Search Results - "SIHONG SONG"

Distinct immune responses to transgene products from rAAV1 and rAAV8 vectors by Lu, Yuanqing, Song, Sihong

“…Recently developed serotypes of recombinant adeno-associated virus (rAAV) vectors have significantly enhanced the use of rAAV vectors for gene therapy…”
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Alpha 1 Antitrypsin Inhibits Dendritic Cell Activation and Attenuates Nephritis in a Mouse Model of Lupus by Elshikha, Ahmed S, Lu, Yuanqing, Chen, Mong-Jen, Akbar, Mohammad, Zeumer, Leilani, Ritter, Andrea, Elghamry, Hanaa, Mahdi, Mahmoud A, Morel, Laurence, Song, Sihong

“…Systemic lupus erythematosus (SLE) is an autoimmune disorder with a worldwide distribution and considerable mortality and morbidity. Although the pathogenesis…”
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The under‐appreciated world of the serpin family of serine proteinase inhibitors by Bouton, Marie‐Christine, Geiger, Margarethe, Sheffield, William P, Irving, James A, Lomas, David A, Song, Sihong, Satyanarayanan, Ritvik S, Zhang, Liqiang, McFadden, Grant, Lucas, Alexandra R

“…In the practice of medicine, many fundamental biological pathways that require tight on/off control, such as inflammation and circulatory homeostasis, are…”
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α1-Antitrypsin Protects β-Cells From Apoptosis by BIN ZHANG, YUANQING LU, CAMPBELL-THOMPSON, Martha, SPENCER, Terry, WASSERFALL, Clive, ATKINSON, Mark, SIHONG SONG

“…α1-Antitrypsin Protects β-Cells From Apoptosis Bin Zhang 1 , Yuanqing Lu 1 , Martha Campbell-Thompson 2 , Terry Spencer 3 , Clive Wasserfall 2 , Mark Atkinson…”
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Alpha-1 antitrypsin inhibits RANKL-induced osteoclast formation and functions by Akbar, Mohammad Ahsanul, Nardo, David, Chen, Mong-Jen, Elshikha, Ahmed S, Ahamed, Rubina, Elsayed, Eslam M, Bigot, Claire, Holliday, Lexie Shannon, Song, Sihong

“…Osteoporosis is a global public health problem affecting more than 200 million people worldwide. We previously showed that treatment with alpha-1 antitrypsin…”
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Human Alpha 1 Antitrypsin Suppresses NF-κB Activity and Extends Lifespan in Adult Drosophila by Yuan, Ye, Van Belkum, Max, O'Brien, Alana, Garcia, Alain, Troncoso, Karla, Elshikha, Ahmed S, Zhou, Lei, Song, Sihong

“…Human alpha 1 antitrypsin (hAAT) is a multifunctional protein that has been shown to have anti-inflammatory and cellular protective properties. While previous…”
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Transgenic Mice Overexpressing Human Alpha-1 Antitrypsin Exhibit Low Blood Pressure and Altered Epithelial Transport Mechanisms in the Inactive and Active Cycles by Liu, Lauren P, Gholam, Mohammed F, Elshikha, Ahmed Samir, Kawakibi, Tamim, Elmoujahid, Nasseem, Moussa, Hassan H, Song, Sihong, Alli, Abdel A

“…Human alpha-1 antitrypsin (hAAT) is a versatile protease inhibitor, but little is known about its targets in the aldosterone-sensitive distal nephron and its…”
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Adipose tissue-derived mesenchymal stem cell-based liver gene delivery by Li, Hong, Zhang, Bin, Lu, Yuanqing, Jorgensen, Marda, Petersen, Bryon, Song, Sihong

“…Background & Aims The adipose tissue represents an accessible, abundant, and replenishable source of adult stem cells for potential applications in…”
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Alpha-1 antitrypsin protein and gene therapies decrease autoimmunity and delay arthritis development in mouse model by Grimstein, Christian, Choi, Young-Kook, Wasserfall, Clive H, Satoh, Minoru, Atkinson, Mark A, Brantly, Mark L, Campbell-Thompson, Martha, Song, Sihong

“…Alpha-1 antitrypsin (AAT) is a multi-functional protein that has anti-inflammatory and tissue protective properties. We previously reported that human AAT…”
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Human Alpha-1 Antitrypsin Attenuates ENaC and MARCKS and Lowers Blood Pressure in Hypertensive Diabetic db/db Mice by Lugo, Carlos I, Liu, Lauren P, Bala, Niharika, Morales, Angelica G, Gholam, Mohammed F, Abchee, Julia C, Elmoujahid, Nasseem, Elshikha, Ahmed Samir, Avdiaj, Rigena, Searcy, Louis A, Denslow, Nancy D, Song, Sihong, Alli, Abdel A

“…Hypertension may develop before or after the onset of diabetes and it is known to increase the risk of developing diabetic nephropathy. Alpha-1 antitrypsin…”
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In Situ Transplantation of Alginate Bioencapsulated Adipose Tissues Derived Stem Cells (ADSCs) via Hepatic Injection in a Mouse Model by Chen, Mong-Jen, Lu, Yuanqing, Simpson, Nicholas E, Beveridge, Mark J, Elshikha, Ahmed S, Akbar, Mohammad Ahsanul, Tsai, Hsin-Yin, Hinske, Stephanie, Qin, Junling, Grunwitz, Christian R, Chen, Tina, Brantly, Mark L, Song, Sihong

“…Adipose tissue derived stem cells (ADSCs) transplantation has recently gained widespread enthusiasm, particularly in the perspective to use them as potential…”
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Immune Depletion With Cellular Mobilization Imparts Immunoregulation and Reverses Autoimmune Diabetes in Nonobese Diabetic Mice by PARKER, Matthew J, SONG XUE, EISENBEIS, Scott, WILLIAMS, John, SCHATZ, Desmond A, HALLER, Michael J, ATKINSON, Mark A, ALEXANDER, John J, WASSERFALL, Clive H, CAMPBELL-THOMPSON, Martha L, BATTAGLIA, Manuela, GREGORI, Silvia, MATHEWS, Clayton E, SIHONG SONG, TROUTT, Misty

“…Immune Depletion With Cellular Mobilization Imparts Immunoregulation and Reverses Autoimmune Diabetes in Nonobese Diabetic Mice Matthew J. Parker 1 , Song Xue…”
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Alpha 1 Antitrypsin Gene Therapy Extends the Lifespan of Lupus-Prone Mice by Elshikha, Ahmed Samir, Yuan, Ye, Lu, Yuanqing, Chen, Mong-Jen, Abboud, Georges, Akbar, Mohammad Ahsanul, Plate, Henrike, Wolney, Hedwig, Hoffmann, Tanja, Tagari, Eleni, Zeumer, Leilani, Morel, Laurence, Song, Sihong

“…Systemic lupus erythematosus (SLE) is a heterogeneous autoimmune disease characterized by high levels of pathogenic autoantibodies and tissue damage. Multiple…”
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The effect of DNA-dependent protein kinase on adeno-associated virus replication by Choi, Young-Kook, Nash, Kevin, Byrne, Barry J, Muzyczka, Nicholas, Song, Sihong

“…DNA-dependent protein kinase (DNA-PK) is a DNA repair enzyme and plays an important role in determining the molecular fate of the rAAV genome. However, the…”
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Improved Method of Recombinant AAV2 Delivery for Systemic Targeted Gene Therapy by Mah, Cathryn, Fraites, Thomas J., Zolotukhin, Irene, Song, Sihong, Flotte, Terence R., Dobson, Jon, Batich, Christopher, Byrne, Barry J.

“…A major hurdle in most current gene therapy modalities is the ability to transduce target tissues at very high efficiencies that ultimately lead to therapeutic…”
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Alpha 1-Antitrypsin Therapy Mitigated Ischemic Stroke Damage in Rats by Moldthan, Huong L., PhD, Hirko, Aaron C., PhD, Thinschmidt, Jeffrey S., MSc, Grant, Maria B., MD, Li, Zhimin, PhD, Peris, Joanna, PhD, Lu, Yuanqing, MD, Elshikha, Ahmed S., MSc, King, Michael A., PhD, Hughes, Jeffrey A., PharmD, PhD, Song, Sihong, PhD

“…Our objective is to develop a new therapy for the treatment of stroke. Currently, the only effective therapy for acute ischemic stroke is the thrombolytic…”
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ALPHA-1 Antitrypsin for the Control of Autoimmunity by Song, Sihong

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ALPHA-1 Antitrypsin for the Control of Autoimmunity by Song, Sihong

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Sustained Secretion of Human Alpha-1-Antitrypsin from Murine Muscle Transduced with Adeno-Associated Virus Vectors by Song, Sihong, Morgan, Michael, Ellis, Tamir, Poirier, Amy, Chesnut, Kye, Wang, Jianming, Brantly, Mark, Muzyczka, Nicholas, Byrne, Barry J., Atkinson, Mark, Flotte, Terence R.

“…Recombinant adeno-associated virus (AAV) vectors have been used to transduce murine skeletal muscle as a platform for secretion of therapeutic proteins. The…”
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DNA-Dependent PK Inhibits Adeno-Associated Virus DNA Integration by Song, Sihong, Lu, Yuanqing, Choi, Young-Kook, Han, Yinong, Tang, Qiushi, Zhao, Ge, Berns, Kenneth I., Flotte, Terence R.

“…Recent studies have shown that recombinant adeno-associated virus (rAAV) can persist in episomal form; however, factors affecting rAAV persistence are poorly…”
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