Search Results - "SIEGMAN, M. J"

Phosphorylation of Molluscan Twitchin by the cAMP-Dependent Protein Kinase by Funabara, Daisuke, Kinoshita, Shigeharu, Watabe, Shugo, Siegman, Marion J, Butler, Thomas M, Hartshorne, David J

“…Catch in certain molluscan muscles is released by an increase in cAMP, and it was suggested that the target of cAMP-dependent protein kinase (PKA) is the high…”
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Lack of endothelium-dependent relaxation in coronary resistance arteries of cholesterol-fed rabbits by Osborne, J A, Siegman, M J, Sedar, A W, Mooers, S U, Lefer, A M

“…The endothelium-dependent contractile responses of subepicardial coronary resistance arteries (286 +/- 18 microns ID, n = 22) from rabbits fed either a 0.5 or…”
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Cooperative activation of myosin by light chain phosphorylation in permeabilized smooth muscle by Vyas, T B, Mooers, S U, Narayan, S R, Witherell, J C, Siegman, M J, Butler, T M

“…The purpose of this study was to determine the quantitative relationship between the number of myosin molecules that increase their ATPase activity and the…”
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Metabolic characteristics of alpha-toxin-permeabilized smooth muscle by Trinkle-Mulcahy, L, Siegman, M J, Butler, T M

“…Rabbit portal veins were permeabilized using Staphylococcus aureus alpha-toxin, and adenosinetriphosphatase (ATPase) was measured as the formation of [3H]ADP,…”
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Hypertrophy of colonic smooth muscle: structural remodeling, chemical composition, and force output by Siegman, M J, Butler, T M, Mooers, S U, Trinkle-Mulcahy, L, Narayan, S, Stirewalt, W S, Starcher, B C

“…The cellular basis of adaptations occurring during the development of megacolon was studied with the lethal spotted mouse model. Age-dependent changes in the…”
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Control of cross-bridge cycling by myosin light chain phosphorylation in mammalian smooth muscle by BUTLER, T. M, SIEGMAN, M. J

“…This review focuses on experiments in which the single turnover of myosin‐bound ADP is used to characterize the regulation of the cross‐bridge cycle by myosin…”
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Cross-bridge cycling at rest and during activation. Turnover of myosin-bound ADP in permeabilized smooth muscle by VYAS, T. B, MOOERS, S. U, NARAYAN, S. R, SIEGMAN, M. J, BUTLER, T. M

“…Single turnover experiments were performed on myosin-bound ADP by measuring the time course of incorporation of [3H]ADP following rapid formation of [3H]ATP by…”
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Rapid turnover of myosin light chain phosphate during cross-bridge cycling in smooth muscle by Butler, T M, Narayan, S R, Mooers, S U, Siegman, M J

“…The rate of phosphatase-mediated dephosphorylation of the regulatory light chain of smooth muscle myosin was determined under nearly steady-state conditions in…”
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Slowing of cross-bridge cycling in smooth muscle without evidence of an internal load by Butler, T M, Siegman, M J, Mooers, S U

“…We have tested whether the slowing in velocity of shortening that occurs in mammalian smooth muscle under conditions of high force output and dephosphorylated…”
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Phosphatase inhibition with okadaic acid does not alter the relationship between force and myosin light chain phosphorylation in permeabilized smooth muscle by Siegman, M J, Butler, T M, Mooers, S U

“…The phosphatase inhibitor, okadaic acid, has been used to test the hypothesis that myosin light chain phosphatase activity plays a central role in latchbridge…”
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Myosin-product complex in the resting state and during relaxation of smooth muscle by Butler, T M, Siegman, M J, Mooers, S U, Narayan, S R

“…Previous findings suggested that in resting smooth muscle ADP is bound to myosin and that phosphorylation of the myosin, and its subsequent interaction with…”
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High-energy phosphate metabolism in vascular smooth muscle by BUTLER, T. M, SIEGMAN, M. J

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ADP release from myosin in permeabilized smooth muscle by Butler, T M, Pacifico, D S, Siegman, M J

“…The purpose of this study was to determine the nucleotide bound to myosin and its rate of release under relaxed and activated conditions in permeabilized…”
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Phosphorylation of a Twitchin-Related Protein Controls Catch and Calcium Sensitivity of Force Production in Invertebrate Smooth Muscle by Siegman, Marion J., Funabara, Daisuke, Kinoshita, Shigeharu, Watabe, Shugo, Hartshorne, David J., Butler, Thomas M.

“…``Catch'' is a condition of prolonged, high-force maintenance at resting intracellular Ca2+concentration ([Ca2+]) and very low energy usage, occurring in…”
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Altered isoactin gene expression in the affected bowel segments of the lethal spotted mouse by Liddell, R A, Mooers, S U, Siegman, M J, McHugh, K M

“…Actin is a key contractile protein associated with the normal differentiation and function of gastrointestinal smooth muscle cells. Distinct changes in…”
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Thiophosphorylation of the 130-kDa Subunit Is Associated with a Decreased Activity of Myosin Light Chain Phosphatase in α-Toxin-permeabilized Smooth Muscle by Trinkle-Mulcahy, Laura, Ichikawa, Kazuhito, Hartshorne, David J., Siegman, Marion J., Butler, Thomas M.

“…Pretreatment of α-toxin-permeabilized smooth muscle with ATPγS (adenosine 5ʹ-O-(thiotriphosphate)) under conditions resulting in minimal (<1%)…”
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Chemical energy usage during stimulation and stretch of mammalian smooth muscle by BUTLER, T. M, SIEGMAN, M. J, MOOERS, S. V

“…High energy phosphate usage was measured in the rabbit taenia coli subjected to stimulation and stretch (0.12 Lo/min) and was compared to that observed…”
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The Myosin Cross-Bridge Cycle and Its Control by Twitchin Phosphorylation in Catch Muscle by Butler, Thomas M., Narayan, Srinivasa R., Mooers, Susan U., Hartshorne, David J., Siegman, Marion J.

“…The anterior byssus retractor muscle of Mytilus edulis was used to characterize the myosin cross-bridge during catch, a state of tonic force maintenance with a…”
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Chemical energy usage during shortening and work production in mammalian smooth muscle by Butler, T M, Siegman, M J, Mooers, S U

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Regulation of Catch Muscle by Twitchin Phosphorylation: Effects on Force, ATPase, and Shortening by Butler, Thomas M., Mooers, Susan U., Li, Chenqing, Narayan, Srinivasa, Siegman, Marion J.

“…Recent experiments on permeabilized anterior byssus retractor muscle (ABRM) of Mytilus edulis have shown that phosphorylation of twitchin releases catch force…”
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