Search Results - "SIGMUND, Curt D"

Angiotensin II Signal Transduction: An Update on Mechanisms of Physiology and Pathophysiology by Forrester, Steven J, Booz, George W, Sigmund, Curt D, Coffman, Thomas M, Kawai, Tatsuo, Rizzo, Victor, Scalia, Rosario, Eguchi, Satoru

“…The renin-angiotensin-aldosterone system plays crucial roles in cardiovascular physiology and pathophysiology. However, many of the signaling mechanisms have…”
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How Is the Brain Renin–Angiotensin System Regulated? by Nakagawa, Pablo, Sigmund, Curt D

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Mechanisms of brain renin angiotensin system-induced drinking and blood pressure: importance of the subfornical organ by Coble, Jeffrey P, Grobe, Justin L, Johnson, Alan Kim, Sigmund, Curt D

“…It is critical for cells to maintain a homeostatic balance of water and electrolytes because disturbances can disrupt cellular function, which can lead to…”
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A colorful view of the brain renin-angiotensin system by Sigmund, Curt D, Grobe, Justin L

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Hypothalamic ERK Mediates the Anorectic and Thermogenic Sympathetic Effects of Leptin by RAHMOUNI, Kamal, SIGMUND, Curt D, HAYNES, William G, MARK, Allyn L

“…Hypothalamic ERK Mediates the Anorectic and Thermogenic Sympathetic Effects of Leptin Kamal Rahmouni 1 2 , Curt D. Sigmund 1 2 , William G. Haynes 2 and Allyn…”
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Lethal Infection of K18-hACE2 Mice Infected with Severe Acute Respiratory Syndrome Coronavirus by MCCRAY, Paul B, PEWE, Lecia, MEYERHOLZ, David K, KIRBY, Patricia, LOOK, Dwight C, PERLMAN, Stanley, WOHLFORD-LENANE, Christine, HICKEY, Melissa, MANZEL, Lori, LEI SHI, NETLAND, Jason, HONG PENG JIA, HALABI, Carmen, SIGMUND, Curt D

“…Article Usage Stats Services JVI Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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Minireview: Overview of the Renin-Angiotensin System—An Endocrine and Paracrine System by Lavoie, Julie L, Sigmund, Curt D

“…Since the discovery of renin as a pressor substance in 1898, the renin-angiotensin (RAS) system has been extensively studied because it remains a prime…”
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Oxidation of CaMKII determines the cardiotoxic effects of aldosterone by He, B Julie, Joiner, Mei-ling A, Singh, Madhu V, Luczak, Elizabeth D, Swaminathan, Paari Dominic, Koval, Olha M, Kutschke, William, Allamargot, Chantal, Yang, Jinying, Guan, Xiaoqun, Zimmerman, Kathy, Grumbach, Isabella M, Weiss, Robert M, Spitz, Douglas R, Sigmund, Curt D, Blankesteijn, W Matthijs, Heymans, Stephane, Mohler, Peter J, Anderson, Mark E

“…The hormone aldosterone can damage the heart after myocardial infarction, such that drugs that inhibit its action are often prescribed. B. Julie He et al . now…”
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Collecting duct-specific knockout of renin attenuates angiotensin II-induced hypertension by Ramkumar, Nirupama, Stuart, Deborah, Rees, Sara, Hoek, Alfred Van, Sigmund, Curt D, Kohan, Donald E

“…The physiological and pathophysiological significance of collecting duct (CD)-derived renin, particularly as it relates to blood pressure (BP) regulation, is…”
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An Intracellular Renin-Angiotensin System in Neurons: Fact, Hypothesis, or Fantasy by Grobe, Justin L, Xu, Di, Sigmund, Curt D

“…Justin L. Grobe 1 , Di Xu 2 and Curt D. Sigmund 1 ,3 ,4 1 Departments of Internal Medicine and 3 Molecular Physiology and Biophysics, 2 Genetics Graduate…”
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RhoBTB1 protects against hypertension and arterial stiffness by restraining phosphodiesterase 5 activity by Mukohda, Masashi, Fang, Shi, Wu, Jing, Agbor, Larry N, Nair, Anand R, Ibeawuchi, Stella-Rita C, Hu, Chunyan, Liu, Xuebo, Lu, Ko-Ting, Guo, Deng-Fu, Davis, Deborah R, Keen, Henry L, Quelle, Frederick W, Sigmund, Curt D

“…Mice selectively expressing PPARγ dominant negative mutation in vascular smooth muscle exhibit RhoBTB1-deficiency and hypertension. Our rationale was to employ…”
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A brain leptin-renin angiotensin system interaction in the regulation of sympathetic nerve activity by Hilzendeger, Aline M, Morgan, Donald A, Brooks, Leonard, Dellsperger, David, Liu, Xuebo, Grobe, Justin L, Rahmouni, Kamal, Sigmund, Curt D, Mark, Allyn L

“…The sympathetic nervous system, leptin, and renin-angiotensin system (RAS) have been implicated in obesity-associated hypertension. There is increasing…”
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Ablation of the Leptin Receptor in the Hypothalamic Arcuate Nucleus Abrogates Leptin-Induced Sympathetic Activation by Harlan, Shannon M, Morgan, Donald A, Agassandian, Khristofor, Guo, Deng-Fu, Cassell, Martin D, Sigmund, Curt D, Mark, Allyn L, Rahmouni, Kamal

“…RATIONALE:The hypothalamic arcuate nucleus (ARC) is considered a major site for leptin signaling that regulates several physiological processes. OBJECTIVE:To…”
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Selective Deletion of the Brain-Specific Isoform of Renin Causes Neurogenic Hypertension by Shinohara, Keisuke, Liu, Xuebo, Morgan, Donald A, Davis, Deborah R, Sequeira-Lopez, Maria Luisa S, Cassell, Martin D, Grobe, Justin L, Rahmouni, Kamal, Sigmund, Curt D

“…The renin–angiotensin system (RAS) in the brain is a critical determinant of blood pressure, but the mechanisms regulating RAS activity in the brain remain…”
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Studies of salt and stress sensitivity on arterial pressure in renin-b deficient mice by Nakagawa, Pablo, Gomez, Javier, Lu, Ko-Ting, Grobe, Justin L, Sigmund, Curt D

“…Excessive sodium intake is known to increase the risk for hypertension, heart disease, and stroke. Individuals who are more susceptible to the effects of high…”
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Brain-Selective Overexpression of Human Angiotensin-Converting Enzyme Type 2 Attenuates Neurogenic Hypertension by Feng, Yumei, Xia, Huijing, Cai, Yanhui, Halabi, Carmen M, Becker, Lenice K, Santos, Robson A.S, Speth, Robert C, Sigmund, Curt D, Lazartigues, Eric

“…RATIONALE:Angiotensin converting enzyme type 2 (ACE2) is a new member of the brain renin-angiotensin system, that might be activated by an overactive…”
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Dual gain and loss of cullin 3 function mediates familial hyperkalemic hypertension by Cornelius, Ryan J, Zhang, Chong, Erspamer, Kayla J, Agbor, Larry N, Sigmund, Curt D, Singer, Jeffrey D, Yang, Chao-Ling, Ellison, David H

“…Familial hyperkalemic hypertension is caused by mutations in with-no-lysine kinases (WNKs) or in proteins that mediate their degradation, kelch-like 3 (KLHL3)…”
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Divergent mechanism regulating fluid intake and metabolism by the brain renin-angiotensin system by Sigmund, Curt D

“…The purpose of this review is two-fold. First, I will highlight recent advances in our understanding of the mechanisms regulating angiotensin II (ANG II)…”
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Increased Susceptibility of Mice Lacking Renin-b to Angiotensin II–Induced Organ Damage by Nakagawa, Pablo, Nair, Anand R., Agbor, Larry N., Gomez, Javier, Wu, Jing, Zhang, Shao Yang, Lu, Ko-Ting, Morgan, Donald A., Rahmouni, Kamal, Grobe, Justin L., Sigmund, Curt D.

“…Several cardiac and renal diseases are attributed to a dysregulation of the renin-angiotensin system. Renin, the rate-limiting enzyme of the renin-angiotensin…”
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Methods for the Comprehensive in vivo Analysis of Energy Flux, Fluid Homeostasis, Blood Pressure, and Ventilatory Function in Rodents by Reho, John J, Nakagawa, Pablo, Mouradian, Jr, Gary C, Grobe, Connie C, Saravia, Fatima L, Burnett, Colin M L, Kwitek, Anne E, Kirby, John R, Segar, Jeffrey L, Hodges, Matthew R, Sigmund, Curt D, Grobe, Justin L

“…Cardiovascular disease represents the leading cause of death in the United States, and metabolic diseases such as obesity represent the primary impediment to…”
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