Search Results - "SILVENNOINEN, O"

The transcriptional co-activator SND1 is a novel regulator of alternative splicing in prostate cancer cells by Cappellari, M, Bielli, P, Paronetto, M P, Ciccosanti, F, Fimia, G M, Saarikettu, J, Silvennoinen, O, Sette, C

“…Splicing abnormalities have profound impact in human cancer. Several splicing factors, including SAM68, have pro-oncogenic functions, and their increased…”
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STAT‐5 is activated constitutively in T cells, B cells and monocytes from patients with primary Sjögren's syndrome by Pertovaara, M., Silvennoinen, O., Isomäki, P.

“…Summary The expression and phosphorylation of signal transducer and activator of transcription‐1 (STAT‐1) have been shown to be markedly increased in the…”
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Increased expression of the proprotein convertase enzyme FURIN in rheumatoid arthritis by Valli, A, Ranta, N, Grönholm, A, Silvennoinen, O, Pesu, M, Isomäki, P

“…Objective: FURIN is a proprotein convertase enzyme that inhibits the proinflammatory function of T cells and myeloid cells. Elevated FURIN expression levels…”
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Expression of IL-10 family cytokines in rheumatoid arthritis: elevated levels of IL-19 in the joints by Alanärä, T, Karstila, K, Moilanen, T, Silvennoinen, O, Isomäki, P

“…Objectives: Interleukin (IL)-10 functions as an anti-inflammatory cytokine in rheumatoid arthritis (RA). New IL-10 family cytokines IL-19, IL-20, IL-22, IL-24,…”
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The expression of SOCS is altered in rheumatoid arthritis by Isomäki, P., Alanärä, T., Isohanni, P., Lagerstedt, A., Korpela, M., Moilanen, T., Visakorpi, T., Silvennoinen, O.

“…Objectives. Cytokines play a key pathogenic role in rheumatoid arthritis (RA). Several cytokines signal through the JAK-STAT pathway, which is negatively…”
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Differential nuclear localization and kinase activity of alternative ErbB4 intracellular domains by SUNDVALL, M, PERI, L, MÄÄTTÄ, J. A, TVOROGOV, D, PAATERO, I, SAVISALO, M, SILVENNOINEN, O, YARDEN, Y, ELENIUS, K

“…Cleavable isoforms of the ErbB4 receptor tyrosine kinase release a soluble intracellular domain (ICD) that may translocate to the nucleus and regulate…”
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Not Just Contrastive: Constructions with Negated Restrictives in English by Silvennoinen, Olli O.

“…When restrictive adverbs are negated, an additive reading is produced (e.g., not only). This is particularly common in correlative constructions with a…”
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Signaling Through the Hematopoietic Cytokine Receptors by Ihle, J N, Witthuhn, B A, Quelle, F W, Yamamoto, K, Silvennoinen, O

“…Hematopoiesis is regulated through the interaction of a variety of growth factors with specific receptors of the cytokine receptor superfamily. Although…”
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Receptor tyrosine phosphatase beta is expressed in the form of proteoglycan and binds to the extracellular matrix protein tenascin by Barnea, G, Grumet, M, Milev, P, Silvennoinen, O, Levy, J B, Sap, J, Schlessinger, J

“…The extracellular domain of receptor type protein tyrosine phosphatase beta (RPTP beta) exhibits striking sequence similarity with a soluble, rat brain…”
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Human inducible pluripotent stem cell-derived sensory neurons express multiple functional ion channels and GPCRs by Saarnilehto, M, Pekkanen-Mattila, M, Aalto-Setälä, K, Silvennoinen, O, Koivisto, A

“…Abstract Aims Aim of the study was to characterize functional ion channel and GPCR responses by using selective pharmacological tools and intracellular calcium…”
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Structure of the Murine Jak2 Protein-Tyrosine Kinase and its Role in Interleukin 3 Signal Transduction by Silvennoinen, Olli, Witthuhn, Bruce A., Quelle, Frederick W., Cleveland, John L., Yi, Taolin, Ihle, James N.

“…Interleukin 3 (IL-3) regulates the proliferation and differentiation of hematopoietic cells. Although the IL-3 receptor chains lack kinase catalytic domains,…”
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The cloning of a receptor-type protein tyrosine phosphatase expressed in the central nervous system by Levy, J.B., Canoll, P.D., Silvennoinen, O., Barnea, G., Morse, B., Honegger, A.M., Huang, J.T., Cannizzaro, L.A., Park, S.H., Druck, T.

“…We have isolated cDNA clones and deduced the complete amino acid sequence of a large receptor-type protein tyrosine phosphatase containing 2307 amino acids…”
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Activation of JAK2 Kinase Mediated by the Interleukin 6 Signal Transducer gp130 by Narazaki, Masashi, Witthuhn, Bruce A., Yoshida, Kanji, Silvennoinen, Olli, Yasukawa, Kiyoshi, Ihle, James N., Kishimoto, Tadamitsu, Taga, Tetsuya

“…The interleukin 6 receptor-associated signal transducer, gp130, is shared by receptor complexes for leukemia inhibitory factor, oncostatin M, ciliary…”
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The catalytic activity of the CD45 membrane‐proximal phosphatase domain is required for TCR signaling and regulation by Desai, D.M., Sap, J., Silvennoinen, O., Schlessinger, J., Weiss, A.

“…Cell surface expression of CD45, a receptor‐like protein tyrosine phosphatase (PTPase), is required for T cell antigen receptor (TCR)‐mediated signal…”
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High-efficiency expression/cloning of epidermal growth factor-receptor-binding proteins with Src homology 2 domains by Margolis, B, Silvennoinen, O, Comoglio, F, Roonprapunt, C, Skolnik, E, Ullrich, A, Schlessinger, J

“…Src homology 2 domains bind to tyrosine-phosphorylated growth factor receptors and are found in proteins that serve as substrates for tyrosine kinases, such as…”
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Stat4, a novel gamma interferon activation site-binding protein expressed in early myeloid differentiation by Yamamoto, K, Quelle, F W, Thierfelder, W E, Kreider, B L, Gilbert, D J, Jenkins, N A, Copeland, N G, Silvennoinen, O, Ihle, J N

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Identification of a carbonic anhydrase-like domain in the extracellular region of RPTP gamma defines a new subfamily of receptor tyrosine phosphatases by BARNEA, G, SILVENNOINEN, O, SAP, J, SCHLESSINGER, J, HONEGGER, A. M, CANOLL, P. D, D'EUSTACHIO, P, MORSE, B, LEVY, J. B, LAFORGIA, S, HUEBNER, K, MUSACCHIO, J. M

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Beta interferon and oncostatin M activate Raf-1 and mitogen-activated protein kinase through a JAK1-dependent pathway by Stancato, Louis F., Sakatsume, Minoru, David, Michael, Dent, Paul, Dong, Fan, Petricoin, Emanuel F., Krolewski, John J., Silvennoinen, Olli, Saharinen, Pipsa, Pierce, Jacalyn, Marshall, Christopher J., Sturgill, Thomas, Finbloom, David S., Larner, Andrew C.

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Typology and usage. The case of negation by Matti Miestamo, Ksenia Shagal, Olli O. Silvennoinen

“…Linguistic typology has recently started paying more and more attention to language use as an explanatory factor. In this approach, naturally occurring…”
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Mechanism of the Prorelaxing Effect of Thyroxine on the Sphincter of Oddi by Laukkarinen, J., Sand, J., Aittomäki, S., Pörsti, I., Kööbi, P., Kalliovalkama, J., Silvennoinen, O., Nordback, I.

“…Background: Disturbances in the function of sphincter of Oddi (SO) may prevent normal bile flow and thus enhance the probability of common bile duct stone…”
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