Search Results - "SIEGALL, C"

Development of potent monoclonal antibody auristatin conjugates for cancer therapy by Senter, Peter D, Doronina, Svetlana O, Toki, Brian E, Torgov, Michael Y, Mendelsohn, Brian A, Cerveny, Charles G, Chace, Dana F, DeBlanc, Ron L, Gearing, R Patrick, Bovee, Tim D, Siegall, Clay B, Francisco, Joseph A, Wahl, Alan F, Meyer, Damon L

“…We describe the in vitro and in vivo properties of monoclonal antibody (mAb)-drug conjugates consisting of the potent synthetic dolastatin 10 analogs…”
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Agonistic properties and in vivo antitumor activity of the anti-CD40 antibody SGN-14 by FRANCISCO, J. A, DONALDSON, K. L, CHACE, D, SIEGALL, C. B, WAHL, A. F

“…Ligation of CD40 is essential for primary B-cell activation and expansion and yet has suppressive or apoptotic effects on some CD40-expressing neoplasia…”
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Characterization of vascular leak syndrome induced by the toxin component of Pseudomonas exotoxin-based immunotoxins and its potential inhibition with nonsteroidal anti-inflammatory drugs by SIEGALL, C. B, LIGGITT, D, CHACE, D, MIXAN, B, SUGAI, J, DAVIDSON, T, STEINITZ, M

“…Clinical trials of immunotoxins in cancer patients have been limited in many cases by vascular leak syndrome (VLS). Recently, rats were identified as a model…”
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Targeted toxins as anticancer agents by Siegall, C B

“…Transformed cells, such as those found in breast cancer, often overexpress a variety of cell surface receptors and antigens. Antibodies or growth factors that…”
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Characterization of an Interleukin-6-Mediated Autocrine Growth Loop in the Human Multiple Myeloma Cell Line, U266 by Schwab, Gisela, Siegall, Clay B., Aarden, Lucien A., Neckers, Leonard M., Nordan, Richard P.

“…It has been reported recently that freshly isolated human myeloma cell cultures proliferate in response to added interleukin-6 (IL-6). Endogenous levels of…”
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Functional Analysis of Domains II, Ib, and III of Pseudomonas exotoxin by Siegall, C B, Chaudhary, V K, FitzGerald, D J, Pastan, I

“…Pseudomonas exotoxin is composed of three structural domains that are responsible for cell recognition, membrane translocation, and ADP-ribosylation. The…”
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Advances in immunotoxin biology and therapy: a summary of the Fourth International Symposium on Immunotoxins by Frankel, A E, FitzGerald, D, Siegall, C, Press, O W

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Prevention of Immunotoxin-Mediated Vascular Leak Syndrome in Rats with Retention of Antitumor Activity by Siegall, Clay B., Liggitt, Denny, Chace, Dana, Tepper, Mark A., Fell, H. Perry

“…Immunotoxins are hybrid molecules composed of a cell-surface binding domain and a protein toxin moiety that together target specific cell populations for…”
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BR96 sFv-PE40 Immunotoxin: Nonclinical Safety Assessment by Haggerty, H.G., Warner, W.A., Comereski, C.R., Peden, W.M., Mezza, L.E., Damle, B.D., Siegall, C.B., Davidson, T.J.

“…BR96 sFv-PE40, a recombinant DNA-derived fusion protein composed of the heavy- and light-chain variable region domains of the monoclonal antibody BR96 and the…”
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In vitro and in vivo characterization of BR96 sFv-PE40. A single-chain immunotoxin fusion protein that cures human breast carcinoma xenografts in athymic mice and rats by Siegall, CB, Chace, D, Mixan, B, Garrigues, U, Wan, H, Paul, L, Wolff, E, Hellstrom, I, Hellstrom, KE

“…BR96 sFv-PE40 is a single-chain immunotoxin fusion protein targeted to the Ley Ag, which is expressed in many different human carcinomas as well as in normal…”
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Antitumor activity of the single-chain immunotoxin BR96 sFv-PE40 against established breast and lung tumor xenografts by Friedman, PN, Chace, DF, Trail, PA, Siegall, CB

“…We have constructed a single-chain immunotoxin consisting of the variable H and L chains of the carcinoma-reactive mAb BR96, fused to the binding defective…”
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Activity of a single-chain immunotoxin that selectively kills lymphoma and other B-lineage cells expressing the CD40 antigen by FRANCISCO, J. A, GILLILAND, L. K, STEBBINS, M. R, NORRIS, N. A, LEDBETTER, J. A, SIEGALL, C. B

“…We have constructed anti-CD40 immunotoxins consisting of the single chain Fv (sFv) region of the anti-human CD40 mAb G28-5 fused to a truncated form of…”
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In Vivo Efficacy and Toxicity of a Single-Chain Immunotoxin Targeted to CD40 by Francisco, Joseph A., Schreiber, George J., Comereski, Chuck R., Mezza, Laurence E., Warner, Garvin L., Davidson, Thomas J., Ledbetter, Jeffrey A., Siegall, Clay B.

“…G28-5 sFv-PE40 is a single-chain immunotoxin targeted to CD40, which is highly expressed on human hematologic malignancies, including non-Hodgkin's lymphoma,…”
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Cytotoxic activities of a fusion protein comprised of TGF alpha and Pseudomonas exotoxin by Siegall, C B, Xu, Y H, Chaudhary, V K, Adhya, S, Fitzgerald, D, Pastan, I

“…A cDNA encoding transforming growth factor type alpha (TGF alpha) was fused to the 5' end of a gene encoding a modified form of Pseudomonas exotoxin A (PE),…”
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Cytotoxic effects of a recombinant chimeric toxin on rapidly proliferating vascular smooth muscle cells by EPSTEIN, S. E, SIEGALL, C. B, BIRO, S, YA-MIN FU, FITZGERALD, D, PASTAN, I

“…Restenosis after percutaneous transluminal coronary angioplasty is associated with activation of medial smooth muscle cells (SMCs); they proliferate, migrate…”
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Selective tumor sensitization to taxanes with the mAb‐drug conjugate cBR96‐doxorubicin by Wahl, Alan F., Donaldson, Karen L., Mixan, Bruce J., Trail, Pamela A., Siegall, Clay B.

“…The chimeric monoclonal antibody cBR96 conjugated to doxorubicin (cBR96‐Dox) is selectively internalized by a wide variety of human carcinomas expressing an…”
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Single-chain fusion toxins for the treatment of breast cancer: antitumor activity of BR96 sFv-PE40 and heregulin-PE40 by Siegall, C B

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Cytotoxic Activity of an Interleukin 6--Pseudomonas Exotoxin Fusion Protein on Human Myeloma Cells by Siegall, Clay B., Chaudhary, Vijay K., FitzGerald, David J., Pastan, Ira

“…A chimeric toxin composed of human interleukin 6 (IL-6) attached to a portion of Pseudomonas exotoxin (PE) devoid of its own cell recognition domain has been…”
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BR96 sFv-PE40, a potent single-chain immunotoxin that selectively kills carcinoma cells by FRIEDMAN, P. N, MCANDREW, S. J, GAWLAK, S. L, CHACE, D, TRAIL, P. A, BROWN, J. P, SIEGALL, C. B

“…We have constructed a single-chain immunotoxin composed of the carcinoma-reactive antibody BR96 and a truncated form of Pseudomonas exotoxin. The chimeric…”
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Betacellulin-Pseudomonas toxin fusion proteins bind but are not cytotoxic to cells expressing HER4; correlation of EGFR for cytotoxic activity by MIXAN, B, COHEN, B. D, BACUS, S. S, FELL, H. P, SIEGALL, C. B

“…Betacellulin (BTC) is a member of the EGF ligand family that directly binds to both EGFR and HER4 and induces the growth of certain epithelial cell types…”
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