Search Results - "SIEGMUND, K. D"

Comprehensive epigenomic profiling of human alveolar epithelial differentiation identifies key epigenetic states and transcription factor co-regulatory networks for maintenance of distal lung identity by Zhou, B, Stueve, T R, Mihalakakos, E A, Miao, L, Mullen, D, Wang, Y, Liu, Y, Luo, J, Tran, E, Siegmund, K D, Lynch, S K, Ryan, A L, Offringa, I A, Borok, Z, Marconett, C N

“…Disruption of alveolar epithelial cell (AEC) differentiation is implicated in distal lung diseases such as chronic obstructive pulmonary disease, idiopathic…”
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DNA methylation profiles in diffuse large B-cell lymphoma and their relationship to gene expression status by Pike, B L, Greiner, T C, Wang, X, Weisenburger, D D, Hsu, Y-H, Renaud, G, Wolfsberg, T G, Kim, M, Weisenberger, D J, Siegmund, K D, Ye, W, Groshen, S, Mehrian-Shai, R, Delabie, J, Chan, W C, Laird, P W, Hacia, J G

“…In an initial epigenetic characterization of diffuse large B-cell lymphoma (DLBCL), we evaluated the DNA methylation levels of over 500 CpG islands. Twelve CpG…”
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Testing Linkage Disequilibrium in Sibships by Siegmund, Kimberly D., Langholz, Bryan, Kraft, Peter, Thomas, Duncan C.

“…We describe the use of multivariate regression for testing allelic association in the presence of linkage, using marker genotype data from sibships. The test…”
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The Methylenetetrahydrofolate Reductase 677C→T Polymorphism and Distal Colorectal Adenoma Risk by LEVINE, A. J, SIEGMUND, K. D, ERVIN, C. M, DIEP, A, LEE, E. R, FRANKL, H. D, HAILE, R. W

“…A common polymorphism in the methylenetetrahydrofolate reductase ( MTHFR ) gene, where a cytosine at nucleotide 677 is replaced by a thymine (677C→T), is…”
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The effect of excimer laser photorefractive keratectomy on intraocular pressure measurements using the Goldmann applanation tonometer by Mardelli, P G, Piebenga, L W, Whitacre, M M, Siegmund, K D

“…The authors determined whether photorefractive keratectomy (PRK) affects Goldmann applanation readings in human eyes. The intraocular pressure (IOP) of 111…”
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Hostility, social support, and coronary heart disease in the National Heart, Lung, and Blood Institute Family Heart Study by Knox, Sarah S., Siegmund, Kimberly D., Weidner, Gerdi, Ellison, R.Curtis, Adelman, Avril, Paton, Catherine

“…This cross-sectional study investigated the association of hostility and social support to coronary heart disease (CHD) in 2 groups of men and women: those…”
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Association of breast cancer DNA methylation profiles with hormone receptor status and response to tamoxifen by WIDSCHWENDTER, Martin, SIEGMUND, Kimberly D, MÜLLER, Hannes M, FIEGL, Heidi, MARTH, Christian, MÜLLER-HOLZNER, Elisabeth, JONES, Peter A, LAIRD, Peter W

“…We have generated DNA methylation profiles of 148 human breast tumors and found significant differences in hormone receptor (HR) status between clusters of DNA…”
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Lipoprotein(a) interactions with lipid and non-lipid risk factors in patients with early onset coronary artery disease: Results from the NHLBI Family Heart Study by Hopkins, Paul N., Hunt, Steven C., Schreiner, Pamela J., Eckfeldt, John H., Borecki, Ingrid B., Ellison, Curtis R., Williams, Roger R., Siegmund, Kimberly D.

“…Background: A positive interaction between high plasma lipoprotein(a) [Lp(a)] and unfavorable plasma lipid levels has been reported to result in very high risk…”
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Multistage sampling for disease Family registries by SIEGMUND, K. D, WHITTEMORE, A. S, THOMAS, D. C

“…The objectives of a family-based disease registry range from characterizing measured genetic factors and gene-environment interaction effects to detecting…”
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Should we consider gene x environment interaction in the hunt for quantitative trait loci? by Gauderman, W J, Morrison, J L, Siegmund, K D

“…We address the question of whether one can obtain increased power for finding a quantitative trait locus (QTL) if a gene x environment (G x E) interaction is…”
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Study-Design Issues in the Development of the University of Southern California Consortium's Colorectal Cancer Family Registry by Haile, Robert W., Siegmund, Kimberly D., Gauderman, W. James, Thomas, Duncan C.

“…The University of Southern California Consortium is a participating center in the National Cancer Institute's Collaborative Family Registry for Colorectal…”
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A frailty approach for modelling diseases with variable age of onset in families: the NHLBI family heart study by Siegmund, Kimberly D., Todorov, Alexandre A., Province, Michael A.

“…We use frailty models to analyse the effect of latent genetic and environmental risk factors on hazard functions in nuclear families. The approach expresses…”
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Production of an antiserum specific to the ADP-ribosylated form of elongation factor 2 from archaebacteria and eukaryotes by Siegmund, Klaus-Detlef, Klink, Friedrich

“…An antiserum to ADP-ribosylated elongation factor 2 (ADPR-EF-2) from S. acidocaldarius was raised in rabbits using stained, homogenized, ADPR-EF-2-containing…”
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Modeling Disease Incidence Rates in Families by Siegmund, Kimberly D., Province, Michael A., Higgins, Millicent, Williams, Roger R., Keller, Jacob, Todorov, Alexandre A.

“…We apply an extended Cox model to study latent genes and measured environmental exposures simultaneously as risk factors for disease. Using this method, we…”
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The role of smoothing techniques in the interpretation of results from genomic scans using sib-pair data by Siegmund, K.D., Todorov, A.A., Rao, D.C., Borecki, I.B.

“…We compare the results of genomic scans conducted with the Haseman‐Elston sib‐ pair method using either (1) the average marker information from several…”
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Probabilities of identity-by-descent patterns in sibships when the parents are not genotyped by Todorov, A.A., Siegmund, K.D., Gu, C., Borecki, I.B., Elston, R.C.

“…An assumption‐free algorithm has been applied to compute the probabilities of all possible identity‐by‐descent (IBD) configurations when the parents have not…”
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Ascertainment Bias in Family-based Case-Control Studies by Siegmund, Kimberly D., Langholz, Bryan

“…In a family-matched case-control study, a population-based sample of cases is selected from a well-defined geographic region over a fixed period of time. For…”
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Diet, cancer and aging in DNA mismatch repair deficient mice by Tsao, Jen-Lan, Dudley, Sandra, Kwok, Brian, Nickel, Andrea E., Laird, Peter W., Siegmund, Kimberly D., Liskay, R. Michael, Shibata, Darryl

“…Diet is an important risk factor for many cancers. High fat/low calcium (HFLC) diets are associated with increased tumorigenesis, whereas caloric restriction…”
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Gene-environment interaction and affected sib pair linkage analysis by Gauderman, W J, Siegmund, K D

“…Gene-environment (GxE) interaction influences risk for many complex disease traits. However, genome screens using affected sib pair linkage techniques are…”
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Stratified case sampling and the use of family controls by Siegmund, Kimberly D., Langholz, Bryan

“…We compare the asymptotic relative efficiency (ARE) of different study designs for estimating gene and gene‐environment interaction effects using matched…”
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