Search Results - "SILVERMAN, M"

Microglia in the Retina: Roles in Development, Maturity, and Disease by Silverman, Sean M, Wong, Wai T

“…Microglia, the primary resident immune cell type, constitute a key population of glia in the retina. Recent evidence indicates that microglia play significant…”
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A 2.4% DETERMINATION OF THE LOCAL VALUE OF THE HUBBLE CONSTANT by Riess, Adam G, Macri, Lucas M, Hoffmann, Samantha L, Scolnic, Dan, Casertano, Stefano, Filippenko, Alexei V, Tucker, Brad E, Reid, Mark J, Jones, David O, Silverman, Jeffrey M, Chornock, Ryan, Challis, Peter, Yuan, Wenlong, Brown, Peter J, Foley, Ryan J

“…We use the Wide Field Camera 3 (WFC3) on the Hubble Space Telescope (HST) to reduce the uncertainty in the local value of the Hubble constant from 3.3% to…”
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Clinicogenomic Analysis of FGFR2 -Rearranged Cholangiocarcinoma Identifies Correlates of Response and Mechanisms of Resistance to Pemigatinib by Silverman, Ian M, Hollebecque, Antoine, Friboulet, Luc, Owens, Sherry, Newton, Robert C, Zhen, Huiling, Féliz, Luis, Zecchetto, Camilla, Melisi, Davide, Burn, Timothy C

“…Pemigatinib, a selective FGFR1-3 inhibitor, has demonstrated antitumor activity in FIGHT-202, a phase II study in patients with cholangiocarcinoma harboring…”
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C3- and CR3-dependent microglial clearance protects photoreceptors in retinitis pigmentosa by Silverman, Sean M, Ma, Wenxin, Wang, Xu, Zhao, Lian, Wong, Wai T

“…Complement activation has been implicated as contributing to neurodegeneration in retinal and brain pathologies, but its role in retinitis pigmentosa (RP), an…”
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A universal trade-off between growth and lag in fluctuating environments by Basan, Markus, Honda, Tomoya, Christodoulou, Dimitris, Hörl, Manuel, Chang, Yu-Fang, Leoncini, Emanuele, Mukherjee, Avik, Okano, Hiroyuki, Taylor, Brian R., Silverman, Josh M., Sanchez, Carlos, Williamson, James R., Paulsson, Johan, Hwa, Terence, Sauer, Uwe

“…The rate of cell growth is crucial for bacterial fitness and drives the allocation of bacterial resources, affecting, for example, the expression levels of…”
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Immune and genomic correlates of response to anti-PD-1 immunotherapy in glioblastoma by Zhao, Junfei, Chen, Andrew X., Gartrell, Robyn D., Silverman, Andrew M., Aparicio, Luis, Chu, Tim, Bordbar, Darius, Shan, David, Samanamud, Jorge, Mahajan, Aayushi, Filip, Ioan, Orenbuch, Rose, Goetz, Morgan, Yamaguchi, Jonathan T., Cloney, Michael, Horbinski, Craig, Lukas, Rimas V., Raizer, Jeffrey, Rae, Ali I., Yuan, Jinzhou, Canoll, Peter, Bruce, Jeffrey N., Saenger, Yvonne M., Sims, Peter, Iwamoto, Fabio M., Sonabend, Adam M., Rabadan, Raul

“…Immune checkpoint inhibitors have been successful across several tumor types; however, their efficacy has been uncommon and unpredictable in glioblastomas…”
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Structure and Regulation of the Type VI Secretion System by Silverman, Julie M, Brunet, Yannick R, Cascales, Eric, Mougous, Joseph D

“…The type VI secretion system (T6SS) is a complex and widespread gram-negative bacterial export pathway with the capacity to translocate protein effectors into…”
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Loss of NAD Homeostasis Leads to Progressive and Reversible Degeneration of Skeletal Muscle by Frederick, David W., Loro, Emanuele, Liu, Ling, Davila, Antonio, Chellappa, Karthikeyani, Silverman, Ian M., Quinn, William J., Gosai, Sager J., Tichy, Elisia D., Davis, James G., Mourkioti, Foteini, Gregory, Brian D., Dellinger, Ryan W., Redpath, Philip, Migaud, Marie E., Nakamaru-Ogiso, Eiko, Rabinowitz, Joshua D., Khurana, Tejvir S., Baur, Joseph A.

“…NAD is an obligate co-factor for the catabolism of metabolic fuels in all cell types. However, the availability of NAD in several tissues can become limited…”
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Haemolysin Coregulated Protein Is an Exported Receptor and Chaperone of Type VI Secretion Substrates by Silverman, Julie M., Agnello, Danielle M., Zheng, Hongjin, Andrews, Benjamin T., Li, Mo, Catalano, Carlos E., Gonen, Tamir, Mougous, Joseph D.

“…Secretion systems require high-fidelity mechanisms to discriminate substrates among the vast cytoplasmic pool of proteins. Factors mediating substrate…”
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Revisiting the Lick Observatory Supernova Search Volume-limited Sample: Updated Classifications and Revised Stripped-envelope Supernova Fractions by Shivvers, Isaac, Modjaz, Maryam, Zheng, WeiKang, Liu, Yuqian, Filippenko, Alexei V., Silverman, Jeffrey M., Matheson, Thomas, Pastorello, Andrea, Graur, Or, Foley, Ryan J., Chornock, Ryan, Smith, Nathan, Leaman, Jesse, Benetti, Stefano

“…We re-examine the classifications of supernovae (SNe) presented in the Lick Observatory Supernova Search (LOSS) volume-limited sample with a focus on the…”
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Tumor-derived IL-6 and trans-signaling among tumor, fat, and muscle mediate pancreatic cancer cachexia by Rupert, Joseph E, Narasimhan, Ashok, Jengelley, Daenique H A, Jiang, Yanlin, Liu, Jianguo, Au, Ernie, Silverman, Libbie M, Sandusky, George, Bonetto, Andrea, Cao, Sha, Lu, Xiaoyu, O'Connell, Thomas M, Liu, Yunlong, Koniaris, Leonidas G, Zimmers, Teresa A

“…Most patients with pancreatic adenocarcinoma (PDAC) suffer cachexia; some do not. To model heterogeneity, we used patient-derived orthotopic xenografts. These…”
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Suicide and Suicidal Attempts in the United States: Costs and Policy Implications by Shepard, Donald S., Gurewich, Deborah, Lwin, Aung K., Reed Jr, Gerald A., Silverman, Morton M.

“…The national cost of suicides and suicide attempts in the United States in 2013 was $58.4 billion based on reported numbers alone. Lost productivity (termed…”
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Functional overexpression and characterization of lipogenesis-related genes in the oleaginous yeast Yarrowia lipolytica by Silverman, Andrew M, Qiao, Kangjian, Xu, Peng, Stephanopoulos, Gregory

“…Single cell oil (SCO) is an attractive energy source due to scalability, utilization of low-cost renewable feedstocks, and type of product(s) made. Engineering…”
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Quantitative proteomic analysis reveals a simple strategy of global resource allocation in bacteria by Hui, Sheng, Silverman, Josh M, Chen, Stephen S, Erickson, David W, Basan, Markus, Wang, Jilong, Hwa, Terence, Williamson, James R

“…A central aim of cell biology was to understand the strategy of gene expression in response to the environment. Here, we study gene expression response to…”
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A short de novo synthesis of nucleoside analogs by Meanwell, Michael, Silverman, Steven M., Lehmann, Johannes, Adluri, Bharanishashank, Wang, Yang, Cohen, Ryan, Campeau, Louis-Charles, Britton, Robert

“…Nucleotide analogs are valuable tools and therapeutics because of their ability to interfere with processes such as DNA synthesis, which are vital to rapidly…”
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Low-resolution sodium D absorption is a bad proxy for extinction by Poznanski, Dovi, Ganeshalingam, Mohan, Silverman, Jeffrey M., Filippenko, Alexei V.

“…ABSTRACT Dust extinction is generally the least tractable systematic uncertainty in astronomy, and particularly in supernova science. Often in the past,…”
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Enantioselective Construction of Spirocyclic Oxindolic Cyclopentanes by Palladium-Catalyzed Trimethylenemethane-[3+2]-Cycloaddition by Trost, Barry M, Cramer, Nicolai, Silverman, Steven M

“…The palladium catalyzed [3+2] trimethylenemethane (TMM) cycloaddition is an efficient method for the construction of cyclopentanes. Herein, we report a…”
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Fourteen months of observations of the possible super-Chandrasekhar mass Type Ia Supernova 2009dc by Silverman, Jeffrey M., Ganeshalingam, Mohan, Li, Weidong, Filippenko, Alexei V., Miller, Adam A., Poznanski, Dovi

“…In this paper, we present and analyse optical photometry and spectra of the extremely luminous and slowly evolving Type Ia supernova (SN Ia) 2009dc, and offer…”
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The unprecedented 2012 outburst of SN 2009ip: a luminous blue variable star becomes a true supernova by Mauerhan, Jon C., Smith, Nathan, Filippenko, Alexei V., Blanchard, Kyle B., Blanchard, Peter K., Casper, Chadwick F. E., Cenko, S. Bradley, Clubb, Kelsey I., Cohen, Daniel P., Fuller, Kiera L., Li, Gary Z., Silverman, Jeffrey M.

“…Some reports of supernova (SN) discoveries turn out not to be true core-collapse explosions. One such case was SN 2009ip, which was recognized to be the…”
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Spectra of Hydrogen-poor Superluminous Supernovae from the Palomar Transient Factory by Quimby, Robert M., Cia, Annalisa De, Gal-Yam, Avishay, Leloudas, Giorgos, Lunnan, Ragnhild, Perley, Daniel A., Vreeswijk, Paul M., Yan, Lin, Bloom, Joshua S., Cenko, S. Bradley, Cooke, Jeff, Ellis, Richard, Filippenko, Alexei V., Kasliwal, Mansi M., Kleiser, Io K. W., Kulkarni, Shrinivas R., Matheson, Thomas, Nugent, Peter E., Pan, Yen-Chen, Silverman, Jeffrey M., Sternberg, Assaf, Sullivan, Mark, Yaron, Ofer

“…Most Type I superluminous supernovae (SLSNe-I) reported to date have been identified by their high peak luminosities and spectra lacking obvious signs of…”
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