Search Results - "SIEGMUND, W."

Impact of Bariatric Surgery on Drug Transport And Metabolism by Siegmund, W

“…[...]the changes are complex and poorly understood, and long-lasting mucosal adaptation of intestinal functions may occur. [...]potential transcriptional and…”
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Intragastric pH and pressure profiles after intake of the high-caloric, high-fat meal as used for food effect studies by Koziolek, M., Schneider, F., Grimm, M., Modeβ, Chr, Seekamp, A., Roustom, T., Siegmund, W., Weitschies, W.

“…The intraluminal conditions of the fed stomach are critical for drug release from solid oral dosage forms and thus, often associated with the occurrence of…”
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LC–MS/MS-based quantification of clinically relevant intestinal uptake and efflux transporter proteins by Gröer, C., Brück, S., Lai, Y., Paulick, A., Busemann, A., Heidecke, C.D., Siegmund, W., Oswald, S.

“…•LC–MS/MS methods for ten drug transporters (ABCB1, ABCC2, ABCC3, ABCG2, OATP1A2, OATP2B1, PEPT1, ASBT, OCT1 and OCT3).•First quantitative assays for ABCC3,…”
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Absolute protein quantification of clinically relevant cytochrome P450 enzymes and UDP-glucuronosyltransferases by mass spectrometry-based targeted proteomics by Gröer, C., Busch, D., Patrzyk, M., Beyer, K., Busemann, A., Heidecke, C.D., Drozdzik, M., Siegmund, W., Oswald, S.

“…•Simultaneous LC–MS/MS-based quantification of 13 relevant metabolizing enzymes.•Comprehensive method validation for all aforementioned enzymes.•Application to…”
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Intestinal fluid volumes and transit of dosage forms as assessed by magnetic resonance imaging by SCHILLER, C., FRÖHLICH, C.‐P., GIESSMANN, T., SIEGMUND, W., MÖNNIKES, H., HOSTEN, N., WEITSCHIES, W.

“…Summary Aim : The gastrointestinal transit of sequentially administered capsules was investigated in relation to the availability of fluid along the intestinal…”
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The Far Ultra-Violet Imager on the Icon Mission by Mende, S. B., Frey, H. U., Rider, K., Chou, C., Harris, S. E., Siegmund, O. H. W., England, S. L., Wilkins, C., Craig, W., Immel, T. J., Turin, P., Darling, N., Loicq, J., Blain, P., Syrstad, E., Thompson, B., Burt, R., Champagne, J., Sevilla, P., Ellis, S.

“…ICON Far UltraViolet (FUV) imager contributes to the ICON science objectives by providing remote sensing measurements of the daytime and nighttime…”
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Impact of ABCC2 haplotypes on transcriptional and posttranscriptional gene regulation and function by Laechelt, S, Turrini, E, Ruehmkorf, A, Siegmund, W, Cascorbi, I, Haenisch, S

“…ABCC2 (MRP2) is an important export pump, expressed at tissue barriers. The genetic variants −24C>T, 1249G>A and 3972C>T are leading to inter-individual…”
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ALICE: The Ultraviolet Imaging Spectrograph Aboard the New Horizons Pluto–Kuiper Belt Mission by Stern, S. Alan, Slater, David C., Scherrer, John, Stone, John, Dirks, Greg, Versteeg, Maarten, Davis, Michael, Gladstone, G. Randall, Parker, Joel W., Young, Leslie A., Siegmund, Oswald H. W.

“…The ALICE instrument is a lightweight (4.4 kg), low-power (4.4 watt) imaging spectrograph aboard the New Horizons mission to the Pluto system and the Kuiper…”
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Europa Ultraviolet Spectrograph (Europa-UVS) by Retherford, K. D., Becker, T. M., Gladstone, G. R., Greathouse, T. K., Davis, M. W., Velez, M. A., Freeman, M. A., Brooks, S. M., Ferrell, S., Giles, R. S., Hendrix, A. R., Hue, V., Johnson, E., Kammer, J. A., Marinan, A. D., D Mamo, B., McGrath, M. A., Molyneux, P. M., Nerney, E. G., Perez, B., Persson, K. B., Pope, S., Raut, U., Rickerson, R., Roth, L., Saur, J., W Siegmund, O. H., Spencer, J. R., Steffl, A. J., Stern, S. A., Trantham, B. J., Versteeg, M. H., Winkenstern, J.

“…Abstract NASA’s Europa Clipper mission is designed to provide a diversity of measurements to further our understanding of the potential habitability of this…”
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Development of new photon-counting detectors for single-molecule fluorescence microscopy by Michalet, X., Colyer, R. A., Scalia, G., Ingargiola, A., Lin, R., Millaud, J. E., Weiss, S., Siegmund, Oswald H. W., Tremsin, Anton S., Vallerga, John V., Cheng, A., Levi, M., Aharoni, D., Arisaka, K., Villa, F., Guerrieri, F., Panzeri, F., Rech, I., Gulinatti, A., Zappa, F., Ghioni, M., Cova, S.

“…Two optical configurations are commonly used in single-molecule fluorescence microscopy: point-like excitation and detection to study freely diffusing…”
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Preventable ADRs leading to hospitalization - results of a long-term prospective safety study with 6,427 ADR cases focusing on elderly patients by Schmiedl, S, Rottenkolber, M, Szymanski, J, Drewelow, B, Siegmund, W, Hippius, M, Farker, K, Guenther, I R, Hasford, J, Thuermann, P A

“…Studies evaluating the impact of age and potentially inappropriate medication (PIM) on avoidable adverse drug reactions (ADRs) are scarce. In this prospective,…”
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Pharmacokinetics and pulmonary distribution of gamithromycin after intravenous administration in foals by Berlin, S., Randow, T., Scheuch, E., Grube, M., Venner, M., Siegmund, W.

“…The long‐acting azalide antibiotic gamithromycin is marketed for intramuscular treatment of bovine and swine infections. Off‐label use in foals leads to severe…”
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Recent Star Formation in the Extreme Outer Disk of M83 by Thilker, David A, Bianchi, Luciana, Boissier, Samuel, de Paz, Armando Gil, Madore, Barry F, Martin, D. Christopher, Meurer, Gerhardt R, Neff, Susan G, Rich, R. Michael, Schiminovich, David, Seibert, Mark, Wyder, Ted K, Barlow, Tom A, Byun, Yong-Ik, Donas, Jose, Forster, Karl, Friedman, Peter G, Heckman, Timothy M, Jelinsky, Patrick N, Lee, Young-Wook, Malina, Roger F, Milliard, Bruno, Morrissey, Patrick, Siegmund, Oswald H. W, Small, Todd, Szalay, Alex S, Welsh, Barry Y

“…Ultraviolet imaging with the Galaxy Evolution Explorer (GALEX) has revealed an extensive sample of UV-bright stellar complexes in the extreme outer disk of…”
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Pharmacological indices and pulmonary distribution of rifampicin after repeated oral administration in healthy foals by Berlin, S., Kirschbaum, A., Spieckermann, L., Oswald, S., Keiser, M., Grube, M., Venner, M., Siegmund, W.

“…Summary Background The treatment of equine lung infections by Rhodococcus equi with rifampicin is empirically based because pharmacokinetic/pharmacodynamic…”
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Intestinal and hepatic contributions to the pharmacokinetic interaction between gamithromycin and rifampicin after single‐dose and multiple‐dose administration in healthy foals by Berlin, S., Wallstabe, S., Scheuch, E., Oswald, S., Hasan, M., Wegner, D., Grube, M., Venner, M., Ullrich, A., Siegmund, W.

“…Summary Background Standard treatment of foals with severe abscessing lung infection caused by Rhodococcus equi using rifampicin and a macrolide antibiotic can…”
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Dose-Dependent Pharmacokinetics and Metabolisms of Prolonged-Release Ketamine Tablets in Healthy Subjects by Hasan, M, Modess, C, Roustom, T, Wegner, D, Oswald, S, Rey, H, Zimmer, M, Siegmund, W

“…There is ample new evidence, firstly, that metabolites of NK, as the 2R,6R/2S,6S-enantiomers of hydroxynorketamin (HNK), exert neuro-modulating effects by…”
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Perfusion of human placenta with hemoglobin introduces preeclampsia-like injuries that are prevented by α1 -microglobulin by May, K, Rosenlöf, L, Olsson, M.G, Centlow, M, Mörgelin, M, Larsson, I, Cederlund, M, Rutardottir, S, Siegmund, W, Schneider, H, Åkerström, B, Hansson, S.R

“…Abstract Background Preeclamptic women have increased plasma levels of free fetal hemoglobin (HbF), increased gene expression of placental HbF and accumulation…”
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High Resolution Neutron Resonance Absorption Imaging at a Pulsed Neutron Beamline by Tremsin, A. S., McPhate, J. B., Vallerga, J. V., Siegmund, O. H. W., Kockelmann, W., Schooneveld, E. M., Rhodes, N. J., Feller, W. B.

“…The existence of resonance peaks in neutron absorption spectra in the epithermal range of energies enables unique non-destructive testing techniques. The deep…”
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Imaging of dynamic magnetic fields with spin-polarized neutron beams by Tremsin, A S, Kardjilov, N, Strobl, M, Manke, I, Dawson, M, McPhate, J B, Vallerga, J V, Siegmund, O H W, Feller, W B

“…Precession of neutron spin in a magnetic field can be used for mapping of a magnetic field distribution, as demonstrated previously for static magnetic fields…”
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Impact of Efavirenz on Intestinal Metabolism and Transport: Insights From an Interaction Study With Ezetimibe in Healthy Volunteers by Oswald, S, Meyer zu Schwabedissen, H E, Nassif, A, Modess, C, Desta, Z, Ogburn, E T, Mostertz, J, Keiser, M, Jia, J, Hubeny, A, Ulrich, A, Runge, D, Marinova, M, Lütjohann, D, Kroemer, H K, Siegmund, W

“…Hypercholesterolemia frequently occurs in patients treated with efavirenz who cannot be treated adequately with statins because of drug interactions. These…”
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