Search Results - "SHONE, C. C"

Molecular features of the sortase enzyme family by Bradshaw, William J, Davies, Abigail H, Chambers, Christopher J, Roberts, April K, Shone, Clifford C, Acharya, K. Ravi

“…Bacteria possess complex and varying cell walls with many surface exposed proteins. Sortases are responsible for the covalent attachment of specific proteins…”
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Thioredoxin and Its Reductase Are Present on Synaptic Vesicles, and Their Inhibition Prevents the Paralysis Induced by Botulinum Neurotoxins by Pirazzini, Marco, Azarnia Tehran, Domenico, Zanetti, Giulia, Megighian, Aram, Scorzeto, Michele, Fillo, Silvia, Shone, Clifford C., Binz, Thomas, Rossetto, Ornella, Lista, Florigio, Montecucco, Cesare

“…Botulinum neurotoxins consist of a metalloprotease linked via a conserved interchain disulfide bond to a heavy chain responsible for neurospecific binding and…”
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Super toxins from a super bug: structure and function of Clostridium difficile toxins by Davies, Abigail H, Roberts, April K, Shone, Clifford C, Acharya, K Ravi

“…Clostridium difficile, a highly infectious bacterium, is the leading cause of antibiotic-associated pseudomembranous colitis. In 2009, the number of death…”
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A Novel, Orally Delivered Antibody Therapy and Its Potential to Prevent Clostridioides difficile Infection in Pre-clinical Models by Roberts, April K., Harris, Hannah C., Smith, Michael, Giles, Joanna, Polak, Oktawia, Buckley, Anthony M., Clark, Emma, Ewin, Duncan, Moura, Ines B., Spitall, William, Shone, Clifford C., Wilcox, Mark, Chilton, Caroline, Donev, Rossen

“…Clostridioides difficile infection (CDI) is a toxin-mediated infection in the gut and a major burden on healthcare facilities worldwide. We rationalized that…”
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Cwp84, a Surface-associated Cysteine Protease, Plays a Role in the Maturation of the Surface Layer of Clostridium difficile by Kirby, Jonathan M., Ahern, Helen, Roberts, April K., Kumar, Vivek, Freeman, Zoe, Acharya, K.Ravi, Shone, Clifford C.

“…Clostridium difficile is a major and growing problem as a hospital-associated infection that can cause severe, recurrent diarrhea. The mechanism by which the…”
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The structure of the S-layer of Clostridium difficile by Bradshaw, William J., Roberts, April K., Shone, Clifford C., Acharya, K. Ravi

“…The nosocomially acquired pathogen Clostridium difficile is the primary causative agent of antibiotic associated diarrhoea and causes tens of thousands of…”
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Structure and function of a Clostridium difficile sortase enzyme by Chambers, Christopher J., Roberts, April K., Shone, Clifford C., Acharya, K. Ravi

“…Sortase enzymes are responsible for covalent anchoring of specific proteins to the peptidoglycan of the cell wall of gram-positive bacteria. In some…”
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Genomes of Escherichia coli bacteraemia isolates originating from urinary tract foci contain more virulence-associated genes than those from non-urinary foci and neutropaenic hosts by Dale, Adam P., Pandey, Anish K., Hesp, Richard J., Belogiannis, Konstantinos, Laver, Jay R., Shone, Clifford C., Read, Robert C.

“…Escherichia coli is the leading cause of bacteraemia. In an era of emerging multi-drug-resistant strains, development of effective preventative strategies will…”
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The thioredoxin reductase – Thioredoxin redox system cleaves the interchain disulphide bond of botulinum neurotoxins on the cytosolic surface of synaptic vesicles by Pirazzini, Marco, Tehran, Domenico Azarnia, Zanetti, Giulia, Lista, Florigio, Binz, Thomas, Shone, Clifford C., Rossetto, Ornella, Montecucco, Cesare

“…Botulinum neurotoxins (BoNTs) are Janus toxins, as they are at the same time the most deadly substances known and one of the safest drugs used in human…”
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A Novel Inhibitor Prevents the Peripheral Neuroparalysis of Botulinum Neurotoxins by Azarnia Tehran, Domenico, Zanetti, Giulia, Leka, Oneda, Lista, Florigio, Fillo, Silvia, Binz, Thomas, Shone, Clifford C., Rossetto, Ornella, Montecucco, Cesare, Paradisi, Cristina, Mattarei, Andrea, Pirazzini, Marco

“…Botulinum neurotoxins (BoNTs) form a large class of potent and deadly neurotoxins. Given their growing number, it is of paramount importance to discover novel…”
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Protective antibodies against Clostridium difficile are present in intravenous immunoglobulin and are retained in humans following its administration by Negm, O. H., MacKenzie, B., Hamed, M. R., Ahmad, O. A. J., Shone, C. C., Humphreys, D. P., Ravi Acharya, K., Loscher, C. E., Marszalowska, I., Lynch, M., Wilcox, M. H., Monaghan, T. M.

“…Summary The prevalence of serum antibodies against Clostridium difficile (CD) toxins A and B in healthy populations have prompted interest in evaluating the…”
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Structural Basis for Substrate Recognition in the Enzymatic Component of ADP-ribosyltransferase Toxin CDTa from Clostridium difficile by Sundriyal, Amit, Roberts, April K., Shone, Clifford C., Acharya, K.Ravi

“…ADP-ribosylation is one of the favored modes of cell intoxication employed by several bacteria. Clostridium difficile is recognized to be an important…”
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Preparation of gasification feedstock from leafy biomass by Shone, C. M., Jothi, T. J. S.

“…Dried leaves are a potential source of energy although these are not commonly used beside to satisfy daily energy demands in rural areas. This paper aims at…”
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Botulinum neurotoxin serotype F is a zinc endopeptidase specific for VAMP/synaptobrevin by SCHIAVO, G, SHONE, C. C, ROSSETTO, O, ALEXANDER, F. C. G, MONTECUCCO, C

“…Botulinum neurotoxin serotype F contains the zinc binding motif of zinc endopeptidases. Atomic adsorption analysis of highly purified toxin preparation…”
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Confocal Endomicroscopy of Neuromuscular Junctions Stained with Physiologically Inert Protein Fragments of Tetanus Toxin by Roesl, Cornelia, Evans, Elizabeth R, Dissanayake, Kosala N, Boczonadi, Veronika, Jones, Ross A, Jordan, Graeme R, Ledahawsky, Leire, Allen, Guy C C, Scott, Molly, Thomson, Alanna, Wishart, Thomas M, Hughes, David I, Mead, Richard J, Shone, Clifford C, Slater, Clarke R, Gillingwater, Thomas H, Skehel, Paul A, Ribchester, Richard R

“…Live imaging of neuromuscular junctions (NMJs) in situ has been constrained by the suitability of ligands for inert vital staining of motor nerve terminals…”
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assay for botulinum toxin types A, B and F that requires both functional binding and catalytic activities within the neurotoxin by Evans, E.R, Skipper, P.J.A, Shone, C.C

“…To develop a novel assay technique for the botulinum neurotoxin family (BoNTs) which is dependent on both the endopeptidase and receptor-binding activities of…”
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Expression, purification and cell cytotoxicity of actin-modifying binary toxin from Clostridium difficile by Sundriyal, Amit, Roberts, April K., Ling, Roger, McGlashan, Joanna, Shone, Clifford C., Acharya, K. Ravi

“…Clostridium difficile infection (CDI) is a serious problem within the healthcare environment where the bacterium causes symptoms ranging from mild diarrhoea to…”
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Crossover clustering and rapid decay of linkage disequilibrium in the Xp/Yp pseudoautosomal gene SHOX by May, Celia A, Shone, Angela C, Kalaydjieva, Luba, Sajantila, Antti, Jeffreys, Alec J

“…Crossover between the human sex chromosomes during male meiosis is restricted to the terminal pseudoautosomal pairing regions. An obligatory exchange occurs in…”
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Inhibition of release of neurotransmitters from rat dorsal root ganglia by a novel conjugate of a Clostridium botulinum toxin A endopeptidase fragment and Erythrina cristagalli lectin by Duggan, Michael J, Quinn, Conrad P, Chaddock, John A, Purkiss, John R, Alexander, Frances C G, Doward, Sarah, Fooks, Sarah J, Friis, Lorna M, Hall, Yper H J, Kirby, Elizabeth R, Leeds, Nicola, Moulsdale, Hilary J, Dickenson, Anthony, Green, G Mark, Rahman, Wahida, Suzuki, Rie, Shone, Clifford C, Foster, Keith A

“…Clostridial neurotoxins potently and specifically inhibit neurotransmitter release in defined cell types. Here we report that a catalytically active derivative…”
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Development of novel assays for botulinum type A and B neurotoxins based on their endopeptidase activities by Hallis, B. (Centre for Applied Microbiology and Research, Salisbury, Wiltshire, UK.), James, B.A.F, Shone, C.C

“…A novel assay method based on the endopeptidase activities of the botulinum neurotoxins has been developed and applied to the detection of botulinum type A and…”
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