Search Results - "SHYAMSUNDAR, Murali"

A Randomized Clinical Trial of Hydroxymethylglutaryl― Coenzyme A Reductase Inhibition for Acute Lung Injury (The HARP Study) by CRAIG, Thelma R, DUFFY, Martin J, SHYAMSUNDAR, Murali, MCDOWELL, Cliona, O'KANE, Cecilia M, STUART ELBORN, J, MCAULEY, Daniel F

“…There is no effective pharmacological treatment for acute lung injury (ALI). Statins are a potential new therapy because they modify many of the underlying…”
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Simvastatin Decreases Lipopolysaccharide-induced Pulmonary Inflammation in Healthy Volunteers by Shyamsundar, Murali, McKeown, Scott T. W, O'Kane, Cecilia M, Craig, Thelma R, Brown, Vanessa, Thickett, David R, Matthay, Michael A, Taggart, Clifford C, Backman, Janne T, Elborn, J. Stuart, McAuley, Daniel F

“…Simvastatin inhibits inflammatory responses in vitro and in murine models of lung inflammation in vivo. As simvastatin modulates a number of the underlying…”
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High flow nasal oxygen for acute type two respiratory failure: a systematic review [version 2; peer review: 1 approved, 1 approved with reservations] by Alnajada, Asem Abdulaziz, Blackwood, Bronagh, Mobrad, Abdulmajeed, Akhtar, Adeel, Pavlov, Ivan, Shyamsundar, Murali

“…Background: Acute type two respiratory failure (AT2RF) is characterized by high carbon dioxide levels (PaCO 2 >6kPa). Non-invasive ventilation (NIV), the…”
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Electronic nudge tool technology used in the critical care and peri-anaesthetic setting: a scoping review protocol by McIlmurray, Lisa, Blackwood, Bronagh, Dempster, Martin, Kee, Frank, Gillan, Charles, Hagan, Rachael, Lohfeld, Lynne, Shyamsundar, Murali

“…IntroductionElectronic clinical decision support (eCDS) tools are used to assist clinical decision making. Using computer-generated algorithms with…”
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High-flow nasal cannula therapy for initial oxygen administration in acute hypercapnic respiratory failure: study protocol of randomised controlled unblinded trial by Alnajada, Asem, Blackwood, Bronagh, Mobrad, Abdulmajeed, Akhtar, Adeel, Shyamsundar, Murali

“…IntroductionAcute respiratory failure is a common clinical condition accounting for nearly 116 000 admissions in the UK hospitals. Acute type 2 respiratory…”
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Prevention of post-operative complications by using a HMG-CoA reductase inhibitor in patients undergoing one-lung ventilation for non-cardiac surgery: study protocol for a randomised controlled trial by Shyamsundar, Murali, O'Kane, Cecilia, Perkins, Gavin D, Kennedy, Gavin, Campbell, Christina, Agus, Ashley, Phair, Glenn, McAuley, Danny

“…Postoperative pulmonary complications (PPC) and peri-operative myocardial infarction (MI) have a significant impact on the long-term mortality of surgical…”
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Lung Ultrasound Reproducibly Outperforms Computed Tomography in the Detection of Extravascular Lung Water in Patients Undergoing Haemodialysis by Corcoran, John P, Hew, Mark, Attwood, Ben, Shyamsundar, Murali, Sutherland, Sheera, Ventura, Kristine, Benamore, Rachel, St Noble, Victoria, Piotrowska, Hania E, Pugh, Christopher W, Laursen, Christian B, Gleeson, Fergus V, Rahman, Najib M

“…Lung ultrasound (LUS) is increasingly used as an extension of physical examination, informing clinical diagnosis, and decision making. There is particular…”
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Mucoactive agent use in adult UK Critical Care Units: a survey of health care professionals' perception, pharmacists' description of practice, and point prevalence of mucoactive use in invasively mechanically ventilated patients by Borthwick, Mark, McAuley, Danny, Warburton, John, Anand, Rohan, Bradley, Judy, Connolly, Bronwen, Blackwood, Bronagh, O'Neill, Brenda, Chikhani, Marc, Dark, Paul, Shyamsundar, Murali

“…Mechanical ventilation for acute respiratory failure is one of the most common indications for admission to intensive care units (ICUs). Airway mucus clearance…”
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Aspirin as a potential treatment in sepsis or acute respiratory distress syndrome by Toner, Philip, McAuley, Danny Francis, Shyamsundar, Murali

“…Sepsis is a common condition that is associated with significant morbidity, mortality and health-care cost. Pulmonary and non-pulmonary sepsis are common…”
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Prevalence of phenotypes of acute respiratory distress syndrome in critically ill patients with COVID-19: a prospective observational study by Sinha, Pratik, Calfee, Carolyn S, Cherian, Shiney, Brealey, David, Cutler, Sean, King, Charles, Killick, Charlotte, Richards, Owen, Cheema, Yusuf, Bailey, Catherine, Reddy, Kiran, Delucchi, Kevin L, Shankar-Hari, Manu, Gordon, Anthony C, Shyamsundar, Murali, O'Kane, Cecilia M, McAuley, Daniel F, Szakmany, Tamas

“…In acute respiratory distress syndrome (ARDS) unrelated to COVID-19, two phenotypes, based on the severity of systemic inflammation (hyperinflammatory and…”
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Comparing regression and neural network techniques for personalized predictive analytics to promote lung protective ventilation in Intensive Care Units by Hagan, Rachael, Gillan, Charles J., Spence, Ivor, McAuley, Danny, Shyamsundar, Murali

“…Mechanical ventilation is a lifesaving tool and provides organ support for patients with respiratory failure. However, injurious ventilation due to…”
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International Survey of High-Flow Nasal Therapy Use for Respiratory Failure in Adult Patients by Alnajada, Asem, Blackwood, Bronagh, Messer, Ben, Pavlov, Ivan, Shyamsundar, Murali

“…(1) Background: High-flow nasal therapy (HFNT) has shown several benefits in addressing respiratory failure. However, the quality of evidence and the guidance…”
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Clinical review: the role of ultrasound in estimating extra-vascular lung water by Shyamsundar, Murali, Attwood, Benjamin, Keating, Liza, Walden, Andrew P

“…The estimation of extra-vascular lung water (EVLW) is an essential component in the assessment of critically ill patients. EVLW is independently associated…”
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Keratinocyte Growth Factor Promotes Epithelial Survival and Resolution in a Human Model of Lung Injury by SHYAMSUNDAR, Murali, MCAULEY, Daniel F, MATTHAY, Michael A, O'KANE, Cecilia M, INGRAM, Rebecca J, GIBSON, David S, O'KANE, Donal, MCKEOWN, Scott T, EDWARDS, Alex, TAGGART, Cliff, ELBORN, Joseph S, CALFEE, Carolyn S

“…Increasing epithelial repair and regeneration may hasten resolution of lung injury in patients with the acute respiratory distress syndrome (ARDS). In animal…”
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Extravascular lung water indexed to predicted body weight is a novel predictor of intensive care unit mortality in patients with acute lung injury by Craig, Thelma R, Duffy, Martin J, Shyamsundar, Murali, McDowell, Cliona, McLaughlin, Brian, Elborn, J Stuart, McAuley, Daniel F

“…OBJECTIVES:Acute lung injury and the acute respiratory distress syndrome are characterized by noncardiogenic pulmonary edema, which can be assessed by…”
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Awake prone positioning in acute hypoxaemic respiratory failure: An international expert guidance by Pavlov, Ivan, Li, Jie, Kharat, Aileen, Luo, Jian, Ibarra-Estrada, Miguel, Perez, Yonatan, McNicolas, Bairbre, Poole, Daniele, Roca, Oriol, Vines, David, Tavernier, Elsa, Allen, Thérèse, Shyamsundar, Murali, Ehrmann, Stephan, Simpson, Steven Q., Guérin, Claude, Laffey, John G.

“…Awake prone positioning (APP) of non-intubated patients with acute hypoxaemic respiratory failure (AHRF) has been inconsistently adopted into routine care of…”
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High flow nasal oxygen for acute type two respiratory failure: a systematic review [version 1; peer review: 1 approved, 1 approved with reservations] by Alnajada, Asem Abdulaziz, Blackwood, Bronagh, Mobrad, Abdulmajeed, Akhtar, Adeel, Pavlov, Ivan, Shyamsundar, Murali

“…Background: Acute type two respiratory failure (AT2RF) is characterized by high carbon dioxide levels (PaCO 2 >6kPa). Non-invasive ventilation (NIV), the…”
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Realising the full potential of data-enabled trials in the UK: a call for action by Sydes, Matthew R, Barbachano, Yolanda, Bowman, Louise, Denwood, Tom, Farmer, Andrew, Garfield-Birkbeck, Steph, Gibson, Martin, Gulliford, Martin C, Harrison, David A, Hewitt, Catherine, Logue, Jennifer, Navaie, Will, Norrie, John, O'Kane, Martin, Quint, Jennifer K, Rycroft-Malone, Jo, Sheffield, Jonathan, Smeeth, Liam, Sullivan, Frank, Tizzard, Juliet, Walker, Paula, Wilding, John, Williamson, Paula R, Landray, Martin, Morris, Andrew, Walker, Rhoswyn R, Williams, Hywel C, Valentine, Janet

“…RationaleClinical trials are the gold standard for testing interventions. COVID-19 has further raised their public profile and emphasised the need to deliver…”
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Reply to Letter: “Effect of Simvastatin on Physiological and Biological Outcomes in Patients Undergoing Esophagectomy: A Randomized Placebo-controlled Trial” by Shyamsundar, Murali, McAuley, Daniel F, O’Kane, Cecilia M

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Management standards and burnout among surgeons in the United Kingdom by Houdmont, J, Daliya, P, Adiamah, A, Theophilidou, E, Hassard, J, Lobo, D N

“…Abstract Background Burnout arising from chronic work-related stress is endemic among surgeons in the UK. Identification of contributory and modifiable…”
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