, Robert J., Koss, David A., Cheng, Hengmiao, Li, Jin, Jaynes, Burton H., Ziegler, Carl B., Mann, Donald W., Petras, Carol F., Seibel, Scott B., Silvia, Annette M., George, David M., Lund, Lisa A., Denis, Suzanne St, Hickman, Anne, Haven, Michelle L., Lynch, Michael P.

“…Structure–activity relationship studies of the novel 2-[3-di and trifluoromethyl-5-alkylamino pyrazo-1-lyl]-5-methanesulfonyl (SO 2Me)/5-sulfamoyl (SO 2NH…”
Get full text

In vitro microbiological characterization of a novel azalide, two triamilides and an azalide ketal against bovine and porcine respiratory pathogens by Norcia, Laura J L, Silvia, Annette M, Santoro, Sheryl L, Retsema, Jim, Letavic, Michael A, Bronk, Brian S, Lundy, Kristin M, Yang, Bingwei, Evans, Nigel A, Hayashi, Shigeru F

“…Several novel 15-membered-ring macrolide agents (azalide 1, triamilides 2 and 3, and the azalide 3,6-ketal 4) were identified as potential antibacterial agents…”
Get more information

Synthesis and SAR of heteroaryl-phenyl-substituted pyrazole derivatives as highly selective and potent canine COX-2 inhibitors by Cheng, Hengmiao, Lundy DeMello, Kristin M., Li, Jin, Sakya, Subas M., Ando, Kazuo, Kawamura, K., Kato, Tomoki, Rafka, Robert J., Jaynes, Burton H., Ziegler, Carl B., Stevens, Rod, Lund, Lisa A., Mann, Donald W., Kilroy, Carolyn, Haven, Michelle L., Nimz, Erik L., Dutra, Jason K., Li, Chao, Minich, Martha L., Kolosko, Nicole L., Petras, Carol, Silvia, Annette M., Seibel, Scott B.

“…The discovery of heteroaryl-phenyl-substituted pyrazole derivatives as canine selective COX-2 inhibitors is described. Structure–activity relationship (SAR)…”
Get full text

5-Heteroatom-substituted pyrazoles as canine COX-2 inhibitors: Part 2. Structure–activity relationship studies of 5-alkylethers and 5-thioethers by Sakya, Subas M., Cheng, Hengmiao, Lundy DeMello, Kristin M., Shavnya, Andrei, Minich, Martha L., Rast, Bryson, Dutra, Jason, Li, Chao, Rafka, Robert J., Koss, David A., Li, Jin, Jaynes, Burton H., Ziegler, Carl B., Mann, Donald W., Petras, Carol F., Seibel, Scott B., Silvia, Annette M., George, David M., Hickman, Anne, Haven, Michelle L., Lynch, Michael P.

“…Structure–activity relationship (SAR) studies of novel 2-[3-trifluoromethyl-5-alkyl(thio)ether pyrazo-1-yl]-5-methanesulfonyl pyridine derivatives for canine…”
Get full text

Discovery of a potent, selective and orally active canine COX-2 inhibitor, 2-(3-difluoromethyl-5-phenyl-pyrazol-1-yl)-5-methanesulfonyl-pyridine by Li, Jin, DeMello, Kristin M.Lundy, Cheng, Henry, Sakya, Subas M., Bronk, Brian S., Rafka, Robert J., Jaynes, Burton H., Ziegler, Carl B., Kilroy, Carolyn, Mann, Donald W., Nimz, Eric L., Lynch, Michael P., Haven, Michelle L., Kolosko, Nicole L., Minich, Martha L., Li, Chao, Dutra, Jason K., Rast, Bryson, Crosson, Rhonda M., Morton, Barry J., Kirk, Glen W., Callaghan, Kathleen M., Koss, David A., Shavnya, Andrei, Lund, Lisa A., Seibel, Scott B., Petras, Carol F., Silvia, Annette

“…Structure–activity relationship (SAR) studies of 2-[3-di(and tri)fluoromethyl-5-arylpyrazol-1-yl]-5-methanesulfonylpyridine derivatives for canine COX enzymes…”
Get full text

Structure-activity relationships of hygromycin A and its analogs: protein synthesis inhibition activity in a cell free system by Hayashi, S F, Norcia, L J, Seibel, S B, Silvia, A M

“…Several analogs of hygromycin A were tested in an Escherichia coli cell free protein synthesis inhibition assay and in a Serpulina hyodysenteriae whole cell…”
Get more information

Socioeconomic and Sociocultural Factors Associated with Parenting Choice and Fertility Experience Among Lesbian and Nonlesbian Women by Silvia, Annette M

“…Minorities including lesbians may face disparities that contribute to minority stress, which leads to adverse health outcomes. The purpose of this social…”
Get full text

In vitro microbiological characterization of novel cyclic homopentapeptides, CP-101,680 and CP-163,234, for animal health use by Norcia, L J, Silvia, A M, Dirlam, J P, Schnur, R C, Bergeron, J M, Retsema, J A, Hayashi, S F

“…Two cyclic homopentapeptides, CP-101,680 and CP-163,234 [6a-(3',4'-dichlorophenylamino) analogs of viomycin and capreomycin, respectively], were identified as…”
Get more information

Mycobactericidal activity of sutezolid of patients with pulmonary tuberculosis by Wallis, Robert S, Dawson, Rodney, Friedrich, Sven O, Venter, Amour, Paige, Darcy, Zhu, Tong, Silvia, Annette, Gobey, Jason, Ellery, Craig, Zhang, Yao, Eisenach, Kathleen, Miller, Paul, Diacon, Andreas H

“…Trial Registration: ClinicalTrials.gov NCT01225640…”
Get full text

Rapid Evaluation in Whole Blood Culture of Regimens for XDR-TB Containing PNU-100480 by Wallis, Robert S, Jakubiec, Wesley, Mitton-Fry, Mark, Ladutko, Lynn, Campbell, Sheldon, Paige, Darcy, Silvia, Annette, Miller, Paul F

“…There presently is no rapid method to assess the bactericidal activity of new regimens for tuberculosis. This study examined PNU-100480, TMC207, PA-824, SQ109,…”
Get full text

Mycobactericidal Activity of Sutezolid (PNU-100480) in Sputum (EBA) and Blood (WBA) of Patients with Pulmonary Tuberculosis: e94462 by Wallis, Robert S, Dawson, Rodney, Friedrich, Sven O, Venter, Amour, Paige, Darcy, Zhu, Tong, Silvia, Annette, Gobey, Jason, Ellery, Craig, Zhang, Yao

“…Rationale Sutezolid (PNU-100480) is a linezolid analog with superior bactericidal activity against Mycobacterium tuberculosis in the hollow fiber, whole blood…”
Get full text

Sensitization of bacteria to danofloxacin by temperate prophages by FROSHAUER, S, SILVIA, A. M, CHIDAMBARAM, M, SHARMA, B, WEINSTOCK, G. M

“…Services AAC Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit StumbleUpon…”
Get full text

Synthesis and structure-activity relationships of 7-diazabicycloalkylquinolones, including danofloxacin, a new quinolone antibacterial agent for veterinary medicine by McGuirk, Paul R, Jefson, Martin R, Mann, Douglas D, Elliott, Nancy C, Chang, Polly, Cisek, Eugene P, Cornell, C. Peter, Gootz, Thomas D, Haskell, Susan L

“…A series of novel 6-fluoro-7-diazabicycloalkylquinolonecarboxylic acids substituted with various C8 (H, F, Cl, N) and N1 (ethyl, cyclopropyl, vinyl,…”
Get full text