Search Results - "SHRAM, Megan J"

Assessment of the physical dependence potential of difelikefalin: Randomized placebo-controlled study in patients receiving hemodialysis by Spencer, Robert H, Munera, Catherine, Shram, Megan J, Menzaghi, Frédérique

“…Difelikefalin is a selective kappa opioid receptor agonist approved for treating moderate-to-severe pruritus in adults undergoing hemodialysis (HD)…”
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The novel uncompetitive NMDA receptor antagonist esmethadone (REL-1017) has no meaningful abuse potential in recreational drug users by Shram, Megan J., Henningfield, Jack E., Apseloff, Glen, Gorodetzky, Charles W., De Martin, Sara, Vocci, Frank L., Sapienza, Frank L., Kosten, Thomas R., Huston, Jeff, Buchhalter, August, Ashworth, Judy, Lanier, Ryan, Folli, Franco, Mattarei, Andrea, Guidetti, Clotilde, Comai, Stefano, O’Gorman, Cedric, Traversa, Sergio, Inturrisi, Charles E., Manfredi, Paolo L., Pappagallo, Marco

“…Esmethadone (REL-1017) is the opioid-inactive dextro-isomer of methadone and a low-affinity, low-potency uncompetitive NMDA receptor antagonist. In a Phase 2,…”
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Evaluation of the abuse potential of difelikefalin, a selective kappa‐opioid receptor agonist, in recreational polydrug users by Shram, Megan J., Spencer, Robert H., Qian, Jenny, Munera, Catherine L., Lewis, Michael E., Henningfield, Jack E., Webster, Lynn, Menzaghi, Frédérique

“…Difelikefalin, a selective kappa‐opioid receptor agonist with limited central nervous system penetration, is being developed for the treatment of chronic…”
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Sex differences in yohimbine-induced increases in the reinforcing efficacy of nicotine in adolescent rats by Li, Sophia, Zou, Sheng, Coen, Kathleen, Funk, Douglas, Shram, Megan J., Lê, A.D.

“…Stress is an important factor in the initiation and maintenance of smoking in adolescents. Women are more vulnerable to the development of addiction to smoking…”
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Adolescent male Wistar rats are more responsive than adult rats to the conditioned rewarding effects of intravenously administered nicotine in the place conditioning procedure by Shram, Megan J., Lê, Anh D.

“…The initiation of smoking typically begins during adolescence, suggesting that nicotine may have different motivational effects during this developmental stage…”
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Differences in the In Vitro and In Vivo Pharmacokinetic Profiles of Once-Daily Modified-Release Methylphenidate Formulations in Canada: Examination of Current Bioequivalence Criteria by Shram, Megan J., PhD, Quinn, Anne Marie, MSc, Chen, Nancy, PhD, Faulknor, Janice, MD, Luong, Doanh, MSc, Sellers, Edward M., MD, PhD, Endrenyi, Laszlo, PhD

“…Abstract Background Current Canadian bioequivalence criteria rely on rate and extent of drug exposure, that is, Cmax and AUC. In the case of complex…”
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Use of Remifentanil in a Novel Clinical Paradigm to Characterize Onset and Duration of Opioid Blockade by Samidorphan, a Potent μ-Receptor Antagonist by Shram, Megan J, Silverman, Bernard, Ehrich, Elliot, Sellers, Edward M, Turncliff, Ryan

“…A novel clinical study design was used to evaluate the blockade of a selective short-acting μ-opioid agonist (remifentanil) in 24 opioid-experienced subjects…”
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Oral, intranasal, and intravenous abuse potential of serdexmethylphenidate, a novel prodrug of d-methylphenidate by Shram, Megan J., Setnik, Beatrice, Webster, Lynn, Guenther, Sven, Mickle, Travis C., Braeckman, Rene, Kanski, Jaroslaw, Martin, Andrea, Kelsh, Debra, Vince, Bradley D., Barrett, Andrew C.

“…Serdexmethylphenidate (SDX) chloride (Cl) is a novel prodrug of d-methylphenidate (d-MPH). These studies evaluated the abuse potential of SDX Cl when…”
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Assessment of Pharmacokinetic and Pharmacodynamic Interactions Between Albumin-Fused Mutated Butyrylcholinesterase and Intravenously Administered Cocaine in Recreational Cocaine Users by Shram, Megan J, Cohen-Barak, Orit, Chakraborty, Bijan, Bassan, Merav, Schoedel, Kerri A, Hallak, Hussein, Eyal, Eli, Weiss, Sivan, Gilgun-Serki, Yossi, Gilgun, Yossi, Sellers, Edward M, Faulknor, Janice, Spiegelstein, Ofer

“…Cocaine dependence presents a major public health issue, and to date, no pharmacotherapies are approved for its treatment. TV-1380 is a novel recombinant…”
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Identification of Optimal Measures of Human Abuse Potential: A Post Hoc Assessment of 19 Studies by Shram, Megan J., Levy-Cooperman, Naama, Ratcliffe, Sian, Mills, Catherine, Bartlett, Cynthia, Chen, Nancy, Setnik, Beatrice, Sellers, Edward M., Schoedel, Kerri A.

“…Human abuse potential studies include multiple measures to assess the subjective effects of central nervous system-active drugs. In this retrospective…”
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Abuse potential, pharmacokinetics, pharmacodynamics, and safety of intranasally administered crushed oxycodone HCl abuse-deterrent controlled-release tablets in recreational opioid users by Harris, Stephen C., Perrino, Peter J., Smith, Ira, Shram, Megan J., Colucci, Salvatore V., Bartlett, Cynthia, Sellers, Edward M.

“…The objective of this study was to evaluate abuse potential, pharmacokinetics, pharmacodynamics, and safety of intranasally administered, crushed reformulated…”
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Interaction of Ethanol and Oral ANS‐6637, a Selective ALDH2 Inhibitor in Males: A Randomized, Double‐Blind, Placebo‐Controlled, Single‐Ascending Dose Cohort Study by O’Malley, Stephanie S., Shram, Megan J., Levy‐Cooperman, Naama, Vince, Bradley, Strumph, Peter M., Diamond, Ivan, Blackburn, Brent K.

“…Background ANS‐6637, an orally bioavailable selective and reversible aldehyde dehydrogenase‐2 (ALDH2) inhibitor, is under development for drug and alcohol use…”
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Nicotine Self-Administration, Extinction Responding and Reinstatement in Adolescent and Adult Male Rats: Evidence Against a Biological Vulnerability to Nicotine Addiction during Adolescence by SHRAM, Megan J, FUNK, Douglas, ZHAOXIA LI, LE, Anh D

“…Initiation of smoking behavior typically occurs during adolescence and rarely occurs during adulthood. Despite this epidemiological evidence, relatively little…”
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Periadolescent and adult rats respond differently in tests measuring the rewarding and aversive effects of nicotine by SHRAM, Megan J, FUNK, Douglas, ZHAOXIA LI, LE, Anh D

“…Initiation of tobacco use typically begins during adolescence, and the nature of these first experiences with nicotine may affect the probability of continued…”
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Abuse Potential of Buprenorphine/Samidorphan Combination Compared to Buprenorphine and Placebo: A Phase 1 Randomized Controlled Trial by Pathak, Sanjeev, Vince, Bradley, Kelsh, Debra, Shram, Megan J., Setnik, Beatrice, Lu, Hong, Nangia, Narinder, Stanford, Arielle D., Ehrich, Elliot

“…Buprenorphine/samidorphan combination (BUP/SAM) is an opioid system modulator being investigated as adjunctive treatment for major depressive disorder. BUP/SAM…”
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Effects of stressors on the reinforcing efficacy of nicotine in adolescent and adult rats by Zou, Sheng, Funk, Douglas, Shram, Megan J., Lê, A. D.

“…Rationale and objectives Stress increases drug intake. This depends on the stressor, drug, and aspect of drug seeking assessed. The objectives of these…”
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Evaluation of the Abuse Potential of Extended Release Hydromorphone Versus Immediate Release Hydromorphone by SHRAM, Megan J, SATHYAN, Gayatri, KHANNA, Sarita, TUDOR, Iulia Cristina, NATH, Rajneesh, THIPPHAWONG, John, SELLERS, Edward M

“…Immediate release (IR) hydromorphone has experienced significant misuse and abuse. An extended release (ER) hydromorphone formulation has been developed to…”
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Age differences in the spontaneous acquisition of nicotine self-administration in male Wistar and Long–Evans rats by Shram, Megan J., Li, Zhaoxia, Lê, Anh D.

“…Rationale Epidemiological evidence suggests that adolescents may exhibit a unique susceptibility to the motivational effects of nicotine compared to adults. In…”
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Acute nicotine enhances c-fos mRNA expression differentially in reward-related substrates of adolescent and adult rat brain by Shram, Megan J., Funk, Douglas, Li, Zhaoxia, Lê, A.D.

“…A number of studies have demonstrated that adolescent rodents are more sensitive to the rewarding effects of nicotine compared to adults. To help determine the…”
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Pharmacokinetic and Pharmacodynamic Correlations From 2 Studies Evaluating Abuse Potential of Hydrocodone Extended‐Release Tablets by Schoedel, Kerri A., Gillespie, Michael, Levy‐Cooperman, Naama, Shram, Megan J., Rabinovich‐Guilatt, Laura

“…Pharmacokinetic (PK)/pharmacodynamic (PD) correlations were explored in 2 human abuse potential studies of orally and intranasally administered hydrocodone…”
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