Search Results - "SHOUKAS, Artin A"
-
1
Arginase inhibition restores NOS coupling and reverses endothelial dysfunction and vascular stiffness in old rats
Published in Journal of applied physiology (1985) (01-10-2009)“…Department of 1 Anesthesiology and Critical Care Medicine, Johns Hopkins Medical Institutions, Baltimore, Maryland; ; Department of 2 Biomedical Engineering,…”
Get full text
Journal Article -
2
Arginase reciprocally regulates nitric oxide synthase activity and contributes to endothelial dysfunction in aging blood vessels
Published in Circulation (New York, N.Y.) (21-10-2003)“…BACKGROUND: Although abnormal L-arginine NO signaling contributes to endothelial dysfunction in the aging cardiovascular system, the biochemical mechanisms…”
Get full text
Journal Article -
3
Impaired shear stress-induced nitric oxide production through decreased NOS phosphorylation contributes to age-related vascular stiffness
Published in Journal of applied physiology (1985) (01-12-2006)“…Departments of 1 Biomedical Engineering and 2 Anesthesiology/Critical Care Medicine and 3 Institute of Molecular Cardiobiology, Johns Hopkins Medical…”
Get full text
Journal Article -
4
Dietary inhibition of xanthine oxidase attenuates radiation-induced endothelial dysfunction in rat aorta
Published in Journal of applied physiology (1985) (01-05-2010)“…Radiation exposure is associated with the development of various cardiovascular diseases. Although irradiation is known to cause elevated oxidant stress and…”
Get full text
Journal Article -
5
Arginase Modulates Myocardial Contractility by a Nitric Oxide Synthase 1-Dependent Mechanism
Published in Proceedings of the National Academy of Sciences - PNAS (21-03-2006)“…Cardiac myocytes contain two constitutive NO synthase (NOS) isoforms with distinct spatial locations, which allows for isoformspecific regulation. One…”
Get full text
Journal Article -
6
Measuring ascending aortic stiffness in vivo in mice using ultrasound
Published in Journal of visualized experiments (02-12-2014)“…We present a protocol for measuring in vivo aortic stiffness in mice using high-resolution ultrasound imaging. Aortic diameter is measured by ultrasound and…”
Get full text
Journal Article -
7
Early changes in vasoreactivity after simulated microgravity are due to an upregulation of the endothelium-dependent nitric oxide/cGMP pathway
Published in European journal of applied physiology (01-09-2010)“…Emerging evidence suggests that nitric oxide (NO) plays a pivotal role in the mechanism of vascular hyporesponsiveness contributing to microgravity-induced…”
Get full text
Journal Article -
8
MPST but not CSE is the primary regulator of hydrogen sulfide production and function in the coronary artery
Published in American journal of physiology. Heart and circulatory physiology (01-01-2016)“…Hydrogen sulfide (H2S) has emerged as an important gasotransmitter in the vasculature. In this study, we tested the hypothesis that H2S contributes to coronary…”
Get more information
Journal Article -
9
Single exposure gamma-irradiation amplifies xanthine oxidase activity and induces endothelial dysfunction in rat aorta
Published in Radiation and environmental biophysics (01-06-2007)“…Irradiation of the heart and vasculature can cause a spectrum of cardiovascular complications, including increased risk of myocardial infarction or coronary…”
Get full text
Journal Article -
10
Simulated microgravity produces attenuated baroreflex-mediated pressor, chronotropic, and inotropic responses in mice
Published in American journal of physiology. Heart and circulatory physiology (01-08-2005)“…Whether myocardial contractile impairment contributes to orthostatic intolerance (OI) is controversial. Accordingly, we used transient bilateral carotid…”
Get more information
Journal Article -
11
Knockdown of Arginase I Restores NO Signaling in the Vasculature of Old Rats
Published in Hypertension (Dallas, Tex. 1979) (01-02-2006)“…Arginase, expressed in endothelial cells and upregulated in aging blood vessels, competes with NO synthase (NOS) for l-arginine, thus modulating vasoreactivity…”
Get full text
Journal Article -
12
Alagebrium in combination with exercise ameliorates age-associated ventricular and vascular stiffness
Published in Experimental gerontology (01-08-2012)“…Advanced glycation end-products (AGEs) initiate cellular inflammation and contribute to cardiovascular disease in the elderly. AGE can be inhibited by…”
Get full text
Journal Article -
13
Simulated microgravity-induced aortic remodeling
Published in Journal of applied physiology (1985) (01-06-2009)“…1 Department of Biomedical Engineering and 2 Department of Anesthesiology and Critical Care Medicine, Johns Hopkins University School of Medicine, Baltimore,…”
Get full text
Journal Article -
14
Upregulation of arginase-II contributes to decreased age-related myocardial contractile reserve
Published in European journal of applied physiology (01-08-2012)“…Arginase-II (Arg-II) reciprocally regulates nitric oxide synthase (NOS) and offsets basal myocardial contractility. Furthermore, decreased or absent myocardial…”
Get full text
Journal Article -
15
Nitric Oxide Regulation of Myocardial Contractility and Calcium Cycling: Independent Impact of Neuronal and Endothelial Nitric Oxide Synthases
Published in Circulation research (27-06-2003)“…ABSTRACT—The mechanisms by which nitric oxide (NO) influences myocardial Ca cycling remain controversial. Because NO synthases (NOS) have specific spatial…”
Get full text
Journal Article -
16
Microgravity-induced changes in aortic stiffness and their role in orthostatic intolerance
Published in Journal of applied physiology (1985) (01-03-2007)“…Departments of 1 Biomedical Engineering and of 2 Anesthesiology and Critical Care Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland;…”
Get full text
Journal Article -
17
Cyclohexanone contamination from extracorporeal circuits impairs cardiovascular function
Published in American journal of physiology. Heart and circulatory physiology (01-06-2009)“…Extracorporeal circulation provides critical life support in the face of cardiopulmonary or renal failure, but it also introduces a host of unique morbidities…”
Get more information
Journal Article -
18
Vasopressin-Mediated Enhancement of Adrenergic Vasoconstriction Involves Both the Tyrosine Kinase and the Protein Kinase C Pathways
Published in Anesthesia and analgesia (01-12-2012)“…Vasopressin is frequently used to treat catecholamine-resistant vasodilatory shock. It enhances the vasoconstrictor effects of catecholamines at concentrations…”
Get full text
Journal Article -
19
Erratum to: Upregulation of arginase-II contributes to decreased age-related myocardial contractile reserve
Published in European journal of applied physiology (01-12-2012)Get full text
Journal Article -
20
Chronic isolation of carotid sinus baroreceptor region in conscious normotensive and hypertensive rats
Published in The American journal of physiology (01-07-1998)“…We have developed a chronic technique to isolate the carotid sinus baroreceptor region in the conscious rat model. Our technique, when used in conjunction with…”
Get full text
Journal Article