Search Results - "SIBILLE, Etienne"

Altered GABA-mediated information processing and cognitive dysfunctions in depression and other brain disorders by Prévot, Thomas, Sibille, Etienne

“…Cognitive dysfunctions, including impaired attention, learning, memory, planning and problem solving, occur in depressive episodes, often persist during…”
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Molecular aging of the brain, neuroplasticity, and vulnerability to depression and other brain-related disorders by Sibille, Etienne

“…The increased risk for neurodegenerative and neuropsychiatric disorders associated with extended lifespan has long suggested mechanistic links between…”
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Somatostatin-Positive Gamma-Aminobutyric Acid Interneuron Deficits in Depression: Cortical Microcircuit and Therapeutic Perspectives by Fee, Corey, Banasr, Mounira, Sibille, Etienne

“…The functional integration of external and internal signals forms the basis of information processing and is essential for higher cognitive functions. This…”
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Opposing Effects of Acute versus Chronic Blockade of Frontal Cortex Somatostatin-Positive Inhibitory Neurons on Behavioral Emotionality in Mice by SOUMIER, Amelie, SIBILLE, Etienne

“…Reduced expression of somatostatin (SST) is reported across chronic brain conditions including major depression and normal aging. SST is a signaling…”
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The Role of BDNF in Age-Dependent Changes of Excitatory and Inhibitory Synaptic Markers in the Human Prefrontal Cortex by Oh, Hyunjung, Lewis, David A, Sibille, Etienne

“…Reduced brain-derived neurotrophic factor (BDNF) may underlie age-related synaptic loss, in turn contributing to cerebral atrophy, cognitive decline, and…”
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Differential and spatial expression meta-analysis of genes identified in genome-wide association studies of depression by Wu, Wennie, Howard, Derek, Sibille, Etienne, French, Leon

“…Major depressive disorder (MDD) is the most prevalent psychiatric disorder worldwide and affects individuals of all ages. It causes significant psychosocial…”
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Molecular origin of somatostatin-positive neuron vulnerability by Tomoda, Toshifumi, Sumitomo, Akiko, Newton, Dwight, Sibille, Etienne

“…Reduced somatostatin (SST) and dysfunction of SST-positive (SST + ) neurons are hallmarks of neurological disorders and associated with mood disturbances, but…”
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Effects of aging on circadian patterns of gene expression in the human prefrontal cortex by Chen, Cho-Yi, Logan, Ryan W., Ma, Tianzhou, Lewis, David A., Tseng, George C., Sibille, Etienne, McClung, Colleen A.

“…With aging, significant changes in circadian rhythms occur, including a shift in phase toward a “morning” chronotype and a loss of rhythmicity in circulating…”
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BDNF controls GABAAR trafficking and related cognitive processes via autophagic regulation of p62 by Tomoda, Toshifumi, Sumitomo, Akiko, Shukla, Rammohan, Hirota-Tsuyada, Yuki, Miyachi, Hitoshi, Oh, Hyunjung, French, Leon, Sibille, Etienne

“…Reduced brain-derived neurotrophic factor (BDNF) and gamma-aminobutyric acid (GABA) neurotransmission co-occur in brain conditions (depression, schizophrenia…”
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Brain-Derived Neurotrophic Factor Signaling and Subgenual Anterior Cingulate Cortex Dysfunction in Major Depressive Disorder by Tripp, Adam, Oh, Hyunjung, Guilloux, Jean-Philippe, Martinowich, Keri, Lewis, David A., Sibille, Etienne

“…ObjectiveThe subgenual anterior cingulate cortex is implicated in the pathology and treatment response of major depressive disorder. Low levels of…”
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Integrated behavioral z-scoring increases the sensitivity and reliability of behavioral phenotyping in mice: Relevance to emotionality and sex by Guilloux, Jean-Philippe, Seney, Marianne, Edgar, Nicole, Sibille, Etienne

“…► Mouse behavior related to emotionality is multimodal and varies over time. ► Tools to integrate behavioral parameters from complementary tests are needed. ►…”
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Molecular characterization of depression trait and state by Shukla, Rammohan, Newton, Dwight F., Sumitomo, Akiko, Zare, Habil, Mccullumsmith, Robert, Lewis, David A., Tomoda, Toshifumi, Sibille, Etienne

“…Major depressive disorder (MDD) is a brain disorder often characterized by recurrent episode and remission phases. The molecular correlates of MDD have been…”
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The Age-by-Disease Interaction Hypothesis of Late-Life Depression by McKinney, Brandon Chad, M.D., Ph.D, Sibille, Etienne, Ph.D

“…The phenomenologic diagnosis of depression is successful in increasing diagnostic reliability, but it is a classification scheme without biologic bases. One…”
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Reduced somatostatin in subgenual anterior cingulate cortex in major depression by Tripp, Adam, Kota, Rama S, Lewis, David A, Sibille, Etienne

“…Abstract Converging evidence suggests a central role for dysfunction of the subgenual anterior cingulate cortex (sgACC) in the pathophysiology of major…”
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Biological substrates underpinning diagnosis of major depression by Sibille, Etienne, French, Beverly

“…Major depression is characterized by low mood, a reduced ability to experience pleasure and frequent cognitive, physiological and high anxiety symptoms. It is…”
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Meta-analysis methods for combining multiple expression profiles: comparisons, statistical characterization and an application guideline by Chang, Lun-Ching, Lin, Hui-Min, Sibille, Etienne, Tseng, George C

“…As high-throughput genomic technologies become accurate and affordable, an increasing number of data sets have been accumulated in the public domain and…”
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GL-II-73, a Positive Allosteric Modulator of α5GABAA Receptors, Reverses Dopamine System Dysfunction Associated with Pilocarpine-Induced Temporal Lobe Epilepsy by McCoy, Alexandra M., Prevot, Thomas D., Sharmin, Dishary, Cook, James M., Sibille, Etienne L., Lodge, Daniel J.

“…Although seizures are a hallmark feature of temporal lobe epilepsy (TLE), psychiatric comorbidities, including psychosis, are frequently associated with TLE…”
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Lower Levels of GABAergic Function Markers in Corticotropin-Releasing Hormone-Expressing Neurons in the sgACC of Human Subjects With Depression by Oh, Hyunjung, Newton, Dwight, Lewis, David, Sibille, Etienne

“…A previous transcriptome meta-analysis revealed significantly lower levels of corticotropin-releasing hormone (CRH) mRNA in corticolimbic brain regions in…”
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GABA-related transcripts in the dorsolateral prefrontal cortex in mood disorders by Sibille, Etienne, Morris, Harvey M., Kota, Rama S., Lewis, David A.

“…Reduced cortical γ-aminobutyric acid (GABA) levels and altered markers for subpopulations of GABA interneurons have been reported in major depressive disorder…”
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Sustained Molecular Pathology Across Episodes and Remission in Major Depressive Disorder by Scifo, Enzo, Pabba, Mohan, Kapadia, Fenika, Ma, Tianzhou, Lewis, David A., Tseng, George C., Sibille, Etienne

“…Major depressive disorder (MDD) is a debilitating mental illness and a major cause of lost productivity worldwide. MDD patients often suffer from lifelong…”
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