Search Results - "SHTIEGMAN, K"

Defective ubiquitinylation of EGFR mutants of lung cancer confers prolonged signaling by SHTIEGMAN, K, KOCHUPURAKKAL, B. S, BENJAMIN, S, CORSO, S, GAN, J, YOSEF, R. B, GIORDANO, S, YARDEN, Y, ZWANG, Y, PINES, G, STARR, A, VEXLER, A, CITRI, A, KATZ, M, LAVI, S, BEN-BASAT, Y

“…Several distinct mutations within the kinase domain of the epidermal growth factor receptor (EGFR) are associated with non-small cell lung cancer, but…”
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A mutant EGF-receptor defective in ubiquitylation and endocytosis unveils a role for Grb2 in negative signaling by Waterman, H., Katz, M., Rubin, C., Shtiegman, K., Lavi, S., Elson, A., Jovin, T., Yarden, Y.

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Endocytosis of Receptor Tyrosine Kinases Is Driven by Monoubiquitylation, Not Polyubiquitylation by Mosesson, Yaron, Shtiegman, Keren, Katz, Menachem, Zwang, Yaara, Vereb, Gyorgi, Szollosi, Janos, Yarden, Yosef

“…Growth factors stimulate specific receptor tyrosine kinases, but subsequent receptor endocytosis terminates signaling. The ubiquitin ligase c-Cbl targets…”
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A mutant EGF-receptor defective in ubiquitylation and endocytosis unveils a role for Grb2 in negative signaling by Waterman, Hadassa, Katz, Menachem, Rubin, Chanan, Shtiegman, Keren, Lavi, Sara, Elson, Ari, Jovin, Thomas, Yarden, Yosef

“…Ligand‐induced desensitization of the epidermal growth factor receptor (EGFR) is controlled by c‐Cbl, a ubiquitin ligase that binds multiple signaling…”
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The role of ubiquitylation in signaling by growth factors: implications to cancer by Shtiegman, Keren, Yarden, Yosef

“…Cancer cells depend on multiple, locally produced growth factors. Signaling by growth factors entails phosphorylation events, and its termination is determined…”
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Tal, a Tsg101-specific E3 ubiquitin ligase, regulates receptor endocytosis and retrovirus budding by Amit, Ido, Yakir, Liat, Katz, Menachem, Zwang, Yaara, Marmor, Mina D, Citri, Ami, Shtiegman, Keren, Alroy, Iris, Tuvia, Shmuel, Reiss, Yuval, Roubini, Eli, Cohen, Maya, Wides, Ron, Bacharach, Eran, Schubert, Ullrich, Yarden, Yosef

“…The tumor suppressor gene 101 (tsg101) regulates vesicular trafficking processes in yeast and mammals. We report a novel protein, Tal (Tsg101-associated…”
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Ligand‐Independent Degradation of Epidermal Growth Factor Receptor Involves Receptor Ubiquitylation and Hgs, an Adaptor Whose Ubiquitin‐Interacting Motif Targets Ubiquitylation by Nedd4 by Katz, Menachem, Shtiegman, Keren, Tal‐Or, Pazit, Yakir, Liat, Mosesson, Yaron, Harari, Daniel, Machluf, Yossi, Asao, Hironobu, Jovin, Thomas, Sugamura, Kazuo, Yarden, Yosef

“…Ligand‐dependent endocytosis of the epidermal growth factor receptor (EGFR) involves recruitment of a ubiquitin ligase, and sorting of ubiquitylated receptors…”
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Voluntary Ethanol Consumption in Male Adolescent Hamsters Increases Testosterone and Aggression by Ferris, Craig F, Shtiegman, Keren, King, Jean A

“…The immediate and long-term biologic and behavioral consequences of voluntary ethanol (EtOH) exposure during male adolescence are unknown. In the present…”
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