Search Results - "SILVERMAN, ROBERT"

Viral encounters with 2',5'-oligoadenylate synthetase and RNase L during the interferon antiviral response by SILVERMAN, Robert H

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Early endonuclease-mediated evasion of RNA sensing ensures efficient coronavirus replication by Kindler, Eveline, Gil-Cruz, Cristina, Spanier, Julia, Li, Yize, Wilhelm, Jochen, Rabouw, Huib H, Züst, Roland, Hwang, Mihyun, V'kovski, Philip, Stalder, Hanspeter, Marti, Sabrina, Habjan, Matthias, Cervantes-Barragan, Luisa, Elliot, Ruth, Karl, Nadja, Gaughan, Christina, van Kuppeveld, Frank J M, Silverman, Robert H, Keller, Markus, Ludewig, Burkhard, Bergmann, Cornelia C, Ziebuhr, John, Weiss, Susan R, Kalinke, Ulrich, Thiel, Volker

“…Coronaviruses are of veterinary and medical importance and include highly pathogenic zoonotic viruses, such as SARS-CoV and MERS-CoV. They are known to…”
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Antagonism of the Interferon-Induced OAS-RNase L Pathway by Murine Coronavirus ns2 Protein Is Required for Virus Replication and Liver Pathology by Zhao, Ling, Jha, Babal K., Wu, Ashley, Elliott, Ruth, Ziebuhr, John, Gorbalenya, Alexander E., Silverman, Robert H., Weiss, Susan R.

“…Many viruses induce hepatitis in humans, highlighting the need to understand the underlying mechanisms of virus-induced liver pathology. The murine…”
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Age-related association of fine particles and ozone with severe acute asthma in New York City by Silverman, Robert A., MD, Ito, Kazuhiko, PhD

“…Background Ambient fine particles (particular matter <2.5 μm diameter [PM2.5 ]) and ozone exacerbate respiratory conditions including asthma. There is little…”
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RNA helicase SKIV2L limits antiviral defense and autoinflammation elicited by the OAS-RNase L pathway by Yang, Kun, Dong, Beihua, Asthana, Abhishek, Silverman, Robert H, Yan, Nan

“…The OAS-RNase L pathway is one of the oldest innate RNA sensing pathways that leads to interferon (IFN) signaling and cell death. OAS recognizes viral RNA and…”
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Activation of RNase L is dependent on OAS3 expression during infection with diverse human viruses by Li, Yize, Banerjee, Shuvojit, Wang, Yuyan, Goldstein, Stephen A., Dong, Beihua, Gaughan, Christina, Silverman, Robert H., Weiss, Susan R.

“…The 2′,5′-oligoadenylate (2-5A) synthetase (OAS)–RNase L system is an IFN-induced antiviral pathway. RNase L activity depends on 2-5A, synthesized by OAS…”
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RNase L Activates the NLRP3 Inflammasome during Viral Infections by Chakrabarti, Arindam, Banerjee, Shuvojit, Franchi, Luigi, Loo, Yueh-Ming, Gale, Michael, Núñez, Gabriel, Silverman, Robert H.

“…The NLRP3 inflammasome assembles in response to danger signals, triggering self-cleavage of procaspase-1 and production of the proinflammatory cytokine IL-1β…”
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COVID-19: Coronavirus replication, pathogenesis, and therapeutic strategies by Bergmann, Cornelia C, Silverman, Robert H

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SARS-CoV-2 induces double-stranded RNA-mediated innate immune responses in respiratory epithelial-derived cells and cardiomyocytes by Li, Yize, Renner, David M., Comar, Courtney E., Whelan, Jillian N., Reyes, Hanako M., Cardenas-Diaz, Fabian Leonardo, Truitt, Rachel, Tan, Li Hui, Dong, Beihua, Alysandratos, Konstantinos Dionysios, Huang, Jessie, Palmer, James N., Adappa, Nithin D., Kohanski, Michael A., Kotton, Darrell N., Silverman, Robert H., Yang, Wenli, Morrisey, Edward E., Cohen, Noam A., Weiss, Susan R.

“…Coronaviruses are adept at evading host antiviral pathways induced by viral double-stranded RNA, including interferon (IFN) signaling, oligoadenylate…”
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Effect of asthma exacerbations on health care costs among asthmatic patients with moderate and severe persistent asthma by Ivanova, Jasmina I., MA, Bergman, Rachel, BA, Birnbaum, Howard G., PhD, Colice, Gene L., MD, Silverman, Robert A., MD, McLaurin, Kimmie, MS

“…Background Health care costs increase in patients with more severe asthma, but the effect of asthma exacerbations on costs among patients with more severe…”
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Small self-RNA generated by RNase L amplifies antiviral innate immunity by Malathi, Krishnamurthy, Dong, Beihua, Silverman, Robert H, Gale, Michael

“…Antiviral innate immunity is initiated in response to RNA molecules that are produced in virus-infected cells. These RNAs activate signalling cascades that…”
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molecular basis for selective inhibition of unconventional mRNA splicing by an IRE1-binding small molecule by Cross, Benedict C. S, Bond, Peter J, Sadowski, Pawel G, Jha, Babal Kant, Zak, Jaroslav, Goodman, Jonathan M, Silverman, Robert H, Neubert, Thomas A, Baxendale, Ian R, Ron, David, Harding, Heather P

“…IRE1 couples endoplasmic reticulum unfolded protein load to RNA cleavage events that culminate in the sequence-specific splicing of the Xbp1 mRNA and in the…”
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Interferons at age 50: past, current and future impact on biomedicine by Borden, Ernest C, Sen, Ganes C, Uze, Gilles, Silverman, Robert H, Ransohoff, Richard M, Foster, Graham R, Stark, George R

“…The family of interferon (IFN) proteins has now more than reached the potential envisioned by early discovering virologists: IFNs are not only antivirals with…”
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New insights into the role of RNase L in innate immunity by Chakrabarti, Arindam, Jha, Babal Kant, Silverman, Robert H

“…The interferon (IFN)-inducible 2'-5'-oligoadenylate synthetase (OAS)/RNase L pathway blocks infections by some types of viruses through cleavage of viral and…”
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Cytosolic double-stranded RNA activates the NLRP3 inflammasome via MAVS-induced membrane permeabilization and K+ efflux by Franchi, Luigi, Eigenbrod, Tatjana, Muñoz-Planillo, Raúl, Ozkurede, Ulas, Kim, Yun-Gi, Arindam, Chakrabarti, Gale, Jr, Michael, Silverman, Robert H, Colonna, Marco, Akira, Shizuo, Núñez, Gabriel

“…The nucleotide-binding oligomerization domain-like receptor pyrin domain-containing 3 (Nlrp3) inflammasome plays an important role in inflammation by…”
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Zika Virus Production Is Resistant to RNase L Antiviral Activity by Whelan, Jillian N, Li, Yize, Silverman, Robert H, Weiss, Susan R

“…There is currently no knowledge of how the emerging human pathogen Zika virus (ZIKV) interacts with the antiviral endoribonuclease L (RNase L) pathway during…”
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OAS-RNase L innate immune pathway mediates the cytotoxicity of a DNA-demethylating drug by Banerjee, Shuvojit, Gusho, Elona, Gaughan, Christina, Dong, Beihua, Gu, Xiaorong, Holvey-Bates, Elise, Talukdar, Manisha, Li, Yize, Weiss, Susan R., Sicheri, Frank, Saunthararajah, Yogen, Stark, George R., Silverman, Robert H.

“…Drugs that reverse epigenetic silencing, such as the DNA methyltransferase inhibitor (DNMTi) 5-azacytidine (AZA), have profound effects on transcription and…”
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A novel mechanism of RNase L inhibition: Theiler's virus L protein prevents 2-5A from binding to RNase L by Drappier, Melissa, Jha, Babal Kant, Stone, Sasha, Elliott, Ruth, Zhang, Rong, Vertommen, Didier, Weiss, Susan R, Silverman, Robert H, Michiels, Thomas

“…The OAS/RNase L pathway is one of the best-characterized effector pathways of the IFN antiviral response. It inhibits the replication of many viruses and…”
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Guidelines of care for the management of atopic dermatitis: section 2. Management and treatment of atopic dermatitis with topical therapies by Eichenfield, Lawrence F, Tom, Wynnis L, Berger, Timothy G, Krol, Alfons, Paller, Amy S, Schwarzenberger, Kathryn, Bergman, James N, Chamlin, Sarah L, Cohen, David E, Cooper, Kevin D, Cordoro, Kelly M, Davis, Dawn M, Feldman, Steven R, Hanifin, Jon M, Margolis, David J, Silverman, Robert A, Simpson, Eric L, Williams, Hywel C, Elmets, Craig A, Block, Julie, Harrod, Christopher G, Smith Begolka, Wendy, Sidbury, Robert

“…Atopic dermatitis is a common and chronic, pruritic inflammatory skin condition that can affect all age groups. This evidence-based guideline addresses…”
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A randomized trial of benralizumab, an antiinterleukin 5 receptor α monoclonal antibody, after acute asthma by Nowak, Richard M., MD, Parker, Joseph M., MD, Silverman, Robert A., MD, Rowe, Brian H., MD, MSc, Smithline, Howard, MD, Khan, Faiz, MD, Fiening, Jon P., MS, Kim, Keunpyo, PhD, Molfino, Nestor A., MD, MSc

“…Abstract Background Patients with frequent asthma exacerbations resulting in emergency department (ED) visits are at increased risk for future exacerbations…”
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