Search Results - "SHOUKAS, Artin A"

Arginase inhibition restores NOS coupling and reverses endothelial dysfunction and vascular stiffness in old rats by Kim, Jae Hyung, Bugaj, Lukasz J, Oh, Young Jun, Bivalacqua, Trinity J, Ryoo, Sungwoo, Soucy, Kevin G, Santhanam, Lakshmi, Webb, Alanah, Camara, Andre, Sikka, Gautam, Nyhan, Daniel, Shoukas, Artin A, Ilies, Monica, Christianson, David W, Champion, Hunter C, Berkowitz, Dan E

“…Department of 1 Anesthesiology and Critical Care Medicine, Johns Hopkins Medical Institutions, Baltimore, Maryland; ; Department of 2 Biomedical Engineering,…”
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Arginase reciprocally regulates nitric oxide synthase activity and contributes to endothelial dysfunction in aging blood vessels by Berkowitz, Dan E., White, Ron, Li, Dechun, Minhas, Khalid M., Cernetich, Amy, Kim, Soonyul, Burke, Sean, Shoukas, Artin A., Nyhan, Daniel, Champion, Hunter C., Hare, Joshua M.

“…BACKGROUND: Although abnormal L-arginine NO signaling contributes to endothelial dysfunction in the aging cardiovascular system, the biochemical mechanisms…”
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Impaired shear stress-induced nitric oxide production through decreased NOS phosphorylation contributes to age-related vascular stiffness by Soucy, Kevin G, Ryoo, Sungwoo, Benjo, Alexandre, Lim, Hyun Kyo, Gupta, Gaurav, Sohi, Jayson S, Elser, Jeremy, Aon, Miguel A, Nyhan, Daniel, Shoukas, Artin A, Berkowitz, Dan E

“…Departments of 1 Biomedical Engineering and 2 Anesthesiology/Critical Care Medicine and 3 Institute of Molecular Cardiobiology, Johns Hopkins Medical…”
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Dietary inhibition of xanthine oxidase attenuates radiation-induced endothelial dysfunction in rat aorta by SOUCY, Kevin G, HYUN KYO LIM, SHOUKAS, Artin A, BERKOWITZ, Dan E, ATTARZADEH, David O, SANTHANAM, Lakshmi, JAE HYUNG KIM, BHUNIA, Anil K, SEVINC, Baris, RYOO, Sungwoo, VAZQUEZ, Marcelo E, NYHAN, Daniel

“…Radiation exposure is associated with the development of various cardiovascular diseases. Although irradiation is known to cause elevated oxidant stress and…”
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Arginase Modulates Myocardial Contractility by a Nitric Oxide Synthase 1-Dependent Mechanism by Steppan, Jochen, Ryoo, Sungwoo, Schuleri, Karl H., Gregg, Chris, Hasan, Rani K., White, A. Ron, Bugaj, Lukasz J., Khan, Mehnaz, Santhanam, Lakshmi, Nyhan, Daniel, Shoukas, Artin A., Hare, Joshua M., Berkowitz, Dan E.

“…Cardiac myocytes contain two constitutive NO synthase (NOS) isoforms with distinct spatial locations, which allows for isoformspecific regulation. One…”
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Measuring ascending aortic stiffness in vivo in mice using ultrasound by Kuo, Maggie M, Barodka, Viachaslau, Abraham, Theodore P, Steppan, Jochen, Shoukas, Artin A, Butlin, Mark, Avolio, Alberto, Berkowitz, Dan E, Santhanam, Lakshmi

“…We present a protocol for measuring in vivo aortic stiffness in mice using high-resolution ultrasound imaging. Aortic diameter is measured by ultrasound and…”
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Early changes in vasoreactivity after simulated microgravity are due to an upregulation of the endothelium-dependent nitric oxide/cGMP pathway by White, Anthony R., Ryoo, Sungwoo, Bugaj, Lukasz, Attarzadeh, David O., Thiyagarajan, Srikanth, Chen, Kexun, Attwater, Sarah, Abbot, Bryce, Li, Dechun, Champion, Hunter C., Shoukas, Artin A., Nyhan, Daniel, Hare, Joshua M., Berkowitz, Dan E., Tuday, Eric C.

“…Emerging evidence suggests that nitric oxide (NO) plays a pivotal role in the mechanism of vascular hyporesponsiveness contributing to microgravity-induced…”
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MPST but not CSE is the primary regulator of hydrogen sulfide production and function in the coronary artery by Kuo, Maggie M, Kim, Dae Hee, Jandu, Sandeep, Bergman, Yehudit, Tan, Siqi, Wang, Huilei, Pandey, Deepesh R, Abraham, Theodore P, Shoukas, Artin A, Berkowitz, Dan E, Santhanam, Lakshmi

“…Hydrogen sulfide (H2S) has emerged as an important gasotransmitter in the vasculature. In this study, we tested the hypothesis that H2S contributes to coronary…”
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Single exposure gamma-irradiation amplifies xanthine oxidase activity and induces endothelial dysfunction in rat aorta by Soucy, Kevin G, Lim, Hyun Kyo, Benjo, Alexandre, Santhanam, Lakshmi, Ryoo, Sungwoo, Shoukas, Artin A, Vazquez, Marcelo E, Berkowitz, Dan E

“…Irradiation of the heart and vasculature can cause a spectrum of cardiovascular complications, including increased risk of myocardial infarction or coronary…”
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Simulated microgravity produces attenuated baroreflex-mediated pressor, chronotropic, and inotropic responses in mice by Jung, Albert S, Harrison, Robert, Lee, Kwang H, Genut, Jordan, Nyhan, Daniel, Brooks-Asplund, E M, Shoukas, Artin A, Hare, Joshua M, Berkowitz, Dan E

“…Whether myocardial contractile impairment contributes to orthostatic intolerance (OI) is controversial. Accordingly, we used transient bilateral carotid…”
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Knockdown of Arginase I Restores NO Signaling in the Vasculature of Old Rats by White, Anthony R, Ryoo, Sungwoo, Li, Dechun, Champion, Hunter C, Steppan, Jochen, Wang, Danming, Nyhan, Daniel, Shoukas, Artin A, Hare, Joshua M, Berkowitz, Dan E

“…Arginase, expressed in endothelial cells and upregulated in aging blood vessels, competes with NO synthase (NOS) for l-arginine, thus modulating vasoreactivity…”
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Alagebrium in combination with exercise ameliorates age-associated ventricular and vascular stiffness by Steppan, Jochen, Tran, Huang, Benjo, Alexandre M., Pellakuru, Laxsmi, Barodka, Viachaslau, Ryoo, Sungwoo, Nyhan, Sineád M., Lussman, Craig, Gupta, Gaurav, White, Anthony R., Daher, Joao P., Shoukas, Artin A., Levine, Benjamin D., Berkowitz, Dan E.

“…Advanced glycation end-products (AGEs) initiate cellular inflammation and contribute to cardiovascular disease in the elderly. AGE can be inhibited by…”
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Simulated microgravity-induced aortic remodeling by Tuday, Eric C, Nyhan, Daniel, Shoukas, Artin A, Berkowitz, Dan E

“…1 Department of Biomedical Engineering and 2 Department of Anesthesiology and Critical Care Medicine, Johns Hopkins University School of Medicine, Baltimore,…”
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Upregulation of arginase-II contributes to decreased age-related myocardial contractile reserve by Khan, Mehnaz, Steppan, Jochen, Schuleri, Karl, Ryoo, Sungwoo, Tuday, Eric, Bugaj, Lukasz, Santhanam, Lakshmi, Berkowitz, Tal, Nyhan, Daniel, Shoukas, Artin A., Berkowitz, Dan E.

“…Arginase-II (Arg-II) reciprocally regulates nitric oxide synthase (NOS) and offsets basal myocardial contractility. Furthermore, decreased or absent myocardial…”
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Nitric Oxide Regulation of Myocardial Contractility and Calcium Cycling: Independent Impact of Neuronal and Endothelial Nitric Oxide Synthases by Khan, Shakil A, Skaf, Michel W, Harrison, Robert W, Lee, Kwangho, Minhas, Khalid M, Kumar, Anil, Fradley, Mike, Shoukas, Artin A, Berkowitz, Dan E, Hare, Joshua M

“…ABSTRACT—The mechanisms by which nitric oxide (NO) influences myocardial Ca cycling remain controversial. Because NO synthases (NOS) have specific spatial…”
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Microgravity-induced changes in aortic stiffness and their role in orthostatic intolerance by Tuday, Eric C, Meck, Janice V, Nyhan, Daniel, Shoukas, Artin A, Berkowitz, Dan E

“…Departments of 1 Biomedical Engineering and of 2 Anesthesiology and Critical Care Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland;…”
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Cyclohexanone contamination from extracorporeal circuits impairs cardiovascular function by Thompson-Torgerson, Caitlin S, Champion, Hunter C, Santhanam, Lakshmi, Harris, Z Leah, Shoukas, Artin A

“…Extracorporeal circulation provides critical life support in the face of cardiopulmonary or renal failure, but it also introduces a host of unique morbidities…”
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Vasopressin-Mediated Enhancement of Adrenergic Vasoconstriction Involves Both the Tyrosine Kinase and the Protein Kinase C Pathways by Steppan, Jochen, Nyhan, Sineád M., Sikka, Gautam, Uribe, Jorge, Ahuja, Ayushi, White, Anthony R., Shoukas, Artin A., Berkowitz, Dan E.

“…Vasopressin is frequently used to treat catecholamine-resistant vasodilatory shock. It enhances the vasoconstrictor effects of catecholamines at concentrations…”
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Erratum to: Upregulation of arginase-II contributes to decreased age-related myocardial contractile reserve by Khan, Mehnaz, Steppan, Jochen, Schuleri, Karl H., Ryoo, Sungwoo, Tuday, Eric, Bugaj, Lukasz, Santhanam, Lakshmi, Berkowitz, Tal, Nyhan, Daniel, Shoukas, Artin A., Berkowitz, Dan E.

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Chronic isolation of carotid sinus baroreceptor region in conscious normotensive and hypertensive rats by McKeown, K P, Shoukas, A A

“…We have developed a chronic technique to isolate the carotid sinus baroreceptor region in the conscious rat model. Our technique, when used in conjunction with…”
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