Search Results - "SIEGER, Kerry"

The Tumor Suppressor Activity of MDA-7/IL-24 Is Mediated by Intracellular Protein Expression in NSCLC Cells by Sieger, Kerry A, Mhashilkar, Abner M, Stewart, Alexis, Sutton, R.Bryan, Strube, Randall W, Chen, Si Yi, Pataer, Abujiang, Swisher, Stephen G, Grimm, Elizabeth A, Ramesh, Rajagopal, Chada, Sunil

“…mda-7/IL-24 (HGMW-approved symbol IL24) is a tumor suppressor gene whose expression is lost during tumor progression. Gene transfer using adenoviral…”
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Dual Control of Muscle Cell Survival by Distinct Growth Factor-Regulated Signaling Pathways by Lawlor, Margaret A., Feng, Xiuhong, Everding, Daniel R., Sieger, Kerry, Stewart, Claire E. H., Rotwein, Peter

“…Article Usage Stats Services MCB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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Abstract CT127: Phase I adoptive cellular therapy trial with actively personalized, multi-targeted CD8+ T-cells in patients with relapsed and/or refractory solid cancers (ACTologIMA101-101) by Ma, Hong, Kuttruff, Sabrina, Stewart, Chad, Bulliard, Yannick, Stephens, Geoffrey, Schoor, Oliver, Satelli, Arun, Hilf, Norbert, Sieger, Kerry, Fritsche, Jens, Maurer, Dominik, Mohamed, Ali, Weinschenk, Toni, Reinhardt, Carsten, Walter, Steffen, Singh, Harpreet, Hwu, Patrick, Yee, Cassian, Andersson, Borje, Tsimberidou, Apostolia-Marie

“…Abstract Introduction: Adoptive cellular therapy (ACT), which includes the administration of autologous or allogenic anti-tumor T lymphocytes after ex vivo…”
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Feasibility and Safety of Personalized, Multi-Target, Adoptive Cell Therapy (IMA101): First-in-Human Clinical Trial in Patients with Advanced Metastatic Cancer by Tsimberidou, Apostolia M, Guenther, Kerstin, Andersson, Borje S, Mendrzyk, Regina, Alpert, Amir, Wagner, Claudia, Nowak, Anna, Aslan, Katrin, Satelli, Arun, Richter, Fabian, Kuttruff-Coqui, Sabrina, Schoor, Oliver, Fritsche, Jens, Coughlin, Zoe, Mohamed, Ali S, Sieger, Kerry, Norris, Becky, Ort, Rita, Beck, Jennifer, Vo, Henry Hiep, Hoffgaard, Franziska, Ruh, Manuel, Backert, Linus, Wistuba, Ignacio I, Fuhrmann, David, Ibrahim, Nuhad K, Morris, Van Karlyle, Kee, Bryan K, Halperin, Daniel M, Nogueras-Gonzalez, Graciela M, Kebriaei, Partow, Shpall, Elizabeth J, Vining, David, Hwu, Patrick, Singh, Harpreet, Reinhardt, Carsten, Britten, Cedrik M, Hilf, Norbert, Weinschenk, Toni, Maurer, Dominik, Walter, Steffen

“…IMA101 is an actively personalized, multi-targeted adoptive cell therapy (ACT), whereby autologous T cells are directed against multiple novel defined…”
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Melanoma differentiation-associated gene 7/interleukin (IL)-24 is a novel ligand that regulates angiogenesis via the IL-22 receptor by RAMESH, Rajagopal, MHASHILKAR, Abner M, GRIMM, Elizabeth A, RENAULD, Jean-Christophe, KOTENKO, Sergei, CHADA, Sunil, TANAKA, Fumihiro, SAITO, Yuji, BRANCH, Cynthia D, SIEGER, Kerry, MUMM, John B, STEWART, Alexis L, BOQUIO, Amelia, DUMOUTIER, Laure

“…The melanoma differentiation-associated gene 7 (mda-7), also called interleukin (IL)-24, suppresses the growth of some cancers in vitro and in vivo as a result…”
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293 Resultsof the first-in-human clinical trial with personalized multi-target adoptive cell therapy (ACTolog IMA101) by Tsimberidou, Apostolia, Guenther, Kerstin, Alpert, Amir, Andersson, Borje, Coughlin, Zoe, Fritsche, Jens, Hilf, Norbert, Hwu, Patrick, Kalra, Mamta, Kuttruff-Coqui, Sabrina, Maurer, Dominik, Mendrzyk, Regina, Ali, Mohamed, Norris, Becky, Nowak, Anna, Ort, Rita, Reinhardt, Carsten, Richter, Fabian, Satelli, Arun, Schoor, Oliver, Sieger, Kerry, Singh, Harpreet, Vining, David, Wagner, Claudia, Weinschenk, Toni, Yee, Cassian, Steffen, Walter

“…BackgroundACTolog (IMA101) is a personalized multi-target adoptive cell therapy (ACT) approach in which autologous T-cell products are redirected against…”
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Inhibition of human lung cancer growth following adenovirus-mediated mda-7 gene expression in vivo by SAEKI, Tomoyuki, MHASHILKAR, Abner, CHADA, Sunil, RAMESH, Rajagopal, SWANSON, Xin, ZOU-YANG, X. Helena, SIEGER, Kerry, KAWABE, Shinichiro, BRANCH, Cynthia D, ZUMSTEIN, Louis, MEYN, Raymond E, ROTH, Jack A

“…Overexpression of the melanoma differentiation associated gene-7 (mda-7) in vitro results in suppression of lung cancer cell proliferation. However, the…”
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MDA-7 negatively regulates the β-catenin and PI3K signaling pathways in breast and lung tumor cells by Mhashilkar, Abner M, Stewart, Alexis L, Sieger, Kerry, Yang, Heng-Yin, Khimani, Anis H, Ito, Isao, Saito, Yuji, Hunt, Kelly K, Grimm, Elizabeth A, Roth, Jack A, Meyn, Raymond E, Ramesh, Rajagopal, Chada, Sunil

“…mda-7 is a novel tumor suppressor with cytokine properties. Adenoviral mda-7 (Ad-mda7) induces apoptosis and cell death selectively in tumor cells. The…”
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Melanoma differentiation-associated gene-7/IL-24 gene enhances NF-kappa B activation and suppresses apoptosis induced by TNF by Aggarwal, Sita, Takada, Yasunari, Mhashilkar, Abner M, Sieger, Kerry, Chada, Sunil, Aggarwal, Bharat B

“…Melanoma differentiation-associated gene-7 (mda-7), also referred to as IL-24, is a novel growth regulatory cytokine that has been shown to regulate the immune…”
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Melanoma differentiation associated gene-7 (mda-7): a novel anti-tumor gene for cancer gene therapy by Mhashilkar, A M, Schrock, R D, Hindi, M, Liao, J, Sieger, K, Kourouma, F, Zou-Yang, X H, Onishi, E, Takh, O, Vedvick, T S, Fanger, G, Stewart, L, Watson, G J, Snary, D, Fisher, P B, Saeki, T, Roth, J A, Ramesh, R, Chada, S

“…The mda-7 gene (melanoma differentiation associated gene-7) is a novel tumor suppressor gene. The anti-proliferative activity of MDA-7 has been previously…”
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PI3K Blockade by Ad-PTEN Inhibits Invasion and Induces Apoptosis in Radial Growth Phase and Metastatic Melanoma Cells by Stewart, Alexis L., Mhashilkar, Abner M., Yang, Xiaohong Helena, Ekmekcioglu, Suhendan, Saito, Yuji, Sieger, Kerry, Schrock, Robert, Onishi, Eric, Swanson, Xin, Mumm, John B., Zumstein, Lou, Watson, Graham J., Snary, David, Roth, Jack A., Grimm, Elizabeth A., Ramesh, Rajagopal, Chada, Sunil

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MDA-7 Negatively Regulates the [beta]-Catenin and PI3K Signaling Pathways in Breast and Lung Tumor Cells by Mhashilkar, Abner M, Stewart, Alexis L, Sieger, Kerry, Yang, Heng-yin, Khimani, Anis H, Ito, Isao, Saito, Yuji, Hunt, Kelly K, Grimm, Elizabeth A, Roth, Jack A, Meyn, Raymond E, Ramesh, Rajagopal, Chada, Sunil

“…mda-7 is a novel tumor suppressor with cytokine properties. Adenoviral mda-7 (Ad-mda7) induces apoptosis and cell death selectively in tumor cells. The…”
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Inhibition of human lung cancer growth following adenovirus-mediated mda-7gene expression in vivo by Saeki, Tomoyuki, Mhashilkar, Abner, Swanson, Xin, Zou-Yang, X Helena, Sieger, Kerry, Kawabe, Shinichiro, Branch, Cynthia D, Zumstein, Louis, Meyn, Raymond E, Roth, Jack A, Chada, Sunil, Ramesh, Rajagopal

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Biphasic transcriptional regulation of the interferon regulatory factor-1 gene by prolactin: involvement of gamma-interferon-activated sequence and Stat-related proteins by Stevens, A M, Wang, Y F, Sieger, K A, Lu, H F, Yu-Lee, L Y

“…Stimulation of quiescent Nb2 T cells by PRL leads to the rapid transcriptional activation of a T cell activation gene, interferon regulatory factor-1 (IRF-1)…”
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PI3 kinase blockade by Ad-PTEN inhibits invasion and induces apoptosis in RGP and metastatic melanoma cells by Stewart, Alexis L, Mhashilkar, Abner M, Yang, Xiaohong Helena, Ekmekcioglu, Suhendan, Saito, Yuji, Sieger, Kerry, Schrock, Robert, Onishi, Eric, Swanson, Xin, Mumm, John B, Zumstein, Lou, Watson, Graham J, Snary, David, Roth, Jack A, Grimm, Elizabeth A, Ramesh, Rajagopal, Chada, Sunil

“…Melanoma is an aggressive tumor with a propensity to rapidly metastasize. The PTEN gene encodes a phosphatase with an unusual dual specificity for proteins and…”
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Melanoma Differentiation-Associated Gene-7/IL-24 Gene Enhances NF-{kappa}B Activation and Suppresses Apoptosis Induced by TNF by Aggarwal, Sita, Takada, Yasunari, Mhashilkar, Abner M, Sieger, Kerry, Chada, Sunil, Aggarwal, Bharat B

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